NO20053627L - Malonamidderivater som gamma-sekretase inhibitorer - Google Patents

Malonamidderivater som gamma-sekretase inhibitorer

Info

Publication number: NO20053627L
Authority: NO; Norway
Prior art keywords: gamma; secretase inhibitors; malonamide derivatives; malonamide; derivatives
Prior art date: 2003-02-04

Application number

NO20053627A

Other languages

English (en)

Norwegian (no)

Inventor

Jens-Uwe Peters

Guido Galley

Annick Goergler

Helmut Jacobsen

Eric Argirios Kitas

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-02-04

Filing date

2005-07-26

Publication date

2005-08-10

2005-07-26 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2005-08-10 Publication of NO20053627L publication Critical patent/NO20053627L/no

Links

WRIRWRKPLXCTFD-UHFFFAOYSA-N malonamide Chemical class NC(=O)CC(N)=O WRIRWRKPLXCTFD-UHFFFAOYSA-N 0.000 title abstract 2
239000003540 gamma secretase inhibitor Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
208000024827 Alzheimer disease Diseases 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
239000002439 beta secretase inhibitor Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
- C07C323/41—Y being a hydrogen or an acyclic carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Neurology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

NO20053627A 2003-02-04 2005-07-26 Malonamidderivater som gamma-sekretase inhibitorer NO20053627L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP03002190		2003-02-04
PCT/EP2004/000674 WO2004069826A1 (en)	2003-02-04	2004-01-27	Malonamide derivatives as gamma-secretase inhibitors

Publications (1)

Publication Number	Publication Date
NO20053627L true NO20053627L (no)	2005-08-10

Family

ID=32842686

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20053627A NO20053627L (no)	2003-02-04	2005-07-26	Malonamidderivater som gamma-sekretase inhibitorer

Country Status (23)

Country	Link
US (1)	US7375099B2 (de)
EP (1)	EP1592684B1 (de)
JP (1)	JP4662914B2 (de)
KR (1)	KR100810810B1 (de)
CN (1)	CN100480248C (de)
AR (1)	AR042996A1 (de)
AT (1)	ATE402934T1 (de)
BR (1)	BRPI0407262A (de)
CA (1)	CA2514267C (de)
CL (1)	CL2004000174A1 (de)
CO (1)	CO5580761A2 (de)
DE (1)	DE602004015415D1 (de)
ES (1)	ES2311795T3 (de)
HR (1)	HRP20050663A2 (de)
IL (1)	IL169691A (de)
MX (1)	MXPA05008172A (de)
NO (1)	NO20053627L (de)
NZ (1)	NZ541324A (de)
PL (1)	PL378405A1 (de)
RU (1)	RU2330849C2 (de)
TW (1)	TWI293070B (de)
WO (1)	WO2004069826A1 (de)
ZA (1)	ZA200506212B (de)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7521481B2 (en)	2003-02-27	2009-04-21	Mclaurin Joanne	Methods of preventing, treating and diagnosing disorders of protein aggregation
AU2004270361B2 (en) *	2003-09-09	2009-06-25	F. Hoffmann-La Roche Ag	Malonamide derivatives blocking the activity of gama-secretase
WO2005040126A1 (en) *	2003-10-06	2005-05-06	F. Hoffman-La Roche Ag	Substituted dibenzo-azepine and benzo-diazepine derivatives useful as gamma-secretase inhibitors
US7211573B2 (en) *	2004-12-08	2007-05-01	Hoffmann-La Roche Inc.	Malonamide derivatives
AU2006240258A1 (en)	2005-04-20	2006-11-02	Merck Sharp & Dohme Corp.	Benzothiophene derivatives
AR059898A1 (es)	2006-03-15	2008-05-07	Janssen Pharmaceutica Nv	Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
KR101169628B1 (ko)	2006-03-27	2012-07-30	에프. 호프만-라 로슈 아게	감마 세크레테아제 저해제로서의 말론아미드 유도체
CA2663240A1 (en)	2006-09-20	2008-03-27	F. Hoffmann-La Roche Ag	4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepine derivatives
JP5379692B2 (ja)	2006-11-09	2013-12-25	プロビオドルグエージー	潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体
EP2091948B1 (de)	2006-11-30	2012-04-18	Probiodrug AG	Neue inhibitoren von glutaminylcyclase
WO2008092786A1 (en)	2007-02-02	2008-08-07	F. Hoffmann-La Roche Ag	6-oxo-6,7-dihydro-5h-dibenzo[b,d]azepin-7-yl derivatives
CA2679446C (en)	2007-03-01	2016-05-17	Probiodrug Ag	New use of glutaminyl cyclase inhibitors
TW200845978A (en)	2007-03-07	2008-12-01	Janssen Pharmaceutica Nv	3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200900065A (en)	2007-03-07	2009-01-01	Janssen Pharmaceutica Nv	3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
US9656991B2 (en)	2007-04-18	2017-05-23	Probiodrug Ag	Inhibitors of glutaminyl cyclase
US7579464B2 (en) *	2007-05-25	2009-08-25	Hoffmann-La Roche Inc.	Process for preparation of enantiomerically pure compounds
SI2203439T1 (sl)	2007-09-14	2011-05-31	Ortho Mcneil Janssen Pharm	1',3'-disubstituirani 4-fenil-3,4,5,6-tetrahidro-2H-1'H-(1,4')bipiridinil-2'-oni
BRPI0817101A2 (pt)	2007-09-14	2017-05-09	Addex Pharmaceuticals Sa	4-(aril-x-fenil)-1h-piridin-2-onas 1,3-dissubstituídas
ES2409215T3 (es)	2007-09-14	2013-06-25	Janssen Pharmaceuticals, Inc.	4-fenil-1H-piridin-2-onas 1-3-disustituidas
ES2637794T3 (es)	2007-11-14	2017-10-17	Janssen Pharmaceuticals, Inc.	Derivados de imidazo[1,2-A]piridina y su uso como moduladores alostéricos positivos de receptores MGLUR2
ES2439291T3 (es)	2008-09-02	2014-01-22	Janssen Pharmaceuticals, Inc.	Derivados de 3-azabiciclo[3.1.0]hexilo como moduladores de receptores de glutamato metabotrópicos
CA2738849C (en)	2008-10-16	2016-06-28	Addex Pharma S.A.	Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors
ES2401691T3 (es)	2008-11-28	2013-04-23	Ortho-Mcneil-Janssen Pharmaceuticals, Inc.	Derivados de indol y de benzoxacina como moduladores de los receptores metabotrópicos de glutamato
ES2440001T3 (es)	2009-05-12	2014-01-27	Janssen Pharmaceuticals, Inc.	Derivados de 1,2,4-triazolo[4,3-A]piridina y su uso para el tratamiento o prevención de trastornos neurológicos y psiquiátricos
MY153913A (en)	2009-05-12	2015-04-15	Janssen Pharmaceuticals Inc	7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
SG176018A1 (en)	2009-05-12	2011-12-29	Janssen Pharmaceuticals Inc	1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
BR112012008346B1 (pt)	2009-09-11	2021-12-21	Vivoryon Therapeutics N.V.	Derivados heterocíclicos, seu processo de preparação, e composição farmacêutica
US20110190269A1 (en) *	2010-02-01	2011-08-04	Karlheinz Baumann	Gamma secretase modulators
WO2011107530A2 (en)	2010-03-03	2011-09-09	Probiodrug Ag	Novel inhibitors
DK2545047T3 (da)	2010-03-10	2014-07-28	Probiodrug Ag	Heterocycliske inhibitorer af glutaminylcyclase (QC, EC 2.3.2.5)
EP2560953B1 (de)	2010-04-21	2016-01-06	Probiodrug AG	Hemmer der glutaminylzyklase
CN103298809B (zh)	2010-11-08	2016-08-31	杨森制药公司	1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
CA2814998C (en)	2010-11-08	2019-10-29	Janssen Pharmaceuticals, Inc.	1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
ES2552455T3 (es)	2010-11-08	2015-11-30	Janssen Pharmaceuticals, Inc.	Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2
WO2012123563A1 (en)	2011-03-16	2012-09-20	Probiodrug Ag	Benz imidazole derivatives as inhibitors of glutaminyl cyclase
TWI530489B (zh)	2011-03-22	2016-04-21	必治妥美雅史谷比公司	雙（氟烷基）－１，４－苯二氮呯酮化合物
JO3148B1 (ar)	2011-07-27	2017-09-20	Lilly Co Eli	مركب مثبط لإشارات مسار notch
US20150218103A1 (en)	2012-08-25	2015-08-06	The Johns Hopkins University	Gapdh cascade inhibitor compounds and methods of use and treatment of stress induced disorders including mental illness
CN104854094A (zh)	2012-09-21	2015-08-19	百时美施贵宝公司	氟烷基二苯并二氮杂*酮化合物
CN104822677A (zh)	2012-09-21	2015-08-05	百时美施贵宝公司	氟烷基-1,4-苯并二氮杂*酮化合物
US9273075B2 (en)	2012-09-21	2016-03-01	Bristol-Myers Squibb Company	Prodrugs of 1,4-benzodiazepinone compounds
US9249157B2 (en)	2012-09-21	2016-02-02	Bristol-Myers Squibb Company	Tricyclic heterocycle compounds
WO2014047397A1 (en)	2012-09-21	2014-03-27	Bristol-Myers Squibb Company	Fluoroalkyl and fluorocycloalkyl 1,4-benzodiazepinone compounds as notch\|inhibitors
WO2014047369A1 (en)	2012-09-21	2014-03-27	Bristol-Myers Squibb Company	Substituted 1,5-benzodiazepinone compounds
JP2015533811A (ja)	2012-09-21	2015-11-26	ブリストル−マイヤーズスクイブカンパニーＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＣｏｍｐａｎｙ	Ｎ−置換ビス（フルオロアルキル）１，４−ベンゾジアゼピノン化合物
EP2897947B1 (de)	2012-09-21	2016-10-26	Bristol-Myers Squibb Company	Alkyl, fluoroalkyl-1, 4-benzodiazepinonverbindungen
TWI614238B (zh)	2012-09-21	2018-02-11	必治妥美雅史谷比公司	雙（氟烷基）－１，４－苯并二氮呯酮化合物及其前藥
US9492469B2 (en)	2013-04-04	2016-11-15	Bristol-Myers Squibb Company	Combination therapy for the treatment of proliferative diseases
JO3368B1 (ar)	2013-06-04	2019-03-13	Janssen Pharmaceutica Nv	مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar)	2013-09-06	2019-03-13	Janssen Pharmaceutica Nv	مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
US10537573B2 (en)	2014-01-21	2020-01-21	Janssen Pharmaceutica Nv	Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
IL279202B2 (en)	2014-01-21	2023-09-01	Janssen Pharmaceutica Nv	Combinations containing positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic subtype 2 receptor and their use
PL3461819T3 (pl)	2017-09-29	2020-11-30	Probiodrug Ag	Inhibitory cyklazy glutaminylowej
NO345530B1 (en) *	2020-03-20	2021-03-29	Axichem As	Synthesis of capsaicin derivatives
EP4185306A4 (de) *	2020-07-23	2024-11-06	Purdue Research Foundation	Notch-signalhemmer zur behandlung von adipositas und stoffwechselerkrankungen

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS597193A (ja) *	1982-07-02	1984-01-14	Shionogi & Co Ltd	マロニルメチル基の異性化方法
US4968678A (en) *	1988-02-19	1990-11-06	Eli Lilly And Company	Tetrazole excitatory amino acid receptor antagonists
WO1993003011A1 (fr) *	1991-08-08	1993-02-18	Yamanouchi Pharmaceutical Co., Ltd.	Derive d'uree
EP1222176A1 (de) *	1999-10-08	2002-07-17	Bristol-Myers Squibb Pharma Company	Amino-laktam-sulfonamide als inhibitoren der bildung von a-beta-protein
AU2001253090A1 (en)	2000-04-03	2001-10-15	Bristol-Myers Squibb Pharma Company	Cyclic lactams as inhibitors of abeta protein production
US6632812B2 (en)	2000-04-11	2003-10-14	Dupont Pharmaceuticals Company	Substituted lactams as inhibitors of Aβ protein production
AU2004270361B2 (en) *	2003-09-09	2009-06-25	F. Hoffmann-La Roche Ag	Malonamide derivatives blocking the activity of gama-secretase

2004
- 2004-01-27 HR HR20050663A patent/HRP20050663A2/xx not_active Application Discontinuation
- 2004-01-27 CN CNB2004800033052A patent/CN100480248C/zh not_active Expired - Fee Related
- 2004-01-27 PL PL378405A patent/PL378405A1/pl not_active Application Discontinuation
- 2004-01-27 AT AT04705404T patent/ATE402934T1/de active
- 2004-01-27 RU RU2005127666/04A patent/RU2330849C2/ru not_active IP Right Cessation
- 2004-01-27 DE DE602004015415T patent/DE602004015415D1/de not_active Expired - Lifetime
- 2004-01-27 KR KR1020057014244A patent/KR100810810B1/ko not_active Expired - Fee Related
- 2004-01-27 EP EP04705404A patent/EP1592684B1/de not_active Expired - Lifetime
- 2004-01-27 CA CA2514267A patent/CA2514267C/en not_active Expired - Fee Related
- 2004-01-27 NZ NZ541324A patent/NZ541324A/en unknown
- 2004-01-27 BR BR0407262-6A patent/BRPI0407262A/pt not_active IP Right Cessation
- 2004-01-27 MX MXPA05008172A patent/MXPA05008172A/es active IP Right Grant
- 2004-01-27 JP JP2006500017A patent/JP4662914B2/ja not_active Expired - Fee Related
- 2004-01-27 WO PCT/EP2004/000674 patent/WO2004069826A1/en not_active Ceased
- 2004-01-27 ES ES04705404T patent/ES2311795T3/es not_active Expired - Lifetime
- 2004-01-29 US US10/767,784 patent/US7375099B2/en not_active Expired - Fee Related
- 2004-01-30 TW TW093102218A patent/TWI293070B/zh active
- 2004-02-02 AR ARP040100306A patent/AR042996A1/es not_active Application Discontinuation
- 2004-02-02 CL CL200400174A patent/CL2004000174A1/es unknown
2005
- 2005-07-14 IL IL169691A patent/IL169691A/en not_active IP Right Cessation
- 2005-07-25 CO CO05072813A patent/CO5580761A2/es not_active Application Discontinuation
- 2005-07-26 NO NO20053627A patent/NO20053627L/no not_active Application Discontinuation
- 2005-08-03 ZA ZA200506212A patent/ZA200506212B/en unknown

Also Published As

Publication number	Publication date
RU2005127666A (ru)	2006-04-27
US20040220222A1 (en)	2004-11-04
DE602004015415D1 (de)	2008-09-11
JP4662914B2 (ja)	2011-03-30
AU2004210036A1 (en)	2004-08-19
US7375099B2 (en)	2008-05-20
WO2004069826A1 (en)	2004-08-19
CL2004000174A1 (es)	2005-01-14
JP2006516556A (ja)	2006-07-06
HRP20050663A2 (en)	2006-12-31
ES2311795T3 (es)	2009-02-16
PL378405A1 (pl)	2006-04-03
TWI293070B (en)	2008-02-01
CN100480248C (zh)	2009-04-22
RU2330849C2 (ru)	2008-08-10
CA2514267A1 (en)	2004-08-19
CA2514267C (en)	2011-05-17
CO5580761A2 (es)	2005-11-30
ZA200506212B (en)	2006-05-31
NZ541324A (en)	2008-10-31
MXPA05008172A (es)	2005-10-05
KR20050105452A (ko)	2005-11-04
ATE402934T1 (de)	2008-08-15
BRPI0407262A (pt)	2006-01-31
CN1745076A (zh)	2006-03-08
EP1592684A1 (de)	2005-11-09
IL169691A0 (en)	2007-07-04
AR042996A1 (es)	2005-07-13
IL169691A (en)	2011-03-31
EP1592684B1 (de)	2008-07-30
KR100810810B1 (ko)	2008-03-06
TW200423928A (en)	2004-11-16

Legal Events

Date	Code	Title	Description
2009-08-31	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
NO20053627L (no)	2005-08-10	Malonamidderivater som gamma-sekretase inhibitorer
EP1562897A4 (de)	2007-06-27	Phenylcarboxamide als beta-sekretase-hemmer zur behandlung von alzheimer
WO2007011833A3 (en)	2007-03-29	Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease
WO2005004802A3 (en)	2005-09-22	N-alkyl phenylcarboxamide beta-secretase inhibitors for the treatment of alzheimer's disease
WO2005065195A3 (en)	2006-04-06	Phenylamide and pyridylamide beta-secretase inhibitors for the treatment of alzheimer's disease
NO20081482L (no)	2008-05-16	Delta- og epsilon-krystallformer for imatinibmesylat
WO2006044497A3 (en)	2006-09-08	Spiropiperidine compounds useful as beta-secretase inhibitors for the treatment of alzhermer’s disease
WO2005004803A3 (en)	2005-04-21	Phenylcarboxylate beta-secretase inhibitors for the treatment of alzheimer's disease
WO2008030412A3 (en)	2008-11-20	Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease
MXPA03011484A (es)	2004-03-18	Heteroarilos multiciclicos sustituidos con quinuclidinas para el tratamiento de enfermedades.
NO20025601L (no)	2003-01-06	Arylmetylaminderivater for anvendelse som tryptaseinhibitorer
WO2005051914A8 (en)	2005-08-11	Benzylether and benzylamino beta-secretase inhibitors for the treatment of alzheimer's disease
ZA200705018B (en)	2010-04-28	Malonamide derivatives as inhibitors of gamma-secretase for the treatment of Alzheimer's disease
NO20055496L (no)	2006-02-14	Pyrazolokinazolinderivater, metoder for deres fremstilling og deres anvendelse som kinaseinhibitorer
MA29856B1 (fr)	2008-10-03	Derives de diacylindazole en tant qu'inhibiteurs de lipases et de phospholipases
WO2004062625A3 (en)	2005-03-31	Macrocyclic beta-secretase inhibitors for treatment of alzheimer's disease
WO2006099379A3 (en)	2007-06-14	Benzazole derivatives, compositions, and methods of use as b-secretase inhibitors
BR0310106A (pt)	2005-02-22	Composto, processo para a produção de um composto, composição farmacêutica, uso do composto e método para o tratamento de um sujeito em sofrimento de uma condição ou doença patalógica
PT1041072E (pt)	2003-11-28	Acidos dioxociclopentil hidroxamicos
NO20045042L (no)	2004-11-19	7-aryl -3,9-diazabicyklo (3.1.1)non-6-en-derivater og deres anvendelse som renin. inhibitorer ved behandling av hypertensjon, kardiovaskulaere og nyresykdommer
DE60226729D1 (de)	2008-07-03	Hydroxyalkylaminderivate als beta-secretase-inhibitoren und deren verwendung zur behandlung der alzheimerschen krankheit oder ähnlicher krankheiten
NO20056192L (no)	2005-12-27	Kapaseinhibitorer og anvendelse derav
EA200401114A3 (ru)	2005-06-30	Замещённые гидроксиэтиламины
WO2005018545A3 (en)	2005-05-19	Macrocyclic beta-secretase inhibitors for the treatment of alzheimer's disease
WO2008054698A3 (en)	2008-06-19	Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease