NO20043472L - Fremgangsmate for fremstillingen av perindopril med hoy renhet og intermediater nyttige i syntesen - Google Patents

Fremgangsmate for fremstillingen av perindopril med hoy renhet og intermediater nyttige i syntesen

Info

Publication number
NO20043472L
NO20043472L NO20043472A NO20043472A NO20043472L NO 20043472 L NO20043472 L NO 20043472L NO 20043472 A NO20043472 A NO 20043472A NO 20043472 A NO20043472 A NO 20043472A NO 20043472 L NO20043472 L NO 20043472L
Authority
NO
Norway
Prior art keywords
synthesis
preparation
high purity
intermediates useful
purity perindopril
Prior art date
Application number
NO20043472A
Other languages
English (en)
Other versions
NO330223B1 (no
Inventor
Tibor Mezei
Guyla Simig
Marta Porcs-Makkay
Attila Mandi
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of NO20043472L publication Critical patent/NO20043472L/no
Publication of NO330223B1 publication Critical patent/NO330223B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO20043472A 2002-01-30 2004-08-20 Fremgangsmate for fremstillingen av perindopril med hoy renhet og intermediater nyttige i syntesen NO330223B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02290206A EP1333026B1 (en) 2002-01-30 2002-01-30 Process for the preparation of high purity perindopril and intermediates useful in the synthesis
PCT/IB2003/000691 WO2003064388A2 (en) 2002-01-30 2003-01-29 Process for the preparation of high purity perindopril and intermediates useful in the synthesis

Publications (2)

Publication Number Publication Date
NO20043472L true NO20043472L (no) 2004-08-20
NO330223B1 NO330223B1 (no) 2011-03-07

Family

ID=8185713

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20043472A NO330223B1 (no) 2002-01-30 2004-08-20 Fremgangsmate for fremstillingen av perindopril med hoy renhet og intermediater nyttige i syntesen

Country Status (35)

