NO20041338L - Fremgangsmate ved inhibering av kognitiv svekkelse hos voksne med Downs syndrom. - Google Patents
Fremgangsmate ved inhibering av kognitiv svekkelse hos voksne med Downs syndrom.Info
- Publication number
- NO20041338L NO20041338L NO20041338A NO20041338A NO20041338L NO 20041338 L NO20041338 L NO 20041338L NO 20041338 A NO20041338 A NO 20041338A NO 20041338 A NO20041338 A NO 20041338A NO 20041338 L NO20041338 L NO 20041338L
- Authority
- NO
- Norway
- Prior art keywords
- adults
- procedure
- receptor antagonist
- glucocorticoid receptor
- cognitive impairment
- Prior art date
Links
- 208000010877 cognitive disease Diseases 0.000 title abstract 3
- 201000010374 Down Syndrome Diseases 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 208000028698 Cognitive impairment Diseases 0.000 title 1
- 229940126013 glucocorticoid receptor antagonist Drugs 0.000 abstract 3
- 239000003850 glucocorticoid receptor antagonist Substances 0.000 abstract 3
- 231100000876 cognitive deterioration Toxicity 0.000 abstract 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 abstract 2
- 206010044688 Trisomy 21 Diseases 0.000 abstract 1
- 239000008186 active pharmaceutical agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229960000890 hydrocortisone Drugs 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- VKHAHZOOUSRJNA-GCNJZUOMSA-N mifepristone Chemical compound C1([C@@H]2C3=C4CCC(=O)C=C4CC[C@H]3[C@@H]3CC[C@@]([C@]3(C2)C)(O)C#CC)=CC=C(N(C)C)C=C1 VKHAHZOOUSRJNA-GCNJZUOMSA-N 0.000 abstract 1
- 229960003248 mifepristone Drugs 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Toilet Supplies (AREA)
- Bidet-Like Cleaning Device And Other Flush Toilet Accessories (AREA)
- Casting Support Devices, Ladles, And Melt Control Thereby (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31665301P | 2001-08-31 | 2001-08-31 | |
| PCT/US2002/027576 WO2003020216A1 (en) | 2001-08-31 | 2002-08-27 | Methods for inhibiting cognitive deterioration in adults with down's syndrome |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20041338D0 NO20041338D0 (no) | 2004-03-31 |
| NO20041338L true NO20041338L (no) | 2004-05-28 |
| NO332723B1 NO332723B1 (no) | 2012-12-27 |
Family
ID=23230024
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20041338A NO332723B1 (no) | 2001-08-31 | 2004-03-31 | Anvendelse av glukokortikoidreseptorantagonist for fremstilling av medikamenter til inhibering av kognitiv svekkelse hos voksne med Downs syndrom |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7402578B2 (no) |
| EP (1) | EP1432379B1 (no) |
| JP (2) | JP2005501882A (no) |
| KR (1) | KR20040029116A (no) |
| CN (2) | CN1868480A (no) |
| AT (1) | ATE411013T1 (no) |
| CA (1) | CA2459033C (no) |
| DE (1) | DE60229411D1 (no) |
| ES (1) | ES2314103T3 (no) |
| IL (1) | IL160649A0 (no) |
| MX (1) | MXPA04001893A (no) |
| NO (1) | NO332723B1 (no) |
| NZ (1) | NZ531477A (no) |
| WO (1) | WO2003020216A1 (no) |
| ZA (1) | ZA200401754B (no) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100531738C (zh) * | 2001-10-26 | 2009-08-26 | 欧加农股份有限公司 | (11β,17β)-11-(1,3-苯并间二氧杂环戊烯-5-基)-17-羟基-17-(1-丙炔基)雌-4,9-二烯-3-酮在治疗重性抑郁症中的应用 |
| DK2114970T3 (da) | 2007-02-02 | 2011-09-19 | Pfizer Prod Inc | Tricykliske forbindelser og deres anvendelse som glucocorticoidreceptormodulatorer |
| US20110166115A1 (en) * | 2008-07-01 | 2011-07-07 | Corcept Therapeutics, Inc. | Use of mifepristone for the treatment of amyotrophic lateral sclerosis |
| WO2011150209A1 (en) * | 2010-05-26 | 2011-12-01 | Corcept Therapeutics, Inc. | Treatment of muscular dystrophy |
| US10500216B2 (en) | 2011-11-18 | 2019-12-10 | Corcept Therapeutics, Inc. | Optimizing mifepristone absorption |
| US12226412B2 (en) | 2012-05-25 | 2025-02-18 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| US8859774B2 (en) | 2012-05-25 | 2014-10-14 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| US9457141B2 (en) | 2013-06-03 | 2016-10-04 | Bigfoot Biomedical, Inc. | Infusion pump system and method |
| US9943526B2 (en) | 2015-04-21 | 2018-04-17 | Corcept Therapeutics, Inc. | Optimizing mifepristone levels for cushing's patients |
| CN113194931B (zh) | 2018-12-19 | 2023-11-10 | 科塞普特治疗公司 | 含有瑞拉可兰、杂芳基-酮稠合的氮杂十氢化萘化合物的药物制剂 |
| EP4157276A4 (en) | 2020-05-27 | 2024-06-12 | Corcept Therapeutics Incorporated | Concomitant administration of glucocorticoid receptor modulator relacorilant and paclitaxel, a dual substrate of cyp2c8 and cyp3a4 |
| WO2022134033A1 (en) | 2020-12-25 | 2022-06-30 | Corcept Therapeutics Incorporated | Methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| WO2024077169A1 (en) | 2022-10-06 | 2024-04-11 | Corcept Therapeutics Incorporated | Formulations of glucocorticoid receptor modulators |
| US12433882B2 (en) | 2022-10-28 | 2025-10-07 | Corcept Therapeutics Incorporated | Treatments for amyotrophic lateral sclerosis using dazucorilant |
| USD1136464S1 (en) * | 2025-01-15 | 2026-07-21 | Seth Green | Coin sorter |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9807980A (pt) * | 1997-02-05 | 2000-03-28 | Allelix Pharm Eco L P | Uso de um composto e composto para tratar um mamìfero com disfunção cognitiva |
| AU747956B2 (en) * | 1997-10-06 | 2002-05-30 | Board Of Trustees Of The Leland Stanford Junior University | Methods for treating psychosis associated with glucocorticoid related dysfunction |
| CA2328411C (en) * | 1998-05-15 | 2008-12-16 | Alan F. Schatzberg | Glucocorticoid receptor antagonists for the treatment of dementia |
| US6620802B1 (en) * | 1999-11-23 | 2003-09-16 | Corcept Therapeutics, Inc. | Methods of treating mild cognitive impairment using a glucocorticoid-specific receptor antagonist |
| AU2001286930A1 (en) * | 2000-08-30 | 2002-03-13 | The Board Of Trustees Of The Leland Stanford Junior University | Glucocorticoid blocking agents for increasing blood-brain barrier permeability |
| CN1547473A (zh) * | 2001-07-23 | 2004-11-17 | �Ƹ��� | 预防由抗精神病药物引起的体重增加的方法 |
-
2002
- 2002-08-27 AT AT02770441T patent/ATE411013T1/de not_active IP Right Cessation
- 2002-08-27 KR KR10-2004-7003036A patent/KR20040029116A/ko not_active Ceased
- 2002-08-27 NZ NZ531477A patent/NZ531477A/en not_active IP Right Cessation
- 2002-08-27 CA CA2459033A patent/CA2459033C/en not_active Expired - Fee Related
- 2002-08-27 CN CNA200510132945XA patent/CN1868480A/zh active Pending
- 2002-08-27 IL IL16064902A patent/IL160649A0/xx not_active IP Right Cessation
- 2002-08-27 MX MXPA04001893A patent/MXPA04001893A/es active IP Right Grant
- 2002-08-27 DE DE60229411T patent/DE60229411D1/de not_active Expired - Lifetime
- 2002-08-27 WO PCT/US2002/027576 patent/WO2003020216A1/en not_active Ceased
- 2002-08-27 EP EP02770441A patent/EP1432379B1/en not_active Expired - Lifetime
- 2002-08-27 JP JP2003524530A patent/JP2005501882A/ja active Pending
- 2002-08-27 CN CNA028186087A patent/CN1556708A/zh active Pending
- 2002-08-27 ES ES02770441T patent/ES2314103T3/es not_active Expired - Lifetime
- 2002-08-28 US US10/230,575 patent/US7402578B2/en not_active Expired - Lifetime
-
2004
- 2004-03-03 ZA ZA2004/01754A patent/ZA200401754B/en unknown
- 2004-03-31 NO NO20041338A patent/NO332723B1/no not_active IP Right Cessation
-
2008
- 2008-12-08 JP JP2008312752A patent/JP2009102343A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA04001893A (es) | 2005-03-07 |
| ES2314103T3 (es) | 2009-03-16 |
| WO2003020216A1 (en) | 2003-03-13 |
| ZA200401754B (en) | 2005-05-25 |
| CN1556708A (zh) | 2004-12-22 |
| NZ531477A (en) | 2006-10-27 |
| KR20040029116A (ko) | 2004-04-03 |
| EP1432379A1 (en) | 2004-06-30 |
| US20030064974A1 (en) | 2003-04-03 |
| ATE411013T1 (de) | 2008-10-15 |
| NO332723B1 (no) | 2012-12-27 |
| DE60229411D1 (de) | 2008-11-27 |
| CN1868480A (zh) | 2006-11-29 |
| EP1432379B1 (en) | 2008-10-15 |
| JP2005501882A (ja) | 2005-01-20 |
| EP1432379A4 (en) | 2005-07-13 |
| HK1062533A1 (en) | 2004-11-12 |
| NO20041338D0 (no) | 2004-03-31 |
| CA2459033A1 (en) | 2003-03-13 |
| IL160649A0 (en) | 2004-07-25 |
| CA2459033C (en) | 2012-05-22 |
| US7402578B2 (en) | 2008-07-22 |
| JP2009102343A (ja) | 2009-05-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |