NO20054111L - Fremgangsmate for fremtilling av tibolon - Google Patents

Fremgangsmate for fremtilling av tibolon

Info

Publication number: NO20054111L
Authority: NO; Norway
Prior art keywords: tibolone; procedure; producing; compound; formula
Prior art date: 2003-03-04

Application number

NO20054111A

Other languages

English (en)

Norwegian (no)

Other versions

NO20054111D0 (no

Inventor

Alan Kenneth Greenwood

Derek Mchattie

Parveen Bhatarah

Original Assignee

Resolution Chemicals Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-03-04

Filing date

2005-09-05

Publication date

2005-12-02

2005-09-05 Application filed by Resolution Chemicals Ltd filed Critical Resolution Chemicals Ltd

2005-09-05 Publication of NO20054111D0 publication Critical patent/NO20054111D0/no

2005-12-02 Publication of NO20054111L publication Critical patent/NO20054111L/no

Links

238000000034 method Methods 0.000 title abstract 3
WZDGZWOAQTVYBX-XOINTXKNSA-N tibolone Chemical compound C([C@@H]12)C[C@]3(C)[C@@](C#C)(O)CC[C@H]3[C@@H]1[C@H](C)CC1=C2CCC(=O)C1 WZDGZWOAQTVYBX-XOINTXKNSA-N 0.000 title 1
229960001023 tibolone Drugs 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 4
125000002877 alkyl aryl group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
238000006317 isomerization reaction Methods 0.000 abstract 1
230000011987 methylation Effects 0.000 abstract 1
238000007069 methylation reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Steroid Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

NO20054111A 2003-03-04 2005-09-05 Fremgangsmate for fremtilling av tibolon NO20054111L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0304927.7A GB0304927D0 (en)	2003-03-04	2003-03-04	Process for the production of tibolone
PCT/GB2004/000887 WO2004078774A1 (en)	2003-03-04	2004-03-03	Process for the production of tibolone

Publications (2)

Publication Number	Publication Date
NO20054111D0 NO20054111D0 (no)	2005-09-05
NO20054111L true NO20054111L (no)	2005-12-02

Family

ID=9954086

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20054111A NO20054111L (no)	2003-03-04	2005-09-05	Fremgangsmate for fremtilling av tibolon

Country Status (12)

Country	Link
US (1)	US7884222B2 (de)
EP (2)	EP1608670B1 (de)
JP (1)	JP2006519248A (de)
CN (1)	CN100420699C (de)
AU (1)	AU2004218221C1 (de)
BR (1)	BRPI0408104A (de)
CA (1)	CA2517934A1 (de)
GB (1)	GB0304927D0 (de)
NO (1)	NO20054111L (de)
NZ (1)	NZ542298A (de)
WO (1)	WO2004078774A1 (de)
ZA (1)	ZA200507281B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2070942A1 (de) *	2007-12-13	2009-06-17	Bayer Schering Pharma Aktiengesellschaft	Verfahren zur Aromatisierung von 19-Nor-androst-4-en-3-onen zu Estra-1,3,5(10)-trienen
WO2011000540A1 (en) *	2009-06-29	2011-01-06	Merz Pharma Gmbh & Co. Kgaa	Method of preparing 3,3,5,5-tetramethylcyclohexanone
JP2014505721A (ja) *	2011-02-17	2014-03-06	ルピン・リミテッド	レボノルゲストレルを調製するための改良された方法
CN104292285A (zh) *	2014-09-30	2015-01-21	湖北三晶生物科技有限公司	一种高含量脱氢诺龙醋酸酯的合成工艺
CN107365340A (zh) *	2017-07-05	2017-11-21	湖北工业大学	一种3,5‑雌甾二烯‑3,17β‑二醋酸酯的制备方法
CN107200762A (zh) *	2017-07-12	2017-09-26	湖北共同生物科技有限公司	3,5‑雌甾二烯‑3,17β‑二醋酸酯的制备方法
CN109575094B (zh) *	2019-01-17	2021-01-26	浙江仙琚制药股份有限公司	替勃龙中间体的制备方法
CN110981930B (zh) *	2019-12-31	2021-04-20	浙江仙居君业药业有限公司	一种替勃龙的合成方法

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2798879A (en) *	1953-04-15	1957-07-09	Upjohn Co	19-nortestosterone acylates and 3-enol acylates thereof
US2957933A (en) *	1957-06-08	1960-10-25	Basf Ag	Production of compounds of the betacyclo-geranylidene series
US3341557A (en) *	1961-06-05	1967-09-12	Upjohn Co	7-methyltestosterones
BE665514A (de) *	1964-06-16
CH488682A (de) *	1965-07-30	1970-04-15	Ciba Geigy	Verfahren zur Herstellung von 4,9,11-Trienen der 19-Nor-androstanreihe
NL146838B (nl) *	1966-06-24	1975-08-15	Organon Nv	Werkwijze voor het bereiden van (delta)5(10)-3- keto-19-norsteroiden.
US3515719A (en) *	1967-03-15	1970-06-02	Upjohn Co	7-methyl-6,19-epoxy steroids of the androstane series
CH547268A (de) *	1968-10-25	1974-03-29	Merck Patent Gmbh	Verfahren zur herstellung von n-disubstituierten 3-amino3,5-dien-19-nor-steroiden.
AU1005270A (en) *	1969-01-16	1971-07-08	F. Hoffmann-Laroche & Co. Aktiengesellschaft	19 homo steroids
US4000273A (en) *	1973-11-01	1976-12-28	Richardson-Merrell Inc.	Method for the control of fertility
FR2311030A1 (fr)	1975-05-16	1976-12-10	Aries Robert	Esters vinyliques d'hormones sexuelles
NL7510104A (nl) *	1975-08-27	1977-03-01	Akzo Nv	Werkwijze ter bereiding van een oraal werkzaam farmaceutisch preparaat.
GB1527161A (en)	1976-02-19	1978-10-04	Leo A	Enol esters of steroids
JPS5655400A (en) *	1979-10-12	1981-05-15	Mitsubishi Chem Ind Ltd	Improved preparation process of 4,6-dien-3-one steroid
DE3612632A1 (de) *	1986-04-11	1987-10-22	Schering Ag	Verfahren zur herstellung von 7(alpha)-propylsteroiden
DK24089D0 (da)	1989-01-20	1989-01-20	Hans Bundgaard	Novel prodrug derivatives of biologically active agents containing hydroxyl groups or nh-acidic groups
IE63051B1 (en)	1989-03-18	1995-03-22	Akzo Nv	Pharmaceutical composition which contains a pharmaceutically suitable carrier and the compound having the structure (7alpha, 17alpha)-17-Hydroxy-7-methyl-19-nor-17-pregn-5(10)-en-20-yn- 3-one
EP1236470A3 (de)	1991-11-22	2004-09-01	Alcon Laboratories, Inc.	Angiostatische Steroide
JP2746041B2 (ja)	1992-02-14	1998-04-28	三菱化学株式会社	新規なステロイド誘導体
DE4308095A1 (de)	1993-03-13	1994-09-15	Hoechst Ag	Prodrug-Derivate von Arzneimittelwirkstoffen mit Hydroxylgruppen, Verfahren zu deren Herstellung und ihre Verwendung
GB2321455A (en)	1997-01-24	1998-07-29	Norsk Hydro As	Lipophilic derivatives of biologically active compounds
WO1999067270A1 (en)	1998-06-19	1999-12-29	Akzo Nobel N.V.	Cycloalkyl-carboxylic acid esters of 7.alpha.methyl-estr-4-en-3-one 17.beta.-ol (19-nor 7.alpha.-methyltestosterone)
DE69901250T2 (de)	1998-06-19	2002-10-17	Akzo Nobel N.V., Arnheim/Arnhem	7.alpha.-methyl 19-nortestosteron undecanoat mit androgenischer aktivität
CZ298703B6 (cs)	1998-10-16	2007-12-27	N.V. Organon	Vysoce cistý (7alfa, 17alfa)-17-hydroxy-7-methyl-19-nor-17-pregn-5(10)-en-20-yn-3-on se zvýšenou stabilitou
IL144916A0 (en)	1999-03-23	2002-06-30	Holis Eden Pharmaceuticals Inc	Immunomodulatory steroids, in particular the hemihydrate of 16-alpha-bromoepiandrosterone
EP1212345B1 (de) *	1999-04-06	2003-08-06	Akzo Nobel N.V.	Oral wirksame 7-alpha-alkyl androgene
AU4682700A (en)	1999-04-30	2000-11-17	Research Corporation Technologies, Inc.	Bone targeting agents for osteoporosis
CN1187364C (zh)	1999-04-30	2005-02-02	亚其发展公司	类固醇衍生物
TW548277B (en) *	1999-07-16	2003-08-21	Akzo Nobel Nv	Orally active androgens
AUPQ342599A0 (en)	1999-10-14	1999-11-04	University Of Melbourne, The	Conjugates and uses thereof
US20050090476A1 (en) *	2002-01-21	2005-04-28	Arnoldus Maria Van Buggenum Patrick	Process for the preparation of 7alpha-methylsteroids