Country Link
US (2) US7326794B2 (no)
EP (1) EP1333026B1 (no)
JP (1) JP4171423B2 (no)
KR (1) KR100673701B1 (no)
CN (1) CN1300111C (no)
AP (1) AP1741A (no)
AR (1) AR038340A1 (no)
AT (1) ATE365714T1 (no)
AU (1) AU2003206055B2 (no)
BG (1) BG66126B1 (no)
BR (2) BR0307293A (no)
CA (1) CA2474003C (no)
CY (1) CY1106721T1 (no)
CZ (1) CZ305892B6 (no)
DE (1) DE60220877T2 (no)
DK (1) DK1333026T3 (no)
EA (1) EA009277B1 (no)
EE (1) EE05428B1 (no)
ES (1) ES2289060T3 (no)
GE (1) GEP20063899B (no)
HR (1) HRP20040781B8 (no)
HU (1) HU227591B1 (no)
ME (1) ME00444B (no)
MX (1) MXPA04007444A (no)
NO (1) NO330223B1 (no)
NZ (1) NZ534168A (no)
OA (1) OA12759A (no)
PL (1) PL212354B1 (no)
PT (1) PT1333026E (no)
RS (1) RS52465B (no)
SI (1) SI1333026T1 (no)
SK (1) SK287866B6 (no)
UA (1) UA77756C2 (no)
WO (1) WO2003064388A2 (no)
ZA (1) ZA200405548B (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1675827T3 (da) * 2003-10-21 2010-04-19 Servier Lab Ny fremgangsmåde til fremstilling af krystallint perindopril erbumin
SI21704A (en) * 2004-01-14 2005-08-31 Lek Farmacevtska Druzba Dd New crystal form of perindopril, procedure of its preparation, pharmaceutical preparations containing this form and their application in treatment of hypertensia
PT1729739T (pt) * 2004-03-29 2016-12-01 Servier Lab Processo para a preparação de uma composição farmacêutica sólida
SI21800A (sl) * 2004-05-14 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze perindoprila
SI21881A (sl) 2004-10-15 2006-04-30 Diagen, Smartno Pri Ljubljani, D.O.O. Nove kristalne oblike perindopril erbumin hidratov, postopek za njihovo pripravo in farmacevtske oblike, ki vsebujejo te spojine
ES2255872B1 (es) * 2004-12-31 2007-08-16 Quimica Sintetica, S.A. Procedimiento para la preparacion de perindopril erbumina.
PT1679072E (pt) 2005-01-06 2008-12-22 Ipca Lab Ltd Processo para a síntese de derivados de ácido (2s,3as,7as)-1-(s)-alanil-octa-hidro-1h-indole-2-carboxílico e utilização na síntese de perindopril
US7710739B2 (en) 2005-04-28 2010-05-04 Semiconductor Energy Laboratory Co., Ltd. Semiconductor device and display device
WO2006137082A1 (en) * 2005-06-23 2006-12-28 Ramesh Babu Potluri Process for industrially viable preparation of perindopril erbumine
US20070032661A1 (en) * 2005-08-03 2007-02-08 Glenmark Pharmaceuticals Limited Process for the preparation of intermediates of perindopril
CA2618561C (en) * 2005-08-12 2014-04-29 Lek Pharmaceuticals D.D. A process for the preparation of perindopril erbumine
EP1792896A1 (en) * 2005-12-01 2007-06-06 KRKA, tovarna zdravil, d.d., Novo mesto Process for the preparation of perindopril and salts thereof
EP2044010B1 (en) * 2006-05-12 2014-01-08 EGIS Gyógyszergyár Nyilvánosan Müködõ Részvénytársaság New pharmaceutical intermediates in the synthesis of ace-inihibitors and the use thereof
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
PH12018502155B1 (en) 2016-04-20 2024-03-27 Servier Lab Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK144769C (da) 1979-12-06 1982-12-13 Voelund Vaskerimaskiner Tromlevaskemaskine med varmeveksler
US4565819A (en) * 1979-12-07 1986-01-21 Adir Substituted imino diacids, their preparation and pharmaceutical compositions which contain them
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
IN156096B (no) 1981-03-19 1985-05-11 Usv Pharma Corp
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
SI9600169A (en) 1996-05-22 1997-12-31 Krka Tovarna Zdravil Process for preparation of compounds with ace inhibitory effect
FR2807431B1 (fr) 2000-04-06 2002-07-19 Adir Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
FR2827860B1 (fr) 2001-07-24 2004-12-10 Servier Lab Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
AR036187A1 (es) 2001-07-24 2004-08-18 Adir Un proceso para la preparacion de perindopril, compuestos analogos y sus sales, compuesto intermediario 2,5-dioxo-oxazolidina y proceso para preparar un intermediario

Also Published As

Publication number Publication date
EE05428B1 (et) 2011-06-15
WO2003064388A2 (en) 2003-08-07
UA77756C2 (uk) 2007-01-15
NO330223B1 (no) 2011-03-07
HUP0300231A3 (en) 2004-04-28
EP1333026B1 (en) 2007-06-27
NZ534168A (en) 2006-11-30
SK287866B6 (sk) 2012-02-03
HRP20040781A8 (hr) 2009-01-31
JP2005521667A (ja) 2005-07-21
ZA200405548B (en) 2006-09-27
AR038340A1 (es) 2005-01-12
US7326794B2 (en) 2008-02-05
CY1106721T1 (el) 2012-05-23
SI1333026T1 (sl) 2007-10-31
ES2289060T3 (es) 2008-02-01
GEP20063899B (en) 2006-08-10
KR20040078680A (ko) 2004-09-10
EA009277B1 (ru) 2007-12-28
KR100673701B1 (ko) 2007-01-24
CA2474003A1 (en) 2003-08-07
HUP0300231A2 (hu) 2003-08-28
JP4171423B2 (ja) 2008-10-22
EE200400107A (et) 2004-10-15
AP2004003091A0 (en) 2004-09-30
PL358514A1 (en) 2003-07-28
CA2474003C (en) 2009-06-02
EP1333026A1 (en) 2003-08-06
BG108858A (en) 2005-05-31
BR0307293A (pt) 2004-12-21
ATE365714T1 (de) 2007-07-15
ME00444B (me) 2011-10-10
CN1300111C (zh) 2007-02-14
AU2003206055B2 (en) 2008-07-17
BRPI0307293B1 (pt) 2018-03-06
CN1622936A (zh) 2005-06-01
HRP20040781A2 (en) 2004-12-31
MXPA04007444A (es) 2005-06-17
PT1333026E (pt) 2007-09-17
DK1333026T3 (da) 2007-10-22
RS66704A (sr) 2007-02-05
BG66126B1 (bg) 2011-06-30
HRP20040781B1 (en) 2008-12-31
HU227591B1 (hu) 2011-09-28
OA12759A (en) 2006-07-04
WO2003064388A3 (en) 2004-02-05
CZ2004906A3 (cs) 2004-12-15
EA200400929A1 (ru) 2005-06-30
RS52465B (sr) 2013-02-28
HU0300231D0 (en) 2003-03-28
DE60220877D1 (de) 2007-08-09
HRP20040781B8 (hr) 2009-01-31
AP1741A (en) 2007-05-16
CZ305892B6 (cs) 2016-04-27
DE60220877T2 (de) 2008-04-10
US20070197821A1 (en) 2007-08-23
PL212354B1 (pl) 2012-09-28
US20050119492A1 (en) 2005-06-02
US7279595B2 (en) 2007-10-09
SK3292004A3 (en) 2004-12-01
HK1076101A1 (en) 2006-01-06

Similar Documents

Publication Publication Date Title
DK1268424T3 (da) Fremgangsmåde til syntese af perindopril og dets farmaceutisk acceptable salte
IL223579A0 (en) Synthesis of amines and intermediates for the synthesis thereof
DK1333026T3 (da) Fremgangsmåde til fremstilling af perindopril med höj renhed og nyttige mellemforbindelser til syntesen
EG24152A (en) Novel method for the synthesis of s-indoline-2-carboxylic acid and application thereof in synthesis of perindopril
ZA200510324B (en) Novel method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof
SI1420028T1 (sl) Postopek za sintezo perindoprila in njegovih farmacevtsko sprejemljivih soli
SI1367061T1 (sl) Nov postopek za sintezo perindoprila in njegovih farmacevtsko sprejemljivih soli
ZA200601426B (en) Novel method for the synthesis of perindopril and the pharmaceutically-acceptable salts thereof
PL379629A1 (pl) Nowy sposób syntezy perindoprylu oraz jego farmaceutycznie dopuszczalnych soli
PL379628A1 (pl) Nowy sposób syntezy perindoprilu i jego farmaceutycznie dopuszczalnych soli
SI1420029T1 (sl) Postopek za sintezo perindoprila in njegovih farmacevtsko sprejemljivih soli
SI1403275T1 (sl) Nov postopek sinteze perindoprila in njegovih farmacevtsko sprejemljivih soli
PL379625A1 (pl) Nowy sposób syntezy perindoprilu i jego farmaceutycznie dopuszczalnych soli
PL379631A1 (pl) Nowy sposób syntezy perindoprilu i jego farmaceutycznie dopuszczalnych soli
AU2003249069A8 (en) Cyclopentanone and cyclopentanone derivatives as potent activators of hsf-1
SI1422236T1 (sl) Postopek za sintezo perindoprila in njegovih farmacevtsko sprejemljivih soli
NO20044036L (no) Fremgangsmate for fremstilling av morfolinderivater og mellomprodukter derav
EP1486485A4 (en) NEW 5-HYDROXYCARBAMIMIDOYL-2-HYDROXYBENZENESULFONAMIDE DERIVATIVE CRYSTALS

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees