NO20050832L - Selektive estrogenreseptormodulatorer inneholdende en fenylsulonylgruppe - Google Patents

Selektive estrogenreseptormodulatorer inneholdende en fenylsulonylgruppe

Info

Publication number
NO20050832L
NO20050832L NO20050832A NO20050832A NO20050832L NO 20050832 L NO20050832 L NO 20050832L NO 20050832 A NO20050832 A NO 20050832A NO 20050832 A NO20050832 A NO 20050832A NO 20050832 L NO20050832 L NO 20050832L
Authority
NO
Norway
Prior art keywords
estrogen receptor
selective estrogen
phenylsulonyl
group
receptor modulators
Prior art date
Application number
NO20050832A
Other languages
English (en)
Inventor
Timothy Alan Shepherd
Scott Alan Frank
Jeffrey Alan Dodge
Scott Alan Jones
Owen Brendan Wallace
Robert Dean Dally
Kin Chiu Fong
Conrad Wilson Hummel
George Sal Lewis
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NO20050832L publication Critical patent/NO20050832L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/72—Benzo[c]thiophenes; Hydrogenated benzo[c]thiophenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Foreliggende oppfinnelse angår en selektiv østrogenreseptormodulator med formel I eller et fermasøytisk syreaddisjonssalt derav, anvendelig for eksempel ved behandling av endometriose og/eller livmorleiomyoma/Ieiomyomata.
NO20050832A 2002-07-22 2005-02-16 Selektive estrogenreseptormodulatorer inneholdende en fenylsulonylgruppe NO20050832L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39786902P 2002-07-22 2002-07-22
US45023303P 2003-02-25 2003-02-25
PCT/IB2003/003349 WO2004009086A1 (en) 2002-07-22 2003-07-16 Selective estrogen receptor modulators containing a phenylsulfonyl group

Publications (1)

Publication Number Publication Date
NO20050832L true NO20050832L (no) 2005-02-16

Family

ID=30773044

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20050832A NO20050832L (no) 2002-07-22 2005-02-16 Selektive estrogenreseptormodulatorer inneholdende en fenylsulonylgruppe

Country Status (24)

Country Link
US (2) US7399867B2 (no)
EP (1) EP1530470B9 (no)
JP (2) JP4656939B2 (no)
CN (1) CN1668303B (no)
AT (1) ATE433322T1 (no)
AU (1) AU2003253129B2 (no)
BR (1) BR0312675A (no)
CA (1) CA2490580C (no)
CO (1) CO5680445A2 (no)
CR (1) CR7657A (no)
DE (1) DE60327931D1 (no)
EA (1) EA008024B1 (no)
EC (1) ECSP055549A (no)
ES (1) ES2326593T3 (no)
HR (1) HRP20041233A2 (no)
IL (1) IL165745A0 (no)
MX (1) MXPA05000898A (no)
MY (1) MY141879A (no)
NO (1) NO20050832L (no)
NZ (1) NZ537138A (no)
PE (1) PE20040678A1 (no)
PL (1) PL374845A1 (no)
TW (1) TWI314860B (no)
WO (1) WO2004009086A1 (no)

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CN1910167B (zh) * 2004-01-22 2011-08-10 伊莱利利公司 用于治疗血管舒缩症状的选择性雌激素受体调节剂
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CA2754685A1 (en) 2009-03-11 2010-09-16 Pfizer Inc. Substituted indazole amides
EA026675B1 (ru) 2010-06-16 2017-05-31 Эндорешерш, Инк. Способы лечения или предотвращения эстрогензависимых заболеваний
JP6292744B2 (ja) * 2012-09-19 2018-03-14 富士カプセル株式会社 医薬品組成物
ES2671516T3 (es) 2013-02-19 2018-06-06 Novartis Ag Derivados de benzotiofeno y composiciones de los mismos como degradantes selectivos de los receptores de estrógeno
ES2953140T3 (es) 2019-03-08 2023-11-08 Syngenta Crop Protection Ag Compuestos de azol-amida activos de manera plaguicida
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JP2022525809A (ja) 2019-03-22 2022-05-19 シンジェンタ クロップ プロテクション アクチェンゲゼルシャフト 殺虫剤としてのｎ－［１－（５－ブロモ－２－ピリミジン－２－イル－１，２，４－トリアゾール－３－イル）エチル］－２－シクロプロピル－６－（トリフルオロメチル）ピリジン－４－カルボキサミド誘導体及び関連化合物
TWI853009B (zh) 2019-03-29 2024-08-21 瑞士商先正達農作物保護公司 殺有害生物活性之二-醯胺化合物
KR20210149113A (ko) 2019-04-05 2021-12-08 신젠타 크롭 프로텍션 아게 살충 활성 디아진-아미드 화합물
EP4017851A1 (en) 2019-08-23 2022-06-29 Syngenta Crop Protection AG Pesticidally active pyrazine-amide compounds
CN110526881B (zh) * 2019-08-27 2020-09-22 河南省锐达医药科技有限公司 一种萘胺类化合物及其生物学可接受的盐，其制备方法和应用
JP2023515979A (ja) 2020-02-27 2023-04-17 シンジェンタ クロップ プロテクション アクチェンゲゼルシャフト 殺有害生物的に活性なジアジン－ビスアミド化合物
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WO2023283315A1 (en) * 2021-07-07 2023-01-12 South Dakota Board Of Regents Compositions and methods for treatment of cervical and ovarian cancer
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Also Published As

Publication number Publication date
JP4656939B2 (ja) 2011-03-23
ECSP055549A (es) 2005-03-10
AU2003253129A1 (en) 2004-02-09
CN1668303A (zh) 2005-09-14
MXPA05000898A (es) 2005-05-16
IL165745A0 (en) 2006-01-15
ES2326593T3 (es) 2009-10-15
JP2005538089A (ja) 2005-12-15
MY141879A (en) 2010-07-16
BR0312675A (pt) 2005-05-03
EA008024B1 (ru) 2007-02-27
TW200414901A (en) 2004-08-16
HRP20041233A2 (en) 2005-02-28
CA2490580A1 (en) 2004-01-29
PL374845A1 (en) 2005-11-14
JP5220800B2 (ja) 2013-06-26
CN1668303B (zh) 2010-10-27
CO5680445A2 (es) 2006-09-29
CA2490580C (en) 2012-12-11
HK1078003A1 (en) 2006-03-03
EP1530470B1 (en) 2009-06-10
US20080214612A1 (en) 2008-09-04
ATE433322T1 (de) 2009-06-15
JP2010195820A (ja) 2010-09-09
US7585977B2 (en) 2009-09-08
DE60327931D1 (de) 2009-07-23
PE20040678A1 (es) 2004-10-06
AU2003253129B2 (en) 2008-12-11
US7399867B2 (en) 2008-07-15
US20060183736A1 (en) 2006-08-17
WO2004009086A1 (en) 2004-01-29
TWI314860B (en) 2009-09-21
NZ537138A (en) 2007-11-30
EA200500248A1 (ru) 2005-06-30
CR7657A (es) 2005-07-13
EP1530470A1 (en) 2005-05-18
EP1530470B9 (en) 2010-04-07

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