NO20044645L - Substituerte amino-isoksazolinderivater og deres anvendelse som antidepressive midler - Google Patents

Substituerte amino-isoksazolinderivater og deres anvendelse som antidepressive midler

Info

Publication number: NO20044645L
Authority: NO; Norway
Prior art keywords: substituted amino; isoxazoline derivatives; antidepressants; formula; optionally substituted
Prior art date: 2002-04-02

Application number

NO20044645A

Other languages

English (en)

Norwegian (no)

Inventor

Jose Ignacio Andres-Gil

Margaretha Henrica Maria Bakker

Manuell Jesus Alcazar-Vaca

Ana Isabel De Lucas Olivares

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-04-02

Filing date

2004-10-27

Publication date

2004-10-27

2004-10-27 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2004-10-27 Publication of NO20044645L publication Critical patent/NO20044645L/no

Links

XPZOKPQZEPSMFC-UHFFFAOYSA-N 4,5-dihydro-1,2-oxazol-3-amine Chemical class NC1=NOCC1 XPZOKPQZEPSMFC-UHFFFAOYSA-N 0.000 title abstract 2
239000000935 antidepressant agent Substances 0.000 title 1
229940005513 antidepressants Drugs 0.000 title 1
QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 4
208000019901 Anxiety disease Diseases 0.000 abstract 1
208000020401 Depressive disease Diseases 0.000 abstract 1
239000000670 adrenergic alpha-2 receptor antagonist Substances 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
230000037396 body weight Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000005936 piperidyl group Chemical group 0.000 abstract 1
229940076279 serotonin Drugs 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Anesthesiology (AREA)
Child & Adolescent Psychology (AREA)
Addiction (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

NO20044645A 2002-04-02 2004-10-27 Substituerte amino-isoksazolinderivater og deres anvendelse som antidepressive midler NO20044645L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP02076239		2002-04-02
PCT/EP2003/003245 WO2003082878A1 (en)	2002-04-02	2003-03-27	Substituted amino isoxazoline derivatives and their use as anti-depressants.

Publications (1)

Publication Number	Publication Date
NO20044645L true NO20044645L (no)	2004-10-27

Family

ID=28459528

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20044645A NO20044645L (no)	2002-04-02	2004-10-27	Substituerte amino-isoksazolinderivater og deres anvendelse som antidepressive midler

Country Status (24)

Country	Link
US (1)	US7265103B2 (da)
EP (1)	EP1492796B1 (da)
JP (1)	JP4580653B2 (da)
KR (1)	KR20040093061A (da)
CN (1)	CN100349897C (da)
AR (1)	AR039207A1 (da)
AT (1)	ATE372342T1 (da)
BR (1)	BR0308309A (da)
CA (1)	CA2480113C (da)
DE (1)	DE60316134T2 (da)
DK (1)	DK1492796T3 (da)
EA (1)	EA008189B1 (da)
ES (1)	ES2292949T3 (da)
HK (1)	HK1080072A1 (da)
HR (1)	HRP20040871A2 (da)
IL (2)	IL164341A0 (da)
MX (1)	MXPA04008626A (da)
NO (1)	NO20044645L (da)
NZ (1)	NZ536109A (da)
PL (1)	PL211708B1 (da)
PT (1)	PT1492796E (da)
TW (1)	TWI286138B (da)
WO (1)	WO2003082878A1 (da)
ZA (1)	ZA200407904B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR040967A1 (es) *	2002-08-12	2005-04-27	Janssen Pharmaceutica Nv	Derivados de isoxazolina triciclicos c- sustituidos y su uso como anti- depresivos
ATE387455T1 (de) *	2002-08-21	2008-03-15	Janssen Pharmaceutica Nv	C6- und c9-substituierte chromeno(4,3- c)isoxazoline und ihre verwendung als anti- depressiva
JP2008521771A (ja)	2004-11-26	2008-06-26	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	改良された抗精神病活性および抗不安症活性を有するイソキサゾリン−インドール誘導体
CA2691704A1 (en) *	2007-07-03	2009-01-08	F. Hoffmann-La Roche Ag	4-imidazolines and their use as antidepressants
EP2406243B1 (en)	2009-03-10	2014-05-07	Takeda Pharmaceutical Company Limited	Benzofuran derivatives
US20130062732A1 (en)	2011-09-08	2013-03-14	International Business Machines Corporation	Interconnect structures with functional components and methods for fabrication
CN105801510A (zh) *	2016-04-08	2016-07-27	李勇	一种治疗抑郁症的药物组合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2055011T3 (es)	1988-09-19	1994-08-16	Akzo Nv	Un procedimiento para la preparacion de derivados de tetrahidronaftaleno e indano.
AU710059B2 (en) *	1996-01-05	1999-09-09	Aventis Pharmaceuticals Inc.	4,5-dihydronaphth(1,2-C)isoxazoles and derivatives thereof having CNS activity
US6187774B1 (en) *	1996-03-04	2001-02-13	Yoshitomi Pharmaceutical Industries, Ltd.	Fused heterocyclic compounds and pharmaceutical applications thereof
MXPA03007432A (es) *	2001-02-21	2003-11-18	Janssen Pharmaceutica Nv	Derivados de isoxazolinas y su uso como antidepresivos.
AR040967A1 (es) *	2002-08-12	2005-04-27	Janssen Pharmaceutica Nv	Derivados de isoxazolina triciclicos c- sustituidos y su uso como anti- depresivos
ATE387455T1 (de) *	2002-08-21	2008-03-15	Janssen Pharmaceutica Nv	C6- und c9-substituierte chromeno(4,3- c)isoxazoline und ihre verwendung als anti- depressiva

2003
- 2003-03-27 NZ NZ536109A patent/NZ536109A/en unknown
- 2003-03-27 AT AT03714897T patent/ATE372342T1/de not_active IP Right Cessation
- 2003-03-27 EP EP03714897A patent/EP1492796B1/en not_active Expired - Lifetime
- 2003-03-27 MX MXPA04008626A patent/MXPA04008626A/es active IP Right Grant
- 2003-03-27 IL IL16434103A patent/IL164341A0/xx unknown
- 2003-03-27 HR HR20040871A patent/HRP20040871A2/hr not_active Application Discontinuation
- 2003-03-27 CN CNB038074192A patent/CN100349897C/zh not_active Expired - Fee Related
- 2003-03-27 EA EA200401297A patent/EA008189B1/ru not_active IP Right Cessation
- 2003-03-27 US US10/510,220 patent/US7265103B2/en not_active Expired - Lifetime
- 2003-03-27 WO PCT/EP2003/003245 patent/WO2003082878A1/en not_active Ceased
- 2003-03-27 PT PT03714897T patent/PT1492796E/pt unknown
- 2003-03-27 DK DK03714897T patent/DK1492796T3/da active
- 2003-03-27 BR BR0308309-8A patent/BR0308309A/pt not_active IP Right Cessation
- 2003-03-27 KR KR10-2004-7012757A patent/KR20040093061A/ko not_active Ceased
- 2003-03-27 JP JP2003580343A patent/JP4580653B2/ja not_active Expired - Fee Related
- 2003-03-27 ES ES03714897T patent/ES2292949T3/es not_active Expired - Lifetime
- 2003-03-27 CA CA2480113A patent/CA2480113C/en not_active Expired - Fee Related
- 2003-03-27 PL PL371630A patent/PL211708B1/pl unknown
- 2003-03-27 HK HK05112213.1A patent/HK1080072A1/zh unknown
- 2003-03-27 DE DE60316134T patent/DE60316134T2/de not_active Expired - Lifetime
- 2003-04-01 AR ARP030101126A patent/AR039207A1/es unknown
- 2003-04-01 TW TW092107328A patent/TWI286138B/zh not_active IP Right Cessation
2004
- 2004-09-28 IL IL164341A patent/IL164341A/en not_active IP Right Cessation
- 2004-09-30 ZA ZA200407904A patent/ZA200407904B/xx unknown
- 2004-10-27 NO NO20044645A patent/NO20044645L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
CA2480113A1 (en)	2003-10-09
ZA200407904B (en)	2005-10-20
DK1492796T3 (da)	2007-12-03
CN1642960A (zh)	2005-07-20
HK1080072A1 (zh)	2006-04-21
IL164341A0 (en)	2005-12-18
TWI286138B (en)	2007-09-01
EA200401297A1 (ru)	2005-02-24
PT1492796E (pt)	2007-11-16
EP1492796B1 (en)	2007-09-05
JP2005522469A (ja)	2005-07-28
ES2292949T3 (es)	2008-03-16
PL211708B1 (pl)	2012-06-29
KR20040093061A (ko)	2004-11-04
TW200406414A (en)	2004-05-01
DE60316134T2 (de)	2008-05-29
PL371630A1 (en)	2005-06-27
AR039207A1 (es)	2005-02-09
CN100349897C (zh)	2007-11-21
CA2480113C (en)	2012-04-24
JP4580653B2 (ja)	2010-11-17
BR0308309A (pt)	2004-12-28
US7265103B2 (en)	2007-09-04
US20050222125A1 (en)	2005-10-06
WO2003082878A1 (en)	2003-10-09
EP1492796A1 (en)	2005-01-05
NZ536109A (en)	2006-06-30
DE60316134D1 (de)	2007-10-18
AU2003219111A1 (en)	2003-10-13
HRP20040871A2 (en)	2005-04-30
MXPA04008626A (es)	2004-12-06
EA008189B1 (ru)	2007-04-27
ATE372342T1 (de)	2007-09-15
IL164341A (en)	2009-06-15

Legal Events

Date	Code	Title	Description
2010-09-27	FC2A	Withdrawal, rejection or dismissal of laid open patent application

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