2003
- 2003-03-04 GB GBGB0304927.7A patent/GB0304927D0/en not_active Ceased
2004
- 2004-03-03 AU AU2004218221A patent/AU2004218221C1/en not_active Ceased
- 2004-03-03 NZ NZ542298A patent/NZ542298A/en not_active IP Right Cessation
- 2004-03-03 ZA ZA200507281A patent/ZA200507281B/en unknown
- 2004-03-03 EP EP04716642.6A patent/EP1608670B1/de not_active Expired - Lifetime
- 2004-03-03 JP JP2006505910A patent/JP2006519248A/ja active Pending
- 2004-03-03 CA CA002517934A patent/CA2517934A1/en not_active Abandoned
- 2004-03-03 US US10/548,114 patent/US7884222B2/en not_active Expired - Fee Related
- 2004-03-03 WO PCT/GB2004/000887 patent/WO2004078774A1/en not_active Ceased
- 2004-03-03 BR BRPI0408104-8A patent/BRPI0408104A/pt active Search and Examination
- 2004-03-03 EP EP10186130A patent/EP2497776A3/de not_active Withdrawn
- 2004-03-03 CN CNB2004800112393A patent/CN100420699C/zh not_active Expired - Fee Related
2005
- 2005-09-05 NO NO20054111A patent/NO20054111L/no unknown

Also Published As

Publication number	Publication date
CN1780849A (zh)	2006-05-31
US20060173201A1 (en)	2006-08-03
CA2517934A1 (en)	2004-09-16
US7884222B2 (en)	2011-02-08
GB0304927D0 (en)	2003-04-09
EP1608670B1 (de)	2013-09-11
EP1608670A1 (de)	2005-12-28
ZA200507281B (en)	2006-12-27
AU2004218221C1 (en)	2011-07-07
AU2004218221B2 (en)	2010-11-11
NO20054111D0 (no)	2005-09-05
JP2006519248A (ja)	2006-08-24
NZ542298A (en)	2008-07-31
CN100420699C (zh)	2008-09-24
EP2497776A3 (de)	2013-01-02
BRPI0408104A (pt)	2006-03-01
AU2004218221A1 (en)	2004-09-16
WO2004078774A1 (en)	2004-09-16
EP2497776A2 (de)	2012-09-12

Publication	Publication Date	Title
WO2006004100A8 (ja)	2006-02-23	１，２－ジヒドロピリジン－２－オン化合物の製造方法
TW200630376A (en)	2006-09-01	Process for preparing acylphosphanes and derivatives thereof
NO20054111L (no)	2005-12-02	Fremgangsmate for fremtilling av tibolon
IS6435A (is)	2002-06-19	Aðferð til framleiðslu á sítalóprami
DK1706414T3 (da)	2008-10-13	Fremgangsmåde til fluorcytidinderivater
TW200617000A (en)	2006-06-01	Methods of making 2,6-diaryl piperidine derivatives
PL360499A1 (en)	2004-02-09	Method of manufacture of donepezyl
JP2004517891A5 (de)	2005-12-22
AU2001250356A1 (en)	2001-09-24	Method for the production of spirocyclic tetronic acid derivatives
EA200600138A1 (ru)	2006-08-25	Способ получения кристаллического полиморфа ингибитора агрегации тромбоцитов
ATE440851T1 (de)	2009-09-15	Verfahren zur herstellung tertiärer phosphane
MY143324A (en)	2011-04-29	Process for preparing phosphorus compounds having phosphate-phosphonate bond
ATE286048T1 (de)	2005-01-15	Verfahren zur herstellung von carbostyril- derivaten
ATE202080T1 (de)	2001-06-15	Verfahren zur herstellung von 2-cyanobiphenyl verbindungen
ATE312107T1 (de)	2005-12-15	Verfahren zur herstellung von alkyllithium- verbindungen
DE69810578D1 (de)	2003-02-13	Pyrroloazepinverbindungen
DE50204538D1 (de)	2005-11-17	Verfahren zur herstellung von biperiden iv
ATE223377T1 (de)	2002-09-15	Verfahren zur herstellung von difluoracetophenon- derivaten
ATE319722T1 (de)	2006-03-15	Verfahren zur herstellung von vitamin-d analogen
ES2059113T3 (es)	1994-11-01	Metodo para preparar aril-fosfitos estericamente impedidos.
ZA200110167B (en)	2002-10-02	Method for producing condensation compounds.
TH100977B (th)	2010-04-23	กระบวนการสำหรับการเตรียม (3-ไซยาโน-1h-อินดอล-7-อิล) [4-(4-ฟลูออโรฟีนีธิล)พิเพอราซิน-1-อิล]เมธาโนนและเกลือของสารนี้
ATE283850T1 (de)	2004-12-15	Verfahren zur herstellung von 3,6-dihydro-2h- pyran-2-carbonsäureestern
ATE555089T1 (de)	2012-05-15	Verfahren zur herstellung von -ketoacetalen
DE60336739D1 (de)	2011-05-26	Verfahren zur herstellung eines 2-substituierten pyridinderivats