ATE341537T1 - Dolastatin 10 derivate - Google Patents

Dolastatin 10 derivate

Info

Publication number: ATE341537T1
Authority: AT; Austria
Prior art keywords: dolastatin; derivatives
Prior art date: 2001-07-19

Application number

AT02764710T

Other languages

English (en)

Inventor

Toshihiko Fujii

Takehiro Okada

Mikio Taniguchi

Fumio Watanabe

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-07-19

Filing date

2002-07-17

Publication date

2006-10-15

2002-07-17 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2006-10-15 Application granted granted Critical

2006-10-15 Publication of ATE341537T1 publication Critical patent/ATE341537T1/de

Links

OFDNQWIFNXBECV-VFSYNPLYSA-N dolastatin 10 Chemical class CC(C)[C@H](N(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C=1SC=CN=1)CC1=CC=CC=C1 OFDNQWIFNXBECV-VFSYNPLYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Genetics & Genomics (AREA)
Epidemiology (AREA)
Crystallography & Structural Chemistry (AREA)
Biophysics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT02764710T 2001-07-19 2002-07-17 Dolastatin 10 derivate ATE341537T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP01117410		2001-07-19

Publications (1)

Publication Number	Publication Date
ATE341537T1 true ATE341537T1 (de)	2006-10-15

Family

ID=8178073

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02764710T ATE341537T1 (de)	2001-07-19	2002-07-17	Dolastatin 10 derivate

Country Status (30)

Country	Link
US (1)	US6737409B2 (de)
EP (1)	EP1412328B1 (de)
JP (1)	JP2004534859A (de)
KR (2)	KR20060057652A (de)
CN (1)	CN1553897A (de)
AR (1)	AR036175A1 (de)
AT (1)	ATE341537T1 (de)
BR (1)	BR0211289A (de)
CA (1)	CA2453987A1 (de)
CO (1)	CO5550462A2 (de)
DE (1)	DE60215179T2 (de)
DK (1)	DK1412328T3 (de)
ES (1)	ES2272763T3 (de)
GT (1)	GT200200154A (de)
HR (1)	HRP20040043A2 (de)
HU (1)	HUP0401253A2 (de)
IL (1)	IL159890A0 (de)
MX (1)	MXPA04000577A (de)
MY (1)	MY127718A (de)
NO (1)	NO20040198L (de)
NZ (1)	NZ530655A (de)
PA (1)	PA8551001A1 (de)
PE (1)	PE20030258A1 (de)
PL (1)	PL367682A1 (de)
PT (1)	PT1412328E (de)
RU (1)	RU2296750C2 (de)
SI (1)	SI1412328T1 (de)
UY (1)	UY27388A1 (de)
WO (1)	WO2003008378A1 (de)
ZA (1)	ZA200400334B (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7256257B2 (en)	2001-04-30	2007-08-14	Seattle Genetics, Inc.	Pentapeptide compounds and uses related thereto
US7064211B2 (en)	2002-03-22	2006-06-20	Eisai Co., Ltd.	Hemiasterlin derivatives and uses thereof
KR101208266B1 (ko) *	2002-03-22	2012-12-05	에자이 알앤드디 매니지먼트 가부시키가이샤	헤미아스텔린 유도체 및 이의 용도
DK1545613T3 (da)	2002-07-31	2011-11-14	Seattle Genetics Inc	Auristatinkonjugater og deres anvendelse til behandling af cancer, en autoimmun sygdom eller en infektiøs sygdom
EP2478912B1 (de)	2003-11-06	2016-08-31	Seattle Genetics, Inc.	Konjugate von Auristatin mit gegen HER2- oder CD22-gerichtete Antikörper und deren therapeutische Verwendung
MXPA06013998A (es) *	2004-06-02	2007-02-08	Hoffmann La Roche	Sintesis de ester de alquilo de acido amino-alcoxi-heptanoico.
US8288352B2 (en)	2004-11-12	2012-10-16	Seattle Genetics, Inc.	Auristatins having an aminobenzoic acid unit at the N terminus
BRPI0519023A2 (pt) *	2004-12-13	2008-12-23	Hoffmann La Roche	composiÇço farmacÊutica contendo pelo menos um derivado de dolastatina 10
CN101076515A (zh) *	2004-12-13	2007-11-21	霍夫曼-拉罗奇有限公司	制备3－吡咯烷－2－基－丙酸衍生物的新方法
US20060161076A1 (en) *	2005-01-06	2006-07-20	Diamics, Inc.	Systems and methods for collection of cell clusters
US20060189893A1 (en) *	2005-01-06	2006-08-24	Diamics, Inc.	Systems and methods for detecting abnormal cells
MX2007008349A (es) *	2005-01-13	2007-07-25	Hoffmann La Roche	Nueva sintesis de una etapa de aminas disustituidas utiles.
JP4954983B2 (ja)	2005-05-18	2012-06-20	ファーマサイエンス・インコーポレイテッド	Ｂｉｒドメイン結合化合物
WO2007008848A2 (en) *	2005-07-07	2007-01-18	Seattle Genetics, Inc.	Monomethylvaline compounds having phenylalanine carboxy modifications at the c-terminus
ES2708763T3 (es)	2005-07-07	2019-04-11	Seattle Genetics Inc	Compuestos de monometilvalina que tienen modificaciones de la cadena lateral de fenilalanina en el extremo C
US7750116B1 (en)	2006-02-18	2010-07-06	Seattle Genetics, Inc.	Antibody drug conjugate metabolites
CN101535300B (zh)	2006-05-16	2014-05-28	埃格拉医疗公司	Iap bir域结合化合物
US20080003652A1 (en) *	2006-06-28	2008-01-03	Hans Iding	Novel enzymatic process for the manufacture of Boc-Dap-Oh priority to related application(s)
EP2176295B1 (de)	2007-07-16	2014-11-19	Genentech, Inc.	Humanisierte anti-cd79b-antikörper und immunkonjugate und anwendungsverfahren
PE20090943A1 (es)	2007-07-16	2009-08-05	Genentech Inc	Anticuerpos anti-cd79b e inmunoconjugados
KR101607346B1 (ko)	2008-01-31	2016-03-29	제넨테크, 인크.	항-ｃｄ７９ｂ 항체 및 면역접합체 및 사용 방법
DK2265283T3 (da)	2008-03-18	2014-10-20	Seattle Genetics Inc	Auristatin-lægemiddel-linker-konjugater
KR20130009760A (ko)	2010-02-10	2013-01-23	이뮤노젠 아이엔씨	Ｃｄ２０ 항체 및 이의 용도
US9284350B2 (en)	2010-02-12	2016-03-15	Pharmascience Inc.	IAP BIR domain binding compounds
WO2011154359A1 (de)	2010-06-10	2011-12-15	Bayer Pharma Aktiengesellschaft	Neue auristatin-derivate und ihre verwendung
JP5933562B2 (ja)	2010-09-29	2016-06-15	シアトルジェネティックス，インコーポレイテッド	Ｎ−カルボキシアルキル−アウリスタチンおよびその使用
US9029406B2 (en)	2011-03-16	2015-05-12	Seattle Genetics, Inc	N-carboxyalkylauristatins and use thereof
CN110078789A (zh) *	2011-05-27	2019-08-02	Ambrx 公司	含有非天然氨基酸连接的海兔毒素衍生物的组合物、涉及该海兔毒素衍生物的方法及其用途
KR102356286B1 (ko)	2011-05-27	2022-02-08	암브룩스, 인코포레이티드	비-천연 아미노산 연결된 돌라스타틴 유도체를 함유하는 조성물, 이를 수반하는 방법, 및 용도
JP6089108B2 (ja)	2012-09-20	2017-03-01	セルトリオン，インク．	ドラスタチン１０誘導体、その製造方法およびそれを含む抗癌剤組成物
WO2015095953A1 (en)	2013-12-27	2015-07-02	The Centre For Drug Research And Development	Sulfonamide-containing linkage systems for drug conjugates
HUE049175T2 (hu)	2014-09-23	2020-09-28	Hoffmann La Roche	Eljárás anti-CD79b immunkonjugátumok alkalmazására
CN105949277B (zh) *	2015-05-05	2019-03-01	成都永泰诺科技有限公司	一种抗肿瘤化合物及其用途
CN108779146B (zh) *	2016-03-29	2022-03-18	东丽株式会社	肽衍生物及其用途
CN109021065B (zh) *	2017-06-08	2021-10-01	复旦大学	一种制备海兔毒素Dolastatin10的方法
CA3128081A1 (en)	2019-02-12	2020-08-20	Ambrx, Inc.	Compositions containing, methods and uses of antibody-tlr agonist conjugates
CN118119409A (zh)	2021-09-03	2024-05-31	东丽株式会社	癌的治疗和/或预防用药物组合物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2700165B1 (fr) *	1993-01-07	1995-02-17	Rhone Poulenc Rorer Sa	Dérivés de pyrrolidine, leur préparation et les médicaments les contenant.
US6323315B1 (en)	1999-09-10	2001-11-27	Basf Aktiengesellschaft	Dolastatin peptides

2002
- 2002-07-15 US US10/195,698 patent/US6737409B2/en not_active Expired - Fee Related
- 2002-07-17 CN CNA028177622A patent/CN1553897A/zh active Pending
- 2002-07-17 IL IL15989002A patent/IL159890A0/xx unknown
- 2002-07-17 EP EP02764710A patent/EP1412328B1/de not_active Expired - Lifetime
- 2002-07-17 KR KR1020067008692A patent/KR20060057652A/ko not_active Ceased
- 2002-07-17 PL PL02367682A patent/PL367682A1/xx not_active Application Discontinuation
- 2002-07-17 JP JP2003513938A patent/JP2004534859A/ja active Pending
- 2002-07-17 RU RU2004105145/04A patent/RU2296750C2/ru not_active IP Right Cessation
- 2002-07-17 DE DE60215179T patent/DE60215179T2/de not_active Expired - Fee Related
- 2002-07-17 MX MXPA04000577A patent/MXPA04000577A/es active IP Right Grant
- 2002-07-17 DK DK02764710T patent/DK1412328T3/da active
- 2002-07-17 NZ NZ530655A patent/NZ530655A/en unknown
- 2002-07-17 KR KR1020047000854A patent/KR100611540B1/ko not_active Expired - Fee Related
- 2002-07-17 AR ARP020102678A patent/AR036175A1/es not_active Application Discontinuation
- 2002-07-17 SI SI200230447T patent/SI1412328T1/sl unknown
- 2002-07-17 CA CA002453987A patent/CA2453987A1/en not_active Abandoned
- 2002-07-17 BR BR0211289-2A patent/BR0211289A/pt not_active IP Right Cessation
- 2002-07-17 UY UY27388A patent/UY27388A1/es not_active Application Discontinuation
- 2002-07-17 ES ES02764710T patent/ES2272763T3/es not_active Expired - Lifetime
- 2002-07-17 HU HU0401253A patent/HUP0401253A2/hu unknown
- 2002-07-17 WO PCT/EP2002/007931 patent/WO2003008378A1/en not_active Ceased
- 2002-07-17 PT PT02764710T patent/PT1412328E/pt unknown
- 2002-07-17 HR HR20040043A patent/HRP20040043A2/hr not_active Application Discontinuation
- 2002-07-17 MY MYPI20022704A patent/MY127718A/en unknown
- 2002-07-17 AT AT02764710T patent/ATE341537T1/de not_active IP Right Cessation
- 2002-07-18 PA PA20028551001A patent/PA8551001A1/es unknown
- 2002-07-18 GT GT200200154A patent/GT200200154A/es unknown
- 2002-07-19 PE PE2002000643A patent/PE20030258A1/es not_active Application Discontinuation
2004
- 2004-01-15 ZA ZA2004/00334A patent/ZA200400334B/en unknown
- 2004-01-16 NO NO20040198A patent/NO20040198L/no not_active Application Discontinuation
- 2004-01-20 CO CO04003736A patent/CO5550462A2/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
US6737409B2 (en)	2004-05-18
KR20040023661A (ko)	2004-03-18
KR20060057652A (ko)	2006-05-26
JP2004534859A (ja)	2004-11-18
CO5550462A2 (es)	2005-08-31
UY27388A1 (es)	2003-01-31
EP1412328A1 (de)	2004-04-28
AR036175A1 (es)	2004-08-18
GT200200154A (es)	2003-05-16
SI1412328T1 (sl)	2007-02-28
PE20030258A1 (es)	2003-03-19
CN1553897A (zh)	2004-12-08
US20030055002A1 (en)	2003-03-20
NZ530655A (en)	2006-08-31
DE60215179D1 (de)	2006-11-16
WO2003008378A1 (en)	2003-01-30
MXPA04000577A (es)	2004-04-20
HUP0401253A2 (hu)	2004-12-28
IL159890A0 (en)	2004-06-20
HRP20040043A2 (en)	2004-08-31
BR0211289A (pt)	2004-08-03
NO20040198L (no)	2004-02-19
RU2296750C2 (ru)	2007-04-10
DE60215179T2 (de)	2007-10-18
MY127718A (en)	2006-12-29
PT1412328E (pt)	2007-01-31
CA2453987A1 (en)	2003-01-30
RU2004105145A (ru)	2005-07-10
PA8551001A1 (es)	2003-09-17
KR100611540B1 (ko)	2006-08-10
EP1412328B1 (de)	2006-10-04
PL367682A1 (en)	2005-03-07
ZA200400334B (en)	2005-06-29
ES2272763T3 (es)	2007-05-01
DK1412328T3 (da)	2007-02-12

Legal Events

Date

Code

Title

Description

2007-02-15

UEP

Publication of translation of european patent specification

Ref document number: 1412328

Country of ref document: EP

2009-04-15

REN

Ceased due to non-payment of the annual fee

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