NO20035721L - 1,2,4-trioksolan-antimalariamidler - Google Patents
1,2,4-trioksolan-antimalariamidlerInfo
- Publication number
- NO20035721L NO20035721L NO20035721A NO20035721A NO20035721L NO 20035721 L NO20035721 L NO 20035721L NO 20035721 A NO20035721 A NO 20035721A NO 20035721 A NO20035721 A NO 20035721A NO 20035721 L NO20035721 L NO 20035721L
- Authority
- NO
- Norway
- Prior art keywords
- trioxolane
- group
- trioxolanes
- spirocyclohexyl
- antimalarials
- Prior art date
Links
- 239000003430 antimalarial agent Substances 0.000 title 1
- 229940033495 antimalarials Drugs 0.000 title 1
- 201000004792 malaria Diseases 0.000 abstract 2
- MAAKQSASDHJHIR-UHFFFAOYSA-N trioxolane Chemical group C1COOO1 MAAKQSASDHJHIR-UHFFFAOYSA-N 0.000 abstract 2
- RZYIPLSVRHWROD-UHFFFAOYSA-N 1,2,4-trioxolane Chemical class C1OCOO1 RZYIPLSVRHWROD-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- BLUAFEHZUWYNDE-NNWCWBAJSA-N artemisinin Chemical class C([C@](OO1)(C)O2)C[C@H]3[C@H](C)CC[C@@H]4[C@@]31[C@@H]2OC(=O)[C@@H]4C BLUAFEHZUWYNDE-NNWCWBAJSA-N 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 244000045947 parasite Species 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 201000004409 schistosomiasis Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A61P33/12—Schistosomicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D323/00—Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
- C07D323/02—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Dental Preparations (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/886,666 US6486199B1 (en) | 2001-06-21 | 2001-06-21 | Spiro and dispiro 1,2,4-trioxolane antimalarials |
| PCT/US2002/019767 WO2003000676A1 (en) | 2001-06-21 | 2002-06-21 | 1,2,4-trioxolane antimalarials |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20035721D0 NO20035721D0 (no) | 2003-12-19 |
| NO20035721L true NO20035721L (no) | 2004-02-23 |
Family
ID=25389491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20035721A NO20035721L (no) | 2001-06-21 | 2003-12-19 | 1,2,4-trioksolan-antimalariamidler |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6486199B1 (de) |
| EP (1) | EP1414813B1 (de) |
| JP (1) | JP4303585B2 (de) |
| KR (1) | KR100759144B1 (de) |
| CN (1) | CN1545508B (de) |
| AT (1) | ATE339411T1 (de) |
| AU (1) | AU2002327183B2 (de) |
| BR (1) | BRPI0210549B8 (de) |
| CA (1) | CA2451006C (de) |
| CY (1) | CY1106214T1 (de) |
| DE (1) | DE60214733T8 (de) |
| DK (1) | DK1414813T3 (de) |
| ES (1) | ES2271323T3 (de) |
| HU (1) | HUP0400246A3 (de) |
| IL (1) | IL159474A0 (de) |
| MX (1) | MXPA03011915A (de) |
| NO (1) | NO20035721L (de) |
| PL (1) | PL226418B1 (de) |
| PT (1) | PT1414813E (de) |
| RU (1) | RU2271357C2 (de) |
| SI (1) | SI1414813T1 (de) |
| UA (1) | UA78709C2 (de) |
| WO (1) | WO2003000676A1 (de) |
| YU (1) | YU100703A (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE536887T1 (de) * | 2002-06-06 | 2011-12-15 | Univ Washington | Kovalente konjugate zwischen mit artemisinin verwandten endoperoxiden und eisentragenden proteinen und anwendungsverfahren |
| US7371778B2 (en) * | 2002-06-21 | 2008-05-13 | Medicines For Malaria Venture Mmv | Spiro and dispiro 1,2,4-trioxolane antimalarials |
| US6825230B2 (en) * | 2002-06-21 | 2004-11-30 | Medicines For Malaria Venture Mmv | Spiro and dispiro 1,2,4-trixolane antimalarials |
| US20080125441A1 (en) * | 2002-06-21 | 2008-05-29 | Medicines For Malaria Venture Mmv | Spiro and dispiro 1,2,4-trioxolane antimalarials |
| US6906205B2 (en) * | 2002-06-21 | 2005-06-14 | Medicines For Malaria Venture Mmv | Spiro and dispiro 1,2,4-trioxolane antimalarials |
| FR2862304A1 (fr) * | 2003-11-14 | 2005-05-20 | Centre Nat Rech Scient | Molecules duales racemiques ou achirales contenant un derive peroxydique, leur synthese et leurs applications therapeutiques |
| WO2006010362A1 (de) * | 2004-07-23 | 2006-02-02 | Justus-Liebig-Universität Giessen | Aminoadamantan-derivate, verfahren zu ihrer herstellung und ihre verwendung |
| US20060040761A1 (en) * | 2004-08-23 | 2006-02-23 | Sam-Kyu Shin | Scale mark mat for putting practice |
| US8067620B2 (en) * | 2005-05-04 | 2011-11-29 | Medicines For Malaria Venture Mmv | Dispiro 1,2,4-trioxolane antimalarials |
| CN101272777B (zh) * | 2005-05-18 | 2013-01-30 | 兰贝克赛实验室有限公司 | 螺和二螺1,2,4-三氧戊环抗疟药的稳定剂型 |
| WO2007036947A1 (en) * | 2005-09-30 | 2007-04-05 | Ipca Laboratories Limited | Delayed release anti-malarial composition |
| WO2007039915A1 (en) | 2005-10-04 | 2007-04-12 | The Director General, Defence Research And Development Organisation | Anti-malarial compound isolated from gomphostema niveum |
| US20070231300A1 (en) * | 2006-03-28 | 2007-10-04 | Washington, University Of | Covalent conjugates between endoperoxides and transferrin and lactoferrin receptor-binding agents |
| BRPI0709961A2 (pt) | 2006-04-11 | 2011-08-02 | Novartis Ag | compostos orgánicos |
| AP2525A (en) * | 2006-05-17 | 2012-12-05 | Ranbaxy Lab Ltd | Antimarial therapy using a combination of synthetic artemisinin derivative and bisquinoline derivative |
| US8569519B2 (en) * | 2006-05-24 | 2013-10-29 | Ranbaxy Laboratories Limited | Process for the preparation of dispiro 1,2,4-trioxolane antimalarials (OZ277) |
| FR2902100A1 (fr) * | 2006-06-13 | 2007-12-14 | Sanofi Aventis Sa | Molecules duales contenant un derive peroxydique, leur synthese et leurs applications en therapeutique |
| GB0619333D0 (en) * | 2006-09-30 | 2006-11-08 | Univ Liverpool | Dispiro tetraoxane compounds |
| WO2008046109A2 (en) * | 2006-10-13 | 2008-04-17 | University Of Washington | Conjugates of artemisinin-related endoperoxides and hydrazone derivatives for the treatment of cancer |
| FR2924343A1 (fr) * | 2007-12-04 | 2009-06-05 | Palumed Sa | Nouvelles utilisations therapeutiques de molecules duales contenant un derive peroxydique. |
| US20110172445A1 (en) * | 2008-07-01 | 2011-07-14 | National University Corporation Okayama University | Novel Antischistosomal Agent |
| US8618096B2 (en) | 2008-07-21 | 2013-12-31 | The Regents Of The University Of California | Prodrug compositions and methods for using the same in treating cancer and malaria |
| CN103930107A (zh) | 2011-07-14 | 2014-07-16 | 兰贝克赛实验室有限公司 | 青蒿氧烷和哌喹的稳定剂型 |
| CA2937752C (en) * | 2014-02-14 | 2023-02-07 | The Regents Of The University Of California | Cyclic peroxides as prodrugs for selective delivery of agents |
| AU2015370911B2 (en) * | 2014-12-23 | 2020-07-09 | Bergenbio Asa | Inhibitors of Akt kinase |
| RU2601315C1 (ru) * | 2015-06-10 | 2016-11-10 | Федеральное государственное бюджетное учреждение науки Институт нефтехимии и катализа Российской академии наук | Способ получения пентаоксаспироалканов |
| WO2019005977A1 (en) * | 2017-06-27 | 2019-01-03 | The Regents Of The University Of California | TRIOXOLANE AGENTS |
| CN108424371B (zh) * | 2018-01-19 | 2021-07-16 | 北京理工大学 | 2-(4-氨基环己基)-乙酸乙酯的制备方法 |
| US20210386814A1 (en) * | 2020-05-20 | 2021-12-16 | Amanuel Tesfazion | Methods and compound for the treatment of malaria |
| WO2022161490A1 (en) * | 2021-02-01 | 2022-08-04 | Dan Yang | Targeted delivery of 1, 2, 4, 5-tetraoxane compounds and their uses |
| CN117085004B (zh) * | 2023-09-27 | 2026-06-16 | 赣南师范大学 | 一种2,6-二苯亚甲基环己酮类似物在制备抗血吸虫药物中的应用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3621062A (en) | 1966-10-25 | 1971-11-16 | Sterling Drug Inc | 2-(8-cyclohexyloctanoyl or 7-cyclohexylheptanoyl)-1-naphthol |
| US3673222A (en) | 1969-11-26 | 1972-06-27 | Sydney Archer | 2-(8-cyclohexyloctyl or 7-cyclohexylheptyl)-1,4-naphthoquinone and process for preparation and use thereof |
| US3682991A (en) | 1970-10-19 | 1972-08-08 | Sterling Drug Inc | 3,3,5-trimethylcyclohexyl-alkyl-carboxylic acids |
| SU1421743A1 (ru) * | 1987-02-18 | 1988-09-07 | Физико-химический институт им.А.В.Богатского | Способ получени 11-нитро-12- @ (2-метокси)-этокси @ -бензо-9-краун-3 |
| US4916204A (en) | 1987-07-31 | 1990-04-10 | Massachusetts Institute Of Technology | Pure polyanhydride from dicarboxylic acid and coupling agent |
| US4816478A (en) | 1987-08-24 | 1989-03-28 | Thornfeldt Carl R | Treatment of acquired immunodeficiency syndrome |
| US5053342A (en) | 1987-12-24 | 1991-10-01 | Litmus Concepts, Inc. | Fecal occult blood test reagents |
| US5559145A (en) | 1988-06-01 | 1996-09-24 | Oxaco S.A. | 1,2,4-trioxane derivatives |
| US5270344A (en) | 1988-06-24 | 1993-12-14 | Stephen Herman | Method of treating a systemic disorder using trioxolane and diperoxide compounds |
| JP2867529B2 (ja) | 1990-01-22 | 1999-03-08 | 三菱電機株式会社 | 投写型表示装置 |
| US5216175A (en) | 1990-03-23 | 1993-06-01 | Sri International | Antimalarial analogs of artemisinin |
| US5219880A (en) | 1991-03-29 | 1993-06-15 | Dermatologic Research Corporation | Treatment of viral tumors and hemorrhoids with artemisinin and derivatives |
| DE4125201C1 (de) * | 1991-07-30 | 1992-10-01 | Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung Ev, 8000 Muenchen, De | |
| US5510356A (en) | 1991-10-03 | 1996-04-23 | University Of Nebraska Board Of Regents | Bisquinolines and processes for their production and use to treat malaria |
| US5171676A (en) | 1991-10-31 | 1992-12-15 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method of introducing hydroxyl groups into artemisinin and its derivatives |
| US5430148A (en) | 1992-03-31 | 1995-07-04 | Agouron Pharmaceuticals, Inc. | Antiproliferative quinazolines |
| BR9306816A (pt) | 1992-07-28 | 1998-12-08 | Procter & Gamble | Composição farmaceutica para uso tópico contendo um polímero catiônico reticulado e um eter alcoxilado |
| US5721209A (en) | 1995-02-03 | 1998-02-24 | The Regents Of The University Of California | Iron chelator and inhibitor of iron-mediated oxidant injury |
| US5780675A (en) | 1995-04-28 | 1998-07-14 | The University Of New Mexico | Deoxygossylic compounds |
| US5578637A (en) | 1995-05-03 | 1996-11-26 | University Of Washington | Methods of inhibition or killing cancer cells using an endoperoxide |
| US5817692A (en) | 1995-11-22 | 1998-10-06 | The Johns Hopkins University | Endoperoxides useful as antiparasitic agents |
| US5672624A (en) | 1995-11-22 | 1997-09-30 | The Johns Hopkins University | Endoperoxides useful as antiparasitic agents |
| US5932591A (en) | 1996-12-02 | 1999-08-03 | Johns Hopkins University | C3 substituted trioxanes useful as antiparasitic drugs |
-
2001
- 2001-06-21 US US09/886,666 patent/US6486199B1/en not_active Expired - Lifetime
-
2002
- 2002-06-21 UA UA2004010426A patent/UA78709C2/uk unknown
- 2002-06-21 RU RU2004101409/04A patent/RU2271357C2/ru active
- 2002-06-21 AU AU2002327183A patent/AU2002327183B2/en not_active Expired
- 2002-06-21 EP EP02763208A patent/EP1414813B1/de not_active Expired - Lifetime
- 2002-06-21 BR BR0210549-7 patent/BRPI0210549B8/pt not_active IP Right Cessation
- 2002-06-21 PT PT02763208T patent/PT1414813E/pt unknown
- 2002-06-21 YU YU100703A patent/YU100703A/sh unknown
- 2002-06-21 HU HU0400246A patent/HUP0400246A3/hu unknown
- 2002-06-21 MX MXPA03011915A patent/MXPA03011915A/es active IP Right Grant
- 2002-06-21 AT AT02763208T patent/ATE339411T1/de not_active IP Right Cessation
- 2002-06-21 WO PCT/US2002/019767 patent/WO2003000676A1/en not_active Ceased
- 2002-06-21 IL IL15947402A patent/IL159474A0/xx active IP Right Grant
- 2002-06-21 KR KR1020037016719A patent/KR100759144B1/ko not_active Expired - Lifetime
- 2002-06-21 JP JP2003507080A patent/JP4303585B2/ja not_active Expired - Fee Related
- 2002-06-21 DE DE60214733T patent/DE60214733T8/de active Active
- 2002-06-21 PL PL367158A patent/PL226418B1/pl unknown
- 2002-06-21 CA CA2451006A patent/CA2451006C/en not_active Expired - Lifetime
- 2002-06-21 CN CN028164539A patent/CN1545508B/zh not_active Expired - Lifetime
- 2002-06-21 DK DK02763208T patent/DK1414813T3/da active
- 2002-06-21 ES ES02763208T patent/ES2271323T3/es not_active Expired - Lifetime
- 2002-06-21 SI SI200230411T patent/SI1414813T1/sl unknown
-
2003
- 2003-12-19 NO NO20035721A patent/NO20035721L/no not_active Application Discontinuation
-
2006
- 2006-10-23 CY CY20061101517T patent/CY1106214T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MXPA03011915A (es) | Antipaludicos 1,2,4-trioxolano. | |
| DK0507861T3 (de) | ||
| NO20052760D0 (no) | Fremgangsmate for behandling av kreft og beslektede fremgangsmater. | |
| WO2003018022A8 (en) | 2-amino-4-heteroarylaminopyrimidine derivatives for use in the treatment of cancer | |
| LU91928I2 (fr) | Ipilimumab et ses dérivés pharmaceutiquement acceptables (YERVOY®) | |
| NO20045247L (no) | Nukleosidderivater for behandling av hepatitt C-virusinfeksjon | |
| DK1441737T3 (da) | Staurosporin-derivater som inhibitorer af FLT3-receptor-tyrosinkinase-aktivitet | |
| WO2002009713A3 (de) | Selektive pde 2-inhibitoren als arzneimittel zur verbesserung der wahrnehmung | |
| NO20033883L (no) | Heterosykliske derivater for behandling av kreft og andre proliferative sykdommer | |
| AU2001228759A1 (en) | Compositions and methods for treatment of neoplastic diseases with combinations of limonoids, flavonoids and tocotrienols | |
| NO20030301L (no) | Nye heteroarylderivater og anvendelse derav som farmasöytika | |
| NO20043016L (no) | 6-aminomorfinan-derivater, fremgangsmate for fremstilling og anvendelse derav | |
| PL369644A1 (en) | Spiro and dispiro -1,2,4-trioxalane antimalarials | |
| NO20024197D0 (no) | Fremgangsmåte ved fremstilling av 5-cyano-1-(4-fluorfenyl)- 1,3-dihydroisobenzofuraner | |
| NO20033318D0 (no) | 2H-1-benzopyranderivater, fremgangsmåte ved fremstilling samt farmasöytiskesammensetninger derav | |
| WO2002076396A3 (en) | Compounds useful as kinase inhibitors for the treatment of hyperproliferative diseases | |
| MXPA04000272A (es) | Derivados de 4-aminociclohexanol sustituidos. | |
| WO2004108687A3 (en) | Nitrogen-containing heteroaryl derivatives for the treatment of hcv-infection | |
| IT1289154B1 (it) | Derivati di isoflavone loro preparazione e loro impiego terapeutico | |
| PT1408035E (pt) | Metodo de preparacao de derivativos de 1.5-diaril-3-trifluorometilo-delta2-pirazolinas que sejam racemicos e enanciomericamente puros | |
| MY127328A (en) | 5-amino-1-pentene-3-ol substituted derivatives | |
| NO20032297D0 (no) | Fremgangsmåte for fremstilling av distamycinderivater | |
| NO20041542L (no) | Fremgangsmate ved fremstilling av 14 beta-hydroksy-baccatin III-1,14-karbonat | |
| NO20041537L (no) | Fremgangsmate ved fremstilling av 14beta-hydroksy-baccatin III-1, 14-karbonat | |
| AU2002350432A1 (en) | Combination of cimetidine and cysteine derivatives for treating cancer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |