NO20061180L - Heteroarylkjedede pyridiner, pyraziner og pyrimidiner som CRF1-reseptorligander - Google Patents

Heteroarylkjedede pyridiner, pyraziner og pyrimidiner som CRF1-reseptorligander

Info

Publication number
NO20061180L
NO20061180L NO20061180A NO20061180A NO20061180L NO 20061180 L NO20061180 L NO 20061180L NO 20061180 A NO20061180 A NO 20061180A NO 20061180 A NO20061180 A NO 20061180A NO 20061180 L NO20061180 L NO 20061180L
Authority
NO
Norway
Prior art keywords
disorders
compounds
crf
heteroberl
pyrazines
Prior art date
Application number
NO20061180A
Other languages
English (en)
Inventor
Ping Ge
Raymond F Horvath
Bernd Kaiser
Yan Lu Zhang
Yasuchika Yamaguchi
Xuechun Zhang
Suoming Zhang
He Zhao
Stanly John
Neil Moorcroft
Greg Shutske
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34272952&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20061180(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of NO20061180L publication Critical patent/NO20061180L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Det tilveiebringes substituerte heteroarylkjedede pyridin-, pyrazin- og pyrimidinforbindelser som virker som selektive modulatorer av CRF 1-reseptorer. Disse forbindelser er anvendelige ved behandling av flere SNS-lidelser og perifere lidelser, spesielt stress, angst, depresjon, kardiovaskulære lidelser og spiseforstyrrelser. Metoder for behandling av slike lidelser, så vel som pakkede farmasøytiske preparater er også tilveiebragt. Forbindelser ifølge oppfinnelsen er også anvendelige som prober for lokalisering av CRF-reseptorer og som standarder i målinger med henblikk på CRF-reseptorbinding. Det tilveiebringes metoder for anvendelse av forbindelsene i reseptorlokaliseringsstudier.
NO20061180A 2003-09-05 2006-03-14 Heteroarylkjedede pyridiner, pyraziner og pyrimidiner som CRF1-reseptorligander NO20061180L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50041403P 2003-09-05 2003-09-05
PCT/US2004/028899 WO2005023806A2 (en) 2003-09-05 2004-09-03 Heteroaryl fused pyridines, pyrazines and pyrimidines as crf1 receptor ligands

Publications (1)

Publication Number Publication Date
NO20061180L true NO20061180L (no) 2006-03-31

Family

ID=34272952

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20061180A NO20061180L (no) 2003-09-05 2006-03-14 Heteroarylkjedede pyridiner, pyraziner og pyrimidiner som CRF1-reseptorligander

Country Status (19)

Country Link
US (2) US20050113379A1 (no)
EP (1) EP1680424A2 (no)
JP (1) JP2007504271A (no)
KR (1) KR20060088534A (no)
CN (1) CN1878773A (no)
AP (1) AP2006003559A0 (no)
AR (1) AR045582A1 (no)
AU (1) AU2004270713A1 (no)
BR (1) BRPI0414087A (no)
CA (1) CA2537829A1 (no)
CR (1) CR8274A (no)
EA (1) EA200600372A1 (no)
EC (1) ECSP066408A (no)
IL (1) IL174084A0 (no)
MA (1) MA28086A1 (no)
NO (1) NO20061180L (no)
TW (1) TW200530232A (no)
WO (1) WO2005023806A2 (no)
ZA (1) ZA200601978B (no)

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KR20060088534A (ko) 2006-08-04
JP2007504271A (ja) 2007-03-01
AP2006003559A0 (en) 2006-04-30
AR045582A1 (es) 2005-11-02
CR8274A (es) 2008-06-10
EP1680424A2 (en) 2006-07-19
TW200530232A (en) 2005-09-16
ZA200601978B (en) 2007-05-30
MA28086A1 (fr) 2006-08-01
AU2004270713A1 (en) 2005-03-17
WO2005023806A3 (en) 2005-06-02
CA2537829A1 (en) 2005-03-17
US20060199823A1 (en) 2006-09-07
US20050113379A1 (en) 2005-05-26
ECSP066408A (es) 2006-09-18
WO2005023806A2 (en) 2005-03-17
BRPI0414087A (pt) 2006-10-31
IL174084A0 (en) 2008-02-09
EA200600372A1 (ru) 2006-08-25
CN1878773A (zh) 2006-12-13

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