ATE364611T1 - Verfahren zur herstellung von 1,2,3,9-tetrahydro- 9-methyl-3- (2-methyl-1h-imidazol-1-yl)methylö- h-carbazol-4-on - Google Patents

Verfahren zur herstellung von 1,2,3,9-tetrahydro- 9-methyl-3- (2-methyl-1h-imidazol-1-yl)methylö- h-carbazol-4-on

Info

Publication number: ATE364611T1
Authority: AT; Austria
Prior art keywords: methyl; methylö; carbazol; imidazol; tetrahydro
Prior art date: 2002-04-29

Application number

AT03719968T

Other languages

English (en)

Inventor

Sandor Molnar

Csaba Szabo

Sos Erzsebet Meszaros

Szabolcs Salyi

Tivadar Tamas

Original Assignee

Teva Gyogyszergyar Zartkoeruee

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-04-29

Filing date

2003-04-29

Publication date

2007-07-15

2003-04-29 Application filed by Teva Gyogyszergyar Zartkoeruee filed Critical Teva Gyogyszergyar Zartkoeruee

2007-07-15 Application granted granted Critical

2007-07-15 Publication of ATE364611T1 publication Critical patent/ATE364611T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
FELGMEQIXOGIFQ-CYBMUJFWSA-N (3r)-9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1h-carbazol-4-one Chemical compound CC1=NC=CN1C[C@@H]1C(=O)C(C=2C(=CC=CC=2)N2C)=C2CC1 FELGMEQIXOGIFQ-CYBMUJFWSA-N 0.000 abstract 3
229960005343 ondansetron Drugs 0.000 abstract 3
238000000034 method Methods 0.000 abstract 2
238000005891 transamination reaction Methods 0.000 abstract 2
238000006683 Mannich reaction Methods 0.000 abstract 1
239000011541 reaction mixture Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D521/00—Heterocyclic compounds containing unspecified hetero rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)

AT03719968T 2002-04-29 2003-04-29 Verfahren zur herstellung von 1,2,3,9-tetrahydro- 9-methyl-3- (2-methyl-1h-imidazol-1-yl)methylö- h-carbazol-4-on ATE364611T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US37632302P	2002-04-29	2002-04-29

Publications (1)

Publication Number	Publication Date
ATE364611T1 true ATE364611T1 (de)	2007-07-15

Family

ID=29401332

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03719968T ATE364611T1 (de)	2002-04-29	2003-04-29	Verfahren zur herstellung von 1,2,3,9-tetrahydro- 9-methyl-3- (2-methyl-1h-imidazol-1-yl)methylö- h-carbazol-4-on

Country Status (19)

Country	Link
US (2)	US7098345B2 (de)
EP (1)	EP1499623B1 (de)
JP (1)	JP2005529142A (de)
KR (1)	KR20040104654A (de)
CN (1)	CN1665823A (de)
AT (1)	ATE364611T1 (de)
AU (1)	AU2003223764A1 (de)
CA (1)	CA2483566A1 (de)
DE (1)	DE60314400T2 (de)
DK (1)	DK1499623T3 (de)
ES (1)	ES2288606T3 (de)
HR (1)	HRP20041070A2 (de)
IL (1)	IL164904A0 (de)
MX (1)	MXPA04010846A (de)
NO (1)	NO20045192L (de)
PL (1)	PL373191A1 (de)
PT (1)	PT1499623E (de)
WO (1)	WO2003093281A1 (de)
ZA (1)	ZA200408934B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2002230935A1 (en) *	2000-10-30	2002-05-15	Teva Pharmaceutical Industries Ltd.	Novel crystal and solvate forms of ondansetron hydrochloride and processes for their preparation
US20050131045A1 (en) *	2002-04-30	2005-06-16	Judith Aronhime	Novel crystal forms of ondansetron, processes for their preparation, pharmaceutical, compositions containing the novel forms and methods for treating nausea using them
KR20040104677A (ko) *	2002-04-30	2004-12-10	비오갈 기오기스제르갸르 알티.	신규의 온단세트론 결정 형태, 그 제조 방법, 그 신규의결정 형태를 함유하는 약학 조성물 및 이들을 이용한구역질 치료 방법
US7696356B2 (en) *	2004-08-17	2010-04-13	Taro Pharmaceutical Industries Limited	Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one and ondansetron therefrom
WO2006046253A1 (en) *	2004-10-26	2006-05-04	Ipca Laboratories Limited	A one-pot process for the preparation of antiemetic agent, 1,2,3,9-tetrahydro-9-methyl-3[(2-methyl)-1h-imidazole-1-yl)methyl]-4h-carbazol-4-o

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE460359B (sv)	1984-01-25	1989-10-02	Glaxo Group Ltd	3-imidazolylmetyltetrahydrokarbazoloner, foerfarande foer framstaellning av dessa och en farmaceutisk komposition
US4695578A (en) *	1984-01-25	1987-09-22	Glaxo Group Limited	1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances
EP0201165B1 (de)	1985-03-14	1994-07-20	Beecham Group Plc	Arzneimittel zur Behandlung von Emesis
GB8518745D0 (en)	1985-07-24	1985-08-29	Glaxo Group Ltd	Heterocyclic compounds
GB8518742D0 (en)	1985-07-24	1985-08-29	Glaxo Group Ltd	Process
GB8518741D0 (en)	1985-07-24	1985-08-29	Glaxo Group Ltd	Process
GB8518743D0 (en) *	1985-07-24	1985-08-29	Glaxo Group Ltd	Heterocyclic compounds
US4859662A (en)	1986-11-28	1989-08-22	Glaxo Group Limited	Tetrahydro-imidazolylmethylcarbazolones and analogs thereof for treating 5-HT function disturbances
GB8630071D0 (en)	1986-12-17	1987-01-28	Glaxo Group Ltd	Medicaments
GB8816187D0 (en) *	1988-07-07	1988-08-10	Glaxo Group Ltd	Medicaments
US5344658A (en)	1989-06-28	1994-09-06	Glaxo Group Limited	Process and composition using ondansetron
GB8914804D0 (en)	1989-06-28	1989-08-16	Glaxo Group Ltd	Process
JPH06508836A (ja)	1991-06-26	1994-10-06	セプラコア，インコーポレーテッド	光学的に純粋なｒ（＋）オンダンセトロンを使用する嘔吐、吐き気および他の障害の治療のための方法および組成物
CA2106642C (en)	1992-10-14	2005-08-16	Peter Bod	Carbazolone derivatives and process for preparing the same
GB9423588D0 (en)	1994-11-22	1995-01-11	Glaxo Wellcome Inc	Compositions
GB9423511D0 (en)	1994-11-22	1995-01-11	Glaxo Wellcome Inc	Compositions
CN1045437C (zh)	1994-12-29	1999-10-06	中国科学院上海有机化学研究所	恩丹西酮及其生理盐的合成
AU2002230935A1 (en)	2000-10-30	2002-05-15	Teva Pharmaceutical Industries Ltd.	Novel crystal and solvate forms of ondansetron hydrochloride and processes for their preparation
EP1207160A1 (de)	2000-11-20	2002-05-22	Hanmi Pharm. Co., Ltd.	Verfahren zur Herstellung von 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)-methyl)-4H-carbazol-4-one
SK9892003A3 (en)	2001-01-11	2004-05-04	Teva Pharma	An improved process for preparing pure ondansetron hydrochloride dihydrate
WO2003090730A1 (en)	2002-04-25	2003-11-06	Generics [Uk] Limited	Novel crystalline forms of celecoxib and other compounds
KR20040104677A (ko)	2002-04-30	2004-12-10	비오갈 기오기스제르갸르 알티.	신규의 온단세트론 결정 형태, 그 제조 방법, 그 신규의결정 형태를 함유하는 약학 조성물 및 이들을 이용한구역질 치료 방법

2003
- 2003-04-29 DK DK03719968T patent/DK1499623T3/da active
- 2003-04-29 CN CN038154684A patent/CN1665823A/zh active Pending
- 2003-04-29 DE DE60314400T patent/DE60314400T2/de not_active Expired - Fee Related
- 2003-04-29 MX MXPA04010846A patent/MXPA04010846A/es unknown
- 2003-04-29 CA CA002483566A patent/CA2483566A1/en not_active Abandoned
- 2003-04-29 KR KR10-2004-7017346A patent/KR20040104654A/ko not_active Ceased
- 2003-04-29 AU AU2003223764A patent/AU2003223764A1/en not_active Abandoned
- 2003-04-29 HR HR20041070A patent/HRP20041070A2/hr not_active Application Discontinuation
- 2003-04-29 WO PCT/US2003/013221 patent/WO2003093281A1/en not_active Ceased
- 2003-04-29 JP JP2004501420A patent/JP2005529142A/ja active Pending
- 2003-04-29 PT PT03719968T patent/PT1499623E/pt unknown
- 2003-04-29 PL PL03373191A patent/PL373191A1/xx not_active Application Discontinuation
- 2003-04-29 US US10/425,450 patent/US7098345B2/en not_active Expired - Fee Related
- 2003-04-29 EP EP03719968A patent/EP1499623B1/de not_active Expired - Lifetime
- 2003-04-29 AT AT03719968T patent/ATE364611T1/de not_active IP Right Cessation
- 2003-04-29 ES ES03719968T patent/ES2288606T3/es not_active Expired - Lifetime
2004
- 2004-10-28 IL IL16490404A patent/IL164904A0/xx unknown
- 2004-11-04 ZA ZA200408934A patent/ZA200408934B/xx unknown
- 2004-11-26 NO NO20045192A patent/NO20045192L/no not_active Application Discontinuation
2006
- 2006-07-07 US US11/482,486 patent/US20060252942A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1499623A1 (de)	2005-01-26
MXPA04010846A (es)	2005-01-25
US7098345B2 (en)	2006-08-29
AU2003223764A1 (en)	2003-11-17
DK1499623T3 (da)	2007-10-08
ZA200408934B (en)	2006-07-26
IL164904A0 (en)	2005-12-18
US20060252942A1 (en)	2006-11-09
DE60314400D1 (de)	2007-07-26
DE60314400T2 (de)	2008-02-07
CN1665823A (zh)	2005-09-07
ES2288606T3 (es)	2008-01-16
JP2005529142A (ja)	2005-09-29
CA2483566A1 (en)	2003-11-13
KR20040104654A (ko)	2004-12-10
WO2003093281A1 (en)	2003-11-13
EP1499623B1 (de)	2007-06-13
HRP20041070A2 (en)	2005-02-28
PT1499623E (pt)	2007-08-10
NO20045192L (no)	2005-01-28
PL373191A1 (en)	2005-08-22
US20050020655A1 (en)	2005-01-27

Legal Events

Date

Code

Title

Description

2007-10-15

UEP

Publication of translation of european patent specification

Ref document number: 1499623

Country of ref document: EP

2010-01-15

REN

Ceased due to non-payment of the annual fee

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