NO20062357L - Indolinderivater og anvendelse av dem ved behandling av sykdomstilstander som cancer - Google Patents
Indolinderivater og anvendelse av dem ved behandling av sykdomstilstander som cancerInfo
- Publication number
- NO20062357L NO20062357L NO20062357A NO20062357A NO20062357L NO 20062357 L NO20062357 L NO 20062357L NO 20062357 A NO20062357 A NO 20062357A NO 20062357 A NO20062357 A NO 20062357A NO 20062357 L NO20062357 L NO 20062357L
- Authority
- NO
- Norway
- Prior art keywords
- disease states
- cancer
- treatment
- indoline derivatives
- derivatives
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 125000003387 indolinyl group Chemical class N1(CCC2=CC=CC=C12)* 0.000 title 1
- 101100029886 Caenorhabditis elegans lov-1 gene Proteins 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical class C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51408103P | 2003-10-24 | 2003-10-24 | |
| PCT/US2004/035262 WO2005040116A2 (en) | 2003-10-24 | 2004-10-22 | Indolinone derivatives and their use in treating disease-states such as cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20062357L true NO20062357L (no) | 2006-07-14 |
Family
ID=34520168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20062357A NO20062357L (no) | 2003-10-24 | 2006-05-23 | Indolinderivater og anvendelse av dem ved behandling av sykdomstilstander som cancer |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7105563B2 (pt) |
| EP (1) | EP1680401A2 (pt) |
| JP (1) | JP2007509173A (pt) |
| KR (1) | KR20060123184A (pt) |
| CN (1) | CN1898205A (pt) |
| AU (1) | AU2004284084A1 (pt) |
| BR (1) | BRPI0415773A (pt) |
| CA (1) | CA2541460A1 (pt) |
| IL (1) | IL174788A0 (pt) |
| MX (1) | MXPA06004438A (pt) |
| NO (1) | NO20062357L (pt) |
| RU (1) | RU2006117635A (pt) |
| WO (1) | WO2005040116A2 (pt) |
| ZA (1) | ZA200604149B (pt) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10334582A1 (de) * | 2003-07-28 | 2005-02-24 | Basf Ag | Verfahren zur Herstellung von Maleinsäureanhydrid |
| BRPI0416994A (pt) * | 2003-11-26 | 2007-02-06 | Scripps Research Inst | inibidores de proteìna cinase com base em indolinona avançada |
| DE102005015005A1 (de) * | 2005-04-01 | 2006-10-05 | Qiagen Gmbh | Verfahren zur Behandlung einer Biomoleküle enthaltenden Probe |
| JP2009533480A (ja) * | 2006-04-24 | 2009-09-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ３−（アミノメチリデン）２−インドリノン誘導体及びその細胞増殖抑制薬としての使用 |
| US20070286864A1 (en) * | 2006-06-09 | 2007-12-13 | Buck Elizabeth A | Combined treatment with an EGFR kinase inhibitor and an agent that sensitizes tumor cells to the effects of EGFR kinase inhibitors |
| WO2008033562A2 (en) | 2006-09-15 | 2008-03-20 | Xcovery, Inc. | Kinase inhibitor compounds |
| WO2009030270A1 (en) * | 2007-09-03 | 2009-03-12 | Novartis Ag | Dihydroindole derivatives useful in parkinson's disease |
| CA2736177A1 (en) | 2007-09-06 | 2009-03-12 | Boston Biomedical, Inc. | Compositions of kinase inhibitors and their use for treatment of cancer and other diseases related to kinases |
| US8383818B2 (en) | 2008-02-21 | 2013-02-26 | Merck Sharp & Dohme Corp. | Functionally selective alpha2C adrenoreceptor agonists |
| JP5657524B2 (ja) * | 2008-04-24 | 2015-01-21 | エフツージー リミテッド | ピロール抗真菌剤 |
| CN102137866A (zh) * | 2008-06-30 | 2011-07-27 | 赛林药物股份有限公司 | 羟吲哚化合物 |
| EP2318364A2 (en) * | 2008-07-02 | 2011-05-11 | Generics [UK] Limited | Preparation of 3-pyrrole substituted 2-indolinone derivatives |
