NO20062661L - Beta-laktamer for behandling av CNS lidelser - Google Patents
Beta-laktamer for behandling av CNS lidelserInfo
- Publication number
- NO20062661L NO20062661L NO20062661A NO20062661A NO20062661L NO 20062661 L NO20062661 L NO 20062661L NO 20062661 A NO20062661 A NO 20062661A NO 20062661 A NO20062661 A NO 20062661A NO 20062661 L NO20062661 L NO 20062661L
- Authority
- NO
- Norway
- Prior art keywords
- cyano
- hydroxy
- halogen
- alkyl
- represents hydrogen
- Prior art date
Links
- 208000015114 central nervous system disease Diseases 0.000 title 1
- 150000003952 β-lactams Chemical class 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- -1 Calkoxy Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 abstract 1
- 108010078791 Carrier Proteins Proteins 0.000 abstract 1
- 102000003141 Tachykinin Human genes 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000000697 serotonin reuptake Effects 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 108060008037 tachykinin Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Addiction (AREA)
- Anesthesiology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Foreliggende oppfinnelse angår nye forbindelser med formel (I), hvori — representerer en enkel- eller dobbelbinding; R representerer et radikal valgt fra formlene i), ii), iii) og iv) hvori Rer halogen, cyano, C_alkyl, Calkoksy, trifluormetyl eller trifluormetoksy og p er null eller et heltall på fra 1 til 3; Rrepresenterer hydrogen eller C_alky 1; Rrepresenterer hydrogen, hydroksy eller C_alkyl; Rrepresenterer hydrogen eller Rsammen med Rrepresenterer =0 eller =CH; Rrepresenterer fenyl, naftyl, en 9- til 10-leddet, sammensmeltet, bicyklisk heterocyklisk gruppe eller en 5- eller 6-leddet heteroarylgnippe, hvori nevnte grupper eventuelt er substituert med 1 til 3 grupper uavhengig valgt fra trifluormetyl, Calkyl, hydroksy, cyano, Calkoksy, trifluormetoksy, halogen eller S(0)qCalkyl; Rog Rrepresenterer uavhengig hydrogen, cyano, Calkyl; Rg er (CH)R; Rrepresenterer hydrogen, halogen, C.cykloalkyl, hydroksy, nitro, cyano eller C_alkyl eventuelt substituert med en eller to grupper valgt fra halogen, cyano, hydroksy eller C_alkoksy; Rio representerer hydrogen eller C_cykloalkyl; n representerer 1 eller 2; q er 0, 1 eller 2; r er 0 eller et heltall fra 1 til 4; eller et farmasøytisk akseptabelt salt eller solvat derav, fremgangsmåter for deres fremstilling og deres anvendelse ved behandling av tilstander mediert av takykininer og/eller ved selektiv inhibering av serotoningjenopptakningstransporterproteinet.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0326407.4A GB0326407D0 (en) | 2003-11-12 | 2003-11-12 | Chemical compounds |
| PCT/EP2004/012772 WO2005049600A1 (en) | 2003-11-12 | 2004-11-10 | Beta-lactams for treatment of cns disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20062661L true NO20062661L (no) | 2006-06-09 |
Family
ID=29726427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20062661A NO20062661L (no) | 2003-11-12 | 2006-06-09 | Beta-laktamer for behandling av CNS lidelser |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US20080262041A1 (no) |
| EP (1) | EP1689737B1 (no) |
| JP (1) | JP2007510692A (no) |
| KR (1) | KR20060118477A (no) |
| CN (1) | CN1878764A (no) |
| AR (1) | AR046233A1 (no) |
| AT (1) | ATE401321T1 (no) |
| AU (1) | AU2004291296B2 (no) |
| BR (1) | BRPI0416285A (no) |
| CA (1) | CA2546007A1 (no) |
| CY (1) | CY1108404T1 (no) |
| DE (1) | DE602004015144D1 (no) |
| DK (1) | DK1689737T3 (no) |
| ES (1) | ES2310295T3 (no) |
| GB (1) | GB0326407D0 (no) |
| HR (1) | HRP20080501T3 (no) |
| IL (1) | IL175279A0 (no) |
| IS (1) | IS8477A (no) |
| MA (1) | MA28156A1 (no) |
| MY (1) | MY138378A (no) |
| NO (1) | NO20062661L (no) |
| PL (1) | PL1689737T3 (no) |
| PT (1) | PT1689737E (no) |
| RU (1) | RU2006120417A (no) |
| SI (1) | SI1689737T1 (no) |
| TW (1) | TW200528439A (no) |
| WO (1) | WO2005049600A1 (no) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015200142B2 (en) * | 2006-01-24 | 2016-07-07 | Unilever Plc | Novel lactams |
| JP2009523834A (ja) * | 2006-01-24 | 2009-06-25 | バイオシグナル リミテッド | 新規ラクタム |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL130088C (no) * | 1960-03-14 | |||
| FR2676055B1 (fr) * | 1991-05-03 | 1993-09-03 | Sanofi Elf | Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| EP0545478A1 (en) * | 1991-12-03 | 1993-06-09 | MERCK SHARP & DOHME LTD. | Heterocyclic compounds as tachykinin antagonists |
| GB9200535D0 (en) * | 1992-01-10 | 1992-02-26 | Fujisawa Pharmaceutical Co | New compound |
| US5824690A (en) * | 1993-05-06 | 1998-10-20 | Hoechst Marion Roussel Inc. | Substituted pyrrolidin-3-yl-alkyl-piperidines |
| GB9317104D0 (en) * | 1993-08-17 | 1993-09-29 | Zeneca Ltd | Therapeutic heterocycles |
| GB9322643D0 (en) * | 1993-11-03 | 1993-12-22 | Zeneca Ltd | Lactam derivatives |
| MX9701305A (es) * | 1994-08-25 | 1998-05-31 | Merrell Pharma Inc | Piperidinas sustituidas novedosas utiles para el tratamiento de enfermedades alergicas. |
| US5780466A (en) * | 1995-01-30 | 1998-07-14 | Sanofi | Substituted heterocyclic compounds method of preparing them and pharmaceutical compositions in which they are present |
| TW332201B (en) * | 1995-04-06 | 1998-05-21 | Janssen Pharmaceutica Nv | 1,3-Dihydro-1-(phenylalkyl)-2H-imidazol-2-one derivatives |
| US6211199B1 (en) * | 1995-11-17 | 2001-04-03 | Aventis Pharmaceuticals Inc. | Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases |
| FR2779429B1 (fr) * | 1998-06-03 | 2000-07-13 | Synthelabo | Derives d'oxindole, leurs preparations et leurs applications en therapeutique |
| US6204265B1 (en) * | 1998-12-23 | 2001-03-20 | Schering Corporation | Substituted oximes and hydrazones as neurokinin antagonists |
| GB0114867D0 (en) * | 2001-06-18 | 2001-08-08 | Merck Sharp & Dohme | Therapeutic agents |
| GB0412865D0 (en) * | 2004-06-09 | 2004-07-14 | Glaxo Group Ltd | Chemical compounds |
-
2003
- 2003-11-12 GB GBGB0326407.4A patent/GB0326407D0/en not_active Ceased
-
2004
- 2004-11-10 EP EP04797809A patent/EP1689737B1/en not_active Expired - Lifetime
- 2004-11-10 DE DE602004015144T patent/DE602004015144D1/de not_active Expired - Lifetime
- 2004-11-10 WO PCT/EP2004/012772 patent/WO2005049600A1/en not_active Ceased
- 2004-11-10 AU AU2004291296A patent/AU2004291296B2/en not_active Ceased
- 2004-11-10 KR KR1020067009274A patent/KR20060118477A/ko not_active Abandoned
- 2004-11-10 PL PL04797809T patent/PL1689737T3/pl unknown
- 2004-11-10 AT AT04797809T patent/ATE401321T1/de active
- 2004-11-10 RU RU2006120417/04A patent/RU2006120417A/ru not_active Application Discontinuation
- 2004-11-10 HR HR20080501T patent/HRP20080501T3/xx unknown
- 2004-11-10 AR ARP040104145A patent/AR046233A1/es not_active Application Discontinuation
- 2004-11-10 SI SI200430872T patent/SI1689737T1/sl unknown
- 2004-11-10 TW TW093134192A patent/TW200528439A/zh unknown
- 2004-11-10 CA CA002546007A patent/CA2546007A1/en not_active Abandoned
- 2004-11-10 BR BRPI0416285-4A patent/BRPI0416285A/pt not_active IP Right Cessation
- 2004-11-10 JP JP2006538791A patent/JP2007510692A/ja active Pending
- 2004-11-10 DK DK04797809T patent/DK1689737T3/da active
- 2004-11-10 US US10/595,662 patent/US20080262041A1/en not_active Abandoned
- 2004-11-10 MY MYPI20044708A patent/MY138378A/en unknown
- 2004-11-10 ES ES04797809T patent/ES2310295T3/es not_active Expired - Lifetime
- 2004-11-10 PT PT04797809T patent/PT1689737E/pt unknown
- 2004-11-10 CN CNA2004800333979A patent/CN1878764A/zh active Pending
-
2006
- 2006-04-27 IL IL175279A patent/IL175279A0/en unknown
- 2006-05-11 MA MA29020A patent/MA28156A1/fr unknown
- 2006-05-22 IS IS8477A patent/IS8477A/is unknown
- 2006-06-09 NO NO20062661A patent/NO20062661L/no not_active Application Discontinuation
-
2008
- 2008-10-08 CY CY20081101120T patent/CY1108404T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2310295T3 (es) | 2009-01-01 |
| IS8477A (is) | 2006-05-22 |
| SI1689737T1 (sl) | 2008-12-31 |
| MA28156A1 (fr) | 2006-09-01 |
| CA2546007A1 (en) | 2005-06-02 |
| CN1878764A (zh) | 2006-12-13 |
| EP1689737B1 (en) | 2008-07-16 |
| TW200528439A (en) | 2005-09-01 |
| CY1108404T1 (el) | 2014-02-12 |
| DK1689737T3 (da) | 2008-10-27 |
| WO2005049600A1 (en) | 2005-06-02 |
| HRP20080501T3 (en) | 2008-11-30 |
| AR046233A1 (es) | 2005-11-30 |
| HK1094698A1 (en) | 2007-04-04 |
| AU2004291296B2 (en) | 2011-04-07 |
| BRPI0416285A (pt) | 2007-01-23 |
| PL1689737T3 (pl) | 2008-12-31 |
| IL175279A0 (en) | 2006-09-05 |
| AU2004291296A1 (en) | 2005-06-02 |
| DE602004015144D1 (de) | 2008-08-28 |
| ATE401321T1 (de) | 2008-08-15 |
| KR20060118477A (ko) | 2006-11-23 |
| JP2007510692A (ja) | 2007-04-26 |
| MY138378A (en) | 2009-05-29 |
| GB0326407D0 (en) | 2003-12-17 |
| RU2006120417A (ru) | 2007-12-27 |
| PT1689737E (pt) | 2008-10-24 |
| US20080262041A1 (en) | 2008-10-23 |
| EP1689737A1 (en) | 2006-08-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |