BR0312552A - Aplicação de complexos de metais contendo perfluoralquila como agente de contraste na imagem de ressonância magnética para a representação de trombos intravasculares - Google Patents

Aplicação de complexos de metais contendo perfluoralquila como agente de contraste na imagem de ressonância magnética para a representação de trombos intravasculares

Info

Publication number
BR0312552A
BR0312552A BR0312552-1A BR0312552A BR0312552A BR 0312552 A BR0312552 A BR 0312552A BR 0312552 A BR0312552 A BR 0312552A BR 0312552 A BR0312552 A BR 0312552A
Authority
BR
Brazil
Prior art keywords
representation
magnetic resonance
metal complexes
perfluoralkyl
application
Prior art date
Application number
BR0312552-1A
Other languages
English (en)
Inventor
Bernd Misselwitz
Johannes Platzek
Yoko Kawata
Hanns-Joachim Weinmann
Takishi Yokawa
Ulrich Niedballa
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of BR0312552A publication Critical patent/BR0312552A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"APLICAçãO DE COMPLEXOS DE METAIS CONTENDO PERFLUORALQUILA COMO AGENTE DE CONTRASTE NA IMAGEM DE RESSONâNCIA MAGNéTICA PARA A REPRESENTAçãO DE TROMBOS INTRAVASCULARES". A presente invenção refere-se ao emprego de complexos de metal contendo perfluoralquila, que apresentam uma concentração de formação de micélio crítica < 10^ -3^ mol/l, um diâmetro do micélio hidrodinâmico (2 Rh) > 1 nm e uma relaxividade de prótons no plasma (R^ 1^) > 10 I/mmol.s, como agentes de contraste na imagem de ressonância magnética para a representação de trombos intravasculares.
BR0312552-1A 2002-07-10 2003-07-05 Aplicação de complexos de metais contendo perfluoralquila como agente de contraste na imagem de ressonância magnética para a representação de trombos intravasculares BR0312552A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10231799A DE10231799B4 (de) 2002-07-10 2002-07-10 Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Intravasalen Thromben
PCT/EP2003/007274 WO2004006965A2 (de) 2002-07-10 2003-07-05 Verwendung von perfluoralkylhaltigen metallkomplexen als kontrastmittel im mr-imaging zur darstellung von intravasalen thromben

Publications (1)

Publication Number Publication Date
BR0312552A true BR0312552A (pt) 2005-04-26

Family

ID=30009959

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0312552-1A BR0312552A (pt) 2002-07-10 2003-07-05 Aplicação de complexos de metais contendo perfluoralquila como agente de contraste na imagem de ressonância magnética para a representação de trombos intravasculares

Country Status (23)

Country Link
EP (1) EP1519756B1 (pt)
JP (1) JP2005532404A (pt)
CN (1) CN1668338A (pt)
AR (1) AR041187A1 (pt)
AT (1) ATE361103T1 (pt)
AU (2) AU2003281146A1 (pt)
BR (1) BR0312552A (pt)
CA (1) CA2491933A1 (pt)
DE (2) DE10231799B4 (pt)
DK (1) DK1519756T3 (pt)
ES (1) ES2285143T3 (pt)
IL (1) IL165889A0 (pt)
MX (1) MXPA04012950A (pt)
NO (1) NO20050679L (pt)
PE (1) PE20040656A1 (pt)
PL (1) PL374027A1 (pt)
PT (1) PT1519756E (pt)
RS (1) RS20050020A (pt)
RU (1) RU2328310C2 (pt)
TW (1) TW200413008A (pt)
UA (1) UA79294C2 (pt)
WO (2) WO2004006979A2 (pt)
ZA (1) ZA200501172B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006021495A1 (de) * 2006-05-09 2007-11-15 Bayer Schering Pharma Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel zur Diagnose der Alzheimer Krankheit
TW201034691A (en) * 2008-12-05 2010-10-01 Molecular Insight Pharm Inc Technetium-and rhenium-bis(heteroaryl) complexes and methods of use thereof
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
RU2755181C2 (ru) 2016-11-28 2021-09-14 Байер Фарма Акциенгезельшафт Новые хелатные соединения гадолиния с высокой релаксивностью для применения в магнитно-резонансной визуализации
CN107445911B (zh) * 2017-06-19 2019-07-05 南京科技职业学院 一种二核含钆磁共振对比剂及其制备与应用
CN113164628A (zh) 2018-11-23 2021-07-23 拜耳股份有限公司 造影介质制剂及其制备方法
CN109867635A (zh) * 2019-02-14 2019-06-11 华东师范大学 一种t1型胶束磁共振成像造影剂及其制备方法
EP4059925A1 (en) 2021-03-15 2022-09-21 Bayer Aktiengesellschaft New contrast agent for use in magnetic resonance imaging
EP4335840A1 (en) 2022-09-09 2024-03-13 Bayer Aktiengesellschaft New contrast agents for use in diagnostic imaging
EP4335462A1 (en) 2022-09-09 2024-03-13 Bayer AG Contrast agents for use in diagnostic computed tomography imaging

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5571498A (en) * 1994-06-02 1996-11-05 Hemagen/Pfc Emulsions of paramagnetic contrast agents for magnetic resonance imaging (MRI).
DE19603033A1 (de) * 1996-01-19 1997-07-24 Schering Ag Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
WO1998016256A1 (en) * 1996-10-16 1998-04-23 The Burnham Institute Magnetic resonance imaging of thrombi
DE19729013A1 (de) * 1997-07-03 1999-02-04 Schering Ag Oligomere, perfluoralkylhaltige Verbindungen, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
US6019959A (en) * 1997-07-31 2000-02-01 Schering Aktiengesellschaft Oligomeric compounds that contain perfluoroalkyl, process for their production, and their use in NMR diagnosis
DE19914101C1 (de) * 1999-03-22 2000-10-12 Schering Ag Perfluoralkylamide, ihre Herstellung und ihre Verwendung in der Diagnostik
BR0013171A (pt) * 1999-07-29 2002-05-28 Epix Medical Inc Agentes multimericos para formação de imagem de objetivação através de ligação multi-local
DE19948651B4 (de) * 1999-09-29 2006-10-05 Schering Ag Para- und diamagnetische perfluorhaltige Verbindungen enthaltende galenische Formulierungen, deren Herstellung und Verwendung
US6565828B2 (en) * 2000-04-07 2003-05-20 Bristol-Myers Squibb Company Macrocyclic chelants for metallopharmaceuticals
DE10040380B4 (de) * 2000-08-11 2006-03-09 Schering Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Plaques
DE10040381C1 (de) * 2000-08-11 2002-06-06 Schering Ag Perfluoralkylhaltige Komplexe mit Zuckerresten, Verfahren zu deren Herstellung und ihre Verwendung
DE10040858C2 (de) * 2000-08-11 2003-12-18 Schering Ag Perfluoralkylhaltige Komplexe mit polaren Resten, Verfahren zu deren Herstellung und ihre Verwendung
DE10066210B4 (de) * 2000-08-11 2008-02-28 Bayer Schering Pharma Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Plaques

Also Published As

Publication number Publication date
DE10231799A1 (de) 2004-02-12
EP1519756B1 (de) 2007-05-02
RU2005103598A (ru) 2005-11-20
UA79294C2 (en) 2007-06-11
EP1519756A2 (de) 2005-04-06
PL374027A1 (pl) 2005-09-19
ZA200501172B (en) 2006-04-26
PE20040656A1 (es) 2004-12-01
PT1519756E (pt) 2007-07-12
NO20050679L (no) 2005-04-08
AU2003281146A1 (en) 2004-02-02
CN1668338A (zh) 2005-09-14
JP2005532404A (ja) 2005-10-27
CA2491933A1 (en) 2004-01-22
DE50307180D1 (de) 2007-06-14
IL165889A0 (en) 2006-01-15
AU2003281150A1 (en) 2004-02-02
WO2004006979A2 (de) 2004-01-22
AR041187A1 (es) 2005-05-04
DE10231799B4 (de) 2006-10-05
MXPA04012950A (es) 2005-05-16
DK1519756T3 (da) 2007-08-13
WO2004006965A2 (de) 2004-01-22
ES2285143T3 (es) 2007-11-16
ATE361103T1 (de) 2007-05-15
WO2004006965A3 (de) 2004-07-15
RU2328310C2 (ru) 2008-07-10
RS20050020A (sr) 2007-08-03
TW200413008A (en) 2004-08-01

Similar Documents

Publication Publication Date Title
IL180896A0 (en) Method of tumour imaging
BR0312552A (pt) Aplicação de complexos de metais contendo perfluoralquila como agente de contraste na imagem de ressonância magnética para a representação de trombos intravasculares
NO983060L (no) Kontrastmiddel
TW200512006A (en) A method for making a magnetic resonance (MR) imaging agent, a mr imaging contrast agent, a metnod for altering stability of a peptide and a modified peptide
MX348859B (es) Agentes de contraste para formacion de imagenes por perfusion miocardial.
BR0316886A (pt) Composição, processo para a preparação de uma composição, produto para contraste, usos de uma composição e uso de partìculas magnéticas
BR0209198A (pt) Métodos de sìntese de compostos contendo fenol
DK2298362T3 (da) Reagerende paramagnetiske kontrastmidler til magnetresonansbilledteknik
DE69425572D1 (de) Iodierte paramagnetische chelaten, und deren verwendung als kontrastmittel
TW200711664A (en) Compositions containing magnetic iron oxide particles, and use of said compositions in imaging methods
BR0113188A (pt) Aplicação de complexos de metal contendo perfluoroalquila como agentes de contraste na imagem de ressonância magnética para a identificação de placas, tumores e necroses
DK0700393T3 (da) Flourholdige, makrocykliske metalkomplekser
ATE233546T1 (de) Spezifische magnetosomen, verfahren zu ihrer herstellung und ihre verwendung
Chang et al. Toxicity of magnetic resonance imaging agents: small molecule and nanoparticle
ATE200472T1 (de) Verfahren zur herstellung von natriumwolframat
AU2003277280A8 (en) Biphenyls and fluorenes as imaging agents in alzheimer&#39;s disease
GB0130305D0 (en) Compounds for imaging alzheimers disease
EP1284146A4 (en) HYDROPHOBIC IODIC COMPOUND CONTAINING LIPOSOME
NO984555D0 (no) T1- Lever
ITMI20011706A0 (it) Agenti di contrasto radiografici ionici e non ionici, utilizzabili per l&#39;indagine diagnostica combinata tramite raggi-x e risonanza magnetic
DE50303825D1 (de) Modifizierte oxidische nano-partikel mit hydrophoben einschlüssen, verfahren zu ihrer herstellung und verwendung dieser partikel
ATE538083T1 (de) Metallkomplexe von dpta derivaten sowie strahlungsquelle enthaltend die metallkomplexe
EE200100291A (et) Magnetresonantstomograafia kontrastaine
GB2403215A (en) Process for the preparation of nanosized iron oxide by biomimetic route
BRPI0415574A (pt) composto, nanopartìcula, associação de uma nanopartìcula com um composto e composição terapêutica, de diagnóstico, de vacina ou cosmética

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 6A. E 7A. ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 2064 DE 27/07/2010.