NO20052734L - Tablett med flere lag, inneholdende pravastatin og aspirin, og fremgangsmate - Google Patents
Tablett med flere lag, inneholdende pravastatin og aspirin, og fremgangsmateInfo
- Publication number
- NO20052734L NO20052734L NO20052734A NO20052734A NO20052734L NO 20052734 L NO20052734 L NO 20052734L NO 20052734 A NO20052734 A NO 20052734A NO 20052734 A NO20052734 A NO 20052734A NO 20052734 L NO20052734 L NO 20052734L
- Authority
- NO
- Norway
- Prior art keywords
- aspirin
- pravastatin
- layer containing
- tablet containing
- multilayer tablet
- Prior art date
Links
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 title abstract 4
- TUZYXOIXSAXUGO-UHFFFAOYSA-N Pravastatin Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(O)C=C21 TUZYXOIXSAXUGO-UHFFFAOYSA-N 0.000 title abstract 4
- 229960001138 acetylsalicylic acid Drugs 0.000 title abstract 4
- TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 title abstract 4
- 229960002965 pravastatin Drugs 0.000 title abstract 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 4
- 235000012000 cholesterol Nutrition 0.000 abstract 2
- 208000010125 myocardial infarction Diseases 0.000 abstract 2
- 230000004888 barrier function Effects 0.000 abstract 1
- 239000006172 buffering agent Substances 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Det er tilveiebrakt en flerlagstablett med tre eller flere lag som er anvendelig for kolesterolnedsettelse og reduksjon av risiko for myokardinfarkt, som innbefatter et første lag inneholdende aspirin, et annet lag inneholdende pravastatin og et midtre barrierelag som fortrinnsvis inneholder et bufringsmiddel og som skiller det første lag inneholdende aspirin fra det andre lag inneholdende pravastatin og forhindrer eller minimaliserer interaksjon mellom aspirin og pravastatin. En fremgangsmåte for nedsettelse av kolesterol og reduksjon av risiko for myokardinfarkt ved anvendelse av slikt preparat er også tilveiebrakt.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/316,424 US20040115265A1 (en) | 2002-12-11 | 2002-12-11 | Multilayered tablet containing pravastatin and aspirin and method |
| PCT/US2003/038774 WO2004052289A2 (en) | 2002-12-11 | 2003-12-03 | Multilayered tablet containing pravastatin and aspirin |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20052734D0 NO20052734D0 (no) | 2005-06-07 |
| NO20052734L true NO20052734L (no) | 2005-07-07 |
| NO338696B1 NO338696B1 (no) | 2016-10-03 |
Family
ID=32505946
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20052734A NO338696B1 (no) | 2002-12-11 | 2005-06-07 | Farmasøytisk preparat med flere lag inneholdende pravastatin og aspirin, og anvendelse av dette for behandling av sykdom |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20040115265A1 (no) |
| EP (1) | EP1581194B1 (no) |
| JP (1) | JP2006511520A (no) |
| AT (1) | ATE401061T1 (no) |
| AU (1) | AU2003297689A1 (no) |
| CY (1) | CY1108414T1 (no) |
| DE (1) | DE60322264D1 (no) |
| DK (1) | DK1581194T3 (no) |
| ES (1) | ES2308040T3 (no) |
| IS (1) | IS2877B (no) |
| MY (1) | MY140947A (no) |
| NO (1) | NO338696B1 (no) |
| PL (1) | PL206190B1 (no) |
| PT (1) | PT1581194E (no) |
| SI (1) | SI1581194T1 (no) |
| TW (1) | TWI361700B (no) |
| WO (1) | WO2004052289A2 (no) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1617832B1 (en) | 2003-04-29 | 2008-03-12 | Orexigen Therapeutics, Inc. | Compositions for affecting weight loss |
| US8163797B2 (en) * | 2003-12-31 | 2012-04-24 | Actavis Elizabeth Llc | Method of treating with stable pravastatin formulation |
| WO2006072054A1 (en) * | 2004-12-30 | 2006-07-06 | Genzyme Corporation | Zinc-containing treatments for hyperphosphatemia |
| US20060251722A1 (en) * | 2005-05-03 | 2006-11-09 | Novavax, Inc. | Multi-component vitamin and mineral supplement for the optimal absorption of components |
| US8986669B2 (en) * | 2005-09-02 | 2015-03-24 | Genzyme Corporation | Method for removing phosphate and polymer used therefore |
| EP1945196A2 (en) * | 2005-11-08 | 2008-07-23 | Genzyme Corporation | Magnesium-containing polymers for hyperphosphatemia |
| CN101370488B (zh) | 2005-11-22 | 2012-07-18 | 奥雷西根治疗公司 | 增加胰岛素敏感性的组合物 |
| WO2007072060A2 (en) * | 2005-12-23 | 2007-06-28 | Cipla Limited | Particles comprising a core containing a hmg-coa reductase inhibitor and coated with a film |
| CA2635313C (en) | 2005-12-29 | 2013-12-31 | Osmotica Corp. | Triple combination release multi-layered tablet |
| US8916195B2 (en) | 2006-06-05 | 2014-12-23 | Orexigen Therapeutics, Inc. | Sustained release formulation of naltrexone |
| WO2008005217A2 (en) * | 2006-07-05 | 2008-01-10 | Genzyme Corporation | Iron(ii)-containing treatments for hyperphosphatemia |
| US8765178B2 (en) * | 2006-07-19 | 2014-07-01 | Watson Laboratories, Inc. | Controlled release formulations and associated methods |
| KR20170077291A (ko) | 2006-11-09 | 2017-07-05 | 오렉시젠 세러퓨틱스 인크. | 단위 용량 팩키지 |
| DK2089005T3 (da) * | 2006-11-09 | 2010-07-19 | Orexigen Therapeutics Inc | Lagdelte farmaceutiske formuleringer omfattende et hurtigt opløsende mellemlag |
| ES2841379T3 (es) | 2007-03-13 | 2021-07-08 | Jds Therapeutics Llc | Procedimientos y composiciones para la liberación sostenida de cromo |
| WO2009002867A2 (en) | 2007-06-26 | 2008-12-31 | Nutrition 21, Inc. | Multiple unit dosage form having a therapeutic agents in combination with a nutritional supplement |
| NZ583899A (en) | 2007-10-12 | 2011-12-22 | Ferring Int Ct Sa | Process for the manufacure of a pharmaceutical product comprising citric acid, magnesium oxide, potassium bicarbonate and sodium picosulfate, pharmaceutical composition comprising granules obtained by such process and intermediate |
| WO2009158114A1 (en) | 2008-05-30 | 2009-12-30 | Orexigen Therapeutics, Inc. | Methods for treating visceral fat conditions |
| MX344303B (es) | 2010-01-11 | 2016-12-13 | Orexigen Therapeutics Inc | Metodos para proveer terapia de perdida de peso en pacientes con depresion mayor. |
| TR201005325A2 (tr) | 2010-06-30 | 2012-01-23 | Bi̇lgi̇ç Mahmut | Atorvastatin ve aspirin içeren farmasötik formülasyonlar |
| KR20120068277A (ko) * | 2010-12-17 | 2012-06-27 | 한미사이언스 주식회사 | ＨＭＧ－ＣｏＡ 환원효소 억제제 및 아스피린을 포함하는 약제학적 복합제제 |
| CN103459099B (zh) * | 2011-01-28 | 2015-08-26 | 英塔茨科技公司 | 与一个可移动的远程机器人相互交流 |
| CN110893181A (zh) | 2012-06-06 | 2020-03-20 | 纳丙药业有限责任公司 | 治疗超重和肥胖症的方法 |
| EP2810644A1 (en) * | 2013-06-06 | 2014-12-10 | Ferrer Internacional, S.A. | Oral formulation for the treatment of cardiovascular diseases |
| CA3014308A1 (en) | 2016-02-11 | 2017-08-17 | Nutrition 21, Llc | Chromium containing compositions for improving health and fitness |
| JP7109748B2 (ja) * | 2018-12-11 | 2022-08-01 | 日本ジェネリック株式会社 | アジルサルタンとアムロジピンベシル酸塩含有固形製剤及び固形製剤の製造方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4590183A (en) * | 1985-04-22 | 1986-05-20 | Sterling Drug Inc. | Gastric cytoprotection with sodium thiosulfate in oral administration of aspirin |
