NO20051854L - Vedvarende frigivelse opioidformuleringer og fremgangsmater for anvendelse. - Google Patents

Vedvarende frigivelse opioidformuleringer og fremgangsmater for anvendelse.

Info

Publication number
NO20051854L
NO20051854L NO20051854A NO20051854A NO20051854L NO 20051854 L NO20051854 L NO 20051854L NO 20051854 A NO20051854 A NO 20051854A NO 20051854 A NO20051854 A NO 20051854A NO 20051854 L NO20051854 L NO 20051854L
Authority
NO
Norway
Prior art keywords
hours
less
sustained release
methods
subunit
Prior art date
Application number
NO20051854A
Other languages
English (en)
Inventor
Garth Boehm
Alfred Liang
Original Assignee
Alpharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alpharma Inc filed Critical Alpharma Inc
Publication of NO20051854L publication Critical patent/NO20051854L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Det beskrives en kombinasjon av to forskjellige subenheter med forskjellige frigivningsprofiler i nye, orale doseringsformer for opprettholdt frigivning. Særlig inkluderer de orale doseringsformer en subenhet som omfatter et opioid analgetikum og et materiale for opprettholdt frigivning der oppløsningshastigheten in vitro for subenheten, målt ved standard USP Drug Release test i henhold til U.S. Pharmacopeia XXV1 (2003) <724> er mindre enn rundt 10 % innen rundt 6 timer og minst rundt 60 % innen rundt 24 timer; mindre enn rundt 10 % innen rundt 8 timer og minst rundt 60 % innen rundt 24 timer; mindre enn rundt 10 % innen rundt I 0 timer og minst rundt 60 % innen rundt 24 timer; eller mindre enn rundt 10 % innen rundt 12 timer og minst rundt 60 % innen rundt 24 timer; idet doseringsformen gir en varighet for den terapeutiske effekt på rundt 24 timer.
NO20051854A 2002-09-20 2005-04-15 Vedvarende frigivelse opioidformuleringer og fremgangsmater for anvendelse. NO20051854L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41221702P 2002-09-20 2002-09-20
PCT/US2003/029634 WO2004026256A2 (en) 2002-09-20 2003-09-22 Sustained-release opioid formulations and methods of use

Publications (1)

Publication Number Publication Date
NO20051854L true NO20051854L (no) 2005-06-15

Family

ID=32030832

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20051854A NO20051854L (no) 2002-09-20 2005-04-15 Vedvarende frigivelse opioidformuleringer og fremgangsmater for anvendelse.

Country Status (6)

Country Link
US (1) US20050020613A1 (no)
EP (1) EP1545468A4 (no)
AU (1) AU2003272601B2 (no)
CA (1) CA2498798A1 (no)
NO (1) NO20051854L (no)
WO (1) WO2004026256A2 (no)

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AU2003272601A1 (en) 2004-04-08
US20050020613A1 (en) 2005-01-27
CA2498798A1 (en) 2004-04-01
EP1545468A4 (en) 2007-06-20
WO2004026256A3 (en) 2004-07-01
EP1545468A2 (en) 2005-06-29
AU2003272601B2 (en) 2009-05-07

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