NO20062773L - Tiazoler og oksazoler nyttige som modulatorer av ATP-bindingskasettransportere - Google Patents

Tiazoler og oksazoler nyttige som modulatorer av ATP-bindingskasettransportere

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Publication number
NO20062773L
NO20062773L NO20062773A NO20062773A NO20062773L NO 20062773 L NO20062773 L NO 20062773L NO 20062773 A NO20062773 A NO 20062773A NO 20062773 A NO20062773 A NO 20062773A NO 20062773 L NO20062773 L NO 20062773L
Authority
NO
Norway
Prior art keywords
modulators
binding cassette
thiazoles
atp binding
cassette transporters
Prior art date
Application number
NO20062773A
Other languages
English (en)
Inventor
Mark T Miller
Peter D J Grooten-Huis
Matthew Hamilton
Sarah S Hadida Ruah
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of NO20062773L publication Critical patent/NO20062773L/no

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    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
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    • A61K31/42—Oxazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Ophthalmology & Optometry (AREA)
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  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Foreliggende oppfinnelse vedrører modulatorer av ATP-bindende kassett ("ABC")-transportører eller fragmenter derav; omfattende Cystisk Fibrose-Transmembran Regulator ("CFTR"), sammensetninger derav, og metoder dermed. Foreliggende oppfinnelse vedrører også fremgangsmåter for å behandle ABC-transportør-medierte sykdommer ved bruk av slike modulatorer.
NO20062773A 2003-11-14 2006-06-13 Tiazoler og oksazoler nyttige som modulatorer av ATP-bindingskasettransportere NO20062773L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52035503P 2003-11-14 2003-11-14
PCT/US2004/038566 WO2005049018A1 (en) 2003-11-14 2004-11-15 Thiazoles and oxazoles useful as modulators of atp-binding cassette transporters

Publications (1)

Publication Number Publication Date
NO20062773L true NO20062773L (no) 2006-08-08

Family

ID=34619457

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20062773A NO20062773L (no) 2003-11-14 2006-06-13 Tiazoler og oksazoler nyttige som modulatorer av ATP-bindingskasettransportere

Country Status (16)

Country Link
US (3) US7407976B2 (no)
EP (2) EP2140865A1 (no)
JP (1) JP4869072B2 (no)
KR (1) KR20060121185A (no)
CN (2) CN101675928A (no)
AT (1) ATE437640T1 (no)
AU (1) AU2004290581B2 (no)
CA (1) CA2545719A1 (no)
DE (1) DE602004022319D1 (no)
ES (1) ES2328824T3 (no)
MX (1) MXPA06005343A (no)
NO (1) NO20062773L (no)
NZ (1) NZ547220A (no)
RU (1) RU2006120549A (no)
WO (1) WO2005049018A1 (no)
ZA (1) ZA200604578B (no)

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