NO20061419L - Triaza-spiropiperidinderivater for anvendelse som Glyt-1-inhibitorer i behandling av nevrologiske og nevropsykiatriske lidelser - Google Patents
Triaza-spiropiperidinderivater for anvendelse som Glyt-1-inhibitorer i behandling av nevrologiske og nevropsykiatriske lidelserInfo
- Publication number
- NO20061419L NO20061419L NO20061419A NO20061419A NO20061419L NO 20061419 L NO20061419 L NO 20061419L NO 20061419 A NO20061419 A NO 20061419A NO 20061419 A NO20061419 A NO 20061419A NO 20061419 L NO20061419 L NO 20061419L
- Authority
- NO
- Norway
- Prior art keywords
- lower alkyl
- hydrogen
- trifluoromethyl
- halogen
- group
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 230000000926 neurological effect Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract 1
- 206010012289 Dementia Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000019771 cognition Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000004064 dysfunction Effects 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000001771 impaired effect Effects 0.000 abstract 1
- 230000000626 neurodegenerative effect Effects 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical compound C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Oppfinnelsen angår forbindelser med den generelle formel (I) hvor A-A er -CH2-CH2-, -CH2-CH2-CH2-, -CH2-O- eller -O-CH2-; X er hydrogen eller hydroksy; R1 er aryl eller heteroaryl, usubstituert eller substituert med én eller flere substituenter valgt fra gruppen som består av lavere alkyl, lavere alkoksy, halogen eller trifluormetyl; R2 er aryl eller heteroaryl, usubstituert eller substituert med én eller flere substituenter valgt fra gruppen som består av lavere alkyl, lavere alkoksy, halogen eller trifluormetyl, eller er lavere alkyl, -(CH2)n-cykloalkyl, -(CH2)n-CF3, -(CH2)p-O-lavere alkyl, -(CH2)i,2-fenyl, eventuelt substituert med halogen, lavere alkyl, lavere alkoksy eller trifluormetyl, eller er -(CH2)P-NR'R", hvor R' og R" sammen med N-atomet danner en heterocyklisk ring, valgt fra gruppen som består av piperidin, morfolin, tiomorfolin eller 1,1-diokso-tiomorfolin; R3, R4 er uavhengig av hverandre hydrogen, lavere alkyl, fenyl eller benzyl; R5 er hydrogen, lavere alkyl eller benzyl; R6 er hydrogen eller lavere alkyl; n er 0, 1 eller 2; og p er 2 eller 3; og farmasøytisk akseptable syreaddisjonssalter derav for behandling av psykoser, smerte, nevrodegenerativ dysfunksjon relatert til hukommelse og læring, schizofreni, demens og andre sykdommer hvor kognitive prosesser er svekket, så som oppmerksomhetssvikt-lidelser eller Alzheimers sykdom.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03024415 | 2003-10-23 | ||
| PCT/EP2004/011552 WO2005040166A1 (en) | 2003-10-23 | 2004-10-14 | Triaza-spiropiperidine derivatives for use as glyt-1 inhibitors in the treatment of neurological and neuropsychiatric disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20061419L true NO20061419L (no) | 2006-07-14 |
Family
ID=34486099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20061419A NO20061419L (no) | 2003-10-23 | 2006-03-28 | Triaza-spiropiperidinderivater for anvendelse som Glyt-1-inhibitorer i behandling av nevrologiske og nevropsykiatriske lidelser |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7189850B2 (no) |
| EP (1) | EP1678177B1 (no) |
| JP (1) | JP4490434B2 (no) |
| KR (1) | KR100798161B1 (no) |
| CN (1) | CN100467468C (no) |
| AR (1) | AR046186A1 (no) |
| AU (1) | AU2004283843B2 (no) |
| BR (1) | BRPI0415833A (no) |
| CA (1) | CA2543308C (no) |
| CO (1) | CO5690643A2 (no) |
| DE (1) | DE602004010419T2 (no) |
| ES (1) | ES2297502T3 (no) |
| IL (1) | IL174734A (no) |
| MX (1) | MXPA06004305A (no) |
| NO (1) | NO20061419L (no) |
| RU (1) | RU2006117368A (no) |
| TW (1) | TW200526662A (no) |
| WO (1) | WO2005040166A1 (no) |
| ZA (1) | ZA200603221B (no) |
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| JP5266042B2 (ja) | 2005-04-11 | 2013-08-21 | エール ユニヴァーシティ | 統合失調症前駆症の治療方法 |
| DE102005038141A1 (de) * | 2005-08-12 | 2007-02-15 | Grünenthal GmbH | Substituierte 8-(3-Aminopropyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-on-Derivate |
| MX2008011216A (es) | 2006-03-08 | 2008-09-11 | Hoffmann La Roche | 1,5-dihidro-imidazol-2-onas 4-amino-1,5-substituidas. |
| US20090326027A1 (en) * | 2006-03-16 | 2009-12-31 | Steven Coulton | N-Phenyl-2-0X0-1,4-Diazaspiro [4.5] Dec-3-EN-1-YL Acetamide Derivatives And Their Use As Glycine Transporter Inhibitors |
| GB0607398D0 (en) * | 2006-04-12 | 2006-05-24 | Glaxo Group Ltd | Compounds |
| EP2035420A2 (en) * | 2006-06-20 | 2009-03-18 | Wyeth a Corporation of the State of Delaware | Kv1.5 potassium channel inhibitors |
| US20120004273A1 (en) * | 2007-01-20 | 2012-01-05 | Nadia Mamoona Ahmad | Glyt1 transporter inhibitors and uses thereof in treatment of neurological and neuropsychiatric disorders |
| TW200846328A (en) * | 2007-02-01 | 2008-12-01 | Glaxo Group Ltd | GlyT1 transporter inhibitors and uses thereof in treatment of neurological and neuropsychiatric disorders |
| GB0701985D0 (en) * | 2007-02-01 | 2007-03-14 | Glaxo Group Ltd | Compounds |
| US20090325993A1 (en) * | 2007-02-01 | 2009-12-31 | Nadia Mamoona Ahmad | GLYT1 Transporter Inhibitors and Uses Thereof in Treatment of Neurological and Neuropsychiatric Disorders |
| JP2010517962A (ja) * | 2007-02-01 | 2010-05-27 | グラクソ グループ リミテッド | ＧｌｙＴ１トランスポーター阻害薬および神経学的および神経精神病学的障害の治療におけるその使用 |
| US20100048656A1 (en) * | 2007-02-01 | 2010-02-25 | Nadia Mamoona Ahmad | Glyt1 transporter inhibitors and uses thereof in treatment of neurological and neuropsychiatric disorders |
| GB0701955D0 (en) * | 2007-02-01 | 2007-03-14 | Glaxo Group Ltd | Compounds |
| WO2008151156A1 (en) | 2007-05-31 | 2008-12-11 | Sepracor Inc. | Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors |
| KR101150628B1 (ko) | 2007-07-03 | 2012-05-31 | 에프. 호프만-라 로슈 아게 | 4-이미다졸린 및 항우울제로서 이의 용도 |
| EP2178842A2 (en) | 2007-08-22 | 2010-04-28 | Abbott GmbH & Co. KG | 4-benzylaminoquinolines, pharmaceutical compositions containing them and their use |
| WO2009034062A1 (en) * | 2007-09-11 | 2009-03-19 | Glaxo Group Limited | Compounds which inhibit the glycine transporter and uses thereof in medicine |
| US9413889B2 (en) * | 2007-09-18 | 2016-08-09 | Telecommunication Systems, Inc. | House number normalization for master street address guide (MSAG) address matching |
| US7981904B2 (en) * | 2008-03-20 | 2011-07-19 | Takeda Pharmaceutical Company Limited | Acetyl CoA carboxylase inhibitors |
| ES2397764T3 (es) | 2008-04-01 | 2013-03-11 | Abbott Gmbh & Co. Kg | Tetrahidroisoquinolinas, composiciones farmacéuticas que las contienen, y su uso en terapia |
| RU2517701C2 (ru) * | 2009-01-27 | 2014-05-27 | Ф. Хоффманн-Ля Рош Аг | Ароиламино- и гетероароиламино-замещенные пиперидины в качестве ингибиторов glyt-1 |
| AR075442A1 (es) | 2009-02-16 | 2011-03-30 | Abbott Gmbh & Co Kg | Derivados de aminotetralina, composiciones farmaceuticas que las contienen y sus usos en terapia |
| TW201038569A (en) | 2009-02-16 | 2010-11-01 | Abbott Gmbh & Co Kg | Heterocyclic compounds, pharmaceutical compositions containing them, and their use in therapy |
| US9452980B2 (en) | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
| US8846743B2 (en) | 2010-08-13 | 2014-09-30 | Abbott Laboratories | Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9045459B2 (en) | 2010-08-13 | 2015-06-02 | AbbVie Deutschland GmbH & Co. KG | Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US8877794B2 (en) | 2010-08-13 | 2014-11-04 | Abbott Laboratories | Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9051280B2 (en) | 2010-08-13 | 2015-06-09 | AbbVie Deutschland GmbH & Co. KG | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US8883839B2 (en) | 2010-08-13 | 2014-11-11 | Abbott Laboratories | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy |
| CN103429243B (zh) | 2010-10-25 | 2016-06-08 | G1治疗公司 | Cdk抑制剂 |
| US8691830B2 (en) | 2010-10-25 | 2014-04-08 | G1 Therapeutics, Inc. | CDK inhibitors |
| US9309200B2 (en) | 2011-05-12 | 2016-04-12 | AbbVie Deutschland GmbH & Co. KG | Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| JP2014521682A (ja) | 2011-08-05 | 2014-08-28 | アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー | アミノクロマン、アミノチオクロマンおよびアミノ−１，２，３，４−テトラヒドロキノリン誘導体、これらを含有する医薬組成物、ならびに治療におけるこれらの使用 |
| EP2780328A1 (en) | 2011-11-18 | 2014-09-24 | Abbvie Deutschland GmbH & Co. KG | N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9365512B2 (en) | 2012-02-13 | 2016-06-14 | AbbVie Deutschland GmbH & Co. KG | Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy |
| AU2013239816B2 (en) | 2012-03-29 | 2017-08-24 | G1 Therapeutics, Inc. | Lactam kinase inhibitors |
| JP2015157764A (ja) * | 2012-06-14 | 2015-09-03 | 大正製薬株式会社 | グリシントランスポーター阻害物質 |
| JP6435315B2 (ja) | 2013-03-15 | 2018-12-05 | ジー１、セラピューティクス、インコーポレイテッドＧ１ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | 高活性抗新生物薬及び抗増殖剤 |
| US9650334B2 (en) | 2013-03-15 | 2017-05-16 | Abbvie Inc. | Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| CA2906166C (en) | 2013-03-15 | 2023-03-14 | G1 Therapeutics, Inc. | Hspc-sparing treatments for rb-positive abnormal cellular proliferation |
| US9656955B2 (en) | 2013-03-15 | 2017-05-23 | Abbvie Inc. | Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| MX2016004936A (es) | 2013-10-17 | 2016-12-20 | Abbvie Deutschland | Derivados de aminocromano, aminotiocromano y amino-1,2,3,4-tetrahi droquinilina, composiciones farmaceuticas que los contienen, y su uso en terapia. |
| WO2015055771A1 (en) | 2013-10-17 | 2015-04-23 | AbbVie Deutschland GmbH & Co. KG | Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy |
| CA2936111C (en) | 2014-01-06 | 2023-03-14 | Algomedix, Inc. | Trpa1 modulators |
| US20150297608A1 (en) | 2014-04-17 | 2015-10-22 | G1 Therapeutics, Inc. | Tricyclic Lactams for Use as Anti-Neoplastic and Anti-Proliferative Agents |
| EP3134406A1 (en) * | 2014-04-24 | 2017-03-01 | Dart Neuroscience (Cayman) Ltd | Substituted 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole and 4,5,6,7-tetrahydro-2h-pyrazolo [4,3-c]pyridine compounds as glyt1 inhibitors |
| US9550754B2 (en) | 2014-09-11 | 2017-01-24 | AbbVie Deutschland GmbH & Co. KG | 4,5-dihydropyrazole derivatives, pharmaceutical compositions containing them, and their use in therapy |
| WO2016040848A1 (en) | 2014-09-12 | 2016-03-17 | G1 Therapeutics, Inc. | Treatment of rb-negative tumors using topoisomerase inhibitors in combination with cyclin dependent kinase 4/6 inhibitors |
| WO2016040858A1 (en) | 2014-09-12 | 2016-03-17 | G1 Therapeutics, Inc. | Combinations and dosing regimes to treat rb-positive tumors |
| US10040759B2 (en) | 2014-11-05 | 2018-08-07 | Dart Neuroscience (Cayman) Ltd. | Substituted azetidinyl compounds as GlyT1 inhibitors |
| MY195528A (en) | 2016-03-17 | 2023-01-30 | Hoffmann La Roche | 5-Ethyl-4-Methyl-Pyrazole-3-Carboxamide Derivative Having Activity as Agonist of Taar |
| WO2018005863A1 (en) | 2016-07-01 | 2018-01-04 | G1 Therapeutics, Inc. | Pyrimidine-based compounds for the treatment of cancer |
| AR110728A1 (es) | 2017-01-06 | 2019-04-24 | G1 Therapeutics Inc | Terapia combinada para el tratamiento del cáncer |
| CA3067873A1 (en) | 2017-06-29 | 2019-01-03 | G1 Therapeutics, Inc. | Morphic forms of g1t38 and methods of manufacture thereof |
| RS67557B1 (sr) | 2018-08-24 | 2026-01-30 | Pharmacosmos Holding As | Unapređena sinteza 1,4-diazaspiro[5.5]undekan-3-ona |
| US10988479B1 (en) | 2020-06-15 | 2021-04-27 | G1 Therapeutics, Inc. | Morphic forms of trilaciclib and methods of manufacture thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0921125B1 (en) * | 1997-12-05 | 2002-01-30 | F. Hoffmann-La Roche Ag | 1,3,8-Triazaspiro[4,5]decan-4-on derivatives |
| PT921125E (pt) * | 1997-12-05 | 2002-06-28 | Hoffmann La Roche | Derivados de 1,38-triaza-espiro 4,5 decan-4-ona |
| CN100372838C (zh) * | 2003-02-17 | 2008-03-05 | 弗·哈夫曼-拉罗切有限公司 | 哌啶-苯磺酰胺衍生物 |
-
2004
- 2004-10-14 ES ES04790408T patent/ES2297502T3/es not_active Expired - Lifetime
- 2004-10-14 KR KR1020067007791A patent/KR100798161B1/ko not_active Expired - Fee Related
- 2004-10-14 MX MXPA06004305A patent/MXPA06004305A/es active IP Right Grant
- 2004-10-14 BR BRPI0415833-4A patent/BRPI0415833A/pt not_active IP Right Cessation
- 2004-10-14 DE DE602004010419T patent/DE602004010419T2/de not_active Expired - Lifetime
- 2004-10-14 RU RU2006117368/04A patent/RU2006117368A/ru not_active Application Discontinuation
- 2004-10-14 WO PCT/EP2004/011552 patent/WO2005040166A1/en not_active Ceased
- 2004-10-14 EP EP04790408A patent/EP1678177B1/en not_active Expired - Lifetime
- 2004-10-14 CA CA2543308A patent/CA2543308C/en not_active Expired - Fee Related
- 2004-10-14 CN CNB2004800309109A patent/CN100467468C/zh not_active Expired - Fee Related
- 2004-10-14 JP JP2006536007A patent/JP4490434B2/ja not_active Expired - Fee Related
- 2004-10-14 AU AU2004283843A patent/AU2004283843B2/en not_active Ceased
- 2004-10-18 US US10/967,534 patent/US7189850B2/en not_active Expired - Fee Related
- 2004-10-20 TW TW093131857A patent/TW200526662A/zh unknown
- 2004-10-21 AR ARP040103809A patent/AR046186A1/es not_active Application Discontinuation
-
2006
- 2006-03-28 NO NO20061419A patent/NO20061419L/no not_active Application Discontinuation
- 2006-04-03 IL IL174734A patent/IL174734A/en not_active IP Right Cessation
- 2006-04-21 ZA ZA200603221A patent/ZA200603221B/xx unknown
- 2006-05-03 CO CO06041532A patent/CO5690643A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2297502T3 (es) | 2008-05-01 |
| IL174734A0 (en) | 2006-08-20 |
| CA2543308A1 (en) | 2005-05-06 |
| AR046186A1 (es) | 2005-11-30 |
| DE602004010419D1 (de) | 2008-01-10 |
| US20050107373A1 (en) | 2005-05-19 |
| CO5690643A2 (es) | 2006-10-31 |
| CN1871238A (zh) | 2006-11-29 |
| KR20060076317A (ko) | 2006-07-04 |
| ZA200603221B (en) | 2009-04-29 |
| EP1678177B1 (en) | 2007-11-28 |
| TW200526662A (en) | 2005-08-16 |
| IL174734A (en) | 2010-05-31 |
| BRPI0415833A (pt) | 2007-01-02 |
| DE602004010419T2 (de) | 2008-10-09 |
| KR100798161B1 (ko) | 2008-01-28 |
| RU2006117368A (ru) | 2007-12-10 |
| AU2004283843A1 (en) | 2005-05-06 |
| CN100467468C (zh) | 2009-03-11 |
| JP4490434B2 (ja) | 2010-06-23 |
| JP2007509097A (ja) | 2007-04-12 |
| EP1678177A1 (en) | 2006-07-12 |
| MXPA06004305A (es) | 2006-06-05 |
| WO2005040166A1 (en) | 2005-05-06 |
| US7189850B2 (en) | 2007-03-13 |
| CA2543308C (en) | 2012-03-06 |
| AU2004283843B2 (en) | 2010-04-22 |
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