NO20060975L - 1-Benzoyl-piperazinderivater som glycin gjenopptaksinhibitorer for behandling av psykoser - Google Patents

1-Benzoyl-piperazinderivater som glycin gjenopptaksinhibitorer for behandling av psykoser

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Publication number
NO20060975L
NO20060975L NO20060975A NO20060975A NO20060975L NO 20060975 L NO20060975 L NO 20060975L NO 20060975 A NO20060975 A NO 20060975A NO 20060975 A NO20060975 A NO 20060975A NO 20060975 L NO20060975 L NO 20060975L
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NO
Norway
Prior art keywords
alkyl
halogen
substituted
alkoxy
aryl
Prior art date
Application number
NO20060975A
Other languages
English (en)
Inventor
Henri Stalder
Roger David Norcross
Emmanuel Pinard
Synese Jolidon
Daniela Alberti-Giani
Robert Narquizian
Matthias Heinrich Nettekoven
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO20060975L publication Critical patent/NO20060975L/no

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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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  • Plural Heterocyclic Compounds (AREA)

Abstract

Oppfinnelsen angår forbindelser med formel (I) hvor Ar er substituert aryl eller usubstituert eller substituert 6-leddet heteroaryl, inneholdende ett, to eller tre nitrogenatomer og hvor aryl- og heteroarylgruppene kan være substituert med én eller flere substituenter valgt fra gruppen bestående av hydroksy, halogen, CN, (C1-C6)-alkyl, (C1-C6)-alkyl substituert med halogen, (C1-C6)-alkoksy, (C1-C6)-alkoksy substituert med halogen, NR7R8, C(O)R9 eller SO2R10; R1 er hydrogen eller (C1-C6)-alkyl; R2 er halogen, (C1-C6)-alkyl, (C2-C6)-alkenyl, hvor et hydrogenatom kan være erstattet av CN, C(O)-R9 eller (C1-C6)-alkyl eller er (C2-C6)-alkynyl, (C1-C6)-alkyl substituert med halogen, -(CH2)n-(C3-C7)-cykloalkyl, -(CH2)n-heterocykloalkyl, -C(O)-R9, -(CH2)n-aryl eller -(CH2)n- 5- eller 6-leddet heteroaryl inneholdende ett, to eller tre heteroatomer, valgt fra gruppen bestående av oksygen, svovel eller nitrogen hvor aryl, cykloalkyl, heterocykloalkyl og heteroaryl er usubstituert eller substituert med én eller flere substituenter valgt fra gruppen bestående av hydroksy, halogen, (C1-C6)-alkyl, (C1-C6)-alkyl substituert med halogen eller (C1-C6)-alkoksy; R3, R4 og R6 uavhengig av hverandre er hydrogen, hydroksy, halogen, (C1-C6)alkyl eller (C1-C6)-alkoksy; R5 er N02, CN, C(O)R9, SO2R10 eller NR11R12; R7 og R8 uavhengig av hverandre er hydrogen eller (C1-C6)-alkyl; og de andre substituentene er som definert i kravene; og farmasøytisk akseptable syreaddisjonssalter derav for behandling av psykoser, smerte, neurodegenerativ dysfunksjon av hukommelse og læring, schizofreni, demens og andre sykdommer hvor kognitive prosesser er svekket, så som oppmerksomhetssvikt-lidelser eller Alzheimer's sykdom.
NO20060975A 2003-09-09 2006-02-28 1-Benzoyl-piperazinderivater som glycin gjenopptaksinhibitorer for behandling av psykoser NO20060975L (no)

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WO2005023261A1 (en) 2005-03-17
BRPI0413536B1 (pt) 2019-03-19
AU2004269892A1 (en) 2005-03-17
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MY140470A (en) 2009-12-31
KR100774621B1 (ko) 2007-11-14
EP1703909A1 (en) 2006-09-27
BRPI0413536B8 (pt) 2021-05-25
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CA2538135A1 (en) 2005-03-17
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