TR200301613T2 - Sapogenin türevleri, bunların sentezi ve kullanımı, bunların kullanım metotları. - Google Patents

Sapogenin türevleri, bunların sentezi ve kullanımı, bunların kullanım metotları.

Info

Publication number
TR200301613T2
TR200301613T2 TR2003/01613T TR200301613T TR200301613T2 TR 200301613 T2 TR200301613 T2 TR 200301613T2 TR 2003/01613 T TR2003/01613 T TR 2003/01613T TR 200301613 T TR200301613 T TR 200301613T TR 200301613 T2 TR200301613 T2 TR 200301613T2
Authority
TR
Turkey
Prior art keywords
synthesis
derivatives
methods
sapogenin
usage
Prior art date
Application number
TR2003/01613T
Other languages
English (en)
Inventor
Barraclough Paul
Hanson Jim
Gunning Phil
Rees Daryl
Xia Zongqin
Hu Year
Original Assignee
Phytotech Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phytotech Limited filed Critical Phytotech Limited
Publication of TR200301613T2 publication Critical patent/TR200301613T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Bulus, belirli steroidal sapogeninleri ve bunlarin türevlerini, ve bunlarin, kognitif fonksiyonsuzluk, kognitif olmayan nöro-dejenerasyon, kognitif olmayan nöro-müsküler dejenerasyon ve kognitif, nöral ve nöro-müsküler hasar yoklugunda reseptör kaybinin tedavisinde kullanimlarini sunar. Sentez metotlari, tedavi ve farmasötik kompozisyonlar da ortaya konulmaktadir.
TR2003/01613T 2001-03-28 2002-03-28 Sapogenin türevleri, bunların sentezi ve kullanımı, bunların kullanım metotları. TR200301613T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0107822.9A GB0107822D0 (en) 2001-03-28 2001-03-28 Sapogenin derivatives their synthesis and use methods based upon their use

Publications (1)

Publication Number Publication Date
TR200301613T2 true TR200301613T2 (tr) 2004-08-23

Family

ID=9911795

Family Applications (2)

Application Number Title Priority Date Filing Date
TR2007/00134T TR200700134T1 (tr) 2001-03-28 2002-03-28 Sapogenin türevleri, bunların sentezi ve kullanımı, bunların kullanım metotları.
TR2003/01613T TR200301613T2 (tr) 2001-03-28 2002-03-28 Sapogenin türevleri, bunların sentezi ve kullanımı, bunların kullanım metotları.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
TR2007/00134T TR200700134T1 (tr) 2001-03-28 2002-03-28 Sapogenin türevleri, bunların sentezi ve kullanımı, bunların kullanım metotları.

Country Status (24)

Country Link
US (1) US20040147495A1 (tr)
EP (1) EP1383787B1 (tr)
JP (1) JP2004525945A (tr)
KR (1) KR20040007479A (tr)
CN (1) CN1678325A (tr)
AR (2) AR033079A1 (tr)
AT (1) ATE416185T1 (tr)
AU (1) AU2002242894B2 (tr)
BR (1) BR0208533A (tr)
CA (1) CA2442150A1 (tr)
CZ (1) CZ20032620A3 (tr)
GB (1) GB0107822D0 (tr)
HR (1) HRP20030770A2 (tr)
IL (1) IL158115A0 (tr)
MX (1) MXPA03008800A (tr)
NO (1) NO20034364L (tr)
NZ (1) NZ529136A (tr)
PE (1) PE20021042A1 (tr)
PL (1) PL364825A1 (tr)
RU (1) RU2311423C2 (tr)
TR (2) TR200700134T1 (tr)
UA (1) UA78696C2 (tr)
WO (1) WO2002079221A2 (tr)
ZA (2) ZA200307478B (tr)

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FI3932932T3 (fi) 2013-03-13 2025-10-15 Sage Therapeutics Inc Neuroaktiivisia steroideja ja niiden käyttömenetelmiä
KR101480982B1 (ko) * 2013-03-20 2015-02-03 (주)셀인바이오 골형성 유도 화합물 및 이의 응용
CN104177469A (zh) * 2013-05-28 2014-12-03 江苏柯菲平医药有限公司 一种知母中菝葜皂苷元衍生物的制备方法
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Also Published As

Publication number Publication date
JP2004525945A (ja) 2004-08-26
WO2002079221A3 (en) 2003-04-17
ZA200407460B (en) 2009-09-30
EP1383787A2 (en) 2004-01-28
ZA200307478B (en) 2009-04-29
EP1383787B1 (en) 2008-12-03
CZ20032620A3 (cs) 2004-04-14
KR20040007479A (ko) 2004-01-24
US20040147495A1 (en) 2004-07-29
BR0208533A (pt) 2004-04-20
WO2002079221A2 (en) 2002-10-10
IL158115A0 (en) 2004-03-28
PE20021042A1 (es) 2002-11-19
NO20034364L (no) 2003-11-28
PL364825A1 (en) 2004-12-27
NZ529136A (en) 2005-12-23
HRP20030770A2 (en) 2005-08-31
MXPA03008800A (es) 2004-10-15
TR200700134T1 (tr) 2007-02-21
AR033079A1 (es) 2003-12-03
GB0107822D0 (en) 2001-05-23
CN1678325A (zh) 2005-10-05
RU2003131883A (ru) 2005-05-10
UA78696C2 (en) 2007-04-25
AU2002242894B2 (en) 2008-08-21
CA2442150A1 (en) 2002-10-10
ATE416185T1 (de) 2008-12-15
AR040402A1 (es) 2005-04-06
NO20034364D0 (no) 2003-09-29
RU2311423C2 (ru) 2007-11-27

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