NO20042024L - 4-(4-alkoksy-3-hydroksyfenyl)-2-pyrrolidonderivater som PDE4-inhibitorer for behandling av nevrologiske syndromer - Google Patents

4-(4-alkoksy-3-hydroksyfenyl)-2-pyrrolidonderivater som PDE4-inhibitorer for behandling av nevrologiske syndromer

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Publication number
NO20042024L
NO20042024L NO20042024A NO20042024A NO20042024L NO 20042024 L NO20042024 L NO 20042024L NO 20042024 A NO20042024 A NO 20042024A NO 20042024 A NO20042024 A NO 20042024A NO 20042024 L NO20042024 L NO 20042024L
Authority
NO
Norway
Prior art keywords
hydroxyphenyl
alkoxy
treatment
pde4 inhibitors
pyrrolidone derivatives
Prior art date
Application number
NO20042024A
Other languages
English (en)
Norwegian (no)
Inventor
Hans Juergen Ernst Hess
Allen Hopper
Ashok Tehim
Michael De Vivo
Ruiping Liu
Erik Kuester
Original Assignee
Memory Pharm Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Memory Pharm Corp filed Critical Memory Pharm Corp
Publication of NO20042024L publication Critical patent/NO20042024L/no

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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • AIDS & HIV (AREA)
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  • Ophthalmology & Optometry (AREA)
NO20042024A 2001-10-16 2004-05-14 4-(4-alkoksy-3-hydroksyfenyl)-2-pyrrolidonderivater som PDE4-inhibitorer for behandling av nevrologiske syndromer NO20042024L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32931401P 2001-10-16 2001-10-16
PCT/US2002/032834 WO2003032981A1 (en) 2001-10-16 2002-10-16 4-(4-alkoxy-3-hydroxyphenyl)-2-pyrrolidone derivatives as pde-4 inhibitors for the treatment of neurological syndromes

Publications (1)

Publication Number Publication Date
NO20042024L true NO20042024L (no) 2004-05-14

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NO20042024A NO20042024L (no) 2001-10-16 2004-05-14 4-(4-alkoksy-3-hydroksyfenyl)-2-pyrrolidonderivater som PDE4-inhibitorer for behandling av nevrologiske syndromer

Country Status (20)

Country Link
US (3) US7235579B2 (de)
EP (1) EP1435944B1 (de)
JP (2) JP4484515B2 (de)
KR (2) KR20090080573A (de)
CN (1) CN1604776A (de)
AT (1) ATE444065T1 (de)
AU (1) AU2002335015B8 (de)
BR (1) BR0213660A (de)
CA (1) CA2463469A1 (de)
CO (1) CO5570674A2 (de)
DE (1) DE60233884D1 (de)
ES (1) ES2334650T3 (de)
HR (1) HRP20040409A2 (de)
IL (1) IL161317A0 (de)
MX (1) MXPA04003516A (de)
NO (1) NO20042024L (de)
NZ (1) NZ532288A (de)
RU (2) RU2340600C2 (de)
WO (1) WO2003032981A1 (de)
ZA (1) ZA200402856B (de)

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WO2009067607A2 (en) * 2007-11-20 2009-05-28 Memory Pharmaceuticals Corporation Combinations of pde4 inhibitors and antipsychotics for the treatment of psychotic disorders
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