NO20052055L - Sammensetninger og fremgangsmater for behandling av prostata- og andre cancere - Google Patents

Sammensetninger og fremgangsmater for behandling av prostata- og andre cancere

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Publication number
NO20052055L
NO20052055L NO20052055A NO20052055A NO20052055L NO 20052055 L NO20052055 L NO 20052055L NO 20052055 A NO20052055 A NO 20052055A NO 20052055 A NO20052055 A NO 20052055A NO 20052055 L NO20052055 L NO 20052055L
Authority
NO
Norway
Prior art keywords
hsp
dosage unit
unit form
cancers
mrna
Prior art date
Application number
NO20052055A
Other languages
English (en)
Other versions
NO338310B1 (no
Inventor
Martin Gleave
Maxim Signaevsky
Palma Rocchi
Original Assignee
Univ British Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ British Columbia filed Critical Univ British Columbia
Publication of NO20052055L publication Critical patent/NO20052055L/no
Publication of NO338310B1 publication Critical patent/NO338310B1/no

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
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    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Den foreliggende oppfinnelse gjør bruk av terapeutiske midler som målsøker vannesjokkprotein (hsp) 27 in vivo for behandling til individer, spesielt mennesker, som lider av prostatacancer og andre cancere som overuttrykker hsp 27. I følge oppfinnelsen administreres et terapeutisk middel i en terapeutisk effektiv mengde, for eksempel et antisens oligonukleotid eller en RNAi-nukleotidinhibitor med sekvensspesifisitet for hsp 27 mRNA, for eksempel human hsp 27 mRNA, til et individ som lider av prostatacancer eller annen cancer som uttrykker forhøyete nivåer av hsp 27. Det terapeutiske middelet er passende formulert i en farmasøytisk sammensetning som inkluderer en farmasøytisk akseptabel bærer, pakket i en doseringsenhetsform En foretrukket doseringsenhetsform er en injiserbar doseringsenhetsform.
NO20052055A 2002-10-02 2005-04-27 Sammensetninger og anvendelser av disse for behandling av prostata- og andre cancere NO338310B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41585902P 2002-10-02 2002-10-02
US46395203P 2003-04-18 2003-04-18
PCT/CA2003/001588 WO2004030660A2 (en) 2002-10-02 2003-10-02 Compositions for treatment of prostate and other cancers

Publications (2)

Publication Number Publication Date
NO20052055L true NO20052055L (no) 2005-06-23
NO338310B1 NO338310B1 (no) 2016-08-08

Family

ID=32073392

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20052055A NO338310B1 (no) 2002-10-02 2005-04-27 Sammensetninger og anvendelser av disse for behandling av prostata- og andre cancere
NO20160655A NO20160655A1 (no) 2002-10-02 2016-04-20 Sammensetninger og fremgangsmåter for behandling av prostata- og andre cancere

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20160655A NO20160655A1 (no) 2002-10-02 2016-04-20 Sammensetninger og fremgangsmåter for behandling av prostata- og andre cancere

Country Status (17)

Country Link
US (8) US7101991B2 (no)
EP (2) EP1545561B1 (no)
JP (2) JP5127138B2 (no)
KR (1) KR101142080B1 (no)
CN (1) CN1703229B (no)
AT (1) ATE465743T1 (no)
AU (1) AU2003278028B2 (no)
CA (1) CA2498026C (no)
DE (1) DE60332363D1 (no)
DK (1) DK1545561T3 (no)
ES (1) ES2345330T3 (no)
IL (1) IL167621A (no)
MX (1) MXPA05003551A (no)
NO (2) NO338310B1 (no)
NZ (1) NZ538841A (no)
WO (1) WO2004030660A2 (no)
ZA (1) ZA200502603B (no)

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US9381209B2 (en) * 2007-03-05 2016-07-05 The University Of British Columbia Treatment of squamous cell carcinoma with HSP27 antisense oligonucleotides and radiotherapy
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JP5746968B2 (ja) * 2008-07-18 2015-07-08 オンコジェネックス・テクノロジーズ・インコーポレーテッド アンチセンス製剤
WO2011054811A1 (en) 2009-11-03 2011-05-12 Santaris Pharma A/S Rna antagonists targeting hsp27 combination therapy
KR101217866B1 (ko) 2010-08-18 2013-01-03 한국원자력의학원 혈관신생 억제용 약학 조성물 및 혈관신생 억제용 활성물질을 스크리닝하는 방법
DE102010056610A1 (de) * 2010-12-31 2012-07-05 Volker A. Erdmann Pharmazeutische Zusammensetzung enthaltend L-DNA
JP5658696B2 (ja) * 2011-02-25 2015-01-28 株式会社ファンケル 皮膚のストレス蓄積度の評価方法
CA2747509C (en) 2011-05-12 2017-07-18 Oncogenex Technologies Inc. Treatment of pulmonary and pleural fibrosis using hsp27 inhibitors
WO2013114339A1 (en) 2012-02-02 2013-08-08 The Universityof British Columbia Combination therapy for cancer using hsp27 inhibitor and egfr tyrosine kinase inhibitors or anti-folates
GB201204785D0 (en) 2012-03-19 2012-05-02 Queen Mary & Westfield College Method for determining prognosis of prostate cancer in a subject
KR101374585B1 (ko) * 2012-05-02 2014-03-17 연세대학교 산학협력단 ＨＳＰ２７ 발현을 억제하는 ｓｈＲＮＡ
US9950001B2 (en) 2012-08-20 2018-04-24 The Regents Of The University Of California Polynucleotides having bioreversible groups
EP3174541A1 (de) 2014-07-28 2017-06-07 Technische Universität Dresden Thymin- und chinazolin-dion-derivate zur hemmung von hsp27
MX2018006527A (es) * 2015-11-30 2018-11-29 Univ British Columbia Inhibidores de oligonucleotidos antisentido (aso) del transportador de monocarboxilato4 (mct4) para su uso como agentes terapeuticos en el tratamiento de cancer.
WO2019050948A1 (en) 2017-09-05 2019-03-14 Regeneron Pharmaceuticals, Inc. ADMINISTRATION OF A GENE EDITION SYSTEM HAVING ONLY ONE RETROVIRAL PARTICLE AND METHODS OF GENERATING AND USING

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US9381209B2 (en) 2007-03-05 2016-07-05 The University Of British Columbia Treatment of squamous cell carcinoma with HSP27 antisense oligonucleotides and radiotherapy

Also Published As

Publication number Publication date
US7550580B2 (en) 2009-06-23
DK1545561T3 (da) 2010-08-02
CN1703229B (zh) 2011-01-05
US20150232843A1 (en) 2015-08-20
EP1545561A2 (en) 2005-06-29
JP5237996B2 (ja) 2013-07-17
NO338310B1 (no) 2016-08-08
KR20050050111A (ko) 2005-05-27
US9404109B2 (en) 2016-08-02
US7723312B2 (en) 2010-05-25
ATE465743T1 (de) 2010-05-15
AU2003278028B2 (en) 2008-12-18
US7101991B2 (en) 2006-09-05
US20060040886A1 (en) 2006-02-23
EP2216029A2 (en) 2010-08-11
IL167621A (en) 2011-11-30
JP2006503904A (ja) 2006-02-02
CA2498026A1 (en) 2004-04-15
US20140315978A1 (en) 2014-10-23
CA2498026C (en) 2015-06-30
NO20160655A1 (no) 2016-04-20
WO2004030660A3 (en) 2004-06-10
JP5127138B2 (ja) 2013-01-23
MXPA05003551A (es) 2005-10-19
US20160326527A1 (en) 2016-11-10
EP1545561B1 (en) 2010-04-28
US9580712B2 (en) 2017-02-28
ZA200502603B (en) 2006-06-28
US20040127441A1 (en) 2004-07-01
JP2010215669A (ja) 2010-09-30
US20060276424A1 (en) 2006-12-07
ES2345330T3 (es) 2010-09-21
KR101142080B1 (ko) 2012-05-03
NZ538841A (en) 2006-10-27
US7847091B2 (en) 2010-12-07
US8772470B1 (en) 2014-07-08
US20090221678A1 (en) 2009-09-03
US9085769B2 (en) 2015-07-21
AU2003278028A1 (en) 2004-04-23
CN1703229A (zh) 2005-11-30
WO2004030660A2 (en) 2004-04-15
EP2216029A3 (en) 2010-12-22
DE60332363D1 (de) 2010-06-10

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