NO20053624L - Tetrahydro-4H-pyrido [1,2-A] pyrimidiner og beslektede forbindelser som er anvendbare som HIV-integrase inhibitorer - Google Patents

Tetrahydro-4H-pyrido [1,2-A] pyrimidiner og beslektede forbindelser som er anvendbare som HIV-integrase inhibitorer

Info

Publication number
NO20053624L
NO20053624L NO20053624A NO20053624A NO20053624L NO 20053624 L NO20053624 L NO 20053624L NO 20053624 A NO20053624 A NO 20053624A NO 20053624 A NO20053624 A NO 20053624A NO 20053624 L NO20053624 L NO 20053624L
Authority
NO
Norway
Prior art keywords
compounds
pyrido
pyrimidines
tetrahydro
hiv
Prior art date
Application number
NO20053624A
Other languages
English (en)
Norwegian (no)
Other versions
NO20053624D0 (no
Inventor
Benedetta Crescenzi
Ester Muraglia
Giovanna Pescatore
Michael Rowley
Vincenzo Summa
Olaf Kinzel
Frederica Orvieto
Original Assignee
Angeletti P Ist Richerche Bio
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angeletti P Ist Richerche Bio filed Critical Angeletti P Ist Richerche Bio
Publication of NO20053624D0 publication Critical patent/NO20053624D0/no
Publication of NO20053624L publication Critical patent/NO20053624L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NO20053624A 2002-12-27 2005-07-26 Tetrahydro-4H-pyrido [1,2-A] pyrimidiner og beslektede forbindelser som er anvendbare som HIV-integrase inhibitorer NO20053624L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43683002P 2002-12-27 2002-12-27
US52877603P 2003-12-12 2003-12-12
PCT/GB2003/005543 WO2004058757A1 (fr) 2002-12-27 2003-12-18 Tetrahydro-4h-pyrido[1,2-a]pyrimidines et composes associes utilises en tant qu'inhibiteurs de l'integrase du vih

Publications (2)

Publication Number Publication Date
NO20053624D0 NO20053624D0 (no) 2005-07-26
NO20053624L true NO20053624L (no) 2005-09-26

Family

ID=32685467

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20053624A NO20053624L (no) 2002-12-27 2005-07-26 Tetrahydro-4H-pyrido [1,2-A] pyrimidiner og beslektede forbindelser som er anvendbare som HIV-integrase inhibitorer

Country Status (20)

Country Link
US (2) US7414045B2 (fr)
EP (1) EP1578748B1 (fr)
JP (1) JP4733986B2 (fr)
KR (1) KR20050087865A (fr)
CN (1) CN100343253C (fr)
AT (1) ATE481401T1 (fr)
AU (2) AU2003292436B2 (fr)
BR (1) BR0317749A (fr)
CA (1) CA2509554C (fr)
DE (1) DE60334248D1 (fr)
EC (1) ECSP055890A (fr)
HR (1) HRP20050593A2 (fr)
IS (1) IS7892A (fr)
MA (1) MA27583A1 (fr)
MX (1) MXPA05007010A (fr)
NO (1) NO20053624L (fr)
NZ (1) NZ540729A (fr)
PL (1) PL377354A1 (fr)
RU (1) RU2329265C2 (fr)
WO (2) WO2004058756A1 (fr)

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US7173022B2 (en) * 2004-05-28 2007-02-06 Bristol-Myers Squibb Company Bicyclic heterocycles as HIV integrase inhibitors
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US7192948B2 (en) * 2004-05-28 2007-03-20 Bristol-Myers Squibb Company Bicyclic heterocycles as HIV integrase inhibitors
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BRPI0613578A2 (pt) 2005-06-30 2012-01-17 Wyeth Corp composito da fórmula i; uso de um composto de fórmula i; e composição farmacêutica
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JP5094725B2 (ja) * 2005-10-04 2012-12-12 イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・エルレ・エルレ Ｈｉｖインテグラーゼ阻害剤
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WO2007058646A1 (fr) * 2005-11-15 2007-05-24 Bristol-Myers Squibb Company Inhibiteurs d’integrase du vih : composes cycliques de la pyrimidinone
WO2007059125A2 (fr) * 2005-11-15 2007-05-24 Bristol-Myers Squibb Company Inhibiteurs de l'integrase du vih
US7902182B2 (en) * 2005-11-16 2011-03-08 Bristol-Myers Squibb Company HIV integrase inhibitors
US8039458B2 (en) * 2005-11-17 2011-10-18 Bristol-Myers Squibb Company HIV integrase inhibitors
WO2007064316A1 (fr) * 2005-11-30 2007-06-07 Bristol-Myers Squibb Company Heterocycles bicycliques en tant qu'inhibiteurs de l'integrase du vih
US20070129379A1 (en) * 2005-12-01 2007-06-07 Bristol-Myers Squibb Company Hiv integrase inhibitors
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US7893055B2 (en) * 2006-06-28 2011-02-22 Bristol-Myers Squibb Company HIV integrase inhibitors
US7763630B2 (en) * 2007-06-06 2010-07-27 Bristol-Myers Squibb Company HIV integrase inhibitors
US8129398B2 (en) * 2008-03-19 2012-03-06 Bristol-Myers Squibb Company HIV integrase inhibitors
EP2349276B1 (fr) * 2008-10-06 2019-11-27 Merck Sharp & Dohme Corp. Inhibiteurs de l'intégrase du vih
SG171308A1 (en) * 2008-12-11 2011-07-28 Shionogi & Co Synthesis of carbamoylpyridone hiv integrase inhibitors and intermediates
US8143244B2 (en) * 2009-02-26 2012-03-27 Bristol-Myers Squibb Company Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
PL2448940T3 (pl) * 2009-07-02 2014-10-31 Sanofi Sa Pochodne 6,7,8,9-tetrahydro-pirymido{1,2-a} pirymidyn-4-onu, ich wytwarzanie i zastosowanie farmaceutyczne
WO2011045330A1 (fr) 2009-10-13 2011-04-21 Tibotec Pharmaceuticals Inhibiteurs macrocycliques d'intégrase
US8383639B2 (en) 2009-10-15 2013-02-26 Bristol-Myers Squibb Company HIV integrase inhibitors
AU2010313571B2 (en) 2009-10-26 2014-07-31 Merck Sharp & Dohme Llc Solid pharmaceutical compositions containing an integrase inhibitor
WO2011121105A1 (fr) 2010-04-02 2011-10-06 Tibotec Pharmaceuticals Inhibiteurs de l'intégrase macrocyclique
UA112517C2 (uk) * 2010-07-06 2016-09-26 Новартіс Аг Тетрагідропіридопіримідинові похідні
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EP2931730B1 (fr) 2012-12-17 2019-08-07 Merck Sharp & Dohme Corp. Dérivés 4-pyridinonetriazines en tant qu'inhibiteurs de l'intégrase du vih
US9493479B2 (en) 2013-04-16 2016-11-15 Merck Sharp & Dohme Corp. Substituted pyrido[1,2-a]pyrazines as HIV integrase inhibitors
SI2997033T1 (en) 2013-05-17 2018-04-30 Merck Sharp & Dohme Corp. FUZYCLE TRICYCLE HETEROCYCLIC COMPOUNDS AS HIV INTEGRATED INHIBITORS
US9951079B2 (en) 2013-06-13 2018-04-24 Merck Sharp & Dohme Corp. Fused tricyclic heterocyclic compounds as HIV integrase inhibitors
CA2924829C (fr) 2013-09-27 2019-10-29 Merck Sharp & Dohme Corp. Derives de quinolizine substitues utiles en tant qu'inhibiteurs de l'integrase du vih
WO2016187788A1 (fr) 2015-05-25 2016-12-01 Merck Sharp & Dohme Corp. Composés hétérocycliques tricycliques fusionnés utiles pour traiter l'infection au vih
US10548910B2 (en) 2015-11-17 2020-02-04 Merck Sharp & Dohme Corp. Amido-substituted pyridotriazine derivatives useful as HIV integrase inhibitors
EP3389380B1 (fr) 2015-12-15 2021-07-21 Merck Sharp & Dohme Corp. Dérivés de quinolizine spirocycliques utiles en tant qu'inhibiteurs de l'intégrase du vih
WO2017113288A1 (fr) 2015-12-31 2017-07-06 Merck Sharp & Dohme Corp. Composés hétérocycliques tricycliques condensés utiles en tant qu'inhibiteurs de l'intégrase du vih
WO2018102634A1 (fr) 2016-12-02 2018-06-07 Merck Sharp & Dohme Corp. Composés hétérocycliques tricycliques utiles en tant qu'inhibiteurs de l'intégrase du vih
JOP20190130A1 (ar) 2016-12-02 2019-06-02 Merck Sharp & Dohme مركبات حلقية غير متجانسة رباعية الحلقات مفيدة كمثبطات إنزيم مدمج لفيروس نقص المناعة البشرية (hiv)
WO2018140368A1 (fr) 2017-01-26 2018-08-02 Merck Sharp & Dohme Corp. Dérivés de quinolizine substitués utiles en tant qu'inhibiteurs de l'intégrase du vih
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WO2021107065A1 (fr) 2019-11-28 2021-06-03 塩野義製薬株式会社 Dérivé de pyridopyrazine polycyclique

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Also Published As

Publication number Publication date
KR20050087865A (ko) 2005-08-31
JP2006513200A (ja) 2006-04-20
CN100343253C (zh) 2007-10-17
NZ540729A (en) 2008-03-28
NO20053624D0 (no) 2005-07-26
HRP20050593A2 (en) 2006-03-31
PL377354A1 (pl) 2006-01-23
MXPA05007010A (es) 2005-08-18
US7968553B2 (en) 2011-06-28
CN1753892A (zh) 2006-03-29
EP1578748A1 (fr) 2005-09-28
US20080176869A1 (en) 2008-07-24
US7414045B2 (en) 2008-08-19
BR0317749A (pt) 2005-11-22
AU2003292437A1 (en) 2004-07-22
DE60334248D1 (de) 2010-10-28
AU2003292436A1 (en) 2004-07-22
WO2004058756A1 (fr) 2004-07-15
WO2004058757A1 (fr) 2004-07-15
RU2329265C2 (ru) 2008-07-20
RU2005123807A (ru) 2006-01-20
CA2509554A1 (fr) 2004-07-15
EP1578748B1 (fr) 2010-09-15
ECSP055890A (es) 2005-09-20
IS7892A (is) 2005-06-13
AU2003292436B2 (en) 2009-07-30
MA27583A1 (fr) 2005-10-03
ATE481401T1 (de) 2010-10-15
JP4733986B2 (ja) 2011-07-27
US20060046985A1 (en) 2006-03-02
CA2509554C (fr) 2011-02-01

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