DK1412328T3 - Dolastatin-10-derivater - Google Patents

Dolastatin-10-derivater

Info

Publication number: DK1412328T3
Authority: DK; Denmark
Prior art keywords: dolastatin; derivatives
Prior art date: 2001-07-19

Application number

DK02764710T

Other languages

English (en)

Inventor

Toshihiko Fujii

Mikio Taniguchi

Takehiro Okada

Fumio Watanabe

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-07-19

Filing date

2002-07-17

Publication date

2007-02-12

2002-07-17 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2007-02-12 Application granted granted Critical

2007-02-12 Publication of DK1412328T3 publication Critical patent/DK1412328T3/da

Links

OFDNQWIFNXBECV-VFSYNPLYSA-N dolastatin 10 Chemical class CC(C)[C@H](N(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C=1SC=CN=1)CC1=CC=CC=C1 OFDNQWIFNXBECV-VFSYNPLYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Genetics & Genomics (AREA)
Epidemiology (AREA)
Crystallography & Structural Chemistry (AREA)
Biophysics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK02764710T 2001-07-19 2002-07-17 Dolastatin-10-derivater DK1412328T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP01117410		2001-07-19
PCT/EP2002/007931 WO2003008378A1 (en)	2001-07-19	2002-07-17	Dolastatin 10 derivatives

Publications (1)

Publication Number	Publication Date
DK1412328T3 true DK1412328T3 (da)	2007-02-12

Family

ID=8178073

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02764710T DK1412328T3 (da)	2001-07-19	2002-07-17	Dolastatin-10-derivater

Country Status (30)

Country	Link
US (1)	US6737409B2 (da)
EP (1)	EP1412328B1 (da)
JP (1)	JP2004534859A (da)
KR (2)	KR20060057652A (da)
CN (1)	CN1553897A (da)
AR (1)	AR036175A1 (da)
AT (1)	ATE341537T1 (da)
BR (1)	BR0211289A (da)
CA (1)	CA2453987A1 (da)
CO (1)	CO5550462A2 (da)
DE (1)	DE60215179T2 (da)
DK (1)	DK1412328T3 (da)
ES (1)	ES2272763T3 (da)
GT (1)	GT200200154A (da)
HR (1)	HRP20040043A2 (da)
HU (1)	HUP0401253A2 (da)
IL (1)	IL159890A0 (da)
MX (1)	MXPA04000577A (da)
MY (1)	MY127718A (da)
NO (1)	NO20040198L (da)
NZ (1)	NZ530655A (da)
PA (1)	PA8551001A1 (da)
PE (1)	PE20030258A1 (da)
PL (1)	PL367682A1 (da)
PT (1)	PT1412328E (da)
RU (1)	RU2296750C2 (da)
SI (1)	SI1412328T1 (da)
UY (1)	UY27388A1 (da)
WO (1)	WO2003008378A1 (da)
ZA (1)	ZA200400334B (da)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7256257B2 (en)	2001-04-30	2007-08-14	Seattle Genetics, Inc.	Pentapeptide compounds and uses related thereto
WO2003082268A2 (en) *	2002-03-22	2003-10-09	Eisai Co. Ltd	Hemiasterlin derivatives and uses thereof in the treatment of cancer
US7064211B2 (en)	2002-03-22	2006-06-20	Eisai Co., Ltd.	Hemiasterlin derivatives and uses thereof
ES2369542T3 (es)	2002-07-31	2011-12-01	Seattle Genetics, Inc.	Conjugados de auristatina y su uso para tratar cáncer, una enfermedad autoinmune o una enfermedad infecciosa.
ES2605443T3 (es)	2003-11-06	2017-03-14	Seattle Genetics, Inc.	Conjugados de auristatina con anticuerpos anti-HER2 o anti-CD22 y su uso en terapia
WO2005118525A1 (en) *	2004-06-02	2005-12-15	F.Hoffmann-La Roche Ag	Synthesis of amino-alkoxy-heptanoic alkyl ester
JP2008519863A (ja)	2004-11-12	2008-06-12	シアトルジェネティクスインコーポレイティッド	Ｎ末端にアミノ安息香酸単位を有するオーリスタチン
EP1828117A1 (en) *	2004-12-13	2007-09-05	F. Hoffmann-Roche AG	Novel process for the manufacture of 3-pyrrolidin-2-yl-propionic acid derivatives
EP1827603A2 (en) *	2004-12-13	2007-09-05	F. Hoffmann-Roche AG	Novel pharmaceutical composition containing at least one dolastatin 10 derivative
US20060161076A1 (en) *	2005-01-06	2006-07-20	Diamics, Inc.	Systems and methods for collection of cell clusters
US20060189893A1 (en) *	2005-01-06	2006-08-24	Diamics, Inc.	Systems and methods for detecting abnormal cells
MX2007008349A (es) *	2005-01-13	2007-07-25	Hoffmann La Roche	Nueva sintesis de una etapa de aminas disustituidas utiles.
WO2006122408A1 (en)	2005-05-18	2006-11-23	Aegera Therapeutics Inc.	Bir domain binding compounds
ES2708763T3 (es)	2005-07-07	2019-04-11	Seattle Genetics Inc	Compuestos de monometilvalina que tienen modificaciones de la cadena lateral de fenilalanina en el extremo C
WO2007008848A2 (en) *	2005-07-07	2007-01-18	Seattle Genetics, Inc.	Monomethylvaline compounds having phenylalanine carboxy modifications at the c-terminus
US7750116B1 (en)	2006-02-18	2010-07-06	Seattle Genetics, Inc.	Antibody drug conjugate metabolites
BRPI0711591A2 (pt)	2006-05-16	2011-11-16	Aegera Therapeutics, Inc.	composto de ligação de domìnio bir da iap
US20080003652A1 (en) *	2006-06-28	2008-01-03	Hans Iding	Novel enzymatic process for the manufacture of Boc-Dap-Oh priority to related application(s)
PT2474557E (pt)	2007-07-16	2014-12-03	Genentech Inc	Anticorpos e imunoconjugados anti-cd79b e métodos de utilização
PE20140625A1 (es)	2007-07-16	2014-05-29	Genentech Inc	ANTICUERPOS ANTI-CD79b E INMUNOCONJUGADOS HUMANIZADOS
DK2657253T3 (da)	2008-01-31	2017-10-09	Genentech Inc	Anti-CD79b-antistoffer og immunkonjugater og fremgangsmåder til anvendelse
WO2009117531A1 (en)	2008-03-18	2009-09-24	Seattle Genetics, Inc.	Auristatin drug linker conjugates
AR080154A1 (es)	2010-02-10	2012-03-14	Immunogen Inc	Anticuerpos cd20 y su utilizacion
NZ602368A (en)	2010-02-12	2014-10-31	Pharmascience Inc	Iap bir domain binding compounds
CN103200950B (zh)	2010-06-10	2016-03-16	西雅图基因公司	新颖的耳他汀衍生物及其用途
US8987209B2 (en)	2010-09-29	2015-03-24	Seattle Genetics, Inc.	N-carboxyalkyl-auristatin and the use thereof
ES2543888T3 (es)	2011-03-16	2015-08-25	Seattle Genetics, Inc.	N-carboxialquil-auristatinas y su utilización
KR20200128601A (ko) *	2011-05-27	2020-11-13	암브룩스, 인코포레이티드	비-천연 아미노산 연결된 돌라스타틴 유도체를 함유하는 조성물, 이를 수반하는 방법, 및 용도
DK2714685T3 (da) *	2011-05-27	2017-01-09	Ambrx Inc	Sammensætninger indeholdende, fremgangsmåder der involverer, og anvendelser af ikke-naturlige aminosyrebundne dolastatinderivater
US9278996B2 (en)	2012-09-20	2016-03-08	Celltrion, Inc.	Dolastatin-10 derivative, method of producing the same and anticancer drug composition containing the same
KR102384740B1 (ko)	2013-12-27	2022-04-07	자임워크스 인코포레이티드	약물 접합체를 위한 설폰아마이드-함유 연결 시스템
CA2979671C (en)	2014-09-23	2020-03-10	Genentech, Inc.	Methods of using anti-cd79b immunoconjugates
CN105949277B (zh) *	2015-05-05	2019-03-01	成都永泰诺科技有限公司	一种抗肿瘤化合物及其用途
ES2948846T3 (es) *	2016-03-29	2023-09-20	Toray Industries	Derivado peptídico y uso del mismo
CN109021065B (zh) *	2017-06-08	2021-10-01	复旦大学	一种制备海兔毒素Dolastatin10的方法
CN119455003A (zh)	2019-02-12	2025-02-18	Ambrx公司	包含抗体-tlr激动剂缀合物的组合物、方法和用途
CA3230737A1 (en)	2021-09-03	2023-03-09	Toray Industries, Inc.	Pharmaceutical composition for cancer treatment and/or prevention

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2700165B1 (fr) *	1993-01-07	1995-02-17	Rhone Poulenc Rorer Sa	Dérivés de pyrrolidine, leur préparation et les médicaments les contenant.
US6323315B1 (en)	1999-09-10	2001-11-27	Basf Aktiengesellschaft	Dolastatin peptides

2002
- 2002-07-15 US US10/195,698 patent/US6737409B2/en not_active Expired - Fee Related
- 2002-07-17 ES ES02764710T patent/ES2272763T3/es not_active Expired - Lifetime
- 2002-07-17 NZ NZ530655A patent/NZ530655A/en unknown
- 2002-07-17 IL IL15989002A patent/IL159890A0/xx unknown
- 2002-07-17 AR ARP020102678A patent/AR036175A1/es not_active Application Discontinuation
- 2002-07-17 HR HR20040043A patent/HRP20040043A2/hr not_active Application Discontinuation
- 2002-07-17 HU HU0401253A patent/HUP0401253A2/hu unknown
- 2002-07-17 JP JP2003513938A patent/JP2004534859A/ja active Pending
- 2002-07-17 WO PCT/EP2002/007931 patent/WO2003008378A1/en not_active Ceased
- 2002-07-17 MX MXPA04000577A patent/MXPA04000577A/es active IP Right Grant
- 2002-07-17 KR KR1020067008692A patent/KR20060057652A/ko not_active Ceased
- 2002-07-17 PL PL02367682A patent/PL367682A1/xx not_active Application Discontinuation
- 2002-07-17 AT AT02764710T patent/ATE341537T1/de not_active IP Right Cessation
- 2002-07-17 DE DE60215179T patent/DE60215179T2/de not_active Expired - Fee Related
- 2002-07-17 EP EP02764710A patent/EP1412328B1/en not_active Expired - Lifetime
- 2002-07-17 KR KR1020047000854A patent/KR100611540B1/ko not_active Expired - Fee Related
- 2002-07-17 CA CA002453987A patent/CA2453987A1/en not_active Abandoned
- 2002-07-17 UY UY27388A patent/UY27388A1/es not_active Application Discontinuation
- 2002-07-17 BR BR0211289-2A patent/BR0211289A/pt not_active IP Right Cessation
- 2002-07-17 SI SI200230447T patent/SI1412328T1/sl unknown
- 2002-07-17 MY MYPI20022704A patent/MY127718A/en unknown
- 2002-07-17 PT PT02764710T patent/PT1412328E/pt unknown
- 2002-07-17 DK DK02764710T patent/DK1412328T3/da active
- 2002-07-17 CN CNA028177622A patent/CN1553897A/zh active Pending
- 2002-07-17 RU RU2004105145/04A patent/RU2296750C2/ru not_active IP Right Cessation
- 2002-07-18 GT GT200200154A patent/GT200200154A/es unknown
- 2002-07-18 PA PA20028551001A patent/PA8551001A1/es unknown
- 2002-07-19 PE PE2002000643A patent/PE20030258A1/es not_active Application Discontinuation
2004
- 2004-01-15 ZA ZA2004/00334A patent/ZA200400334B/en unknown
- 2004-01-16 NO NO20040198A patent/NO20040198L/no not_active Application Discontinuation
- 2004-01-20 CO CO04003736A patent/CO5550462A2/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
HUP0401253A2 (hu)	2004-12-28
ATE341537T1 (de)	2006-10-15
EP1412328A1 (en)	2004-04-28
DE60215179T2 (de)	2007-10-18
IL159890A0 (en)	2004-06-20
US20030055002A1 (en)	2003-03-20
PE20030258A1 (es)	2003-03-19
JP2004534859A (ja)	2004-11-18
NZ530655A (en)	2006-08-31
PT1412328E (pt)	2007-01-31
WO2003008378A1 (en)	2003-01-30
US6737409B2 (en)	2004-05-18
SI1412328T1 (sl)	2007-02-28
MY127718A (en)	2006-12-29
EP1412328B1 (en)	2006-10-04
AR036175A1 (es)	2004-08-18
DE60215179D1 (de)	2006-11-16
RU2004105145A (ru)	2005-07-10
PL367682A1 (en)	2005-03-07
MXPA04000577A (es)	2004-04-20
ZA200400334B (en)	2005-06-29
CA2453987A1 (en)	2003-01-30
CO5550462A2 (es)	2005-08-31
CN1553897A (zh)	2004-12-08
KR100611540B1 (ko)	2006-08-10
NO20040198L (no)	2004-02-19
UY27388A1 (es)	2003-01-31
BR0211289A (pt)	2004-08-03
RU2296750C2 (ru)	2007-04-10
PA8551001A1 (es)	2003-09-17
GT200200154A (es)	2003-05-16
KR20060057652A (ko)	2006-05-26
KR20040023661A (ko)	2004-03-18
ES2272763T3 (es)	2007-05-01
HRP20040043A2 (en)	2004-08-31

