NO20060307L - Anvendelse av kinoazolinderivatet ZD6474 kombinert med platinaforbindelser og eventuelt ioniserende straling i behandling av sykdommer assosoiert med angiogenese og/eller okt vaskulaert permeabilitet - Google Patents

Anvendelse av kinoazolinderivatet ZD6474 kombinert med platinaforbindelser og eventuelt ioniserende straling i behandling av sykdommer assosoiert med angiogenese og/eller okt vaskulaert permeabilitet

Info

Publication number
NO20060307L
NO20060307L NO20060307A NO20060307A NO20060307L NO 20060307 L NO20060307 L NO 20060307L NO 20060307 A NO20060307 A NO 20060307A NO 20060307 A NO20060307 A NO 20060307A NO 20060307 L NO20060307 L NO 20060307L
Authority
NO
Norway
Prior art keywords
ionizing radiation
vascular permeability
combination
antitumor agent
possibly
Prior art date
Application number
NO20060307A
Other languages
English (en)
Other versions
NO333122B1 (no
Inventor
Stephen Robert Wedge
Anderson Joseph Ryan
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0316176A external-priority patent/GB0316176D0/en
Priority claimed from GB0406546A external-priority patent/GB0406546D0/en
Priority claimed from GB0407753A external-priority patent/GB0407753D0/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NO20060307L publication Critical patent/NO20060307L/no
Publication of NO333122B1 publication Critical patent/NO333122B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Foreliggende oppfinnelse angår en metode for å produsere en antiangiogen og/eller vaskulær permeabilitetsreduserende effekt hos et varmblodig dyr så som et menneske som eventuelt behandles med ioniserende stiåling, spesielt en metode for behandling av kreft, spesielt kreft som involverer en fast tumor, som omfatter administiering av ZD6474 i kombinasjon med et platina-antitumor-middel; et farmasøytisk preparat omfattende ZD6474 og et platina-antitumor-middel; et kombinasjonsprodukt omfattende ZD6474 og et platina-antitumor-middel for anvendelse ved en metode for behandling av en menneske- eller dyrekropp ved terapi; et sett omfattende ZD6474 og et platina-antitumor-middel; anvendelse av ZD6474 og et platina-antitumor-middel ved fremstilling av et medikament for anvendelse for å produsere en antiangiogen og/eller vaskulær permeabilitetsreduserende effekt hos et varmblodig dyr så som et menneske som eventuelt behandles med ioniserende stiåling.
NO20060307A 2003-07-10 2006-01-20 Anvendelse av 4-(4-brom-2-fluoranilino)-6-metoksy-7-(1-metylpiperidin-4-ylmetoksy)kinazolin kombinert med platinaforbindelser ved fremstilling av medikamenter for a produsere en antikreft-effekt eller antitumor-effekt hos et varmblodig dyr sa som et menneske samt farmasoytisk preparat inneholdende samme NO333122B1 (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0316176A GB0316176D0 (en) 2003-07-10 2003-07-10 Combination therapy
GB0406546A GB0406546D0 (en) 2004-03-24 2004-03-24 Combination therapy
GB0407753A GB0407753D0 (en) 2004-04-06 2004-04-06 Combination therapy
PCT/GB2004/002932 WO2005004870A1 (en) 2003-07-10 2004-07-07 Use of the quinazoline derivative zd6474 combined with platinum compounds and optionally ionising radiation in the treatment of diseases associated with angiogenesis and/or increased vascular permeability

Publications (2)

Publication Number Publication Date
NO20060307L true NO20060307L (no) 2006-02-08
NO333122B1 NO333122B1 (no) 2013-03-04

Family

ID=34068756

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20060307A NO333122B1 (no) 2003-07-10 2006-01-20 Anvendelse av 4-(4-brom-2-fluoranilino)-6-metoksy-7-(1-metylpiperidin-4-ylmetoksy)kinazolin kombinert med platinaforbindelser ved fremstilling av medikamenter for a produsere en antikreft-effekt eller antitumor-effekt hos et varmblodig dyr sa som et menneske samt farmasoytisk preparat inneholdende samme

Country Status (14)

Country Link
US (3) US20060167027A1 (no)
EP (1) EP1648465B1 (no)
JP (1) JP2007526886A (no)
KR (2) KR20060033782A (no)
AT (1) ATE478671T1 (no)
AU (1) AU2004255022B2 (no)
BR (1) BRPI0412426A (no)
CA (1) CA2531862C (no)
DE (1) DE602004028834D1 (no)
IL (1) IL172853A (no)
MX (1) MXPA06000114A (no)
NO (1) NO333122B1 (no)
NZ (1) NZ544458A (no)
WO (1) WO2005004870A1 (no)

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GB0126879D0 (en) * 2001-11-08 2002-01-02 Astrazeneca Ab Combination therapy
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GB0223380D0 (en) * 2002-10-09 2002-11-13 Astrazeneca Ab Combination therapy
KR20050100683A (ko) * 2003-02-13 2005-10-19 아스트라제네카 아베 5-ｆｕ 또는/및 ｃｐｔ-11과 ｚｄ6474의 병용 요법
GB0310401D0 (en) * 2003-05-07 2003-06-11 Astrazeneca Ab Therapeutic agent
EP1648465B1 (en) * 2003-07-10 2010-08-25 AstraZeneca AB Use of the quinazoline derivative zd6474 combined with platinum compounds and optionally ionising radiation in the treatment of diseases associated with angiogenesis and/or increased vascular permeability
MXPA06010755A (es) * 2004-03-23 2006-12-15 Astrazeneca Ab Terapia de combinacion.
ATE428421T1 (de) 2004-09-17 2009-05-15 Eisai R&D Man Co Ltd Medizinische zusammensetzung mit verbesserter stabilität und reduzierten gelierungseigenschaften
KR20070072543A (ko) * 2004-09-27 2007-07-04 아스트라제네카 아베 Ｚｄ6474 및 이마티닙을 포함하는 병합법
GB0424339D0 (en) * 2004-11-03 2004-12-08 Astrazeneca Ab Combination therapy
JP4989476B2 (ja) 2005-08-02 2012-08-01 エーザイ・アール・アンド・ディー・マネジメント株式会社 血管新生阻害物質の効果を検定する方法
GB0519879D0 (en) 2005-09-30 2005-11-09 Astrazeneca Ab Chemical process
AU2006309551B2 (en) 2005-11-07 2012-04-19 Eisai R & D Management Co., Ltd. Use of combination of anti-angiogenic substance and c-kit kinase inhibitor
PL1971338T3 (pl) * 2005-12-22 2011-07-29 Astrazeneca Ab Połączenie ZD6474 i premetreksedu
CN104706637A (zh) 2006-05-18 2015-06-17 卫材R&D管理有限公司 针对甲状腺癌的抗肿瘤剂
CN1899616A (zh) * 2006-07-20 2007-01-24 中国人民解放军军事医学科学院生物工程研究所 非受体酪氨酸激酶c－Abl特异性抑制剂的新用途
WO2008026748A1 (en) 2006-08-28 2008-03-06 Eisai R & D Management Co., Ltd. Antitumor agent for undifferentiated gastric cancer
WO2008037996A1 (en) * 2006-09-29 2008-04-03 Astrazeneca Ab Combination of zd6474 and bevacizumab for cancer therapy
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US8952035B2 (en) 2007-11-09 2015-02-10 Eisai R&D Management Co., Ltd. Combination of anti-angiogenic substance and anti-tumor platinum complex
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MY162940A (en) 2009-08-19 2017-07-31 Eisai R&D Man Co Ltd Quinoline derivative-containing pharmaceutical composition
CN102958523B (zh) 2010-06-25 2014-11-19 卫材R&D管理有限公司 使用具有激酶抑制作用的组合的抗肿瘤剂
CN103402519B (zh) 2011-04-18 2015-11-25 卫材R&D管理有限公司 肿瘤治疗剂
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KR20150098605A (ko) 2012-12-21 2015-08-28 에자이 알앤드디 매니지먼트 가부시키가이샤 퀴놀린 유도체의 비정질 형태 및 그의 제조방법
NZ714049A (en) 2013-05-14 2020-05-29 Eisai R&D Man Co Ltd Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
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PT3524595T (pt) 2014-08-28 2022-09-19 Eisai R&D Man Co Ltd Derivado de quinolina altamente puro e método para produção do mesmo
LT3263106T (lt) 2015-02-25 2024-01-10 Eisai R&D Management Co., Ltd. Chinolino darinių kartumo sumažinimo būdas
KR102662228B1 (ko) 2015-03-04 2024-05-02 머크 샤프 앤드 돔 코포레이션 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
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GB0008269D0 (en) * 2000-04-05 2000-05-24 Astrazeneca Ab Combination chemotherapy
GB0126879D0 (en) * 2001-11-08 2002-01-02 Astrazeneca Ab Combination therapy
GB0218526D0 (en) * 2002-08-09 2002-09-18 Astrazeneca Ab Combination therapy
AU2003249000B2 (en) * 2002-08-09 2007-04-05 Astrazeneca Ab Combination of ZD6474, an inhibitor of the vasuclar endothelial growth factor receptor, with radiotherapy in the treatment of cancer
GB0223380D0 (en) * 2002-10-09 2002-11-13 Astrazeneca Ab Combination therapy
KR20050100683A (ko) * 2003-02-13 2005-10-19 아스트라제네카 아베 5-ｆｕ 또는/및 ｃｐｔ-11과 ｚｄ6474의 병용 요법
EP1648465B1 (en) * 2003-07-10 2010-08-25 AstraZeneca AB Use of the quinazoline derivative zd6474 combined with platinum compounds and optionally ionising radiation in the treatment of diseases associated with angiogenesis and/or increased vascular permeability
MXPA06010755A (es) * 2004-03-23 2006-12-15 Astrazeneca Ab Terapia de combinacion.
KR20070072543A (ko) * 2004-09-27 2007-07-04 아스트라제네카 아베 Ｚｄ6474 및 이마티닙을 포함하는 병합법
GB0424339D0 (en) * 2004-11-03 2004-12-08 Astrazeneca Ab Combination therapy
PL1971338T3 (pl) * 2005-12-22 2011-07-29 Astrazeneca Ab Połączenie ZD6474 i premetreksedu
WO2008037996A1 (en) * 2006-09-29 2008-04-03 Astrazeneca Ab Combination of zd6474 and bevacizumab for cancer therapy

Also Published As

Publication number Publication date
BRPI0412426A (pt) 2006-09-05
CA2531862C (en) 2011-10-25
US20100215773A1 (en) 2010-08-26
JP2007526886A (ja) 2007-09-20
IL172853A (en) 2012-05-31
MXPA06000114A (es) 2006-04-27
DE602004028834D1 (de) 2010-10-07
EP1648465A1 (en) 2006-04-26
NZ544458A (en) 2009-04-30
AU2004255022B2 (en) 2007-08-23
EP1648465B1 (en) 2010-08-25
HK1089378A1 (en) 2006-12-01
ATE478671T1 (de) 2010-09-15
CA2531862A1 (en) 2005-01-20
NO333122B1 (no) 2013-03-04
US20060167027A1 (en) 2006-07-27
KR20120093411A (ko) 2012-08-22
AU2004255022A1 (en) 2005-01-20
IL172853A0 (en) 2006-06-11
US20120263802A1 (en) 2012-10-18
WO2005004870A1 (en) 2005-01-20
KR20060033782A (ko) 2006-04-19

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