NO963464L - Nye opioidpeptider for behandling av smerte og anvendelse derav - Google Patents
Nye opioidpeptider for behandling av smerte og anvendelse deravInfo
- Publication number
- NO963464L NO963464L NO963464A NO963464A NO963464L NO 963464 L NO963464 L NO 963464L NO 963464 A NO963464 A NO 963464A NO 963464 A NO963464 A NO 963464A NO 963464 L NO963464 L NO 963464L
- Authority
- NO
- Norway
- Prior art keywords
- peptides
- phenylalanine
- tyrosyl residue
- residue
- naphthylalanine
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
En serie nye opioidpeptider for behandling av smerte og farmasøytisk akseptable preparater omfattende disse peptidcne. Det beskrives også fremgangsmåter for bekjempelse av smerte hos pasienter ved bruk av preparatene. Peptidcne har en høy grad av selektivitet for u-opioidreseptoren. Disse peptidene er sterkt lipofile. Til tross for deres lipofile karakter krysser de ikke lett blod-hjerne barrieren (BBB). Peptidene er spesielt velegnet som analgetiske midler idet de virker vesentlig på periferiske |> opioidreseptorer. På grunn av at disse peptidene virker periferisk unngår de i det vesentlige frembringelse av bivirkninger som normalt er forbundet med sentral analgetisk virkning. Forbindelsen har formelen (l): X¿R!¿R2¿R3¿Q¿R4¿N d) og derivater og analoger derav, hvor X er valgt fra gruppen bestående av H og C i .5 alkyl; Y og Z er uavhengig valgt fra gruppen bestående av H, cyklisk aralkyl og C\.6 alkyl; R! er en tyrosylrest, 2', 6'-dimetyltyrosylrest, eller en analog eller derivat derav; R3 er en aromatisk aminosyre; R4 er en aromatisk aminosyrerest; R2 er en aminosyre som har R-konfigurasjonen forutsatt at når RI er en tyrosylrest, R2 er D-alanin, X, Y og Z er H, og R3 er fenylalanin, så er R4 ikke fenylalanin usubstituert eller substituert med 4NC>2 e"er ^3; når RI er en tyrosylrest, R2 er D-alanin, X, Y og Z er H, og R4 er fenylalanin, så er R3 ikke fenylalanin usubstituert eller substituert med 4NO2I når RI er en tyrosylrest, R2 er D-alanin, X, Y og Z er H, og R4 er l'-naftylalanin, så er R3 ikke l'-naftylalanin eller 2'-naftyIalanin; og når RI er en tyrosylrest, R2 er D-alanin, og X, Y og Z er H, så er verken R3 eller R4 tryptofan; og Q er en amidbinding eller en innskutt amidbinding mimetisk.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9403263A GB9403263D0 (en) | 1994-02-21 | 1994-02-21 | Novel opiod peptides |
| GB9408179A GB9408179D0 (en) | 1994-02-21 | 1994-04-25 | Novel opioid peptides for the treatment of pain and use thereof |
| SE9401519A SE9401519D0 (sv) | 1994-05-03 | 1994-05-03 | Novel opioid peptides for the tratment of pain and use thereof |
| PCT/SE1995/000158 WO1995022557A1 (en) | 1994-02-21 | 1995-02-15 | Novel opioid peptides for the treatment of pain and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO963464L true NO963464L (no) | 1996-08-20 |
Family
ID=27267061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO963464A NO963464L (no) | 1994-02-21 | 1996-08-20 | Nye opioidpeptider for behandling av smerte og anvendelse derav |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0746567B1 (no) |
| JP (1) | JPH09509168A (no) |
| AT (1) | ATE217011T1 (no) |
| BR (1) | BR9506847A (no) |
| CA (1) | CA2181367A1 (no) |
| CZ (1) | CZ288523B6 (no) |
| DE (1) | DE69526577T2 (no) |
| EE (1) | EE03265B1 (no) |
| ES (1) | ES2176322T3 (no) |
| FI (1) | FI963252L (no) |
| HR (1) | HRP950413A2 (no) |
| HU (1) | HUT74731A (no) |
| IS (1) | IS4261A (no) |
| MX (1) | MX9603489A (no) |
| NO (1) | NO963464L (no) |
| NZ (1) | NZ281742A (no) |
| PL (1) | PL181092B1 (no) |
| SK (1) | SK93596A3 (no) |
| TW (1) | TW408131B (no) |
| WO (1) | WO1995022557A1 (no) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9503924D0 (sv) | 1995-08-18 | 1995-11-07 | Astra Ab | Novel opioid peptides |
| DE69623635T2 (de) * | 1995-06-07 | 2003-05-08 | Torrey Pines Institute For Molecular Studies, San Diego | Mu-opioidligande: agonisten und antagonisten |
| GB9516994D0 (en) * | 1995-08-18 | 1995-10-18 | Iaf Biochem Int | Solution synthesis of peripheral acting analgestic opioid tetrapeptides |
| MX9709494A (es) * | 1996-12-04 | 1998-07-31 | Pfizer | Compuestos peptidicos ciclicos, procedimiento para su produccion, composiciones que los contienen y uso de los mismos. |
| US5885958A (en) | 1997-03-25 | 1999-03-23 | Administrators Of The Tulane Educational Fund | Mu-opiate receptor peptides |
| US6548637B1 (en) | 1998-06-18 | 2003-04-15 | Sepracor, Inc. | Ligands for opioid receptors |
| SE9900961D0 (sv) | 1999-03-16 | 1999-03-16 | Astra Ab | Novel compounds |
| US7115664B2 (en) | 2000-03-16 | 2006-10-03 | Sepracor Inc. | Peptidomimetic ligands for cellular receptors and ion channels |
| EP1303186B1 (en) * | 2000-07-18 | 2011-01-26 | Cornell Research Foundation, Inc. | Medicinal uses of mu-opioid receptor agonists |
| SI2656854T1 (sl) | 2003-02-04 | 2015-09-30 | Cornell Research Foundation, Inc. | Uporabe aromatsko-kationskega peptida |
| JP4879020B2 (ja) | 2003-05-01 | 2012-02-15 | コーネル リサーチ ファウンデイション インコーポレイテッド | 細胞に分子を送達する方法及び担体複合体 |
| CA2851972C (en) | 2004-01-23 | 2015-06-23 | Cornell Research Foundation, Inc. | Methods for reducing oxidative damage |
| JP4173909B1 (ja) | 2005-04-28 | 2008-10-29 | ファイザー・リミテッド | アミノ酸誘導体 |
| CA2947335A1 (en) | 2005-09-16 | 2007-03-29 | Cornell Research Foundation, Inc. | Methods for reducing cd36 expression |
| EP1782819A1 (en) | 2005-11-03 | 2007-05-09 | Cognis IP Management GmbH | Oligopeptides and their use |
| US7842662B2 (en) | 2006-11-10 | 2010-11-30 | Cara Therapeutics, Inc. | Synthetic peptide amide dimers |
| US8236766B2 (en) | 2006-11-10 | 2012-08-07 | Cara Therapeutics, Inc. | Uses of synthetic peptide amides |
| MX2009005000A (es) | 2006-11-10 | 2009-10-12 | Cara Therapeutics Inc | Amidas de peptidos sinteticos. |
| US7713937B2 (en) | 2006-11-10 | 2010-05-11 | Cara Therapeutics, Inc. | Synthetic peptide amides and dimeric forms thereof |
| US8906859B2 (en) | 2006-11-10 | 2014-12-09 | Cera Therapeutics, Inc. | Uses of kappa opioid synthetic peptide amides |
| CN102127152B (zh) * | 2007-06-11 | 2012-07-04 | 北京大学 | 一种抗阿片肽的拮抗肽与该拮抗肽的应用 |
| CN102127151B (zh) * | 2007-06-11 | 2012-07-04 | 北京大学 | 抗阿片肽的拮抗肽与该拮抗肽的应用 |
| CN101805396B (zh) * | 2007-06-28 | 2011-09-14 | 北京大学 | 抗阿片肽的拮抗肽与该拮抗肽的应用 |
| CN101817877B (zh) * | 2007-06-28 | 2011-09-14 | 北京大学 | 一种抗阿片肽的活性片段 |
| EP3103467A1 (en) | 2008-02-07 | 2016-12-14 | Cornell University | Methods for preventing or treating insulin resistance |
| DK2262520T3 (en) | 2008-02-26 | 2017-08-07 | Univ Cornell | COMPOSITIONS FOR PREVENTION AND TREATMENT OF Kidney Injury |
| CN112469729A (zh) * | 2018-05-31 | 2021-03-09 | 悉尼大学 | 镇痛剂及其使用方法 |
| JP7437578B2 (ja) * | 2019-03-20 | 2024-02-26 | 国立大学法人東北大学 | 新規オピオイドペプチド、その糖鎖付加体及びそれらを含む医薬組成物 |
| CN113968902B (zh) * | 2020-07-25 | 2023-05-26 | 兰州大学 | 亮氨酸-脑啡肽类似物及其制备方法和应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL8005121A (nl) * | 1979-09-20 | 1981-03-24 | Erba Farmitalia | Biologisch actieve peptiden. |
| PT644772E (pt) * | 1992-11-12 | 2003-08-29 | Conseils De Rec Appl Scient S | Peptidos opioides |
| SE9300012D0 (sv) * | 1993-01-05 | 1993-01-05 | Astra Ab | New peptides |
-
1995
- 1995-02-13 IS IS4261A patent/IS4261A/is unknown
- 1995-02-15 CA CA002181367A patent/CA2181367A1/en not_active Abandoned
- 1995-02-15 BR BR9506847A patent/BR9506847A/pt not_active Application Discontinuation
- 1995-02-15 NZ NZ281742A patent/NZ281742A/en unknown
- 1995-02-15 JP JP7521753A patent/JPH09509168A/ja not_active Abandoned
- 1995-02-15 ES ES95910838T patent/ES2176322T3/es not_active Expired - Lifetime
- 1995-02-15 SK SK935-96A patent/SK93596A3/sk unknown
- 1995-02-15 HU HU9602281A patent/HUT74731A/hu unknown
- 1995-02-15 EP EP95910838A patent/EP0746567B1/en not_active Expired - Lifetime
- 1995-02-15 FI FI963252A patent/FI963252L/fi unknown
- 1995-02-15 MX MX9603489A patent/MX9603489A/es unknown
- 1995-02-15 AT AT95910838T patent/ATE217011T1/de not_active IP Right Cessation
- 1995-02-15 DE DE69526577T patent/DE69526577T2/de not_active Expired - Fee Related
- 1995-02-15 CZ CZ19962391A patent/CZ288523B6/cs not_active IP Right Cessation
- 1995-02-15 WO PCT/SE1995/000158 patent/WO1995022557A1/en not_active Ceased
- 1995-02-15 EE EE9600071A patent/EE03265B1/xx not_active IP Right Cessation
- 1995-02-15 PL PL95315947A patent/PL181092B1/pl unknown
- 1995-02-16 TW TW084101429A patent/TW408131B/zh not_active IP Right Cessation
- 1995-07-19 HR HR9401519-5A patent/HRP950413A2/hr not_active Application Discontinuation
-
1996
- 1996-08-20 NO NO963464A patent/NO963464L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE217011T1 (de) | 2002-05-15 |
| EP0746567B1 (en) | 2002-05-02 |
| AU690648B2 (en) | 1998-04-30 |
| FI963252A7 (fi) | 1996-08-20 |
| CZ288523B6 (cs) | 2001-07-11 |
| HUT74731A (en) | 1997-02-28 |
| CZ239196A3 (en) | 1996-12-11 |
| PL315947A1 (en) | 1996-12-09 |
| DE69526577D1 (de) | 2002-06-06 |
| EP0746567A1 (en) | 1996-12-11 |
| HU9602281D0 (en) | 1996-10-28 |
| JPH09509168A (ja) | 1997-09-16 |
| FI963252A0 (fi) | 1996-08-20 |
| DE69526577T2 (de) | 2003-01-02 |
| MX9603489A (es) | 1997-03-29 |
| IS4261A (is) | 1995-08-22 |
| NZ281742A (en) | 1997-06-24 |
| WO1995022557A1 (en) | 1995-08-24 |
| BR9506847A (pt) | 1997-09-30 |
| PL181092B1 (pl) | 2001-05-31 |
| FI963252L (fi) | 1996-08-20 |
| CA2181367A1 (en) | 1995-08-24 |
| SK93596A3 (en) | 1997-05-07 |
| TW408131B (en) | 2000-10-11 |
| HRP950413A2 (en) | 1997-10-31 |
| EE03265B1 (et) | 2000-04-17 |
| AU1865195A (en) | 1995-09-04 |
| ES2176322T3 (es) | 2002-12-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |