NO20054127L - HIV-hemmende 1,2,4-triaziner - Google Patents
HIV-hemmende 1,2,4-triazinerInfo
- Publication number
- NO20054127L NO20054127L NO20054127A NO20054127A NO20054127L NO 20054127 L NO20054127 L NO 20054127L NO 20054127 A NO20054127 A NO 20054127A NO 20054127 A NO20054127 A NO 20054127A NO 20054127 L NO20054127 L NO 20054127L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- amino
- substituted
- aminocarbonyl
- optionally substituted
- Prior art date
Links
- 150000003920 1,2,4-triazines Chemical class 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 5
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 4
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 4
- 125000001475 halogen functional group Chemical group 0.000 abstract 4
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- -1 pirazinyl Chemical group 0.000 abstract 3
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 2
- YWFARCBGCLDLFI-UHFFFAOYSA-N 1,2,4-triazine-6-carboxylic acid Chemical compound OC(=O)C1=CN=CN=N1 YWFARCBGCLDLFI-UHFFFAOYSA-N 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 1
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 abstract 1
- RFMGZZUEKLSMTR-UHFFFAOYSA-N 3-N-(4-chlorophenyl)-6-fluoro-1,2,4-triazine-3,5-diamine Chemical compound ClC1=CC=C(C=C1)NC=1N=NC(=C(N=1)N)F RFMGZZUEKLSMTR-UHFFFAOYSA-N 0.000 abstract 1
- 101100240519 Caenorhabditis elegans nhr-13 gene Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000004494 ethyl ester group Chemical group 0.000 abstract 1
- 125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002098 pyridazinyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furnace Details (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP0301289 | 2003-02-07 | ||
| PCT/EP2004/050084 WO2004074266A1 (en) | 2003-02-07 | 2004-02-05 | Hiv inhibiting 1,2,4-triazines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20054127L true NO20054127L (no) | 2005-09-05 |
Family
ID=32892827
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20054127A NO20054127L (no) | 2003-02-07 | 2005-09-05 | HIV-hemmende 1,2,4-triaziner |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7585861B2 (pl) |
| EP (1) | EP1597242B1 (pl) |
| JP (1) | JP4783725B2 (pl) |
| KR (1) | KR20050105190A (pl) |
| CN (2) | CN102503903A (pl) |
| AP (1) | AP2005003365A0 (pl) |
| AT (1) | ATE402152T1 (pl) |
| AU (1) | AU2004213173B2 (pl) |
| BR (1) | BRPI0407306A (pl) |
| CA (1) | CA2513123C (pl) |
| DE (1) | DE602004015254D1 (pl) |
| EA (1) | EA010379B1 (pl) |
| ES (1) | ES2311146T3 (pl) |
| HR (1) | HRP20050690A2 (pl) |
| IL (1) | IL170120A (pl) |
| MX (1) | MXPA05008368A (pl) |
| NO (1) | NO20054127L (pl) |
| PL (1) | PL232814B1 (pl) |
| WO (1) | WO2004074266A1 (pl) |
| ZA (1) | ZA200506254B (pl) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005231507B2 (en) | 2004-04-08 | 2012-03-01 | Targegen, Inc. | Benzotriazine inhibitors of kinases |
| AU2005271161B2 (en) * | 2004-08-10 | 2011-05-12 | Janssen Pharmaceutica N.V. | HIV inhibiting 1,2,4-triazin-6-one derivatives |
| NZ588896A (en) | 2004-08-25 | 2012-05-25 | Targegen Inc | Heterocyclic compounds and methods of use |
| EP1799667B1 (en) | 2004-09-20 | 2013-03-20 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as therapeutic agents |
| EP1804799B1 (en) | 2004-09-20 | 2013-08-21 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| US7951805B2 (en) | 2004-09-20 | 2011-05-31 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase |
| EP2289510A1 (en) | 2004-09-20 | 2011-03-02 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes |
| CA2580856A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| EP2316458A1 (en) | 2004-09-20 | 2011-05-04 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase |
| US7767677B2 (en) | 2004-09-20 | 2010-08-03 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
| EP2029138A1 (en) | 2005-06-03 | 2009-03-04 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
| US8604042B2 (en) | 2005-11-01 | 2013-12-10 | Targegen, Inc. | Bi-aryl meta-pyrimidine inhibitors of kinases |
| US8133900B2 (en) | 2005-11-01 | 2012-03-13 | Targegen, Inc. | Use of bi-aryl meta-pyrimidine inhibitors of kinases |
| WO2007053452A1 (en) | 2005-11-01 | 2007-05-10 | Targegen, Inc. | Bi-aryl meta-pyrimidine inhibitors of kinases |
| EP2121613A2 (en) * | 2007-01-31 | 2009-11-25 | Vertex Pharmaceuticals, Inc. | 2-aminopyridine derivatives useful as kinase inhibitors |
| JP2011523646A (ja) | 2008-05-21 | 2011-08-18 | アリアド・ファーマシューティカルズ・インコーポレイテッド | キナーゼ阻害剤としてのリン誘導体 |
| US8569337B2 (en) | 2008-07-23 | 2013-10-29 | Vertex Pharmaceuticals Incorporated | Tri-cyclic pyrazolopyridine kinase inhibitors |
| NZ590784A (en) | 2008-07-23 | 2012-12-21 | Vertex Pharma | Pyrazolopyridine kinase inhibitors |
| MX2011000837A (es) | 2008-07-23 | 2011-04-05 | Vertex Pharma | Inhibidores de pirazolpiridina cinasa triciclica. |
| MX2011001319A (es) | 2008-08-06 | 2011-04-05 | Vertex Pharma | Inhibidores de aminopiridina cinasa. |
| WO2010129668A1 (en) | 2009-05-06 | 2010-11-11 | Vertex Pharmaceuticals Incorporated | Pyrazolopyridines |
| EP2582702A1 (en) | 2010-01-27 | 2013-04-24 | Vertex Pharmaceuticals Incorporated | Pyrazolopyrimidine kinase inhibitors |
| EP2528917B1 (en) | 2010-01-27 | 2016-10-19 | Vertex Pharmaceuticals Incorporated | Pyrazolopyridines useful for the treatment of autoimmune, inflammatory or (hyper)proliferative diseases |
| AU2011209649A1 (en) | 2010-01-27 | 2012-08-09 | Vertex Pharmaceuticals Incorporated | Pyrazolopyrazine kinase inhibitors |
| AU2010363329A1 (en) | 2010-11-07 | 2013-05-09 | Targegen, Inc. | Compositions and methods for treating myelofibrosis |
| WO2016044445A2 (en) | 2014-09-17 | 2016-03-24 | Ironwood Pharmaceuticals, Inc. | sGC STIMULATORS |
| KR102218333B1 (ko) | 2016-06-07 | 2021-02-22 | 자코바이오 파마슈티칼스 컴퍼니 리미티드 | Shp2 억제제로서 유용한 신규한 헤테로환형 유도체 |
| SG11201908820VA (en) | 2017-03-23 | 2019-10-30 | Jacobio Pharmaceuticals Co Ltd | Novel heterocyclic derivatives useful as shp2 inhibitors |
| CN112839935A (zh) | 2018-09-26 | 2021-05-25 | 北京加科思新药研发有限公司 | 可用作shp2抑制剂的新型杂环衍生物 |
| WO2021071984A1 (en) * | 2019-10-08 | 2021-04-15 | Skyhawk Therapeutics, Inc. | Compounds for modulating splicing |
| KR20220119653A (ko) | 2019-12-20 | 2022-08-30 | 테나야 테라퓨틱스, 인코포레이티드 | 플루오로알킬-옥사디아졸 및 이의 용도 |
| CN111333543B (zh) * | 2020-04-17 | 2022-09-16 | 武汉工程大学 | 一种利匹韦林中间体的合成方法 |
| US20240252502A1 (en) | 2021-05-04 | 2024-08-01 | Tenaya Therapeutics, Inc. | Hdac6 inhibitors for treatment of metabolic disease and hfpef |
| CN115745848A (zh) * | 2022-12-07 | 2023-03-07 | 上海优合生物科技有限公司 | 一种氨基胍的加工合成工艺 |
| CN117658936B (zh) * | 2023-11-30 | 2025-06-06 | 上海予君生物科技发展有限公司 | 一种3,5,6-三氯-[1,2,4]-三嗪的合成方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3459731A (en) | 1966-12-16 | 1969-08-05 | Corn Products Co | Cyclodextrin polyethers and their production |
| CZ154398A3 (cs) | 1995-11-23 | 1998-08-12 | Janssen Pharmaceutica N.V. | Pevné směsi cyklodextrinů připravené vytlačováním taveniny |
| NO311614B1 (no) * | 1996-10-01 | 2001-12-17 | Janssen Pharmaceutica Nv | Substituerte diamino-1,3,5-triazinderivater |
| JP3440263B2 (ja) | 1998-03-27 | 2003-08-25 | エルジー・ライフ・サイエンシーズ・リミテッド | 新規アスコルビン酸誘導体及びその調製方法 |
| NZ506679A (en) * | 1998-03-27 | 2002-11-26 | Janssen Pharmaceutica Nv | HIV inhibiting pyrimidine derivatives |
| EP0945447A1 (en) * | 1998-03-27 | 1999-09-29 | Janssen Pharmaceutica N.V. | Trisubstituted 1,3,5-triazine derivatives for treatment of HIV infections |
| ID28376A (id) * | 1998-11-10 | 2001-05-17 | Janssen Pharmaceutica Nv | Pirimidina yang menghambat replikasi hiv |
| CN1207290C (zh) * | 1998-11-10 | 2005-06-22 | 詹森药业有限公司 | 2,4－二取代三嗪衍生物 |
| CA2406562C (en) * | 2000-05-08 | 2009-09-15 | Janssen Pharmaceutica N.V. | Hiv replication inhibiting pyrimidines and triazines |
| EP1370265B8 (en) | 2001-03-15 | 2013-10-30 | Janssen Pharmaceutica NV | Hiv inhibiting pyrazinone derivatives |
| JO3429B1 (ar) | 2001-08-13 | 2019-10-20 | Janssen Pharmaceutica Nv | مشتقات برميدينات مثبطة فيروس الايدز |
-
2004
- 2004-02-05 CN CN201110305993XA patent/CN102503903A/zh active Pending
- 2004-02-05 AT AT04708367T patent/ATE402152T1/de not_active IP Right Cessation
- 2004-02-05 ES ES04708367T patent/ES2311146T3/es not_active Expired - Lifetime
- 2004-02-05 HR HR20050690A patent/HRP20050690A2/xx not_active Application Discontinuation
- 2004-02-05 JP JP2006502005A patent/JP4783725B2/ja not_active Expired - Fee Related
- 2004-02-05 KR KR1020057013955A patent/KR20050105190A/ko not_active Withdrawn
- 2004-02-05 CA CA2513123A patent/CA2513123C/en not_active Expired - Fee Related
- 2004-02-05 CN CNA2004800035861A patent/CN1747941A/zh active Pending
- 2004-02-05 EA EA200501268A patent/EA010379B1/ru not_active IP Right Cessation
- 2004-02-05 BR BRPI0407306-1A patent/BRPI0407306A/pt not_active IP Right Cessation
- 2004-02-05 US US10/544,584 patent/US7585861B2/en not_active Expired - Lifetime
- 2004-02-05 MX MXPA05008368A patent/MXPA05008368A/es active IP Right Grant
- 2004-02-05 EP EP04708367A patent/EP1597242B1/en not_active Expired - Lifetime
- 2004-02-05 AU AU2004213173A patent/AU2004213173B2/en not_active Ceased
- 2004-02-05 DE DE602004015254T patent/DE602004015254D1/de not_active Expired - Lifetime
- 2004-02-05 AP AP2005003365A patent/AP2005003365A0/xx unknown
- 2004-02-05 PL PL378107A patent/PL232814B1/pl unknown
- 2004-02-05 WO PCT/EP2004/050084 patent/WO2004074266A1/en not_active Ceased
-
2005
- 2005-08-04 ZA ZA200506254A patent/ZA200506254B/en unknown
- 2005-08-04 IL IL170120A patent/IL170120A/en active IP Right Grant
- 2005-09-05 NO NO20054127A patent/NO20054127L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20050690A2 (en) | 2006-08-31 |
| CA2513123C (en) | 2013-04-23 |
| US20070037811A1 (en) | 2007-02-15 |
| WO2004074266A8 (en) | 2004-11-11 |
| PL232814B1 (pl) | 2019-07-31 |
| EA010379B1 (ru) | 2008-08-29 |
| EP1597242A1 (en) | 2005-11-23 |
| ZA200506254B (en) | 2008-02-27 |
| CN1747941A (zh) | 2006-03-15 |
| JP4783725B2 (ja) | 2011-09-28 |
| MXPA05008368A (es) | 2005-11-04 |
| EP1597242B1 (en) | 2008-07-23 |
| ES2311146T3 (es) | 2009-02-01 |
| IL170120A (en) | 2013-04-30 |
| AP2005003365A0 (en) | 2005-09-30 |
| AU2004213173B2 (en) | 2010-07-29 |
| CN102503903A (zh) | 2012-06-20 |
| KR20050105190A (ko) | 2005-11-03 |
| EA200501268A1 (ru) | 2006-02-24 |
| JP2006516983A (ja) | 2006-07-13 |
| US7585861B2 (en) | 2009-09-08 |
| CA2513123A1 (en) | 2004-09-02 |
| PL378107A1 (pl) | 2006-03-06 |
| WO2004074266A1 (en) | 2004-09-02 |
| DE602004015254D1 (de) | 2008-09-04 |
| BRPI0407306A (pt) | 2006-02-21 |
| AU2004213173A1 (en) | 2004-09-02 |
| ATE402152T1 (de) | 2008-08-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |