NO20050679L - Anvendelse av metallkomplekser inneholdende perfluoralkyl som kontrastmidler i magnetisk resonansbildedannelse for a fremvise intravaskulaere tromber - Google Patents

Anvendelse av metallkomplekser inneholdende perfluoralkyl som kontrastmidler i magnetisk resonansbildedannelse for a fremvise intravaskulaere tromber

Info

Publication number
NO20050679L
NO20050679L NO20050679A NO20050679A NO20050679L NO 20050679 L NO20050679 L NO 20050679L NO 20050679 A NO20050679 A NO 20050679A NO 20050679 A NO20050679 A NO 20050679A NO 20050679 L NO20050679 L NO 20050679L
Authority
NO
Norway
Prior art keywords
metal complexes
exhibit
magnetic resonance
resonance imaging
contrast agents
Prior art date
Application number
NO20050679A
Other languages
English (en)
Norwegian (no)
Inventor
Hanns-Joachim Weinmann
Johannes Platzek
Ulrich Niedballa
Bernd Misselwitz
Yoko Kawata
Takishi Yokawa
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of NO20050679L publication Critical patent/NO20050679L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO20050679A 2002-07-10 2005-02-09 Anvendelse av metallkomplekser inneholdende perfluoralkyl som kontrastmidler i magnetisk resonansbildedannelse for a fremvise intravaskulaere tromber NO20050679L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10231799A DE10231799B4 (de) 2002-07-10 2002-07-10 Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Intravasalen Thromben
PCT/EP2003/007274 WO2004006965A2 (fr) 2002-07-10 2003-07-05 Utilisation de complexes metalliques contenant du perfluoroalkyle en tant qu'agents de contraste en imagerie par resonance magnetique pour la representation de thrombus intravasculaires

Publications (1)

Publication Number Publication Date
NO20050679L true NO20050679L (no) 2005-04-08

Family

ID=30009959

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20050679A NO20050679L (no) 2002-07-10 2005-02-09 Anvendelse av metallkomplekser inneholdende perfluoralkyl som kontrastmidler i magnetisk resonansbildedannelse for a fremvise intravaskulaere tromber

Country Status (23)

Country Link
EP (1) EP1519756B1 (fr)
JP (1) JP2005532404A (fr)
CN (1) CN1668338A (fr)
AR (1) AR041187A1 (fr)
AT (1) ATE361103T1 (fr)
AU (2) AU2003281146A1 (fr)
BR (1) BR0312552A (fr)
CA (1) CA2491933A1 (fr)
DE (2) DE10231799B4 (fr)
DK (1) DK1519756T3 (fr)
ES (1) ES2285143T3 (fr)
IL (1) IL165889A0 (fr)
MX (1) MXPA04012950A (fr)
NO (1) NO20050679L (fr)
PE (1) PE20040656A1 (fr)
PL (1) PL374027A1 (fr)
PT (1) PT1519756E (fr)
RS (1) RS20050020A (fr)
RU (1) RU2328310C2 (fr)
TW (1) TW200413008A (fr)
UA (1) UA79294C2 (fr)
WO (2) WO2004006979A2 (fr)
ZA (1) ZA200501172B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006021495A1 (de) * 2006-05-09 2007-11-15 Bayer Schering Pharma Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel zur Diagnose der Alzheimer Krankheit
TW201034691A (en) * 2008-12-05 2010-10-01 Molecular Insight Pharm Inc Technetium-and rhenium-bis(heteroaryl) complexes and methods of use thereof
EP3101012A1 (fr) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft Nouveaux composés de chélate de gadolinium pour une utilisation dans l'imagerie par résonance magnétique
RU2755181C2 (ru) 2016-11-28 2021-09-14 Байер Фарма Акциенгезельшафт Новые хелатные соединения гадолиния с высокой релаксивностью для применения в магнитно-резонансной визуализации
CN107445911B (zh) * 2017-06-19 2019-07-05 南京科技职业学院 一种二核含钆磁共振对比剂及其制备与应用
CN113164628A (zh) 2018-11-23 2021-07-23 拜耳股份有限公司 造影介质制剂及其制备方法
CN109867635A (zh) * 2019-02-14 2019-06-11 华东师范大学 一种t1型胶束磁共振成像造影剂及其制备方法
EP4059925A1 (fr) 2021-03-15 2022-09-21 Bayer Aktiengesellschaft Nouvel agent de contraste pour une utilisation dans l'imagerie par résonance magnétique
EP4335840A1 (fr) 2022-09-09 2024-03-13 Bayer Aktiengesellschaft Nouveaux agents de contraste pour l'imagerie diagnostique
EP4335462A1 (fr) 2022-09-09 2024-03-13 Bayer AG Nouveaux agents de contraste pour l'imagerie diagnostique par tomodensitometrie

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5571498A (en) * 1994-06-02 1996-11-05 Hemagen/Pfc Emulsions of paramagnetic contrast agents for magnetic resonance imaging (MRI).
DE19603033A1 (de) * 1996-01-19 1997-07-24 Schering Ag Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
WO1998016256A1 (fr) * 1996-10-16 1998-04-23 The Burnham Institute Imagerie par resonance magnetique utilisee detecter un thrombus
DE19729013A1 (de) * 1997-07-03 1999-02-04 Schering Ag Oligomere, perfluoralkylhaltige Verbindungen, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
US6019959A (en) * 1997-07-31 2000-02-01 Schering Aktiengesellschaft Oligomeric compounds that contain perfluoroalkyl, process for their production, and their use in NMR diagnosis
DE19914101C1 (de) * 1999-03-22 2000-10-12 Schering Ag Perfluoralkylamide, ihre Herstellung und ihre Verwendung in der Diagnostik
BR0013171A (pt) * 1999-07-29 2002-05-28 Epix Medical Inc Agentes multimericos para formação de imagem de objetivação através de ligação multi-local
DE19948651B4 (de) * 1999-09-29 2006-10-05 Schering Ag Para- und diamagnetische perfluorhaltige Verbindungen enthaltende galenische Formulierungen, deren Herstellung und Verwendung
US6565828B2 (en) * 2000-04-07 2003-05-20 Bristol-Myers Squibb Company Macrocyclic chelants for metallopharmaceuticals
DE10040380B4 (de) * 2000-08-11 2006-03-09 Schering Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Plaques
DE10040381C1 (de) * 2000-08-11 2002-06-06 Schering Ag Perfluoralkylhaltige Komplexe mit Zuckerresten, Verfahren zu deren Herstellung und ihre Verwendung
DE10040858C2 (de) * 2000-08-11 2003-12-18 Schering Ag Perfluoralkylhaltige Komplexe mit polaren Resten, Verfahren zu deren Herstellung und ihre Verwendung
DE10066210B4 (de) * 2000-08-11 2008-02-28 Bayer Schering Pharma Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Plaques

Also Published As

Publication number Publication date
DE10231799A1 (de) 2004-02-12
EP1519756B1 (fr) 2007-05-02
RU2005103598A (ru) 2005-11-20
UA79294C2 (en) 2007-06-11
EP1519756A2 (fr) 2005-04-06
PL374027A1 (pl) 2005-09-19
ZA200501172B (en) 2006-04-26
PE20040656A1 (es) 2004-12-01
PT1519756E (pt) 2007-07-12
AU2003281146A1 (en) 2004-02-02
CN1668338A (zh) 2005-09-14
JP2005532404A (ja) 2005-10-27
CA2491933A1 (fr) 2004-01-22
DE50307180D1 (de) 2007-06-14
IL165889A0 (en) 2006-01-15
AU2003281150A1 (en) 2004-02-02
WO2004006979A2 (fr) 2004-01-22
AR041187A1 (es) 2005-05-04
DE10231799B4 (de) 2006-10-05
MXPA04012950A (es) 2005-05-16
DK1519756T3 (da) 2007-08-13
WO2004006965A2 (fr) 2004-01-22
ES2285143T3 (es) 2007-11-16
ATE361103T1 (de) 2007-05-15
WO2004006965A3 (fr) 2004-07-15
RU2328310C2 (ru) 2008-07-10
BR0312552A (pt) 2005-04-26
RS20050020A (sr) 2007-08-03
TW200413008A (en) 2004-08-01

Similar Documents

Publication Publication Date Title
Aime et al. Conformational and coordination equilibria on DOTA complexes of lanthanide metal ions in aqueous solution studied by 1H-NMR spectroscopy
Aime et al. Prototropic vs whole water exchange contributions to the solvent relaxation enhancement in the aqueous solution of a cationic Gd3+ macrocyclic complex
NO20050679L (no) Anvendelse av metallkomplekser inneholdende perfluoralkyl som kontrastmidler i magnetisk resonansbildedannelse for a fremvise intravaskulaere tromber
Caravan et al. The interaction of MS-325 with human serum albumin and its effect on proton relaxation rates
Aime et al. Prototropic and water-exchange processes in aqueous solutions of Gd (III) chelates
Ranganathan et al. Polymethylated DOTA ligands. 2. Synthesis of rigidified lanthanide chelates and studies on the effect of alkyl substitution on conformational mobility and relaxivity
Caravan et al. The Gd3+ complex of a fatty acid analogue of DOTP binds to multiple albumin sites with variable water relaxivities
Delli Castelli et al. Combined high resolution NMR and 1H and 17O relaxometric study sheds light on the solution structure and dynamics of the lanthanide (III) complexes of HPDO3A
Thompson et al. A highly stable gadolinium complex with a fast, associative mechanism of water exchange
Powell et al. Structural and dynamic parameters obtained from 17O NMR, EPR, and NMRD studies of monomeric and dimeric Gd3+ Complexes of interest in Magnetic Resonance Imaging: an integrated and theoretically self-consistent approach1
MX2023010737A (es) Nuevo agente de contraste para utilizar en imagenes por resonancia magnetica.
Bryson et al. A β-cyclodextrin “click cluster” decorated with seven paramagnetic chelates containing two water exchange sites
Lebdušková et al. A gadolinium (III) complex of a carboxylic-phosphorus acid derivative of diethylenetriamine covalently bound to inulin, a potential macromolecular MRI contrast agent
IL180896A0 (en) Method of tumour imaging
YU10603A (sh) Upotreba metalnih kompleksa koji sadrže perfluoroalkile kao kontrastnog sredstva u mr vizualizaciji za predstavljanje plaka, tumora i nekroza
WO2000030688A3 (fr) Chelates polycarboxyliques amphipathiques et complexes contenant des metaux paramagnetiques en tant qu'agents de contraste pour irm
Boros et al. Gd (DOTAlaP): exploring the boundaries of fast water exchange in gadolinium-based magnetic resonance imaging contrast agents
DE59404438D1 (de) Fluorhaltige makrocyclische metallkomplexe
AU3159701A (en) Agent for dyeing keratin containing fibers
AU2001277549A1 (en) Use of metal complexes containing perfluoroalkyl as contrast agents in mr-imaging for the representation of plaques, tumours and necroses
Bovens et al. Multinuclear Magnetic Resonance Study on the Structure and Dynamics of Lanthanide (III) Complexes of Cyclic DTPA Derivatives in Aqueous Solution1
David et al. Guanidinium derivatives act as high affinity antagonists of Na+ ions in occlusion sites of Na+, K (+)-ATPase.
ITMI20011706A0 (it) Agenti di contrasto radiografici ionici e non ionici, utilizzabili per l'indagine diagnostica combinata tramite raggi-x e risonanza magnetic
Cornily et al. Evaluation of neovessels in atherosclerotic plaques of rabbits using an albumin‐binding intravascular contrast agent and MRI
Neya et al. Proton NMR study of the myoglobin reconstituted with meso-tetra (n-propyl) hemin

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application