NO20050011L - Farmasoytisk anvendelse av nitrogenholdig oksid, hemoksygenase-1 og produkter av hemdegradering - Google Patents
Farmasoytisk anvendelse av nitrogenholdig oksid, hemoksygenase-1 og produkter av hemdegraderingInfo
- Publication number
- NO20050011L NO20050011L NO20050011A NO20050011A NO20050011L NO 20050011 L NO20050011 L NO 20050011L NO 20050011 A NO20050011 A NO 20050011A NO 20050011 A NO20050011 A NO 20050011A NO 20050011 L NO20050011 L NO 20050011L
- Authority
- NO
- Norway
- Prior art keywords
- products
- hemoxygenase
- hem
- degradation
- nitrogen
- Prior art date
Links
- 230000015556 catabolic process Effects 0.000 title 1
- 238000006731 degradation reaction Methods 0.000 title 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 title 1
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 abstract 4
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 abstract 2
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 abstract 2
- 102000002737 Heme Oxygenase-1 Human genes 0.000 abstract 2
- 108010018924 Heme Oxygenase-1 Proteins 0.000 abstract 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 2
- 229910002091 carbon monoxide Inorganic materials 0.000 abstract 2
- GWZYPXHJIZCRAJ-UHFFFAOYSA-N Biliverdin Natural products CC1=C(C=C)C(=C/C2=NC(=Cc3[nH]c(C=C/4NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)O)C(=C2C)CCC(=O)O)NC1=O GWZYPXHJIZCRAJ-UHFFFAOYSA-N 0.000 abstract 1
- RCNSAJSGRJSBKK-NSQVQWHSSA-N Biliverdin IX Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(\C=C/2C(=C(C)C(=C/C=3C(=C(C=C)C(=O)N=3)C)/N\2)CCC(O)=O)N1 RCNSAJSGRJSBKK-NSQVQWHSSA-N 0.000 abstract 1
- QBUVFDKTZJNUPP-UHFFFAOYSA-N biliverdin-IXalpha Natural products N1C(=O)C(C)=C(C=C)C1=CC1=C(C)C(CCC(O)=O)=C(C=C2C(=C(C)C(C=C3C(=C(C=C)C(=O)N3)C)=N2)CCC(O)=O)N1 QBUVFDKTZJNUPP-UHFFFAOYSA-N 0.000 abstract 1
- 239000007857 degradation product Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000003278 haem Chemical class 0.000 abstract 1
- 229910052742 iron Inorganic materials 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Inorganic Chemistry (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Transplantation (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
Abstract
Det beskrives en behandling behandling av sykdommer som anvender nitrogen oksyd (NO), hem oksygenase-1 (HO-1), og hemdegraderingsprodukter som karbonmonoksyd (CO), biliverdin, bilirubin og jern.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39045702P | 2002-06-21 | 2002-06-21 | |
| PCT/US2003/019609 WO2004000368A1 (en) | 2002-06-21 | 2003-06-20 | Pharmaceutical use of nitric oxide, heme oxygenase-1 and products of heme degradation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20050011L true NO20050011L (no) | 2005-03-18 |
Family
ID=30000561
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20050011A NO20050011L (no) | 2002-06-21 | 2005-01-03 | Farmasoytisk anvendelse av nitrogenholdig oksid, hemoksygenase-1 og produkter av hemdegradering |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20040131703A1 (no) |
| EP (1) | EP1515753A4 (no) |
| JP (1) | JP2005533812A (no) |
| CN (1) | CN1674942A (no) |
| AU (1) | AU2003279236B8 (no) |
| CA (1) | CA2490392A1 (no) |
| EA (1) | EA200500062A1 (no) |
| HR (1) | HRP20041204A2 (no) |
| MX (1) | MXPA04012863A (no) |
| NO (1) | NO20050011L (no) |
| PL (1) | PL375161A1 (no) |
| RS (1) | RS110504A (no) |
| WO (1) | WO2004000368A1 (no) |
Families Citing this family (69)
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| US8128963B2 (en) * | 1996-09-27 | 2012-03-06 | The Trustees Of Columbia University In The City Of New York | Methods for treating ischemic disorders using carbon monoxide |
| CA2254645A1 (en) * | 1998-11-23 | 2000-05-23 | Pulmonox Medical Corporation | Method and apparatus for treatment of respiratory infections by nitric oxide inhalation |
| US20070086954A1 (en) * | 1998-11-23 | 2007-04-19 | Miller Christopher C | Method and apparatus for treatment of respiratory infections by nitric oxide inhalation |
| US7678390B2 (en) * | 1999-04-01 | 2010-03-16 | Yale University | Carbon monoxide as a biomarker and therapeutic agent |
| US7516742B2 (en) * | 1999-11-24 | 2009-04-14 | Cardinal Health 207, Inc. | Method and apparatus for delivery of inhaled nitric oxide to spontaneous-breathing and mechanically-ventilated patients with intermittent dosing |
| US6432077B1 (en) * | 2000-12-26 | 2002-08-13 | Sensormedics Corporation | Device and method for treatment of surface infections with nitric oxide |
| US7122018B2 (en) * | 2000-12-26 | 2006-10-17 | Sensormedics Corporation | Device and method for treatment of wounds with nitric oxide |
| MXPA03012031A (es) * | 2001-06-21 | 2005-07-01 | Univ Yale | El monoxido de carbono mejoraresultados en transplantes de tejido y organo y suprime apoptosis. |
| NZ534912A (en) * | 2002-02-04 | 2007-08-31 | Alfama Investigacao E Desenvol | supramolecule aggregate comprising CO containing organometallic or transition metal complex and anti-inflammatory agent or biphosphonate phosphonate derivative |
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| WO2003088748A1 (en) | 2002-04-15 | 2003-10-30 | Beth Israel Deaconess Medical Center | Use of heme oxygenase-1 and products of heme degradation |
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| JP4549847B2 (ja) | 2002-05-17 | 2010-09-22 | イエール ユニバーシティ | 肝炎の治療方法 |
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| DE10249552A1 (de) | 2002-10-23 | 2004-05-13 | Vifor (International) Ag | Wasserlösliche Eisen-Kohlenhydrat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel |
| PL377733A1 (pl) * | 2002-11-07 | 2006-02-06 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Leczenie wstrząsu krwotocznego |
| US20070117769A1 (en) * | 2003-09-29 | 2007-05-24 | Maines Mahin D | Methods of modulating cell cycle and cell signaling pathways using biliverdin reductase |
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| EP1888510A4 (en) | 2005-05-27 | 2013-01-16 | Univ North Carolina | NITROGEN OXIDE-RELATED PARTICLES FOR NITROGEN OXIDE THERAPEUTICS AND BIOMEDICAL APPLICATIONS |
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- 2003-06-20 PL PL03375161A patent/PL375161A1/xx unknown
- 2003-06-20 AU AU2003279236A patent/AU2003279236B8/en not_active Withdrawn - After Issue
- 2003-06-20 JP JP2004516066A patent/JP2005533812A/ja not_active Withdrawn
- 2003-06-20 EP EP03742119A patent/EP1515753A4/en not_active Withdrawn
- 2003-06-20 RS YUP-1105/04A patent/RS110504A/sr unknown
- 2003-06-20 CA CA002490392A patent/CA2490392A1/en not_active Abandoned
- 2003-06-20 WO PCT/US2003/019609 patent/WO2004000368A1/en not_active Ceased
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- 2003-06-20 HR HR20041204A patent/HRP20041204A2/xx not_active Application Discontinuation
- 2003-06-20 US US10/600,182 patent/US20040131703A1/en not_active Abandoned
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2007
- 2007-10-31 US US11/931,645 patent/US20080171021A1/en not_active Abandoned
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| US20080171021A1 (en) | 2008-07-17 |
| EA200500062A1 (ru) | 2005-06-30 |
| HRP20041204A2 (en) | 2005-06-30 |
| CA2490392A1 (en) | 2003-12-31 |
| EP1515753A4 (en) | 2009-07-15 |
| MXPA04012863A (es) | 2005-03-31 |
| JP2005533812A (ja) | 2005-11-10 |
| RS110504A (sr) | 2007-02-05 |
| US20040131703A1 (en) | 2004-07-08 |
| PL375161A1 (en) | 2005-11-28 |
| CN1674942A (zh) | 2005-09-28 |
| AU2003279236A1 (en) | 2004-01-06 |
| AU2003279236B2 (en) | 2009-01-22 |
| AU2003279236B8 (en) | 2009-02-19 |
| EP1515753A1 (en) | 2005-03-23 |
| WO2004000368A1 (en) | 2003-12-31 |
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