NO20045192L - Prosess for fremstilling av 1,2,3,9-tetrahydro-9-metyl-3-[(2-metyl-1H-imidazol-1-yl)metyl]-4H-karbazol-4-on - Google Patents

Prosess for fremstilling av 1,2,3,9-tetrahydro-9-metyl-3-[(2-metyl-1H-imidazol-1-yl)metyl]-4H-karbazol-4-on

Info

Publication number
NO20045192L
NO20045192L NO20045192A NO20045192A NO20045192L NO 20045192 L NO20045192 L NO 20045192L NO 20045192 A NO20045192 A NO 20045192A NO 20045192 A NO20045192 A NO 20045192A NO 20045192 L NO20045192 L NO 20045192L
Authority
NO
Norway
Prior art keywords
methyl
carbazol
imidazol
tetrahydro
preparation
Prior art date
Application number
NO20045192A
Other languages
English (en)
Inventor
Szabolcs Salyi
Csaba Szabo
Sandor Molnar
Erzsebet Meszaros Sos
Tivadar Tamas
Original Assignee
Teva Gyogyszergyar Reszvenytar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Gyogyszergyar Reszvenytar filed Critical Teva Gyogyszergyar Reszvenytar
Publication of NO20045192L publication Critical patent/NO20045192L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D521/00—Heterocyclic compounds containing unspecified hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

En fremgangsmåte for fremstilling av ondansetron ved transaminering av en ondansetronstrukturanalog som kan fremstilles ved en Mannich-reaksjon, beskrives. Fremgangsmåten representerer en forbedring over kjente fremgangsmåter for fremstilling av ondansetron ved transaminering på grunn av dens store hastighet, selektivitet og lettheten hvorved produktet som kan isoleres fra reaksjonsblandingen.
NO20045192A 2002-04-29 2004-11-26 Prosess for fremstilling av 1,2,3,9-tetrahydro-9-metyl-3-[(2-metyl-1H-imidazol-1-yl)metyl]-4H-karbazol-4-on NO20045192L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37632302P 2002-04-29 2002-04-29
PCT/US2003/013221 WO2003093281A1 (en) 2002-04-29 2003-04-29 Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1h-imidazol-1-yl)methyl]-4h-carbazol-4-one

Publications (1)

Publication Number Publication Date
NO20045192L true NO20045192L (no) 2005-01-28

Family

ID=29401332

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20045192A NO20045192L (no) 2002-04-29 2004-11-26 Prosess for fremstilling av 1,2,3,9-tetrahydro-9-metyl-3-[(2-metyl-1H-imidazol-1-yl)metyl]-4H-karbazol-4-on

Country Status (19)

Country Link
US (2) US7098345B2 (no)
EP (1) EP1499623B1 (no)
JP (1) JP2005529142A (no)
KR (1) KR20040104654A (no)
CN (1) CN1665823A (no)
AT (1) ATE364611T1 (no)
AU (1) AU2003223764A1 (no)
CA (1) CA2483566A1 (no)
DE (1) DE60314400T2 (no)
DK (1) DK1499623T3 (no)
ES (1) ES2288606T3 (no)
HR (1) HRP20041070A2 (no)
IL (1) IL164904A0 (no)
MX (1) MXPA04010846A (no)
NO (1) NO20045192L (no)
PL (1) PL373191A1 (no)
PT (1) PT1499623E (no)
WO (1) WO2003093281A1 (no)
ZA (1) ZA200408934B (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002230935A1 (en) * 2000-10-30 2002-05-15 Teva Pharmaceutical Industries Ltd. Novel crystal and solvate forms of ondansetron hydrochloride and processes for their preparation
US20050131045A1 (en) * 2002-04-30 2005-06-16 Judith Aronhime Novel crystal forms of ondansetron, processes for their preparation, pharmaceutical, compositions containing the novel forms and methods for treating nausea using them
KR20040104677A (ko) * 2002-04-30 2004-12-10 비오갈 기오기스제르갸르 알티. 신규의 온단세트론 결정 형태, 그 제조 방법, 그 신규의결정 형태를 함유하는 약학 조성물 및 이들을 이용한구역질 치료 방법
US7696356B2 (en) * 2004-08-17 2010-04-13 Taro Pharmaceutical Industries Limited Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one and ondansetron therefrom
WO2006046253A1 (en) * 2004-10-26 2006-05-04 Ipca Laboratories Limited A one-pot process for the preparation of antiemetic agent, 1,2,3,9-tetrahydro-9-methyl-3[(2-methyl)-1h-imidazole-1-yl)methyl]-4h-carbazol-4-o

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE460359B (sv) 1984-01-25 1989-10-02 Glaxo Group Ltd 3-imidazolylmetyltetrahydrokarbazoloner, foerfarande foer framstaellning av dessa och en farmaceutisk komposition
US4695578A (en) * 1984-01-25 1987-09-22 Glaxo Group Limited 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances
EP0201165B1 (en) 1985-03-14 1994-07-20 Beecham Group Plc Medicaments for the treatment of emesis
GB8518745D0 (en) 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
GB8518742D0 (en) 1985-07-24 1985-08-29 Glaxo Group Ltd Process
GB8518741D0 (en) 1985-07-24 1985-08-29 Glaxo Group Ltd Process
GB8518743D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
US4859662A (en) 1986-11-28 1989-08-22 Glaxo Group Limited Tetrahydro-imidazolylmethylcarbazolones and analogs thereof for treating 5-HT function disturbances
GB8630071D0 (en) 1986-12-17 1987-01-28 Glaxo Group Ltd Medicaments
GB8816187D0 (en) * 1988-07-07 1988-08-10 Glaxo Group Ltd Medicaments
US5344658A (en) 1989-06-28 1994-09-06 Glaxo Group Limited Process and composition using ondansetron
GB8914804D0 (en) 1989-06-28 1989-08-16 Glaxo Group Ltd Process
JPH06508836A (ja) 1991-06-26 1994-10-06 セプラコア，インコーポレーテッド 光学的に純粋なｒ（＋）オンダンセトロンを使用する嘔吐、吐き気および他の障害の治療のための方法および組成物
CA2106642C (en) 1992-10-14 2005-08-16 Peter Bod Carbazolone derivatives and process for preparing the same
GB9423588D0 (en) 1994-11-22 1995-01-11 Glaxo Wellcome Inc Compositions
GB9423511D0 (en) 1994-11-22 1995-01-11 Glaxo Wellcome Inc Compositions
CN1045437C (zh) 1994-12-29 1999-10-06 中国科学院上海有机化学研究所 恩丹西酮及其生理盐的合成
AU2002230935A1 (en) 2000-10-30 2002-05-15 Teva Pharmaceutical Industries Ltd. Novel crystal and solvate forms of ondansetron hydrochloride and processes for their preparation
EP1207160A1 (en) 2000-11-20 2002-05-22 Hanmi Pharm. Co., Ltd. Process for the preparation of 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)-methyl)-4H-carbazol-4-one
SK9892003A3 (en) 2001-01-11 2004-05-04 Teva Pharma An improved process for preparing pure ondansetron hydrochloride dihydrate
WO2003090730A1 (en) 2002-04-25 2003-11-06 Generics [Uk] Limited Novel crystalline forms of celecoxib and other compounds
KR20040104677A (ko) 2002-04-30 2004-12-10 비오갈 기오기스제르갸르 알티. 신규의 온단세트론 결정 형태, 그 제조 방법, 그 신규의결정 형태를 함유하는 약학 조성물 및 이들을 이용한구역질 치료 방법

Also Published As

Publication number Publication date
EP1499623A1 (en) 2005-01-26
MXPA04010846A (es) 2005-01-25
US7098345B2 (en) 2006-08-29
AU2003223764A1 (en) 2003-11-17
DK1499623T3 (da) 2007-10-08
ZA200408934B (en) 2006-07-26
IL164904A0 (en) 2005-12-18
US20060252942A1 (en) 2006-11-09
DE60314400D1 (de) 2007-07-26
ATE364611T1 (de) 2007-07-15
DE60314400T2 (de) 2008-02-07
CN1665823A (zh) 2005-09-07
ES2288606T3 (es) 2008-01-16
JP2005529142A (ja) 2005-09-29
CA2483566A1 (en) 2003-11-13
KR20040104654A (ko) 2004-12-10
WO2003093281A1 (en) 2003-11-13
EP1499623B1 (en) 2007-06-13
HRP20041070A2 (en) 2005-02-28
PT1499623E (pt) 2007-08-10
PL373191A1 (en) 2005-08-22
US20050020655A1 (en) 2005-01-27

Similar Documents

Publication Publication Date Title
TW200626580A (en) Synthesis of (5-bromo-4-methyl-pyridin-3-ylmethyl)-ethyl-carbamic acid tert-butyl ester
TN2010000149A1 (en) Spiroheterocyclic pyrrolidine dione derivatives useful as pesticides
PL371414A1 (en) Disubstituted thiazolyl carboxanilides and their use as microbicides
EP1427411A4 (en) (-) - 1- (3,4-DICHLORPHENYL) -3-AZABICYCLO ç3.1.0! HEXAN, COMPOSITIONS OF THESE, AND USE AS DOPAMINE RECOVERY INHIBITORS
MX2010009045A (es) Derivados de indola sustituidos.
NO20071629L (no) Fremgangsmate for fremstilling av 2,7-oktadienylderivater
ZA202403308B (en) An efficient new process for synthesis of 2-amino-5-chloro-n-,3-dimethylbenzamide
MX2023002890A (es) Procesos e intermedios para la preparacion de (s)-5-amino-3-(4-((5-fluoro-2-metoxibenzamido)metil)fenil)-1-(1,1 ,1-trifluoropropan-2-il)-1h-pirazol-4-carboxamida.
WO2019010363A8 (en) Synthesis of halichondrins
NO20063132L (no) Naftyridinderivater og deres anvendelse som modulatorer av muskarinreceptorer
ZA202204277B (en) Methods for the preparation of 5-bromo-2-(3-chloro-pyridin-2-yl)-2h-pyrazole-3-carboxylic acid
MXPA05013652A (es) Modulador del receptor canabinoide.
WO2002092564A3 (en) Synthesis of cyclopentadiene derivatives
NO20045192L (no) Prosess for fremstilling av 1,2,3,9-tetrahydro-9-metyl-3-[(2-metyl-1H-imidazol-1-yl)metyl]-4H-karbazol-4-on
WO2008021491A3 (en) Method for synthesis of 8-alkoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones
WO2004111047A3 (en) Cycloalkanepyrrolopyridines as dp receptor antagonists
MY152557A (en) 3-aminocyclopentanecarboxamides as chemokine receptor modulators
NO20060417L (no) Fremgangsmate til fremstilling av 1-okten fra krakk-C4
MX2022006142A (es) Proceso para la sintesis de (3-cloro-2-piridil)hidrazina.
CA3156320A1 (en) 2-AZASPIRO[3,4] OCTANE DERIVATIVES USED AS M4 AGONISTS
WO2008075163A3 (en) An improved process for the preparation of rizatriptan
CA2432138A1 (en) New process for the preparation of eletriptan
PH12022550860A1 (en) 5-oxa-2-azaspiro[3.4]octane derivatives as m4 agonists
MX2009013336A (es) Sintesis de 3-aminopirazoles sustituidos.
DK1389188T3 (da) Fremgangsmåde til fremstilling af biperiden II

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application