ATE364611T1 - Verfahren zur herstellung von 1,2,3,9-tetrahydro- 9-methyl-3- (2-methyl-1h-imidazol-1-yl)methylö- h-carbazol-4-on - Google Patents

Verfahren zur herstellung von 1,2,3,9-tetrahydro- 9-methyl-3- (2-methyl-1h-imidazol-1-yl)methylö- h-carbazol-4-on

Info

Publication number: ATE364611T1
Authority: AT; Austria
Prior art keywords: methyl; methylö; carbazol; imidazol; tetrahydro
Prior art date: 2002-04-29

Application number

AT03719968T

Other languages

English (en)

Inventor

Sandor Molnar

Csaba Szabo

Sos Erzsebet Meszaros

Szabolcs Salyi

Tivadar Tamas

Original Assignee

Teva Gyogyszergyar Zartkoeruee

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-04-29

Filing date

2003-04-29

Publication date

2007-07-15

2003-04-29 Application filed by Teva Gyogyszergyar Zartkoeruee filed Critical Teva Gyogyszergyar Zartkoeruee

2007-07-15 Application granted granted Critical

2007-07-15 Publication of ATE364611T1 publication Critical patent/ATE364611T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
FELGMEQIXOGIFQ-CYBMUJFWSA-N (3r)-9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1h-carbazol-4-one Chemical compound CC1=NC=CN1C[C@@H]1C(=O)C(C=2C(=CC=CC=2)N2C)=C2CC1 FELGMEQIXOGIFQ-CYBMUJFWSA-N 0.000 abstract 3
229960005343 ondansetron Drugs 0.000 abstract 3
238000000034 method Methods 0.000 abstract 2
238000005891 transamination reaction Methods 0.000 abstract 2
238000006683 Mannich reaction Methods 0.000 abstract 1
239000011541 reaction mixture Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D521/00—Heterocyclic compounds containing unspecified hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Hospice & Palliative Care (AREA)
Pharmacology & Pharmacy (AREA)
Otolaryngology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)

AT03719968T 2002-04-29 2003-04-29 Verfahren zur herstellung von 1,2,3,9-tetrahydro- 9-methyl-3- (2-methyl-1h-imidazol-1-yl)methylö- h-carbazol-4-on ATE364611T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US37632302P	2002-04-29	2002-04-29

Publications (1)

Publication Number	Publication Date
ATE364611T1 true ATE364611T1 (de)	2007-07-15

Family

ID=29401332

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03719968T ATE364611T1 (de)	2002-04-29	2003-04-29	Verfahren zur herstellung von 1,2,3,9-tetrahydro- 9-methyl-3- (2-methyl-1h-imidazol-1-yl)methylö- h-carbazol-4-on

Country Status (19)

Country	Link
US (2)	US7098345B2 (de)
EP (1)	EP1499623B1 (de)
JP (1)	JP2005529142A (de)
KR (1)	KR20040104654A (de)
CN (1)	CN1665823A (de)
AT (1)	ATE364611T1 (de)
AU (1)	AU2003223764A1 (de)
CA (1)	CA2483566A1 (de)
DE (1)	DE60314400T2 (de)
DK (1)	DK1499623T3 (de)
ES (1)	ES2288606T3 (de)
HR (1)	HRP20041070A2 (de)
IL (1)	IL164904A0 (de)
MX (1)	MXPA04010846A (de)
NO (1)	NO20045192L (de)
PL (1)	PL373191A1 (de)
PT (1)	PT1499623E (de)
WO (1)	WO2003093281A1 (de)
ZA (1)	ZA200408934B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SK6182003A3 (en) *	2000-10-30	2004-03-02	Teva Pharma	Crystalline and solvated forms of ondansetrone hydrochloride and preparation thereof
HRP20041136A2 (en) *	2002-04-30	2005-04-30	Teva Gy�gyszergy�r R�szv�nyt�rsas�g	Novel crystal forms of ondansetron, processes fortheir preparation, pharmaceutical compositions containing the novel forms and methods for treating nausea using them
US20050131045A1 (en) *	2002-04-30	2005-06-16	Judith Aronhime	Novel crystal forms of ondansetron, processes for their preparation, pharmaceutical, compositions containing the novel forms and methods for treating nausea using them
US7696356B2 (en) *	2004-08-17	2010-04-13	Taro Pharmaceutical Industries Limited	Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one and ondansetron therefrom
WO2006046253A1 (en) *	2004-10-26	2006-05-04	Ipca Laboratories Limited	A one-pot process for the preparation of antiemetic agent, 1,2,3,9-tetrahydro-9-methyl-3[(2-methyl)-1h-imidazole-1-yl)methyl]-4h-carbazol-4-o

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4695578A (en) *	1984-01-25	1987-09-22	Glaxo Group Limited	1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances
PH22672A (en)	1984-01-25	1988-11-14	Glaxo Group Ltd	Imidazolylmethyltetrahydrocarbazolone derivatives, composition and method of use thereof
EP0385517B1 (de)	1985-03-14	1993-04-14	BEECHAM GROUP plc	Arzneimittel zur Behandlung von Erbrechen
GB8518742D0 (en)	1985-07-24	1985-08-29	Glaxo Group Ltd	Process
GB8518741D0 (en)	1985-07-24	1985-08-29	Glaxo Group Ltd	Process
GB8518743D0 (en) *	1985-07-24	1985-08-29	Glaxo Group Ltd	Heterocyclic compounds
GB8518745D0 (en)	1985-07-24	1985-08-29	Glaxo Group Ltd	Heterocyclic compounds
US4859662A (en)	1986-11-28	1989-08-22	Glaxo Group Limited	Tetrahydro-imidazolylmethylcarbazolones and analogs thereof for treating 5-HT function disturbances
GB8630071D0 (en)	1986-12-17	1987-01-28	Glaxo Group Ltd	Medicaments
GB8816187D0 (en) *	1988-07-07	1988-08-10	Glaxo Group Ltd	Medicaments
GB8914804D0 (en)	1989-06-28	1989-08-16	Glaxo Group Ltd	Process
US5344658A (en)	1989-06-28	1994-09-06	Glaxo Group Limited	Process and composition using ondansetron
WO1993000074A1 (en)	1991-06-26	1993-01-07	Sepracor, Inc.	Method and compositions for treating emesis, nausea and other disorders using optically pure r(+) ondansetron
CA2106642C (en)	1992-10-14	2005-08-16	Peter Bod	Carbazolone derivatives and process for preparing the same
GB9423588D0 (en)	1994-11-22	1995-01-11	Glaxo Wellcome Inc	Compositions
GB9423511D0 (en)	1994-11-22	1995-01-11	Glaxo Wellcome Inc	Compositions
CN1045437C (zh)	1994-12-29	1999-10-06	中国科学院上海有机化学研究所	恩丹西酮及其生理盐的合成
SK6182003A3 (en)	2000-10-30	2004-03-02	Teva Pharma	Crystalline and solvated forms of ondansetrone hydrochloride and preparation thereof
EP1207160A1 (de)	2000-11-20	2002-05-22	Hanmi Pharm. Co., Ltd.	Verfahren zur Herstellung von 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)-methyl)-4H-carbazol-4-one
ES2219201T1 (es)	2001-01-11	2004-12-01	Teva Pharmaceutical Industries Ltd.	Procedimiento mejorado para la preparacion de ondansetron clorhidrato dihidrato puro.
AU2002251329A1 (en)	2002-04-25	2003-11-10	Generics (Uk) Limited	Novel crystalline forms of celecoxib and other compounds
HRP20041136A2 (en)	2002-04-30	2005-04-30	Teva Gy�gyszergy�r R�szv�nyt�rsas�g	Novel crystal forms of ondansetron, processes fortheir preparation, pharmaceutical compositions containing the novel forms and methods for treating nausea using them

2003
- 2003-04-29 AT AT03719968T patent/ATE364611T1/de not_active IP Right Cessation
- 2003-04-29 US US10/425,450 patent/US7098345B2/en not_active Expired - Fee Related
- 2003-04-29 ES ES03719968T patent/ES2288606T3/es not_active Expired - Lifetime
- 2003-04-29 WO PCT/US2003/013221 patent/WO2003093281A1/en not_active Ceased
- 2003-04-29 PL PL03373191A patent/PL373191A1/xx not_active Application Discontinuation
- 2003-04-29 MX MXPA04010846A patent/MXPA04010846A/es unknown
- 2003-04-29 EP EP03719968A patent/EP1499623B1/de not_active Expired - Lifetime
- 2003-04-29 CN CN038154684A patent/CN1665823A/zh active Pending
- 2003-04-29 DK DK03719968T patent/DK1499623T3/da active
- 2003-04-29 JP JP2004501420A patent/JP2005529142A/ja active Pending
- 2003-04-29 CA CA002483566A patent/CA2483566A1/en not_active Abandoned
- 2003-04-29 PT PT03719968T patent/PT1499623E/pt unknown
- 2003-04-29 DE DE60314400T patent/DE60314400T2/de not_active Expired - Fee Related
- 2003-04-29 AU AU2003223764A patent/AU2003223764A1/en not_active Abandoned
- 2003-04-29 KR KR10-2004-7017346A patent/KR20040104654A/ko not_active Ceased
- 2003-04-29 HR HR20041070A patent/HRP20041070A2/hr not_active Application Discontinuation
2004
- 2004-10-28 IL IL16490404A patent/IL164904A0/xx unknown
- 2004-11-04 ZA ZA200408934A patent/ZA200408934B/xx unknown
- 2004-11-26 NO NO20045192A patent/NO20045192L/no not_active Application Discontinuation
2006
- 2006-07-07 US US11/482,486 patent/US20060252942A1/en not_active Abandoned

Also Published As

Publication number	Publication date
HRP20041070A2 (en)	2005-02-28
AU2003223764A1 (en)	2003-11-17
KR20040104654A (ko)	2004-12-10
ES2288606T3 (es)	2008-01-16
IL164904A0 (en)	2005-12-18
NO20045192L (no)	2005-01-28
CN1665823A (zh)	2005-09-07
PL373191A1 (en)	2005-08-22
ZA200408934B (en)	2006-07-26
US20060252942A1 (en)	2006-11-09
EP1499623B1 (de)	2007-06-13
WO2003093281A1 (en)	2003-11-13
DK1499623T3 (da)	2007-10-08
DE60314400T2 (de)	2008-02-07
CA2483566A1 (en)	2003-11-13
US20050020655A1 (en)	2005-01-27
PT1499623E (pt)	2007-08-10
DE60314400D1 (de)	2007-07-26
JP2005529142A (ja)	2005-09-29
US7098345B2 (en)	2006-08-29
MXPA04010846A (es)	2005-01-25
EP1499623A1 (de)	2005-01-26

Legal Events

Date

Code

Title

Description

2007-10-15

UEP

Publication of translation of european patent specification

Ref document number: 1499623

Country of ref document: EP

2010-01-15

REN

Ceased due to non-payment of the annual fee

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