| JP3172749B2 (ja) * | 1992-02-17 | 2001-06-04 | ライオン株式会社 | イブプロフェン含有製剤 |
| IT1255522B (it) * | 1992-09-24 | 1995-11-09 | Ubaldo Conte | Compressa per impiego terapeutico atta a cedere una o piu' sostanze attive con differenti velocita' |
| IT1264517B1 (it) * | 1993-05-31 | 1996-09-24 | Ekita Investments Nv | Compressa farmaceutica atta al rilascio in tempi successivi dei principi attivi in essa veicolati |
| FR2772615B1 (fr) * | 1997-12-23 | 2002-06-14 | Lipha | Comprime multicouche pour la liberation instantanee puis prolongee de substances actives |
| US6235311B1 (en) * | 1998-03-18 | 2001-05-22 | Bristol-Myers Squibb Company | Pharmaceutical composition containing a combination of a statin and aspirin and method |
| EP1063973B1 (en) * | 1998-03-19 | 2016-11-16 | Bristol-Myers Squibb Company | Biphasic controlled release delivery system for high solubility pharmaceuticals and method |
| US6669955B2 (en) * | 2001-08-28 | 2003-12-30 | Longwood Pharmaceutical Research, Inc. | Combination dosage form containing individual dosage units of a cholesterol-lowering agent, an inhibitor of the renin-angiotensin system, and aspirin |
-
2002
- 2002-12-11 US US10/316,424 patent/US20040115265A1/en not_active Abandoned
-
2003
- 2003-12-03 WO PCT/US2003/038774 patent/WO2004052289A2/en not_active Ceased
- 2003-12-03 PL PL377265A patent/PL206190B1/pl unknown
- 2003-12-03 JP JP2004559355A patent/JP2006511520A/ja active Pending
- 2003-12-03 AT AT03812825T patent/ATE401061T1/de active
- 2003-12-03 AU AU2003297689A patent/AU2003297689A1/en not_active Abandoned
- 2003-12-03 PT PT03812825T patent/PT1581194E/pt unknown
- 2003-12-03 EP EP03812825A patent/EP1581194B1/en not_active Expired - Lifetime
- 2003-12-03 ES ES03812825T patent/ES2308040T3/es not_active Expired - Lifetime
- 2003-12-03 DE DE60322264T patent/DE60322264D1/de not_active Expired - Lifetime
- 2003-12-03 DK DK03812825T patent/DK1581194T3/da active
- 2003-12-03 SI SI200331302T patent/SI1581194T1/sl unknown
- 2003-12-08 TW TW092134590A patent/TWI361700B/zh active
- 2003-12-10 MY MYPI20034728A patent/MY140947A/en unknown
-
2005
- 2005-06-07 NO NO20052734A patent/NO338696B1/no not_active IP Right Cessation
- 2005-06-10 IS IS7889A patent/IS2877B/is unknown
-
2008
- 2008-10-14 CY CY20081101137T patent/CY1108414T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL206190B1 (pl) | 2010-07-30 |
| SI1581194T1 (sl) | 2008-12-31 |
| IS2877B (is) | 2014-04-15 |
| NO338696B1 (no) | 2016-10-03 |
| PT1581194E (pt) | 2008-09-24 |
| WO2004052289A2 (en) | 2004-06-24 |
| DE60322264D1 (de) | 2008-08-28 |
| DK1581194T3 (da) | 2008-10-20 |
| ES2308040T3 (es) | 2008-12-01 |
| TW200505432A (en) | 2005-02-16 |
| AU2003297689A8 (en) | 2004-06-30 |
| CY1108414T1 (el) | 2014-02-12 |
| US20040115265A1 (en) | 2004-06-17 |
| IS7889A (is) | 2005-06-10 |
| TWI361700B (en) | 2012-04-11 |
| PL377265A1 (pl) | 2006-01-23 |
| MY140947A (en) | 2010-02-12 |
| EP1581194B1 (en) | 2008-07-16 |
| JP2006511520A (ja) | 2006-04-06 |
| EP1581194A2 (en) | 2005-10-05 |
| EP1581194A4 (en) | 2006-03-15 |
| ATE401061T1 (de) | 2008-08-15 |
| AU2003297689A1 (en) | 2004-06-30 |
| WO2004052289A3 (en) | 2005-03-24 |
| NO20052734D0 (no) | 2005-06-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |