PL378107A1 - 1,2,4-triazyny hamujące HIV - Google Patents

1,2,4-triazyny hamujące HIV

Info

Publication number
PL378107A1
PL378107A1 PL378107A PL37810704A PL378107A1 PL 378107 A1 PL378107 A1 PL 378107A1 PL 378107 A PL378107 A PL 378107A PL 37810704 A PL37810704 A PL 37810704A PL 378107 A1 PL378107 A1 PL 378107A1
Authority
PL
Poland
Prior art keywords
triazines
hiv inhibiting
hiv
inhibiting
medicine
Prior art date
Application number
PL378107A
Other languages
English (en)
Other versions
PL232814B1 (pl
Inventor
Paulus Joannes Lewi
Paul Adrian Jan Janssen
Jonge Marc René De
Lucien Maria Henricus Koymans
Hendrik Maarten Vinkers
Frederik Frans Desiré Daeyaert
Jan Heeres
Ruben Gerardus George Leenders
Georges Joseph Cornelius Hoornaert
Amuri Kilonda
Donald William Ludovici
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of PL378107A1 publication Critical patent/PL378107A1/pl
Publication of PL232814B1 publication Critical patent/PL232814B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furnace Details (AREA)

Abstract

Przedmiotem niniejszego wynalazku są inhibitory replikacji i HIV o wzorze (I) zdefiniowanym w zgłoszeniu, ich zastosowanie jako leku, sposób ich wytwarzania oraz zawierające je kompozycje farmaceutyczne.
PL378107A 2003-02-07 2004-02-05 Pochodne 1,2,4-triazynowe, ich zastosowanie i zawierająca je kompozycja farmaceutyczna PL232814B1 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
WOPCT/EP03/01289 2003-02-07
EP0301289 2003-02-07
PCT/EP2004/050084 WO2004074266A1 (en) 2003-02-07 2004-02-05 Hiv inhibiting 1,2,4-triazines

Publications (2)

Publication Number Publication Date
PL378107A1 true PL378107A1 (pl) 2006-03-06
PL232814B1 PL232814B1 (pl) 2019-07-31

Family

ID=32892827

Family Applications (1)

Application Number Title Priority Date Filing Date
PL378107A PL232814B1 (pl) 2003-02-07 2004-02-05 Pochodne 1,2,4-triazynowe, ich zastosowanie i zawierająca je kompozycja farmaceutyczna

Country Status (20)

Country Link
US (1) US7585861B2 (pl)
EP (1) EP1597242B1 (pl)
JP (1) JP4783725B2 (pl)
KR (1) KR20050105190A (pl)
CN (2) CN102503903A (pl)
AP (1) AP2005003365A0 (pl)
AT (1) ATE402152T1 (pl)
AU (1) AU2004213173B2 (pl)
BR (1) BRPI0407306A (pl)
CA (1) CA2513123C (pl)
DE (1) DE602004015254D1 (pl)
EA (1) EA010379B1 (pl)
ES (1) ES2311146T3 (pl)
HR (1) HRP20050690A2 (pl)
IL (1) IL170120A (pl)
MX (1) MXPA05008368A (pl)
NO (1) NO20054127L (pl)
PL (1) PL232814B1 (pl)
WO (1) WO2004074266A1 (pl)
ZA (1) ZA200506254B (pl)

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EP2543376A1 (en) 2004-04-08 2013-01-09 Targegen, Inc. Benzotriazine inhibitors of kinases
US7923554B2 (en) * 2004-08-10 2011-04-12 Janssen Pharmaceutica N.V. HIV inhibiting 1,2,4-triazin-6-one derivatives
US7652051B2 (en) 2004-08-25 2010-01-26 Targegen, Inc. Heterocyclic compounds and methods of use
AU2005286728A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase
MX2007003318A (es) 2004-09-20 2007-05-18 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como agentes terapeuticos.
MX2007003332A (es) 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de estearoil-coa-desaturasa.
BRPI0515500A (pt) 2004-09-20 2008-07-29 Xenon Pharmaceuticals Inc derivados piridazina para inibição de estearoil-coa-desaturase
CN101084211A (zh) 2004-09-20 2007-12-05 泽农医药公司 杂环衍生物及其作为治疗剂的用途
AU2005286647A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
BRPI0515482A (pt) 2004-09-20 2008-07-22 Xenon Pharmaceuticals Inc derivados heterocìclicos e seus usos como agentes terapêuticos
CA2618646A1 (en) 2005-06-03 2007-11-15 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
US8604042B2 (en) 2005-11-01 2013-12-10 Targegen, Inc. Bi-aryl meta-pyrimidine inhibitors of kinases
JP5191391B2 (ja) 2005-11-01 2013-05-08 ターゲジェン インコーポレーティッド キナーゼのビ−アリールメタ−ピリミジン阻害剤
US8133900B2 (en) 2005-11-01 2012-03-13 Targegen, Inc. Use of bi-aryl meta-pyrimidine inhibitors of kinases
AU2008210455A1 (en) * 2007-01-31 2008-08-07 Vertex Pharmaceuticals Incorporated 2-aminopyridine derivatives useful as kinase inhibitors
MX353308B (es) 2008-05-21 2018-01-08 Ariad Pharma Inc Derivados fosforosos como inhibidores de cinasa.
US8569337B2 (en) 2008-07-23 2013-10-29 Vertex Pharmaceuticals Incorporated Tri-cyclic pyrazolopyridine kinase inhibitors
AU2009274023A1 (en) 2008-07-23 2010-01-28 Vertex Pharmaceuticals Incorporated Tri-cyclic pyrazolopyridine kinase inhibitors
ES2402087T3 (es) 2008-07-23 2013-04-26 Vertex Pharmaceuticals Incorporated Inhibidores de la pirazolopiridina quinasa
CA2732765A1 (en) 2008-08-06 2010-02-11 Vertex Pharmaceuticals Incorporated Aminopyridine kinase inhibitors
CA2760705A1 (en) 2009-05-06 2010-11-11 Vertex Pharmaceuticals Incorporated Pyrazolopyridines
CA2787079A1 (en) 2010-01-27 2011-08-04 Vertex Pharmaceuticals Incorporated Pyrazolopyrazine kinase inhibitors
JP5769733B2 (ja) 2010-01-27 2015-08-26 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ ピラゾロピリジンキナーゼ阻害剤
EP2582702A1 (en) 2010-01-27 2013-04-24 Vertex Pharmaceuticals Incorporated Pyrazolopyrimidine kinase inhibitors
AU2010363329A1 (en) 2010-11-07 2013-05-09 Targegen, Inc. Compositions and methods for treating myelofibrosis
US20170298055A1 (en) 2014-09-17 2017-10-19 Ironwood Pharmaceuticals, Inc. sGC STIMULATORS
MX388576B (es) 2016-06-07 2025-03-20 Jacobio Pharmaceuticals Co Ltd Derivados heterociclicos novedosos utiles como inhibidores de shp2.
EA202190196A1 (ru) 2017-03-23 2021-08-31 Джакобио Фармасьютикалс Ко., Лтд. Новые гетероциклические производные, применимые в качестве ингибиторов shp2
US20210393623A1 (en) 2018-09-26 2021-12-23 Jacobio Pharmaceuticals Co., Ltd. Novel Heterocyclic Derivatives Useful as SHP2 Inhibitors
WO2021071984A1 (en) * 2019-10-08 2021-04-15 Skyhawk Therapeutics, Inc. Compounds for modulating splicing
MX2022007376A (es) 2019-12-20 2022-09-02 Tenaya Therapeutics Inc Fluoroalqull-oxadiazoles y sus usos.
CN111333543B (zh) * 2020-04-17 2022-09-16 武汉工程大学 一种利匹韦林中间体的合成方法
US20240252502A1 (en) 2021-05-04 2024-08-01 Tenaya Therapeutics, Inc. Hdac6 inhibitors for treatment of metabolic disease and hfpef
CN115745848A (zh) * 2022-12-07 2023-03-07 上海优合生物科技有限公司 一种氨基胍的加工合成工艺
CN117658936B (zh) * 2023-11-30 2025-06-06 上海予君生物科技发展有限公司 一种3,5,6-三氯-[1,2,4]-三嗪的合成方法

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BR9611562A (pt) 1995-11-23 1999-03-02 Janssen Pharmaceutica Nv Misturas sólidas de ciclodextrinas preparadas via extrusão sob fusão
NO311614B1 (no) * 1996-10-01 2001-12-17 Janssen Pharmaceutica Nv Substituerte diamino-1,3,5-triazinderivater
EP0945447A1 (en) * 1998-03-27 1999-09-29 Janssen Pharmaceutica N.V. Trisubstituted 1,3,5-triazine derivatives for treatment of HIV infections
EA002973B1 (ru) * 1998-03-27 2002-12-26 Янссен Фармацевтика Н.В. Производные пиримидина в качестве ингибиторов репликации вируса иммунодефицита человека
CN1295567A (zh) 1998-03-27 2001-05-16 株式会社Lg化学 作为新型抗氧剂的聚乙氧基化抗坏血酸衍生物及其制备方法
SK287270B6 (sk) 1998-11-10 2010-05-07 Janssen Pharmaceutica N. V. Derivát pyrimidínu
SI1129079T1 (sl) * 1998-11-10 2006-06-30 Janssen Pharmaceutica Nv 2,4-disubstituirani triazinski derivati z anti-HIV aktivnostjo
AU783981C (en) * 2000-05-08 2007-05-03 Janssen Pharmaceutica N.V. HIV replication inhibitors
US7105522B2 (en) 2001-03-15 2006-09-12 Janssen Pharmaceutica, N.V. HIV inhibiting pyrazinone derivatives
JO3429B1 (ar) * 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز

Also Published As

Publication number Publication date
EP1597242B1 (en) 2008-07-23
JP2006516983A (ja) 2006-07-13
KR20050105190A (ko) 2005-11-03
IL170120A (en) 2013-04-30
CN102503903A (zh) 2012-06-20
AU2004213173A1 (en) 2004-09-02
EA200501268A1 (ru) 2006-02-24
PL232814B1 (pl) 2019-07-31
JP4783725B2 (ja) 2011-09-28
CA2513123A1 (en) 2004-09-02
CA2513123C (en) 2013-04-23
ATE402152T1 (de) 2008-08-15
HRP20050690A2 (en) 2006-08-31
US20070037811A1 (en) 2007-02-15
EP1597242A1 (en) 2005-11-23
WO2004074266A8 (en) 2004-11-11
MXPA05008368A (es) 2005-11-04
NO20054127L (no) 2005-09-05
WO2004074266A1 (en) 2004-09-02
BRPI0407306A (pt) 2006-02-21
ES2311146T3 (es) 2009-02-01
AP2005003365A0 (en) 2005-09-30
AU2004213173B2 (en) 2010-07-29
CN1747941A (zh) 2006-03-15
US7585861B2 (en) 2009-09-08
ZA200506254B (en) 2008-02-27
DE602004015254D1 (de) 2008-09-04
EA010379B1 (ru) 2008-08-29

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