NO20062373L - Komposittbiomaterialer omfattende kalsiumfosfatmateriale, kollagen og glykosaminoglykaner - Google Patents
Komposittbiomaterialer omfattende kalsiumfosfatmateriale, kollagen og glykosaminoglykanerInfo
- Publication number
- NO20062373L NO20062373L NO20062373A NO20062373A NO20062373L NO 20062373 L NO20062373 L NO 20062373L NO 20062373 A NO20062373 A NO 20062373A NO 20062373 A NO20062373 A NO 20062373A NO 20062373 L NO20062373 L NO 20062373L
- Authority
- NO
- Norway
- Prior art keywords
- collagen
- glycosaminoglycans
- calcium phosphate
- phosphate material
- composite biomaterials
- Prior art date
Links
- 102000008186 Collagen Human genes 0.000 title abstract 4
- 108010035532 Collagen Proteins 0.000 title abstract 4
- 229920001436 collagen Polymers 0.000 title abstract 4
- 229920002683 Glycosaminoglycan Polymers 0.000 title abstract 3
- 239000002131 composite material Substances 0.000 title abstract 2
- 239000012620 biological material Substances 0.000 title 1
- 229910000389 calcium phosphate Inorganic materials 0.000 title 1
- 239000001506 calcium phosphate Substances 0.000 title 1
- 235000011010 calcium phosphates Nutrition 0.000 title 1
- 239000000463 material Substances 0.000 title 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 title 1
- 239000007864 aqueous solution Substances 0.000 abstract 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 229910052797 bismuth Inorganic materials 0.000 abstract 1
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 229910052802 copper Inorganic materials 0.000 abstract 1
- 239000010949 copper Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052698 phosphorus Inorganic materials 0.000 abstract 1
- 239000011574 phosphorus Substances 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
- A61L24/0084—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing fillers of phosphorus-containing inorganic compounds, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0003—Not used, see subgroups
- A61C8/0004—Consolidating natural teeth
- A61C8/0006—Periodontal tissue or bone regeneration
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Composite Materials (AREA)
- Materials Engineering (AREA)
- Inorganic Chemistry (AREA)
- Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Dentistry (AREA)
- Materials For Medical Uses (AREA)
- Dental Preparations (AREA)
- Curing Cements, Concrete, And Artificial Stone (AREA)
- Peptides Or Proteins (AREA)
Abstract
Det er beskrevet en fremgangsmåte for fremstilling av et komposittmateriale omfattende kollagen, brusjit og et eller flere glykosaminoglykaner, hvor fremgangsmåten omfatter trirmene med tilveiebringelse av en sur vandig oppløsning omfattende kollagen, en kalsiumkilde og en fosforkilde og et eller flere glykosaminoglykaner, og utfelling av kollagenet, bmsjiten og det ene eller de flere glykosaminoklykanene sammen fra den vandige oppløsningen for å danne et tredobbelt kopresipitat.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0325161A GB2407580B (en) | 2003-10-28 | 2003-10-28 | Biomaterial |
| PCT/GB2004/004550 WO2005051447A1 (en) | 2003-10-28 | 2004-10-28 | Composite biomaterials comprising calcium phospate materials, collagen and glycosaminoglycans |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20062373L true NO20062373L (no) | 2006-05-24 |
Family
ID=29725523
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20062373A NO20062373L (no) | 2003-10-28 | 2006-05-24 | Komposittbiomaterialer omfattende kalsiumfosfatmateriale, kollagen og glykosaminoglykaner |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7780994B2 (no) |
| EP (1) | EP1689460B1 (no) |
| JP (2) | JP4981451B2 (no) |
| KR (1) | KR101332647B1 (no) |
| CN (2) | CN100427151C (no) |
| AU (1) | AU2004292384B2 (no) |
| CA (1) | CA2543587A1 (no) |
| ES (1) | ES2397141T3 (no) |
| GB (1) | GB2407580B (no) |
| NO (1) | NO20062373L (no) |
| PL (1) | PL1689460T3 (no) |
| WO (1) | WO2005051447A1 (no) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040081704A1 (en) | 1998-02-13 | 2004-04-29 | Centerpulse Biologics Inc. | Implantable putty material |
| US20020114795A1 (en) | 2000-12-22 | 2002-08-22 | Thorne Kevin J. | Composition and process for bone growth and repair |
| US7166133B2 (en) * | 2002-06-13 | 2007-01-23 | Kensey Nash Corporation | Devices and methods for treating defects in the tissue of a living being |
| US7744651B2 (en) | 2002-09-18 | 2010-06-29 | Warsaw Orthopedic, Inc | Compositions and methods for treating intervertebral discs with collagen-based materials |
| US20040054414A1 (en) | 2002-09-18 | 2004-03-18 | Trieu Hai H. | Collagen-based materials and methods for augmenting intervertebral discs |
| CN100394989C (zh) | 2002-11-15 | 2008-06-18 | 华沙整形外科股份有限公司 | 包含微粒状基于胶原材料的组合物的制药应用和包含所述组合物的滑膜关节 |
| GB2407580B (en) * | 2003-10-28 | 2009-02-25 | Univ Cambridge Tech | Biomaterial |
| GB2424223C (en) * | 2005-03-07 | 2011-02-02 | Massachusetts Inst Technology | Biomaterial. |
| US8118779B2 (en) | 2006-06-30 | 2012-02-21 | Warsaw Orthopedic, Inc. | Collagen delivery device |
| US8399619B2 (en) | 2006-06-30 | 2013-03-19 | Warsaw Orthopedic, Inc. | Injectable collagen material |
| GB2440721A (en) | 2006-08-11 | 2008-02-13 | Univ Cambridge Tech | Composite biomaterial formed by cooling a fluid composition on a porous solid and removing solidified crystals of the liquid carrier |
| US7718616B2 (en) | 2006-12-21 | 2010-05-18 | Zimmer Orthobiologics, Inc. | Bone growth particles and osteoinductive composition thereof |
| GB2454326A (en) * | 2007-10-29 | 2009-05-06 | Orthomimetics Ltd | Elastic porous biomaterial as synthetic bone or scaffold |
| GB2457756A (en) | 2008-01-09 | 2009-09-02 | Univ Aberdeen | Bioceramic calcium phosphosilicate compositions |
| JP5478872B2 (ja) * | 2008-11-05 | 2014-04-23 | 国立大学法人東北大学 | 人工骨材 |
| EP2389204B1 (en) | 2009-01-23 | 2019-07-03 | Royal College of Surgeons in Ireland | Layered scaffold suitable for osteochondral repair |
| JP2012519556A (ja) * | 2009-03-05 | 2012-08-30 | バイオミメティック セラピューティクス, インコーポレイテッド | 骨軟骨欠損を治療するための血小板由来増殖因子組成物および方法 |
| US8568590B2 (en) * | 2009-05-07 | 2013-10-29 | Phillip Barak | Phosphate recovery from acid phase anaerobic digesters |
| GB201003656D0 (en) | 2010-03-05 | 2010-04-21 | Tigenix Ltd | Fabrication process |
| KR20110117382A (ko) * | 2010-04-21 | 2011-10-27 | 주식회사 메가젠임플란트 | 표면에 콜라겐이 결합된 이상인산칼슘 골대체재의 제조방법 및 그 방법에 의해 제조된 골대체재 |
| US8613938B2 (en) | 2010-11-15 | 2013-12-24 | Zimmer Orthobiologics, Inc. | Bone void fillers |
| US8551525B2 (en) | 2010-12-23 | 2013-10-08 | Biostructures, Llc | Bone graft materials and methods |
| US20130338237A1 (en) | 2010-12-31 | 2013-12-19 | Ahmet Cuneyt Tas | Preparation of brushite and octacalcium phosphate granules |
| WO2012093939A1 (en) * | 2011-01-05 | 2012-07-12 | Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg | Particles comprising calcium phosphate and use thereof |
| EP2529764A1 (de) | 2011-05-31 | 2012-12-05 | Curasan AG | Biologisch degradierbares kompositmaterial |
| CN102416200B (zh) * | 2011-12-02 | 2013-09-11 | 四川大学 | 一种构建胶原基生物大分子/羟基磷灰石微球复合支架材料的制备方法 |
| US10207027B2 (en) | 2012-06-11 | 2019-02-19 | Globus Medical, Inc. | Bioactive bone graft substitutes |
| WO2014060443A2 (en) | 2012-10-15 | 2014-04-24 | Royal College Of Surgeons In Ireland | A composite scaffold for use as a tissue engineering implant |
| CN102872481A (zh) * | 2012-10-22 | 2013-01-16 | 天津市赛宁生物工程技术有限公司 | 可重建生物骨板 |
| CA2963595C (en) | 2014-10-28 | 2023-07-11 | Biovotec As | Micronized eggshell membrane particles and the use thereof to promote the healing of wounds |
| SG11201704277XA (en) * | 2014-11-27 | 2017-06-29 | Toyo Boseki | Porous composite, bone regeneration material, and method for producing porous composite |
| WO2016136913A1 (ja) * | 2015-02-25 | 2016-09-01 | 国立大学法人東京医科歯科大学 | 医療用デバイス、歯科用、頭頸部外科用及び整形外科用デバイス構造、並びに骨への医療用デバイスの接合方法 |
| KR102702872B1 (ko) | 2015-06-24 | 2024-09-05 | 바이오보텍 에이에스 | 미립자 난각막을 포함하는 조직 공학 스캐폴드 |
| CN104921956A (zh) * | 2015-06-24 | 2015-09-23 | 苏州乔纳森新材料科技有限公司 | 一种牙齿修复材料及其制备方法 |
| GB201519923D0 (en) | 2015-11-11 | 2015-12-23 | Biovotec Dac And Biovotec As | Dry biocompatible disintegrateable films for delivering particulate egg shell membrane to a wound |
| JP6995437B2 (ja) * | 2017-11-10 | 2022-02-04 | 多木化学株式会社 | コラーゲン-コンドロイチン硫酸のゲル材料 |
| CN108815576A (zh) * | 2018-07-06 | 2018-11-16 | 宣城南巡智能科技有限公司 | 一种复合型骨基质材料及其制备工艺 |
| DE102019211781A1 (de) | 2019-08-06 | 2021-02-11 | Gebr. Brasseler Gmbh & Co. Kg | Zubereitung und Fertigmischung zur Verwendung in medizinischen oder dentalen Anwendungen, medizinisches oder dentales Produkt sowie dessen Verwendung und seine Herstellung |
| CN111249523B (zh) * | 2020-03-10 | 2021-07-13 | 四川大学 | 仿骨复合材料支架及其制备方法 |
| CN112121233A (zh) * | 2020-07-17 | 2020-12-25 | 上海摩漾生物科技有限公司 | 酪蛋白钙磷微球胶原蛋白填充剂及其制备方法以及酪蛋白钙磷微球的制备方法 |
| WO2026025053A1 (en) * | 2024-07-26 | 2026-01-29 | Miach Orthopaedics, Inc. | Injectable collagen implants and compositions and related systems, and methods of preparation and use thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2585576B1 (fr) * | 1985-07-30 | 1992-01-03 | Bioetica Sa | Produit de remplacement de la matrice osseuse favorisant l'osteogenese |
| JPS63229058A (ja) * | 1987-03-17 | 1988-09-22 | 大鳥 泰雅 | 骨形成材料の製法 |
| US5034059A (en) * | 1989-02-17 | 1991-07-23 | Norian Corporation | Composition comprising octacalcium phosphate crystals and polypeptide |
| US5320844A (en) * | 1992-03-12 | 1994-06-14 | Liu Sung Tsuen | Composite materials for hard tissue replacement |
| US5532217A (en) * | 1992-04-24 | 1996-07-02 | Silver; Frederick H. | Process for the mineralization of collagen fibers, product produced thereby and use thereof to repair bone |
| EP0842670A1 (en) * | 1996-11-13 | 1998-05-20 | Katsunari Nishihara | Biomedical materials |
| US6432710B1 (en) * | 1998-05-22 | 2002-08-13 | Isolagen Technologies, Inc. | Compositions for regenerating tissue that has deteriorated, and methods for using such compositions |
| WO2000016822A1 (en) * | 1998-09-21 | 2000-03-30 | The Brigham And Women's Hospital, Inc. | Compositions and methods for tissue repair |
| CA2391947C (en) * | 1999-12-09 | 2008-07-15 | Dr. H. C. Robert Mathys Stiftung | Brushite hydraulic cement stabilized with a magnesium salt |
| JP3916516B2 (ja) * | 2002-06-10 | 2007-05-16 | 独立行政法人科学技術振興機構 | 硬組織−軟組織界面再生用足場材料 |
| CN1403165A (zh) * | 2002-09-26 | 2003-03-19 | 东南大学 | 用于硬组织修复的活性组合物及其制备方法 |
| GB2407580B (en) * | 2003-10-28 | 2009-02-25 | Univ Cambridge Tech | Biomaterial |
-
2003
- 2003-10-28 GB GB0325161A patent/GB2407580B/en not_active Expired - Fee Related
-
2004
- 2004-10-28 EP EP04791593A patent/EP1689460B1/en not_active Expired - Lifetime
- 2004-10-28 CA CA002543587A patent/CA2543587A1/en not_active Abandoned
- 2004-10-28 PL PL04791593T patent/PL1689460T3/pl unknown
- 2004-10-28 US US10/595,587 patent/US7780994B2/en active Active
- 2004-10-28 AU AU2004292384A patent/AU2004292384B2/en not_active Ceased
- 2004-10-28 JP JP2006537412A patent/JP4981451B2/ja not_active Expired - Fee Related
- 2004-10-28 KR KR1020067010357A patent/KR101332647B1/ko not_active Expired - Fee Related
- 2004-10-28 ES ES04791593T patent/ES2397141T3/es not_active Expired - Lifetime
- 2004-10-28 CN CNB2004800321261A patent/CN100427151C/zh not_active Expired - Fee Related
- 2004-10-28 CN CN200810169017.4A patent/CN101391117B/zh not_active Expired - Fee Related
- 2004-10-28 WO PCT/GB2004/004550 patent/WO2005051447A1/en not_active Ceased
-
2006
- 2006-05-24 NO NO20062373A patent/NO20062373L/no not_active Application Discontinuation
-
2012
- 2012-02-02 JP JP2012020970A patent/JP2012110739A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP4981451B2 (ja) | 2012-07-18 |
| PL1689460T3 (pl) | 2013-03-29 |
| US20070134285A1 (en) | 2007-06-14 |
| GB2407580B (en) | 2009-02-25 |
| CA2543587A1 (en) | 2005-06-09 |
| WO2005051447A1 (en) | 2005-06-09 |
| JP2012110739A (ja) | 2012-06-14 |
| CN100427151C (zh) | 2008-10-22 |
| KR20070031846A (ko) | 2007-03-20 |
| EP1689460B1 (en) | 2012-10-10 |
| CN101391117A (zh) | 2009-03-25 |
| KR101332647B1 (ko) | 2013-12-03 |
| CN1874797A (zh) | 2006-12-06 |
| AU2004292384B2 (en) | 2011-03-03 |
| US7780994B2 (en) | 2010-08-24 |
| AU2004292384A1 (en) | 2005-06-09 |
| ES2397141T3 (es) | 2013-03-05 |
| GB0325161D0 (en) | 2003-12-03 |
| JP2007512038A (ja) | 2007-05-17 |
| GB2407580A (en) | 2005-05-04 |
| CN101391117B (zh) | 2014-02-26 |
| EP1689460A1 (en) | 2006-08-16 |
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