Publication	Publication Date	Title
ATE319451T1 (de)	2006-03-15	Tetrahydrochinolin-derivate
ATE312827T1 (de)	2005-12-15	3-substituierte-4-pyrimidonderivate
DE60123851D1 (de)	2006-11-23	Fernsehplauderzimmer
DE60227316D1 (de)	2008-08-14	En
DE60219033D1 (de)	2007-05-03	Spülrohranordnung
DE60228827D1 (de)	2008-10-23	Hrzeuggenerator
DE50206021D1 (de)	2006-05-04	Schlauchklemme
DE60135540D1 (de)	2008-10-09	noporen
DE60222752D1 (de)	2007-11-15	Unterwasserkommunikationsssystem
DE60213841D1 (de)	2006-09-21	Hydrazono-malonitrile
DE60231527D1 (de)	2009-04-23	Aerosolspritzdüse
NO20014597D0 (no)	2001-09-21	Fremgangsmåte
DE50211604D1 (de)	2008-03-13	Chlag
EE200300447A (et)	2003-12-15	Asendatud bensofuraan-2-karboksamiidide derivaadid
DE60130930D1 (de)	2007-11-22	Polarisationsmodendispersion-kompensator
DE50204794D1 (de)	2005-12-08	Kugelgelenk
DE50211290D1 (de)	2008-01-10	Handzange
DE50214628D1 (de)	2010-10-14	Ckaufbaudynamik
DE60219393D1 (de)	2007-05-24	Kraftfahrzeugkarrosseriestruktur
EP1572867A4 (en)	2008-03-05	REASONS FOR EXPRESSION OF ENDOTHELIAL CELLS
DE60206075D1 (de)	2005-10-13	Kurbenwellenphasenverschiebungsmechanismus
DE50203984D1 (de)	2005-09-22	Kugelgelenk
DE60223031D1 (de)	2007-11-29	Arylpiperazin gebundene tetrahydroindolonderivate
ATE355059T1 (de)	2006-03-15	Isoxazolopyridinone
DE60137209D1 (de)	2009-02-12	Kaltfräsvorrichtung