BRPI0414087A - composto, métodos para tratar um distúrbio, para demostrar a presença de receptores de crf em amostras de célula ou tecido, e para inibir a ligação de crf a um receptor de crf1, composição farmacêutica, e, embalagem - Google Patents

composto, métodos para tratar um distúrbio, para demostrar a presença de receptores de crf em amostras de célula ou tecido, e para inibir a ligação de crf a um receptor de crf1, composição farmacêutica, e, embalagem

Info

Publication number
BRPI0414087A
BRPI0414087A BRPI0414087-7A BRPI0414087A BRPI0414087A BR PI0414087 A BRPI0414087 A BR PI0414087A BR PI0414087 A BRPI0414087 A BR PI0414087A BR PI0414087 A BRPI0414087 A BR PI0414087A
Authority
BR
Brazil
Prior art keywords
crf
methods
treating
disorder
compounds
Prior art date
Application number
BRPI0414087-7A
Other languages
English (en)
Inventor
Ping Ge
Raymond F Horvath
Lu Yan Zhang
Yasuchika Yamaguchi
Bernd Kaiser
Xuechun Zhang
Suoming Zhang
He Zhao
Stanly John
Neil Moorcroft
Greg Shutske
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34272952&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0414087(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Neurogen Corp filed Critical Neurogen Corp
Publication of BRPI0414087A publication Critical patent/BRPI0414087A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

"COMPOSTO, MéTODOS PARA TRATAR UM DISTúRBIO, PARA DEMONSTRAR A PRESENçA DE RECEPTORES DE CRF EM AMOSTRAS DE CéLULA OU TECIDO, E PARA INIBIR A LIGAçãO DE CRF A UM RECEPTOR DE CRF1, COMPOSIçãO FARMACêUTICA, E, EMBALAGEM". Compostos de piridina, pirazina e pirimidina fundidos a heteroarila substituído que atuam como moduladores seletivos de receptores de CRF1 são fornecidos. Estes compostos são úteis no tratamento de vários distúrbios do CNS e periféricos, particularmente estresse, ansiedade, depressão, distúrbios cardiovasculares e distúrbios da alimentação. Métodos de tratamento de tais distúrbios e bem como composições farmacêuticas embaladas também são fornecidas. Os compostos da invenção também são úteis como sondas para a localização de receptores de CRF e como padrões nos ensaios para a ligação do receptor de CRF. Métodos de usar os compostos em estudos de localização de receptor são dados.
BRPI0414087-7A 2003-09-05 2004-09-03 composto, métodos para tratar um distúrbio, para demostrar a presença de receptores de crf em amostras de célula ou tecido, e para inibir a ligação de crf a um receptor de crf1, composição farmacêutica, e, embalagem BRPI0414087A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50041403P 2003-09-05 2003-09-05
PCT/US2004/028899 WO2005023806A2 (en) 2003-09-05 2004-09-03 Heteroaryl fused pyridines, pyrazines and pyrimidines as crf1 receptor ligands

Publications (1)

Publication Number Publication Date
BRPI0414087A true BRPI0414087A (pt) 2006-10-31

Family

ID=34272952

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0414087-7A BRPI0414087A (pt) 2003-09-05 2004-09-03 composto, métodos para tratar um distúrbio, para demostrar a presença de receptores de crf em amostras de célula ou tecido, e para inibir a ligação de crf a um receptor de crf1, composição farmacêutica, e, embalagem

Country Status (19)

Country Link
US (2) US20050113379A1 (pt)
EP (1) EP1680424A2 (pt)
JP (1) JP2007504271A (pt)
KR (1) KR20060088534A (pt)
CN (1) CN1878773A (pt)
AP (1) AP2006003559A0 (pt)
AR (1) AR045582A1 (pt)
AU (1) AU2004270713A1 (pt)
BR (1) BRPI0414087A (pt)
CA (1) CA2537829A1 (pt)
CR (1) CR8274A (pt)
EA (1) EA200600372A1 (pt)
EC (1) ECSP066408A (pt)
IL (1) IL174084A0 (pt)
MA (1) MA28086A1 (pt)
NO (1) NO20061180L (pt)
TW (1) TW200530232A (pt)
WO (1) WO2005023806A2 (pt)
ZA (1) ZA200601978B (pt)

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Also Published As

Publication number Publication date
WO2005023806A2 (en) 2005-03-17
US20060199823A1 (en) 2006-09-07
ECSP066408A (es) 2006-09-18
KR20060088534A (ko) 2006-08-04
EA200600372A1 (ru) 2006-08-25
IL174084A0 (en) 2008-02-09
AU2004270713A1 (en) 2005-03-17
MA28086A1 (fr) 2006-08-01
CA2537829A1 (en) 2005-03-17
CN1878773A (zh) 2006-12-13
AP2006003559A0 (en) 2006-04-30
EP1680424A2 (en) 2006-07-19
CR8274A (es) 2008-06-10
TW200530232A (en) 2005-09-16
NO20061180L (no) 2006-03-31
JP2007504271A (ja) 2007-03-01
WO2005023806A3 (en) 2005-06-02
ZA200601978B (en) 2007-05-30
US20050113379A1 (en) 2005-05-26
AR045582A1 (es) 2005-11-02

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