NO20062474L - Antivirale midler bestaende av diazaindol-dikarbonyl-piperazinyl - Google Patents

Antivirale midler bestaende av diazaindol-dikarbonyl-piperazinyl

Info

Publication number
NO20062474L
NO20062474L NO20062474A NO20062474A NO20062474L NO 20062474 L NO20062474 L NO 20062474L NO 20062474 A NO20062474 A NO 20062474A NO 20062474 A NO20062474 A NO 20062474A NO 20062474 L NO20062474 L NO 20062474L
Authority
NO
Norway
Prior art keywords
diazaindole
dicarbonyl
piperazinyl
antiviral agents
agents consisting
Prior art date
Application number
NO20062474A
Other languages
English (en)
Other versions
NO336261B1 (no
Inventor
John F Kadow
Nicholas A Meanwell
John A Bender
Zhong Yang
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO20062474L publication Critical patent/NO20062474L/no
Publication of NO336261B1 publication Critical patent/NO336261B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Oppfinnelsen omfatter substituerte diazaindol-dikarbonyl-piperazinyl-derivater med den qenerelle formel I Q er valgt fra gruppen som består av - - kan representere en binding; T er -C(O)- eller -CH(CN)-; og -Y- er valgt fra gruppen som består av preparater av disse og anvendelsen av dem for behandling av HIV-infeksjon.
NO20062474A 2003-11-26 2006-05-30 Diazaindol-derivater, farmasøytiske preparater omfattende slike, slike preparater som i tillegg omfatter et ytterligere middel for behandling av AIDS samt slike forbindelser og preparater for behandling av HIV-infeksjon og AIDS NO336261B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52562403P 2003-11-26 2003-11-26
PCT/US2004/037213 WO2005054247A1 (en) 2003-11-26 2004-11-04 Diazaindole-dicarbonyl-piperazinyl antiviral agents

Publications (2)

Publication Number Publication Date
NO20062474L true NO20062474L (no) 2006-08-21
NO336261B1 NO336261B1 (no) 2015-07-06

Family

ID=34652366

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20062474A NO336261B1 (no) 2003-11-26 2006-05-30 Diazaindol-derivater, farmasøytiske preparater omfattende slike, slike preparater som i tillegg omfatter et ytterligere middel for behandling av AIDS samt slike forbindelser og preparater for behandling av HIV-infeksjon og AIDS

Country Status (29)

Country Link
US (2) US20050124623A1 (no)
EP (1) EP1751161B1 (no)
JP (1) JP2007512332A (no)
KR (1) KR20070008526A (no)
CN (1) CN1906199A (no)
AR (1) AR046720A1 (no)
AT (1) ATE473981T1 (no)
AU (1) AU2004295309A1 (no)
BR (1) BRPI0417007A (no)
CA (1) CA2547347C (no)
CY (1) CY1110831T1 (no)
DE (1) DE602004028173D1 (no)
DK (1) DK1751161T3 (no)
ES (1) ES2347253T3 (no)
HR (1) HRP20100433T1 (no)
IL (1) IL175809A (no)
IS (1) IS2890B (no)
MX (1) MXPA06005730A (no)
NO (1) NO336261B1 (no)
NZ (1) NZ546904A (no)
PE (1) PE20050587A1 (no)
PL (1) PL1751161T3 (no)
PT (1) PT1751161E (no)
RU (1) RU2362777C2 (no)
SI (1) SI1751161T1 (no)
TW (1) TWI336253B (no)
UA (1) UA85502C2 (no)
WO (1) WO2005054247A1 (no)
ZA (1) ZA200604331B (no)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7449476B2 (en) 2004-05-26 2008-11-11 Bristol-Myers Squibb Company Tetrahydrocarboline antiviral agents
US20060100209A1 (en) * 2004-11-09 2006-05-11 Chong-Hui Gu Formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US20060100432A1 (en) * 2004-11-09 2006-05-11 Matiskella John D Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US7851476B2 (en) * 2005-12-14 2010-12-14 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine
US7807671B2 (en) * 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
AR070454A1 (es) * 2008-02-27 2010-04-07 Nycomed Gmbh Pirrolopirimidincarboxamidas y composiciones farmaceuticas que las comprenden
AR077898A1 (es) 2009-08-26 2011-09-28 Nycomed Gmbh Metilpirrolopirimidincarboxamidas
WO2011041713A2 (en) * 2009-10-02 2011-04-07 Glaxosmithkline Llc Piperazinyl antiviral agents
JP5813785B2 (ja) 2011-02-04 2015-11-17 デュケイン ユニバーシティー オブ ザ ホリー スピリット 抗チューブリン活性を有する二環式および三環式のピリミジンチロシンキナーゼ阻害剤ならびに患者の処置方法
EP2978762A1 (en) * 2013-03-27 2016-02-03 Bristol-Myers Squibb Company Piperazine and homopiperazine derivatives as hiv attachment inhibitors
US9586957B2 (en) * 2013-03-27 2017-03-07 VIIV Healthcare UK (No.5) Limited 2-keto amide derivatives as HIV attachment inhibitors
MY195016A (en) 2014-08-04 2023-01-03 Nuevolution As Optionally Fused Heterocyclyl-Substituted Derivatives of Pyrimidine Useful for The Treatment of Inflammatory, Metabolic, Oncologic and Autoimmune Diseases
US20180086749A1 (en) * 2015-05-11 2018-03-29 University Of Kansas Inhibitors of viruses
IL321754A (en) 2017-06-30 2025-08-01 Univ California Compositions and methods for modulating hair growth
AU2020405446A1 (en) 2019-12-20 2022-05-26 Nuevolution A/S Compounds active towards nuclear receptors
BR112022012205A2 (pt) 2019-12-20 2022-09-13 Nuevolution As Compostos ativos para receptores nucleares
US12649736B2 (en) 2019-12-20 2026-06-09 The Regents Of The University Of California Synthesis of compounds to promote hair growth
JP7713954B2 (ja) 2020-03-31 2025-07-28 ヌエヴォリューション・アクティーゼルスカブ 核内受容体に対して活性な化合物
CA3174252A1 (en) 2020-03-31 2021-10-07 Nuevolution A/S Compounds active towards nuclear receptors
EP4172159A4 (en) 2020-06-30 2024-01-10 The Regents of the University of California Compositions and methods for modulating hair growth
CN116693541A (zh) * 2023-06-15 2023-09-05 安徽大学 一种4-氯-5h-吡咯并[3,2-d]嘧啶的合成方法

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US5023265A (en) * 1990-06-01 1991-06-11 Schering Corporation Substituted 1-H-pyrrolopyridine-3-carboxamides
IT1265057B1 (it) 1993-08-05 1996-10-28 Dompe Spa Tropil 7-azaindolil-3-carbossiamidi
US5424329A (en) * 1993-08-18 1995-06-13 Warner-Lambert Company Indole-2-carboxamides as inhibitors of cell adhesion
GB9420521D0 (en) 1994-10-12 1994-11-30 Smithkline Beecham Plc Novel compounds
DE19814838C2 (de) 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
DE69934311D1 (de) 1998-06-30 2007-01-18 Lilly Co Eli BICYCLISCHE sPLA 2-INHIBITOREN
US6469006B1 (en) * 1999-06-15 2002-10-22 Bristol-Myers Squibb Company Antiviral indoleoxoacetyl piperazine derivatives
TWI269654B (en) 1999-09-28 2007-01-01 Baxter Healthcare Sa N-substituted indole-3-glyoxylamide compounds having anti-tumor action
US6476034B2 (en) * 2000-02-22 2002-11-05 Bristol-Myers Squibb Company Antiviral azaindole derivatives
US6573262B2 (en) * 2000-07-10 2003-06-03 Bristol-Myers Sqibb Company Composition and antiviral activity of substituted indoleoxoacetic piperazine derivatives
DE10037310A1 (de) 2000-07-28 2002-02-07 Asta Medica Ag Neue Indolderivate und deren Verwendung als Arzneimittel
US20040110785A1 (en) * 2001-02-02 2004-06-10 Tao Wang Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
PL364279A1 (en) * 2001-02-02 2004-12-13 Bristol-Myers Squibb Company Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
US20030207910A1 (en) * 2001-02-02 2003-11-06 Tao Wang Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
US6825201B2 (en) 2001-04-25 2004-11-30 Bristol-Myers Squibb Company Indole, azaindole and related heterocyclic amidopiperazine derivatives
US20030236277A1 (en) 2002-02-14 2003-12-25 Kadow John F. Indole, azaindole and related heterocyclic pyrrolidine derivatives
US7037913B2 (en) 2002-05-01 2006-05-02 Bristol-Myers Squibb Company Bicyclo 4.4.0 antiviral derivatives
US20040063744A1 (en) 2002-05-28 2004-04-01 Tao Wang Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides
US6900206B2 (en) 2002-06-20 2005-05-31 Bristol-Myers Squibb Company Indole, azaindole and related heterocyclic sulfonylureido piperazine derivatives
US20040063746A1 (en) 2002-07-25 2004-04-01 Alicia Regueiro-Ren Indole, azaindole and related heterocyclic ureido and thioureido piperazine derivatives
US20050075364A1 (en) * 2003-07-01 2005-04-07 Kap-Sun Yeung Indole, azaindole and related heterocyclic N-substituted piperazine derivatives

Also Published As

Publication number Publication date
US20080125439A1 (en) 2008-05-29
US7902204B2 (en) 2011-03-08
TWI336253B (en) 2011-01-21
SI1751161T1 (sl) 2010-11-30
PT1751161E (pt) 2010-09-08
NO336261B1 (no) 2015-07-06
KR20070008526A (ko) 2007-01-17
RU2362777C2 (ru) 2009-07-27
TW200529825A (en) 2005-09-16
RU2006122661A (ru) 2008-01-10
CY1110831T1 (el) 2015-06-10
PE20050587A1 (es) 2005-08-11
CN1906199A (zh) 2007-01-31
ES2347253T3 (es) 2010-10-27
IL175809A (en) 2012-06-28
BRPI0417007A (pt) 2007-01-16
UA85502C2 (en) 2009-01-26
CA2547347A1 (en) 2005-06-16
DE602004028173D1 (de) 2010-08-26
HRP20100433T1 (hr) 2010-09-30
IS2890B (is) 2014-09-15
PL1751161T3 (pl) 2010-12-31
JP2007512332A (ja) 2007-05-17
NZ546904A (en) 2010-01-29
AR046720A1 (es) 2005-12-21
MXPA06005730A (es) 2006-08-17
ATE473981T1 (de) 2010-07-15
WO2005054247A1 (en) 2005-06-16
AU2004295309A1 (en) 2005-06-16
EP1751161B1 (en) 2010-07-14
IL175809A0 (en) 2006-10-05
CA2547347C (en) 2012-05-15
ZA200604331B (en) 2007-10-31
EP1751161A1 (en) 2007-02-14
IS8479A (is) 2006-05-23
US20050124623A1 (en) 2005-06-09
DK1751161T3 (da) 2010-11-08

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Legal Events

Date Code Title Description
CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: VIIV HEALTHCARE UK (NO. 5) LIMITED, GB

MM1K Lapsed by not paying the annual fees