NO963464L - Nye opioidpeptider for behandling av smerte og anvendelse derav - Google Patents
Nye opioidpeptider for behandling av smerte og anvendelse deravInfo
- Publication number
- NO963464L NO963464L NO963464A NO963464A NO963464L NO 963464 L NO963464 L NO 963464L NO 963464 A NO963464 A NO 963464A NO 963464 A NO963464 A NO 963464A NO 963464 L NO963464 L NO 963464L
- Authority
- NO
- Norway
- Prior art keywords
- peptides
- phenylalanine
- tyrosyl residue
- residue
- naphthylalanine
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
En serie nye opioidpeptider for behandling av smerte og farmasøytisk akseptable preparater omfattende disse peptidcne. Det beskrives også fremgangsmåter for bekjempelse av smerte hos pasienter ved bruk av preparatene. Peptidcne har en høy grad av selektivitet for u-opioidreseptoren. Disse peptidene er sterkt lipofile. Til tross for deres lipofile karakter krysser de ikke lett blod-hjerne barrieren (BBB). Peptidene er spesielt velegnet som analgetiske midler idet de virker vesentlig på periferiske |> opioidreseptorer. På grunn av at disse peptidene virker periferisk unngår de i det vesentlige frembringelse av bivirkninger som normalt er forbundet med sentral analgetisk virkning. Forbindelsen har formelen (l): X¿R!¿R2¿R3¿Q¿R4¿N d) og derivater og analoger derav, hvor X er valgt fra gruppen bestående av H og C i .5 alkyl; Y og Z er uavhengig valgt fra gruppen bestående av H, cyklisk aralkyl og C\.6 alkyl; R! er en tyrosylrest, 2', 6'-dimetyltyrosylrest, eller en analog eller derivat derav; R3 er en aromatisk aminosyre; R4 er en aromatisk aminosyrerest; R2 er en aminosyre som har R-konfigurasjonen forutsatt at når RI er en tyrosylrest, R2 er D-alanin, X, Y og Z er H, og R3 er fenylalanin, så er R4 ikke fenylalanin usubstituert eller substituert med 4NC>2 e"er ^3; når RI er en tyrosylrest, R2 er D-alanin, X, Y og Z er H, og R4 er fenylalanin, så er R3 ikke fenylalanin usubstituert eller substituert med 4NO2I når RI er en tyrosylrest, R2 er D-alanin, X, Y og Z er H, og R4 er l'-naftylalanin, så er R3 ikke l'-naftylalanin eller 2'-naftyIalanin; og når RI er en tyrosylrest, R2 er D-alanin, og X, Y og Z er H, så er verken R3 eller R4 tryptofan; og Q er en amidbinding eller en innskutt amidbinding mimetisk.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9403263A GB9403263D0 (en) | 1994-02-21 | 1994-02-21 | Novel opiod peptides |
| GB9408179A GB9408179D0 (en) | 1994-02-21 | 1994-04-25 | Novel opioid peptides for the treatment of pain and use thereof |
| SE9401519A SE9401519D0 (sv) | 1994-05-03 | 1994-05-03 | Novel opioid peptides for the tratment of pain and use thereof |
| PCT/SE1995/000158 WO1995022557A1 (en) | 1994-02-21 | 1995-02-15 | Novel opioid peptides for the treatment of pain and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO963464L true NO963464L (no) | 1996-08-20 |
Family
ID=27267061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO963464A NO963464L (no) | 1994-02-21 | 1996-08-20 | Nye opioidpeptider for behandling av smerte og anvendelse derav |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0746567B1 (no) |
| JP (1) | JPH09509168A (no) |
| AT (1) | ATE217011T1 (no) |
| BR (1) | BR9506847A (no) |
| CA (1) | CA2181367A1 (no) |
