NO20055921L - Heterocykliske metylsulfonderivater - Google Patents
Heterocykliske metylsulfonderivaterInfo
- Publication number
- NO20055921L NO20055921L NO20055921A NO20055921A NO20055921L NO 20055921 L NO20055921 L NO 20055921L NO 20055921 A NO20055921 A NO 20055921A NO 20055921 A NO20055921 A NO 20055921A NO 20055921 L NO20055921 L NO 20055921L
- Authority
- NO
- Norway
- Prior art keywords
- substituent
- heterocyclic
- methylsulfone
- derivatives
- heterocyclic group
- Prior art date
Links
- -1 Heterocyclic methylsulfone derivatives Chemical class 0.000 title 1
- 125000001424 substituent group Chemical group 0.000 abstract 5
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 102000013455 Amyloid beta-Peptides Human genes 0.000 abstract 1
- 108010090849 Amyloid beta-Peptides Proteins 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- RCCPEORTSYDPMB-UHFFFAOYSA-N hydroxy benzenecarboximidothioate Chemical compound OSC(=N)C1=CC=CC=C1 RCCPEORTSYDPMB-UHFFFAOYSA-N 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/14—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyrane Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003187796 | 2003-06-30 | ||
| JP2004099151 | 2004-03-30 | ||
| PCT/JP2004/009132 WO2005000798A1 (fr) | 2003-06-30 | 2004-06-29 | Derive de methyle sulfone heterocyclique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20055921L true NO20055921L (no) | 2006-01-24 |
Family
ID=33554493
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20055921A NO20055921L (no) | 2003-06-30 | 2005-12-13 | Heterocykliske metylsulfonderivater |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7932271B2 (fr) |
| EP (1) | EP1640366A4 (fr) |
| JP (1) | JP4523914B2 (fr) |
| KR (1) | KR20060066057A (fr) |
| AU (1) | AU2004251987C1 (fr) |
| CA (1) | CA2526487A1 (fr) |
| IL (1) | IL172139A0 (fr) |
| MX (1) | MXPA05013631A (fr) |
| NO (1) | NO20055921L (fr) |
| PL (1) | PL379466A1 (fr) |
| RU (1) | RU2336270C2 (fr) |
| TW (1) | TWI328005B (fr) |
| WO (1) | WO2005000798A1 (fr) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0108591D0 (en) | 2001-04-05 | 2001-05-23 | Merck Sharp & Dohme | Therapeutic agents |
| GB0120347D0 (en) | 2001-08-21 | 2001-10-17 | Merck Sharp & Dohme | Therapeutic agents |
| KR100927304B1 (ko) * | 2001-12-27 | 2009-11-18 | 다이이찌 세이야꾸 가부시기가이샤 | β-아밀로이드 단백 생산·분비 저해제 |
| GB0223039D0 (en) | 2002-10-04 | 2002-11-13 | Merck Sharp & Dohme | Therapeutic compounds |
| PL379466A1 (pl) | 2003-06-30 | 2006-09-18 | Daiichi Sankyo Company , Limited | Heterocykliczne pochodne metylosulfonu |
| AU2006234441B2 (en) * | 2005-04-08 | 2011-07-07 | Daiichi Sankyo Company, Limited | Pyridylmethylsulfone derivative |
| BRPI0713463A2 (pt) * | 2006-06-22 | 2012-01-24 | Atrazeneca Ab E Astex Therapeutics Ltd | composto, formulação farmacêutica, uso de um composto, e, métodos para inibir a atividade de bace e para tratar ou prevenie uma patologia |
| JP2008115166A (ja) * | 2006-10-10 | 2008-05-22 | Daiichi Sankyo Co Ltd | ピリジルフェニルメチルスルホン誘導体 |
| KR101450356B1 (ko) | 2006-11-24 | 2014-10-15 | 에이씨 이뮨 에스.에이. | 알츠하이머와 같은 아밀로이드 또는 아밀로이드-유사 단백질과 관련된 질환의 치료를 위한 ｎ-(메틸)-1ｈ-피라졸-3-아민, ｎ-(메틸)-피리딘-2-아민 및 ｎ-(메틸)-티아졸-2-아민 유도체 |
| TW200920362A (en) | 2007-09-11 | 2009-05-16 | Daiichi Sankyo Co Ltd | Alkylsulfone derivatives |
| JP2010540629A (ja) * | 2007-10-04 | 2010-12-24 | メルク・シャープ・エンド・ドーム・コーポレイション | カルシウムチャネル遮断薬としての置換アリールスルホン誘導体 |
| EP2311823A1 (fr) | 2009-10-15 | 2011-04-20 | AC Immune S.A. | Composés de 2,6-diaminopyridine appropriés pour le traitement de maladies liées à des protéines amyloïdes ou pour le traitement de maladies oculaires |
| UA103272C2 (uk) * | 2009-12-11 | 2013-09-25 | Ф. Хоффманн-Ля Рош Аг | 2-аміно-5,5-дифтор-5,6-дигідро-4h-оксазини як інгібітори bace1 і/або bace2 |
| JP2013531687A (ja) | 2010-07-16 | 2013-08-08 | パーデュー、ファーマ、リミテッド、パートナーシップ | ナトリウムチャネル遮断剤としてのピリジン化合物 |
| WO2013136170A1 (fr) | 2012-03-16 | 2013-09-19 | Purdue Pharma L.P. | Pyridines substituées en tant que bloqueurs des canaux sodiques |
| EP2935257B1 (fr) | 2012-12-20 | 2018-02-07 | Purdue Pharma LP | Sulfonamides cycliques en tant que bloquants des canaux sodiques |
| US10730866B2 (en) | 2014-04-07 | 2020-08-04 | Purdue Pharma L.P. | Indole derivatives and use thereof |
| EP3436523B1 (fr) * | 2016-03-30 | 2022-07-06 | Nikon Corporation | Composition durcissable, produit durci et élément optique |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3849423A (en) * | 1971-03-22 | 1974-11-19 | Lilly Co Eli | 3-benzylpyridines |
| US4055652A (en) | 1975-07-07 | 1977-10-25 | Syntex (U.S.A.) Inc. | 1-[β(R-thio)phenethyl]imidazoles and derivatives thereof |
| ZA765075B (en) | 1975-09-25 | 1977-08-31 | American Cyanamid Co | Hypolipemic compounds and method of treatment |
| US4116665A (en) * | 1976-04-02 | 1978-09-26 | Eli Lilly And Company | Method of regulating the growth of aquatic weeds with pyridine derivatives |
| FR2375228A1 (fr) | 1976-12-23 | 1978-07-21 | Parcor | Nouveaux benzothiophenes, leurs procedes de preparation et leur application notamment comme hypolipemiants et hypocholesterolemiants |
| DE2724684A1 (de) | 1977-06-01 | 1978-12-14 | Basf Ag | Triazolsubstituierte schwefelverbindungen |
| DE2735314A1 (de) | 1977-08-05 | 1979-02-22 | Basf Ag | Alpha-azolylsulfide und deren derivate |
| US4675316A (en) | 1978-03-10 | 1987-06-23 | Rohm And Haas Company | Substituted azoylmethylarylsulfides and derivatives and pesticidal use thereof |
| US4257954A (en) * | 1978-08-08 | 1981-03-24 | Sterling Drug Inc. | Novel compounds, processes and marking systems |
| ZA794030B (en) * | 1978-08-08 | 1980-07-30 | Sterling Drug Inc | Aryl sulfinic acid derivatives of aliphatic,aromatic or heterocyclic compounds |
| US4379921A (en) | 1980-08-21 | 1983-04-12 | Sumitomo Chemical Company, Limited | Production of triazolylvinyl ketones |
| FR2509725A1 (fr) | 1981-07-15 | 1983-01-21 | Choay Sa | (hydroxyalkyl)phenylsulfures, leurs procedes de preparation et compositions pharmaceutiques les contenant |
| EP0117485A3 (fr) | 1983-02-28 | 1985-01-23 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Dérivés de pyridine, pyrazine et pyrimidine et leur utilisation comme agents fongicides |
| DE3406908A1 (de) | 1984-02-25 | 1985-09-05 | Hoechst Ag, 6230 Frankfurt | Neue triazolylalkylderivate, verfahren zu ihrer herstellung sowie ihre verwendung als pflanzenbehandlungsmittel |
| JPS6239563A (ja) | 1985-08-13 | 1987-02-20 | Hokko Chem Ind Co Ltd | β−ニトロフエネチル誘導体および農園芸用殺菌剤 |
| US5359078A (en) | 1989-05-19 | 1994-10-25 | The United States Of America As Represented By The Department Of Health And Human Services | Signal transduction inhibitor compounds |
| DE4215437A1 (de) | 1992-05-11 | 1993-11-18 | Paul Prof Dr Messinger | Darstellung von Alkylacylaten mit ß-ständigen elektronenziehenden Resten im Alkylteil |
| JPH0625168A (ja) * | 1992-07-10 | 1994-02-01 | Nippon Bayeragrochem Kk | 殺菌性ベンジルピリジン類 |
| JPH0656780A (ja) * | 1992-08-01 | 1994-03-01 | Nippon Bayeragrochem Kk | 殺菌性α−置換ベンジルピリジン類 |
| DE19521355A1 (de) * | 1995-06-12 | 1996-12-19 | Hoechst Schering Agrevo Gmbh | Sulfonamide, Verfahren zu deren Herstellung und ihre Verwendung als Herbizide und Pflanzenwachstumsregulatoren |
| JPH0995444A (ja) | 1995-10-02 | 1997-04-08 | Teijin Ltd | アミロイド蛋白凝集阻害剤 |
| ES2300119T3 (es) | 1997-02-27 | 2008-06-01 | Takeda Pharmaceutical Company Limited | Compuestos de amina, su produccion y su uso como inhibidores de la produccion de beta-amiloide. |
| JP3868354B2 (ja) * | 1997-02-27 | 2007-01-17 | 武田薬品工業株式会社 | アミン誘導体、その製造法および剤 |
| GB9902938D0 (en) * | 1999-02-10 | 1999-03-31 | Novartis Ag | Organic compounds |
| NZ514453A (en) | 1999-02-26 | 2003-04-29 | Merck & Co Inc | Novel sulfonamide compounds and uses thereof |
| WO2001070677A1 (fr) | 2000-03-20 | 2001-09-27 | Merck Sharp & Dohme Limited | Dérivés de bicyxloalkyle à pontage à substitution sulphonamido |
| AU2001264872A1 (en) | 2000-06-05 | 2001-12-17 | Ortho-Mcneil Pharmaceutical, Inc. | Method for synthesis of substituted azole libraries |
| JP2004517892A (ja) * | 2000-12-13 | 2004-06-17 | ワイス | β−アミロイド産生の複素環スルホンアミド阻害剤 |
| GB0108591D0 (en) | 2001-04-05 | 2001-05-23 | Merck Sharp & Dohme | Therapeutic agents |
| GB0108592D0 (en) | 2001-04-05 | 2001-05-23 | Merck Sharp & Dohme | Therapeutic agents |
| US7122675B2 (en) | 2001-08-03 | 2006-10-17 | Schering Corporation | Gamma secretase inhibitors |
| AR034390A1 (es) | 2001-08-03 | 2004-02-25 | Schering Corp | Derivados de 1-sulfonil-tetrahidro quinolinas sustituidas, composiciones farmaceuticas y el uso de las mismas para la elaboracion de medicamentos como inhibidores de la gama secretasa |
| JP3711131B2 (ja) | 2001-08-21 | 2005-10-26 | メルク シャープ エンド ドーム リミテッド | 新規のシクロヘキシルスルホン |
| CA2471099C (fr) | 2001-12-20 | 2011-04-12 | Bristol-Myers Squibb Company | Derives d'.alpha.-(n-sulphonamido)acetamide en tant qu'inhibiteurs de .beta.-amyloide |
| KR100927304B1 (ko) * | 2001-12-27 | 2009-11-18 | 다이이찌 세이야꾸 가부시기가이샤 | β-아밀로이드 단백 생산·분비 저해제 |
| DE10201392A1 (de) | 2002-01-16 | 2003-07-31 | Bayer Ag | Phenylsulfoxide und-sulfone |
| TW200302717A (en) | 2002-02-06 | 2003-08-16 | Schering Corp | Novel gamma secretase inhibitors |
| GB0209991D0 (en) | 2002-05-01 | 2002-06-12 | Merck Sharp & Dohme | Therapeutic agents |
| GB0209995D0 (en) | 2002-05-01 | 2002-06-12 | Merck Sharp & Dohme | Therapeutic agents |
| GB0209997D0 (en) | 2002-05-01 | 2002-06-12 | Merck Sharp & Dohme | Therapeutic agents |
| EP1503998B1 (fr) | 2002-05-01 | 2009-07-01 | MERCK SHARP & DOHME LTD. | Sulfamides spirocycliques substitues par heteroaryle utilises comme inhibiteurs de la gamma-secretase |
| KR20050010882A (ko) | 2002-06-11 | 2005-01-28 | 와이어쓰 | 베타 아밀로이드 생산의 치환 페닐술폰아미드 저해제 |
| WO2004017977A2 (fr) * | 2002-08-23 | 2004-03-04 | Eli Lilly And Company | Derives de morpholine |
| GB0223040D0 (en) * | 2002-10-04 | 2002-11-13 | Merck Sharp & Dohme | Therapeutic compounds |
| GB0223039D0 (en) | 2002-10-04 | 2002-11-13 | Merck Sharp & Dohme | Therapeutic compounds |
| GB0223038D0 (en) | 2002-10-04 | 2002-11-13 | Merck Sharp & Dohme | Therapeutic compounds |
| GB0225474D0 (en) | 2002-11-01 | 2002-12-11 | Merck Sharp & Dohme | Therapeutic agents |
| GB0225475D0 (en) | 2002-11-01 | 2002-12-11 | Merck Sharp & Dohme | Therapeutic agents |
| PL379466A1 (pl) | 2003-06-30 | 2006-09-18 | Daiichi Sankyo Company , Limited | Heterocykliczne pochodne metylosulfonu |
-
2004
- 2004-06-29 PL PL379466A patent/PL379466A1/pl not_active Application Discontinuation
- 2004-06-29 US US10/561,838 patent/US7932271B2/en not_active Expired - Fee Related
- 2004-06-29 MX MXPA05013631A patent/MXPA05013631A/es unknown
- 2004-06-29 JP JP2005511074A patent/JP4523914B2/ja not_active Expired - Fee Related
- 2004-06-29 CA CA002526487A patent/CA2526487A1/fr not_active Abandoned
- 2004-06-29 EP EP04746601A patent/EP1640366A4/fr not_active Withdrawn
- 2004-06-29 WO PCT/JP2004/009132 patent/WO2005000798A1/fr not_active Ceased
- 2004-06-29 AU AU2004251987A patent/AU2004251987C1/en not_active Ceased
- 2004-06-29 RU RU2005141552/04A patent/RU2336270C2/ru not_active IP Right Cessation
- 2004-06-29 KR KR1020057025070A patent/KR20060066057A/ko not_active Ceased
- 2004-06-30 TW TW093119651A patent/TWI328005B/zh not_active IP Right Cessation
-
2005
- 2005-11-23 IL IL172139A patent/IL172139A0/en unknown
- 2005-12-13 NO NO20055921A patent/NO20055921L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PL379466A1 (pl) | 2006-09-18 |
| RU2336270C2 (ru) | 2008-10-20 |
| CA2526487A1 (fr) | 2005-01-06 |
| AU2004251987A1 (en) | 2005-01-06 |
| MXPA05013631A (es) | 2006-02-24 |
| EP1640366A1 (fr) | 2006-03-29 |
| HK1090362A1 (zh) | 2006-12-22 |
| RU2005141552A (ru) | 2006-06-27 |
| AU2004251987B2 (en) | 2010-07-01 |
| AU2004251987B8 (en) | 2010-07-22 |
| IL172139A0 (en) | 2006-04-10 |
| TWI328005B (en) | 2010-08-01 |
| JPWO2005000798A1 (ja) | 2006-08-03 |
| US20060241302A1 (en) | 2006-10-26 |
| JP4523914B2 (ja) | 2010-08-11 |
| KR20060066057A (ko) | 2006-06-15 |
| EP1640366A4 (fr) | 2009-05-13 |
| US7932271B2 (en) | 2011-04-26 |
| TW200523251A (en) | 2005-07-16 |
| WO2005000798A1 (fr) | 2005-01-06 |
| AU2004251987C1 (en) | 2010-11-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |