NO20044964L - Flytende preparat som omfatter camptothecinderivat og farmasoytisk preparat som kan fremstilles ved a lyofilisere preparatet - Google Patents

Flytende preparat som omfatter camptothecinderivat og farmasoytisk preparat som kan fremstilles ved a lyofilisere preparatet

Info

Publication number
NO20044964L
NO20044964L NO20044964A NO20044964A NO20044964L NO 20044964 L NO20044964 L NO 20044964L NO 20044964 A NO20044964 A NO 20044964A NO 20044964 A NO20044964 A NO 20044964A NO 20044964 L NO20044964 L NO 20044964L
Authority
NO
Norway
Prior art keywords
prepared
pharmaceutical composition
preparation
camptothecin derivative
lyophilizing
Prior art date
Application number
NO20044964A
Other languages
English (en)
Inventor
Takahiro Lto
Shinji Narisawa
Original Assignee
Tanabe Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co
Publication of NO20044964L publication Critical patent/NO20044964L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Foreliggende oppfinnelsen vedrører et stabilt flytende preparat som omfatter et camptothecinderivat som er fremstilt ved å binde sammen en forbindelse med formel [I] eller et farmasøytisk akseptabelt salt derav, som er justert til pH 5-8, eller et stabilt farmasøytisk preparat som er fremstilt ved å lyofilisere nevnte fiytende preparat. Foreliggende oppfinnelsen vedrører et stabilt flytende preparat som omfatter et camptothecinderivat som er fremstilt ved å binde sammen en forbindelse med formel [I], X' ¿Alk-0- der r' er en substituert eller ikke- subsitituert lavere alkylgmppe, X' er en gmppe med formel -NHR2 (R2 er et hydrogenatom eller en lavere alkylgmppe) eller en hydroksygruppe, og Alk er en rettkjedet eller forgrenet alkylengmppe som eventuelt er avbmtt av et oksygenatom, og et polysakkarid som har karboksylgrupper, via en aminosyre eller et peptid, eller et farmasøytisk akseptabelt salt derav, som er Justert til pH-S-8, eller et stabilt farmasøytisk preparat som er fiemstilt ved & lyofilisere nevnte flytende preparat.
NO20044964A 2002-04-16 2004-11-15 Flytende preparat som omfatter camptothecinderivat og farmasoytisk preparat som kan fremstilles ved a lyofilisere preparatet NO20044964L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002112864 2002-04-16
PCT/JP2003/004745 WO2003086471A2 (en) 2002-04-16 2003-04-15 Lyophilized and liquid preparations comprising a polysaccharide derivative of camptothecin

Publications (1)

Publication Number Publication Date
NO20044964L true NO20044964L (no) 2004-11-15

Family

ID=29243336

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20044964A NO20044964L (no) 2002-04-16 2004-11-15 Flytende preparat som omfatter camptothecinderivat og farmasoytisk preparat som kan fremstilles ved a lyofilisere preparatet

Country Status (21)

Country Link
US (1) US20050215485A1 (no)
EP (1) EP1501549A2 (no)
JP (1) JP3927954B2 (no)
KR (1) KR100700963B1 (no)
CN (1) CN100544769C (no)
AR (1) AR039272A1 (no)
AU (1) AU2003223120B2 (no)
BR (1) BR0309283A (no)
CA (1) CA2480425A1 (no)
HR (1) HRP20040894A2 (no)
ME (1) MEP31308A (no)
MX (1) MXPA04010178A (no)
MY (1) MY136696A (no)
NO (1) NO20044964L (no)
PL (1) PL371677A1 (no)
RS (1) RS91204A (no)
RU (1) RU2315623C2 (no)
TW (1) TW200306314A (no)
UA (1) UA77295C2 (no)
WO (1) WO2003086471A2 (no)
ZA (1) ZA200408008B (no)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1714653B1 (en) * 2004-02-13 2010-11-24 Kabushiki Kaisha Yakult Honsha Aqueous solution preparation containing a camptothecin
US20070207149A1 (en) 2004-04-27 2007-09-06 Wellstat Biologics Corporation Cancer treatment using viruses and camptothecins
CA2612949C (en) 2005-07-14 2015-04-28 Wellstat Biologics Corporation Cancer treatment using viruses, fluoropyrimidines and camptothecins
JP2007260275A (ja) * 2006-03-29 2007-10-11 Transcutaneous Technologies Inc イオントフォレーシス装置及びイオントフォレーシス投与用組成物
WO2011041003A2 (en) 2009-06-22 2011-04-07 Wyeth Llc Compositions and methods for preparing staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions
AU2010264538B2 (en) 2009-06-22 2013-10-03 Wyeth Llc Immunogenic compositions of Staphylococcus aureus antigens
CN102764260B (zh) * 2011-04-30 2014-07-30 正大天晴药业集团股份有限公司 一种喜树碱衍生物的药物组合物及其制备方法
WO2013011598A1 (ja) * 2011-07-15 2013-01-24 コニカミノルタホールディングス株式会社 溶解助剤を利用したリポソーム含有製剤およびその製造方法
CN113304278A (zh) 2014-12-26 2021-08-27 日本化药株式会社 喜树碱类高分子衍生物的药物制剂
RU2726415C2 (ru) 2015-09-03 2020-07-14 Ниппон Каяку Кабусики Каися Фармацевтическая композиция, содержащая полимерное производное камптотецина
US10517961B2 (en) 2015-09-25 2019-12-31 ZY Therapeutics, Inc. Drug formulation based on particulates comprising polysaccharide-vitamin conjugate
RU2018129760A (ru) * 2016-03-01 2020-04-01 Ниппон Каяку Кабусики Кайся Фармацевтический препарат, содержащий полимерное производное на основе камптотецина
CN109481691A (zh) * 2018-11-20 2019-03-19 珠海天香苑生物科技发展股份有限公司 吉西他滨-羧甲基多糖共轭物、制备方法及其用途
MX2024006239A (es) * 2021-11-26 2024-06-11 Astellas Pharma Inc Composicion farmaceutica solida que contiene el compuesto indocianina.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5340817A (en) * 1987-04-14 1994-08-23 Research Triangle Institute Method of treating tumors with anti-tumor effective camptothecin compounds
DK0540099T3 (da) * 1991-10-29 1996-06-17 Glaxo Wellcome Inc Vandopløselige camptothecinderivater
SG50747A1 (en) * 1995-08-02 1998-07-20 Tanabe Seiyaku Co Comptothecin derivatives
IT1282673B1 (it) * 1996-02-23 1998-03-31 Ist Naz Stud Cura Dei Tumori Derivati della camptotecina e loro uso come agenti antitumorali
TW527183B (en) * 1996-06-06 2003-04-11 Daiichi Seiyaku Co Drug complex
US6288072B1 (en) * 1999-12-29 2001-09-11 Monroe E. Wall Camptothecin β-alanine esters with topoisomerase I inhibition
AR030207A1 (es) * 2000-04-07 2003-08-13 Daiichi Seiyaku Co Composicion farmaceutica que contiene un derivado de camptotecina y procedimiento de preparacion de la misma
AU2001271037A1 (en) * 2000-07-13 2002-01-30 Daiichi Pharmaceutical Co., Ltd. Pharmaceutical compositions containing dds compounds
TWI313609B (en) * 2001-08-21 2009-08-21 Mitsubishi Tanabe Pharma Corp Pharmaceutical composition for inhibiting the metastasis or preventing the recurrence of malignant tumor

Also Published As

Publication number Publication date
KR100700963B1 (ko) 2007-03-28
AU2003223120A1 (en) 2003-10-27
EP1501549A2 (en) 2005-02-02
UA77295C2 (en) 2006-11-15
AU2003223120B2 (en) 2006-10-05
BR0309283A (pt) 2005-02-15
WO2003086471A2 (en) 2003-10-23
US20050215485A1 (en) 2005-09-29
PL371677A1 (en) 2005-06-27
AU2003223120A2 (en) 2003-10-27
KR20050000516A (ko) 2005-01-05
AR039272A1 (es) 2005-02-16
CA2480425A1 (en) 2003-10-23
MY136696A (en) 2008-11-28
JP2005523329A (ja) 2005-08-04
RU2004133349A (ru) 2005-05-27
RU2315623C2 (ru) 2008-01-27
HRP20040894A2 (en) 2005-10-31
CN1646172A (zh) 2005-07-27
MXPA04010178A (es) 2005-06-08
JP3927954B2 (ja) 2007-06-13
TW200306314A (en) 2003-11-16
RS91204A (sr) 2006-12-15
ZA200408008B (en) 2005-06-13
CN100544769C (zh) 2009-09-30
WO2003086471A3 (en) 2004-04-15
MEP31308A (en) 2010-10-10

Similar Documents

Publication Publication Date Title
PT1227806E (pt) Formulacao farmaceutica contendo tolterodina e sua utilizacao
ATE178067T1 (de) Camptothecinderivate
EP0513543A1 (de) Amidinophenylalaninderivate, Verfahren zu deren Herstellung, deren Verwendung und diese enthaltende Mittel als Antikoagulantien
KR910002895A (ko) 펩티딜 아미노디올 레닌 억제제
CN109562064A (zh) 包含人胰高血糖素和统计共聚氨基酸的可注射水溶液形式的组合物
NO963464L (no) Nye opioidpeptider for behandling av smerte og anvendelse derav
JPS62500871A (ja) 薬理活性を有するジペプチド化合物及びそれを含む組成物
ID25979A (id) TURUNAN-TURUNAN KOMTOTESIN (Pecahan dari P-963785)
WO2003086471A3 (en) Lyophilized and liquid preparations comprising a polysaccharide derivative of camptothecin
ZA200004680B (en) Certain thiol inhibitors of endothelin-converting enzyme.
EP1485345B1 (de) Hemmstoffe der urokinase, ihre herstellung und verwendung
ES2274106T3 (es) Derivados de pirano como inhibidores tanto de ace como de nep.
KR102335943B1 (ko) 생물학적 물질 및 미생물의 보존과 보호를 위한 글리코펩티드 유도체
DE60133654D1 (de) Arzneimittel enthaltend analgetische peptide
JPH02504280A (ja) ペプチド
JP3240580B2 (ja) アスコルビル−ホスホリル−コレステロール
US7521477B2 (en) Vitamin C derivatives with peptide, preparation method thereof and composition comprising the same
EP0292923A3 (en) Piperidine compounds and pharmaceutical uses thereof
JPS6322524A (ja) 鎮痛剤として有用な環状及び架橋環状ソマトスタチンアナログ
KR19990044553A (ko) 펩티드 유도체
DE202026100346U1 (de) TLR-Agonisten-Konjugatverbindungen
RU2219185C2 (ru) Новое полипептидное соединение
BR0312972A (pt) Derivado de ácidos indolalcanóicos substituìdos e formulações contendo o mesmo para o uso no tratamento de complicações diabéticas
KR20240127500A (ko) 히알루론산 유도체-wkymvm 접합체 및 이의 용도
HK40003871A (en) Compositions in the form of an injectable aqueous solution, comprising human glucagon and a statistical copolyamino acid

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application