| CZ (1) | CZ288523B6 (no) |
| DE (1) | DE69526577T2 (no) |
| EE (1) | EE03265B1 (no) |
| ES (1) | ES2176322T3 (no) |
| FI (1) | FI963252A0 (no) |
| HR (1) | HRP950413A2 (no) |
| HU (1) | HUT74731A (no) |
| IS (1) | IS4261A (no) |
| MX (1) | MX9603489A (no) |
| NO (1) | NO963464L (no) |
| NZ (1) | NZ281742A (no) |
| PL (1) | PL181092B1 (no) |
| SK (1) | SK93596A3 (no) |
| TW (1) | TW408131B (no) |
| WO (1) | WO1995022557A1 (no) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9503924D0 (sv) * | 1995-08-18 | 1995-11-07 | Astra Ab | Novel opioid peptides |
| WO1996040208A1 (en) * | 1995-06-07 | 1996-12-19 | Torrey Pines Institute For Molecular Studies | Novel mu opioid receptor ligands: agonists and antagonists |
| GB9516994D0 (en) * | 1995-08-18 | 1995-10-18 | Iaf Biochem Int | Solution synthesis of peripheral acting analgestic opioid tetrapeptides |
| MX9709494A (es) * | 1996-12-04 | 1998-07-31 | Pfizer | Compuestos peptidicos ciclicos, procedimiento para su produccion, composiciones que los contienen y uso de los mismos. |
| US5885958A (en) * | 1997-03-25 | 1999-03-23 | Administrators Of The Tulane Educational Fund | Mu-opiate receptor peptides |
| AU4572999A (en) * | 1998-06-18 | 2000-01-05 | Sepracor, Inc. | Tetrapeptides, analogs and peptidomimetics which bind selectively mammalian opioid receptors |
| SE9900961D0 (sv) * | 1999-03-16 | 1999-03-16 | Astra Ab | Novel compounds |
| AU2001239896A1 (en) | 2000-03-16 | 2001-10-03 | Sepracor, Inc. | Peptidomimetic ligands for cellular receptors and ion channels |
| CA2416475C (en) * | 2000-07-18 | 2011-10-11 | Cornell Research Foundation, Inc. | Medicinal uses of mu-opioid receptor agonists |
| ES2436011T3 (es) | 2003-02-04 | 2013-12-26 | Cornell Research Foundation, Inc. | Métodos para prevenir la transición de la permeabilidad mitocondrial |
| CN100506841C (zh) | 2003-05-01 | 2009-07-01 | 科内尔研究基金会 | 将分子递送到细胞的方法和载体复合物 |
| RU2376028C2 (ru) | 2004-01-23 | 2009-12-20 | Корнелл Рисеч Фаундейшн, Инк. | Способ уменьшения окислительного повреждения (варианты) |
| KR100925900B1 (ko) | 2005-04-28 | 2009-11-09 | 화이자 리미티드 | 아미노산 유도체 |
| CA2947330C (en) | 2005-09-16 | 2018-06-05 | Cornell Research Foundation, Inc. | Methods for reducing cd36 expression |
| EP1782819A1 (en) | 2005-11-03 | 2007-05-09 | Cognis IP Management GmbH | Oligopeptides and their use |
| US7842662B2 (en) | 2006-11-10 | 2010-11-30 | Cara Therapeutics, Inc. | Synthetic peptide amide dimers |
| US8236766B2 (en) | 2006-11-10 | 2012-08-07 | Cara Therapeutics, Inc. | Uses of synthetic peptide amides |
| US8906859B2 (en) | 2006-11-10 | 2014-12-09 | Cera Therapeutics, Inc. | Uses of kappa opioid synthetic peptide amides |
| PL2064228T3 (pl) | 2006-11-10 | 2013-01-31 | Cara Therapeutics Inc | Syntetyczne amidy peptydowe |
| US7713937B2 (en) | 2006-11-10 | 2010-05-11 | Cara Therapeutics, Inc. | Synthetic peptide amides and dimeric forms thereof |
| CN102127151B (zh) * | 2007-06-11 | 2012-07-04 | 北京大学 | 抗阿片肽的拮抗肽与该拮抗肽的应用 |
| CN102127152B (zh) * | 2007-06-11 | 2012-07-04 | 北京大学 | 一种抗阿片肽的拮抗肽与该拮抗肽的应用 |
| CN101805396B (zh) * | 2007-06-28 | 2011-09-14 | 北京大学 | 抗阿片肽的拮抗肽与该拮抗肽的应用 |
| CN101817877B (zh) * | 2007-06-28 | 2011-09-14 | 北京大学 | 一种抗阿片肽的活性片段 |
| CA2713150C (en) | 2008-02-07 | 2016-01-05 | Cornell University | Methods for preventing or treating insulin resistance |
| DK2262520T3 (en) | 2008-02-26 | 2017-08-07 | Univ Cornell | COMPOSITIONS FOR PREVENTION AND TREATMENT OF Kidney Injury |
| AU2019277212A1 (en) * | 2018-05-31 | 2021-02-04 | The University Of Queensland | Analgesics and methods of use thereof |
| JP7437578B2 (ja) * | 2019-03-20 | 2024-02-26 | 国立大学法人東北大学 | 新規オピオイドペプチド、その糖鎖付加体及びそれらを含む医薬組成物 |
| CN113968902B (zh) * | 2020-07-25 | 2023-05-26 | 兰州大学 | 亮氨酸-脑啡肽类似物及其制备方法和应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL8005121A (nl) * | 1979-09-20 | 1981-03-24 | Erba Farmitalia | Biologisch actieve peptiden. |
| EP0644772B1 (en) * | 1992-11-12 | 2003-04-02 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. | Opioid peptides |
| SE9300012D0 (sv) * | 1993-01-05 | 1993-01-05 | Astra Ab | New peptides |
-
1995
- 1995-02-13 IS IS4261A patent/IS4261A/is unknown
- 1995-02-15 JP JP7521753A patent/JPH09509168A/ja not_active Abandoned
- 1995-02-15 WO PCT/SE1995/000158 patent/WO1995022557A1/en not_active Ceased
- 1995-02-15 MX MX9603489A patent/MX9603489A/es unknown
- 1995-02-15 SK SK935-96A patent/SK93596A3/sk unknown
- 1995-02-15 EE EE9600071A patent/EE03265B1/xx not_active IP Right Cessation
- 1995-02-15 FI FI963252A patent/FI963252A0/fi unknown
- 1995-02-15 AT AT95910838T patent/ATE217011T1/de not_active IP Right Cessation
- 1995-02-15 CZ CZ19962391A patent/CZ288523B6/cs not_active IP Right Cessation
- 1995-02-15 EP EP95910838A patent/EP0746567B1/en not_active Expired - Lifetime
- 1995-02-15 CA CA002181367A patent/CA2181367A1/en not_active Abandoned
- 1995-02-15 NZ NZ281742A patent/NZ281742A/en unknown
- 1995-02-15 PL PL95315947A patent/PL181092B1/pl unknown
- 1995-02-15 DE DE69526577T patent/DE69526577T2/de not_active Expired - Fee Related
- 1995-02-15 BR BR9506847A patent/BR9506847A/pt not_active Application Discontinuation
- 1995-02-15 ES ES95910838T patent/ES2176322T3/es not_active Expired - Lifetime
- 1995-02-15 HU HU9602281A patent/HUT74731A/hu unknown
- 1995-02-16 TW TW084101429A patent/TW408131B/zh not_active IP Right Cessation
- 1995-07-19 HR HR9401519-5A patent/HRP950413A2/hr not_active Application Discontinuation
-
1996
- 1996-08-20 NO NO963464A patent/NO963464L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU690648B2 (en) | 1998-04-30 |
| FI963252A7 (fi) | 1996-08-20 |
| DE69526577D1 (de) | 2002-06-06 |
| ATE217011T1 (de) | 2002-05-15 |
| AU1865195A (en) | 1995-09-04 |
| HUT74731A (en) | 1997-02-28 |
| PL181092B1 (pl) | 2001-05-31 |
| NZ281742A (en) | 1997-06-24 |
| ES2176322T3 (es) | 2002-12-01 |
| CZ239196A3 (en) | 1996-12-11 |
| EE03265B1 (et) | 2000-04-17 |
| PL315947A1 (en) | 1996-12-09 |
| CZ288523B6 (cs) | 2001-07-11 |
| MX9603489A (es) | 1997-03-29 |
| CA2181367A1 (en) | 1995-08-24 |
| EP0746567A1 (en) | 1996-12-11 |
| FI963252L (fi) | 1996-08-20 |
| DE69526577T2 (de) | 2003-01-02 |
| HRP950413A2 (en) | 1997-10-31 |
| FI963252A0 (fi) | 1996-08-20 |
| HU9602281D0 (en) | 1996-10-28 |
| BR9506847A (pt) | 1997-09-30 |
| WO1995022557A1 (en) | 1995-08-24 |
| EP0746567B1 (en) | 2002-05-02 |
| IS4261A (is) | 1995-08-22 |
| TW408131B (en) | 2000-10-11 |
| JPH09509168A (ja) | 1997-09-16 |
| SK93596A3 (en) | 1997-05-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |