UA78709C2 - Spiro or dispiro-1,2,4-trioxolane as antimalarial agents, pharmaceutical composition, method of production - Google Patents

Spiro or dispiro-1,2,4-trioxolane as antimalarial agents, pharmaceutical composition, method of production Download PDF

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Publication number
UA78709C2
UA78709C2 UA2004010426A UA2004010426A UA78709C2 UA 78709 C2 UA78709 C2 UA 78709C2 UA 2004010426 A UA2004010426 A UA 2004010426A UA 2004010426 A UA2004010426 A UA 2004010426A UA 78709 C2 UA78709 C2 UA 78709C2
Authority
UA
Ukraine
Prior art keywords
nmr
spiro
mhz
ether
solution
Prior art date
Application number
UA2004010426A
Other languages
English (en)
Ukrainian (uk)
Inventor
Jonathan L Vennerstrom
William N Charman
Original Assignee
Medicines Malaria Venture Mmv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medicines Malaria Venture Mmv filed Critical Medicines Malaria Venture Mmv
Publication of UA78709C2 publication Critical patent/UA78709C2/uk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A61P33/12—Schistosomicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D323/00—Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
    • C07D323/02—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Dental Preparations (AREA)
UA2004010426A 2001-06-21 2002-06-21 Spiro or dispiro-1,2,4-trioxolane as antimalarial agents, pharmaceutical composition, method of production UA78709C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/886,666 US6486199B1 (en) 2001-06-21 2001-06-21 Spiro and dispiro 1,2,4-trioxolane antimalarials
PCT/US2002/019767 WO2003000676A1 (en) 2001-06-21 2002-06-21 1,2,4-trioxolane antimalarials

Publications (1)

Publication Number Publication Date
UA78709C2 true UA78709C2 (en) 2007-04-25

Family

ID=25389491

Family Applications (1)

Application Number Title Priority Date Filing Date
UA2004010426A UA78709C2 (en) 2001-06-21 2002-06-21 Spiro or dispiro-1,2,4-trioxolane as antimalarial agents, pharmaceutical composition, method of production

Country Status (24)

Country Link
US (1) US6486199B1 (de)
EP (1) EP1414813B1 (de)
JP (1) JP4303585B2 (de)
KR (1) KR100759144B1 (de)
CN (1) CN1545508B (de)
AT (1) ATE339411T1 (de)
AU (1) AU2002327183B2 (de)
BR (1) BRPI0210549B8 (de)
CA (1) CA2451006C (de)
CY (1) CY1106214T1 (de)
DE (1) DE60214733T8 (de)
DK (1) DK1414813T3 (de)
ES (1) ES2271323T3 (de)
HU (1) HUP0400246A3 (de)
IL (1) IL159474A0 (de)
MX (1) MXPA03011915A (de)
NO (1) NO20035721L (de)
PL (1) PL226418B1 (de)
PT (1) PT1414813E (de)
RU (1) RU2271357C2 (de)
SI (1) SI1414813T1 (de)
UA (1) UA78709C2 (de)
WO (1) WO2003000676A1 (de)
YU (1) YU100703A (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2601315C1 (ru) * 2015-06-10 2016-11-10 Федеральное государственное бюджетное учреждение науки Институт нефтехимии и катализа Российской академии наук Способ получения пентаоксаспироалканов

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ATE536887T1 (de) * 2002-06-06 2011-12-15 Univ Washington Kovalente konjugate zwischen mit artemisinin verwandten endoperoxiden und eisentragenden proteinen und anwendungsverfahren
US7371778B2 (en) * 2002-06-21 2008-05-13 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials
US6825230B2 (en) * 2002-06-21 2004-11-30 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trixolane antimalarials
US20080125441A1 (en) * 2002-06-21 2008-05-29 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials
US6906205B2 (en) * 2002-06-21 2005-06-14 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials
FR2862304A1 (fr) * 2003-11-14 2005-05-20 Centre Nat Rech Scient Molecules duales racemiques ou achirales contenant un derive peroxydique, leur synthese et leurs applications therapeutiques
WO2006010362A1 (de) * 2004-07-23 2006-02-02 Justus-Liebig-Universität Giessen Aminoadamantan-derivate, verfahren zu ihrer herstellung und ihre verwendung
US20060040761A1 (en) * 2004-08-23 2006-02-23 Sam-Kyu Shin Scale mark mat for putting practice
US8067620B2 (en) * 2005-05-04 2011-11-29 Medicines For Malaria Venture Mmv Dispiro 1,2,4-trioxolane antimalarials
CN101272777B (zh) * 2005-05-18 2013-01-30 兰贝克赛实验室有限公司 螺和二螺1,2,4-三氧戊环抗疟药的稳定剂型
WO2007036947A1 (en) * 2005-09-30 2007-04-05 Ipca Laboratories Limited Delayed release anti-malarial composition
WO2007039915A1 (en) 2005-10-04 2007-04-12 The Director General, Defence Research And Development Organisation Anti-malarial compound isolated from gomphostema niveum
US20070231300A1 (en) * 2006-03-28 2007-10-04 Washington, University Of Covalent conjugates between endoperoxides and transferrin and lactoferrin receptor-binding agents
BRPI0709961A2 (pt) 2006-04-11 2011-08-02 Novartis Ag compostos orgánicos
AP2525A (en) * 2006-05-17 2012-12-05 Ranbaxy Lab Ltd Antimarial therapy using a combination of synthetic artemisinin derivative and bisquinoline derivative
US8569519B2 (en) * 2006-05-24 2013-10-29 Ranbaxy Laboratories Limited Process for the preparation of dispiro 1,2,4-trioxolane antimalarials (OZ277)
FR2902100A1 (fr) * 2006-06-13 2007-12-14 Sanofi Aventis Sa Molecules duales contenant un derive peroxydique, leur synthese et leurs applications en therapeutique
GB0619333D0 (en) * 2006-09-30 2006-11-08 Univ Liverpool Dispiro tetraoxane compounds
WO2008046109A2 (en) * 2006-10-13 2008-04-17 University Of Washington Conjugates of artemisinin-related endoperoxides and hydrazone derivatives for the treatment of cancer
FR2924343A1 (fr) * 2007-12-04 2009-06-05 Palumed Sa Nouvelles utilisations therapeutiques de molecules duales contenant un derive peroxydique.
US20110172445A1 (en) * 2008-07-01 2011-07-14 National University Corporation Okayama University Novel Antischistosomal Agent
US8618096B2 (en) 2008-07-21 2013-12-31 The Regents Of The University Of California Prodrug compositions and methods for using the same in treating cancer and malaria
CN103930107A (zh) 2011-07-14 2014-07-16 兰贝克赛实验室有限公司 青蒿氧烷和哌喹的稳定剂型
CA2937752C (en) * 2014-02-14 2023-02-07 The Regents Of The University Of California Cyclic peroxides as prodrugs for selective delivery of agents
AU2015370911B2 (en) * 2014-12-23 2020-07-09 Bergenbio Asa Inhibitors of Akt kinase
WO2019005977A1 (en) * 2017-06-27 2019-01-03 The Regents Of The University Of California TRIOXOLANE AGENTS
CN108424371B (zh) * 2018-01-19 2021-07-16 北京理工大学 2-(4-氨基环己基)-乙酸乙酯的制备方法
US20210386814A1 (en) * 2020-05-20 2021-12-16 Amanuel Tesfazion Methods and compound for the treatment of malaria
WO2022161490A1 (en) * 2021-02-01 2022-08-04 Dan Yang Targeted delivery of 1, 2, 4, 5-tetraoxane compounds and their uses
CN117085004B (zh) * 2023-09-27 2026-06-16 赣南师范大学 一种2,6-二苯亚甲基环己酮类似物在制备抗血吸虫药物中的应用

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2601315C1 (ru) * 2015-06-10 2016-11-10 Федеральное государственное бюджетное учреждение науки Институт нефтехимии и катализа Российской академии наук Способ получения пентаоксаспироалканов

Also Published As

Publication number Publication date
AU2002327183B2 (en) 2006-03-09
HUP0400246A2 (hu) 2004-08-30
CN1545508B (zh) 2012-06-06
KR20040030697A (ko) 2004-04-09
IL159474A0 (en) 2004-06-01
RU2004101409A (ru) 2005-06-10
PT1414813E (pt) 2006-12-29
JP4303585B2 (ja) 2009-07-29
EP1414813A1 (de) 2004-05-06
JP2004535436A (ja) 2004-11-25
NO20035721D0 (no) 2003-12-19
DE60214733D1 (de) 2006-10-26
NO20035721L (no) 2004-02-23
EP1414813B1 (de) 2006-09-13
AU2002327183C1 (en) 2003-01-08
BRPI0210549B8 (pt) 2021-05-25
CN1545508A (zh) 2004-11-10
PL226418B1 (pl) 2017-07-31
CA2451006C (en) 2011-08-23
CY1106214T1 (el) 2011-06-08
SI1414813T1 (sl) 2006-12-31
DE60214733T2 (de) 2007-09-13
BRPI0210549B1 (pt) 2020-11-10
CA2451006A1 (en) 2003-01-03
ATE339411T1 (de) 2006-10-15
DK1414813T3 (da) 2007-01-02
YU100703A (sh) 2006-03-03
MXPA03011915A (es) 2004-05-21
HUP0400246A3 (en) 2009-12-28
KR100759144B1 (ko) 2007-09-14
WO2003000676A1 (en) 2003-01-03
BR0210549A (pt) 2005-01-11
RU2271357C2 (ru) 2006-03-10
ES2271323T3 (es) 2007-04-16
US6486199B1 (en) 2002-11-26
DE60214733T8 (de) 2008-02-21
PL367158A1 (en) 2005-02-21

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