| CN101397295B (zh) * | 2008-11-12 | 2012-04-25 | 深圳微芯生物科技有限责任公司 | 作为组蛋白去乙酰化酶抑制剂的2-吲哚满酮衍生物、其制法和用途 |
| EP2246326A1 (de) | 2009-05-02 | 2010-11-03 | Bayer CropScience AG | Verfahren zur Herstellung von Oxindolen und ortho-substituierten Anilinen und ihre Verwendung als Zwischenprodukte für Synthesen |
| FR2948940B1 (fr) * | 2009-08-04 | 2011-07-22 | Servier Lab | Nouveaux derives dihydroindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| PL2485731T4 (pl) | 2009-10-06 | 2017-07-31 | Millennium Pharmaceuticals, Inc. | Związki heterocykliczne użyteczne jako inhibitory PDK1 |
| CN102283826A (zh) * | 2010-06-21 | 2011-12-21 | 中国医学科学院基础医学研究所 | 维甲酸及其类似物用于治疗tsc1/tsc2失活或其上游通路活化导致的肿瘤 |
| GB201014374D0 (en) * | 2010-08-27 | 2010-10-13 | Univ Greenwich | Novel hybrid compounds |
| WO2012028162A1 (de) | 2010-09-01 | 2012-03-08 | Bayer Cropscience Ag | Verfahren zur herstellung von oxindolen und ortho-substituierten anilinen und ihre verwendung als zwischenprodukte für synthesen |
| AU2010363613B2 (en) | 2010-11-01 | 2015-02-05 | Scinopharm (Kunshan) Biochemical Technology Co., Ltd. | Processes for the preparation of 3-((pyrrol-2-yl)methylene)-2-pyrrolones using 2-silyloxy-pyrroles |
| CN102688234B (zh) * | 2011-03-21 | 2015-07-29 | 华东理工大学 | 吲哚酮衍生物作为rsk2抑制剂的合成与应用 |
| IN2014MN02105A (pt) | 2012-04-20 | 2015-09-11 | Annji Pharm Co Ltd | |
| JP6378308B2 (ja) * | 2013-03-13 | 2018-08-22 | ボストン バイオメディカル， インコーポレイテッド | がんの処置のための、がん幹細胞経路キナーゼの阻害剤としての３−（アリールまたはヘテロアリール）メチレンインドリン−２−オン誘導体 |
| CN104211632B (zh) * | 2013-05-31 | 2016-12-28 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | 具有酪氨酸激酶抑制活性的2‑吲哚酮衍生物及其制备方法与应用 |
| FR3008411B1 (fr) * | 2013-07-12 | 2015-07-03 | Servier Lab | Nouveau sel de la 3-[(3-{[4-(4-morpholinylmethyl)-1h-pyrrol-2-yl]methylene}-2-oxo-2,3-dihydro-1h-indol-5-yl)methyl]-1,3-thiazolidine-2,4-dione, sa preparation, et les formulations qui le contiennent |
| WO2016055454A1 (en) * | 2014-10-06 | 2016-04-14 | International Society For Drug Development S.R.L. | Pharmaceutical combination for the treatment of tumors |
| PL3221308T3 (pl) | 2014-11-21 | 2019-03-29 | F2G Limited | Środki przeciwgrzybicze |
| EP3325100A4 (en) | 2015-07-17 | 2019-02-20 | Memorial Sloan-Kettering Cancer Center | COMBINATION THERAPY WITH PDK1 AND PI3K INHIBITORS |
| GB201609222D0 (en) | 2016-05-25 | 2016-07-06 | F2G Ltd | Pharmaceutical formulation |
| US11819503B2 (en) | 2019-04-23 | 2023-11-21 | F2G Ltd | Method of treating coccidioides infection |
| CN114213396B (zh) * | 2022-01-27 | 2023-03-24 | 深圳市乐土生物医药有限公司 | 一种吲哚-2-酮类化合物及其制备方法与用途 |
| CN115855899B (zh) * | 2022-11-24 | 2025-06-10 | 常熟理工学院 | 一种荧光探针检测二氧化硫衍生物的应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| US5854206A (en) * | 1995-08-25 | 1998-12-29 | Corixa Corporation | Compounds and methods for treatment and diagnosis of prostate cancer |
| KR100743287B1 (ko) | 1998-05-29 | 2007-07-26 | 수젠, 인크. | 피롤기로 치환된 2-인돌리논 단백질 인산화 효소 억제제 |
| ES2192878T3 (es) | 1998-12-17 | 2003-10-16 | Hoffmann La Roche | 4,5-azolo-oxindoles. |
| KR20010101266A (ko) | 1998-12-17 | 2001-11-14 | 프리돌린 클라우스너, 롤란드 비. 보레르 | Ｊｎｋ 단백질 키나제의 억제제로서의 4-아릴옥신돌 |
| ES2301255T3 (es) | 1998-12-17 | 2008-06-16 | F. Hoffmann-La Roche Ag | 4,5-pirazinaxindoles como inhibidores de proteinoquinasas. |
| WO2000035906A2 (en) | 1998-12-17 | 2000-06-22 | F. Hoffmann-La Roche Ag | 4- and 5-alkynyloxindoles and 4- and 5-alkenyloxindoles |
| AU3770000A (en) | 1999-03-24 | 2000-10-09 | Sugen, Inc. | Indolinone compounds as kinase inhibitors |
| EP1259234B9 (en) * | 1999-12-30 | 2007-02-14 | Sugen, Inc. | 3-heteroarylidenyl-2-indolinone compounds for modulating protein kinase activity and for use in cancer chemotherapy |
| WO2001083450A2 (en) | 2000-05-02 | 2001-11-08 | Sugen, Inc. | (2-oxindol-3-ylidenyl)acetic acid derivatives and their use as protein kinase inhibitors |
| AR042586A1 (es) | 2001-02-15 | 2005-06-29 | Sugen Inc | 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa |
| JP2005506982A (ja) | 2001-09-10 | 2005-03-10 | スージェン・インコーポレーテッド | キナーゼ阻害剤としての３−（４，５，６，７−テトラヒドロインドール−２−イルメチリデン）−２−インドリノン誘導体 |
| JP2005508953A (ja) | 2001-10-10 | 2005-04-07 | スージェン・インコーポレーテッド | キナーゼ阻害剤としての３−［４−（置換ヘテロサイクリル）−ピロール−２−イルメチリデン］−２−インドリノン誘導体 |
| US20030119839A1 (en) * | 2001-12-13 | 2003-06-26 | Nan-Horng Lin | Protein kinase inhibitors |
| DE60205776T2 (de) * | 2001-12-27 | 2006-06-14 | Theravance Inc | Indolinon-derivative als protein-kinasehemmer |
| TW200306819A (en) | 2002-01-25 | 2003-12-01 | Vertex Pharma | Indazole compounds useful as protein kinase inhibitors |
| WO2004048343A1 (en) | 2002-11-28 | 2004-06-10 | Schering Aktiengesellschaft | Chk-, pdk- and akt-inhibitory pyrimidines, their production and use as pharmaceutical agents |
| US20040266843A1 (en) * | 2003-03-07 | 2004-12-30 | Sugen, Inc. | Sulfonamide substituted indolinones as inhibitors of DNA dependent protein kinase (DNA-PK) |
| US7157577B2 (en) * | 2003-03-07 | 2007-01-02 | Sugen Inc. | 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors |
| ATE446951T1 (de) * | 2003-06-10 | 2009-11-15 | Biondi Ricardo Miguel | Verwendung einer verbingung gemäss formel i zur herstellung einer pharmazeutischen zubereitung |
-
2004
- 2004-10-22 MX MXPA06004438A patent/MXPA06004438A/es not_active Application Discontinuation
- 2004-10-22 US US10/972,023 patent/US7105563B2/en not_active Expired - Fee Related
- 2004-10-22 CN CNA2004800386567A patent/CN1898205A/zh active Pending
- 2004-10-22 RU RU2006117635/04A patent/RU2006117635A/ru not_active Application Discontinuation
- 2004-10-22 WO PCT/US2004/035262 patent/WO2005040116A2/en not_active Ceased
- 2004-10-22 EP EP04796276A patent/EP1680401A2/en not_active Withdrawn
- 2004-10-22 KR KR1020067010000A patent/KR20060123184A/ko not_active Withdrawn
- 2004-10-22 AU AU2004284084A patent/AU2004284084A1/en not_active Abandoned
- 2004-10-22 BR BRPI0415773-7A patent/BRPI0415773A/pt not_active Application Discontinuation
- 2004-10-22 CA CA002541460A patent/CA2541460A1/en not_active Abandoned
- 2004-10-22 JP JP2006536878A patent/JP2007509173A/ja active Pending
-
2006
- 2006-04-04 IL IL174788A patent/IL174788A0/en unknown
- 2006-05-23 ZA ZA200604149A patent/ZA200604149B/en unknown
- 2006-05-23 NO NO20062357A patent/NO20062357L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005040116A2 (en) | 2005-05-06 |
| RU2006117635A (ru) | 2007-12-10 |
| KR20060123184A (ko) | 2006-12-01 |
| WO2005040116A3 (en) | 2005-06-16 |
| BRPI0415773A (pt) | 2006-12-26 |
| US20050090541A1 (en) | 2005-04-28 |
| AU2004284084A1 (en) | 2005-05-06 |
| EP1680401A2 (en) | 2006-07-19 |
| JP2007509173A (ja) | 2007-04-12 |
| ZA200604149B (en) | 2007-11-28 |
| MXPA06004438A (es) | 2006-06-20 |
| CN1898205A (zh) | 2007-01-17 |
| CA2541460A1 (en) | 2005-05-06 |
| US7105563B2 (en) | 2006-09-12 |
| IL174788A0 (en) | 2006-08-20 |
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