NO20062789L - Modifisering av proteinglykosylering i metylotrofisk gjaer - Google Patents

Modifisering av proteinglykosylering i metylotrofisk gjaer

Info

Publication number
NO20062789L
NO20062789L NO20062789A NO20062789A NO20062789L NO 20062789 L NO20062789 L NO 20062789L NO 20062789 A NO20062789 A NO 20062789A NO 20062789 A NO20062789 A NO 20062789A NO 20062789 L NO20062789 L NO 20062789L
Authority
NO
Norway
Prior art keywords
modification
protein glycosylation
methylotrophic yeasts
yeast strains
methylotrophic yeast
Prior art date
Application number
NO20062789A
Other languages
English (en)
Norwegian (no)
Inventor
Roland Henri Contreras
Nico L M Callewaert
Vladimir Kaigorodov
Wouter Vervecken
Original Assignee
Res Corp Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Res Corp Technologies Inc filed Critical Res Corp Technologies Inc
Publication of NO20062789L publication Critical patent/NO20062789L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
NO20062789A 2003-11-14 2006-06-14 Modifisering av proteinglykosylering i metylotrofisk gjaer NO20062789L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/713,970 US7507573B2 (en) 2003-11-14 2003-11-14 Modification of protein glycosylation in methylotrophic yeast
PCT/US2004/037936 WO2005049807A1 (en) 2003-11-14 2004-11-12 Modification of protein glycosylation in methylotrophic yeast

Publications (1)

Publication Number Publication Date
NO20062789L true NO20062789L (no) 2006-07-04

Family

ID=34573857

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20062789A NO20062789L (no) 2003-11-14 2006-06-14 Modifisering av proteinglykosylering i metylotrofisk gjaer

Country Status (9)

Country Link
US (2) US7507573B2 (de)
EP (1) EP1706480A4 (de)
JP (1) JP4794455B2 (de)
CN (1) CN1894398A (de)
AU (1) AU2004291886B2 (de)
CA (1) CA2545693C (de)
IL (1) IL175567A (de)
NO (1) NO20062789L (de)
WO (1) WO2005049807A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060034830A1 (en) * 2000-06-28 2006-02-16 Gerngross Tillman U Immunoglobulins comprising predominantly a GalGlcNAcMan5GLcNAc2 glycoform
EP1294910B1 (de) * 2000-06-30 2008-11-19 VIB vzw Modifikation der proteinglycosylierung in pichia pastoris
CN101084233B (zh) * 2004-04-29 2012-08-15 格利科菲公司 用于在糖蛋白产生中减少或消除α-甘露糖苷酶抗性聚糖的方法
WO2006071280A1 (en) * 2004-12-23 2006-07-06 Glycofi, Inc. Immunoglobulins comprising predominantly a ga1g1cnacman5glcnac2 glycoform
EP1934605B1 (de) * 2005-09-22 2014-03-26 Prosci Incorporated In hefemutanten produzierte glykosylierte polypeptide und verwendungsverfahren dafür
FR2912154B1 (fr) * 2007-02-02 2012-11-02 Glycode Levures genetiquement modifiees pour la production de glycoproteines homogenes
TW201028431A (en) * 2008-10-31 2010-08-01 Lonza Ag Novel tools for the production of glycosylated proteins in host cells
AU2010218139B2 (en) * 2009-02-25 2012-11-01 Merck Sharp & Dohme Corp. Metabolic engineering of a galactose assimilation pathway in the glycoengineered yeast Pichia pastoris
US20110092374A1 (en) * 2009-10-16 2011-04-21 Vib, Vzw Methods for producing substantially homogeneous hybrid or complex n-glycans in methylotrophic yeasts
EP2494050A4 (de) * 2009-10-30 2013-10-30 Merck Sharp & Dohme In glycoengineerter pichia pastoris hergestellter granulozytenkolonienstimulierender faktor
CA2790786C (en) 2010-02-24 2019-09-24 Zymenex A/S Process for production and purification of recombinant lysosomal alpha-mannosidase
CN103637156B (zh) * 2010-04-13 2015-03-25 丰益(上海)生物技术研发中心有限公司 奶酪风味物质的生产及其在食品中的应用
TW201209160A (en) * 2010-04-27 2012-03-01 Lonza Ag Improved glycosylation of proteins in host cells
CN104024849A (zh) 2011-08-12 2014-09-03 生命科技公司 用于高通量聚糖分析的装置、方法、计算机程序产品和试剂盒
DK2912162T3 (en) * 2012-10-23 2018-03-05 Research Corporation Tech Inc PICHIA PASTORIS TRIBES FOR PRODUCTION CONSIDERABLE UNIFORM GLYCAN STRUCTURE
US9764006B2 (en) 2012-12-10 2017-09-19 The General Hospital Corporation Bivalent IL-2 fusion toxins
US9944689B2 (en) 2013-03-07 2018-04-17 The General Hospital Corporation Human CTLA4 mutants and use thereof
WO2015100058A1 (en) * 2013-12-23 2015-07-02 Research Corporation Technologies, Inc. Pichia pastoris surface display system
SG11201700446XA (en) 2014-07-21 2017-02-27 Glykos Finland Oy Production of glycoproteins with mammalian-like n-glycans in filamentous fungi
WO2016077457A1 (en) 2014-11-11 2016-05-19 Clara Foods Co. Methods and compositions for egg white protein production
KR102378455B1 (ko) * 2016-05-03 2022-03-23 브이아이비 브이지더블유 진균의 엔지니어링된 숙주로부터 유래된 복합 글리칸의 생성 수단 및 방법
JP2021534763A (ja) * 2018-08-21 2021-12-16 クララ フーズ カンパニー 微生物におけるタンパク質のグリコシル化の修飾
KR20220034848A (ko) 2019-07-11 2022-03-18 클라라 푸드즈 컴퍼니 단백질 조성물 및 이의 섭취 가능한 제품
US12096784B2 (en) 2019-07-11 2024-09-24 Clara Foods Co. Protein compositions and consumable products thereof
US10927360B1 (en) 2019-08-07 2021-02-23 Clara Foods Co. Compositions comprising digestive enzymes
CN114058673A (zh) * 2021-09-15 2022-02-18 江苏先思达生物科技有限公司 一种脂肪肝检测试剂及其在脂肪肝检测中的应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE100142T1 (de) 1987-10-29 1994-01-15 Zymogenetics Inc Verfahren zur regulierung der proteinglycosylierung.
US5135854A (en) 1987-10-29 1992-08-04 Zymogenetics, Inc. Methods of regulating protein glycosylation
WO1991005057A1 (en) 1989-09-28 1991-04-18 The Salk Institute Biotechnology/Industrial Associates, Inc. Cd4 production in pichia pastoris
WO1992009694A2 (en) 1990-11-30 1992-06-11 Hsc Research And Development Limited Partnership CLONING OF UDP-N-ACETYLGLUCOSAMINE:α-3-D-MANNOSIDE β-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE I
ATE157703T1 (de) 1991-12-16 1997-09-15 Ciba Geigy Ag Endoplasmatisches retikulum-ständige rekombinante dibasische endoprotease und deren verwendungen
DE4301932A1 (de) 1992-08-07 1994-02-10 Boehringer Mannheim Gmbh Hefewirtsstämme mit Defekten in der N-Glycosylierung
US5834251A (en) 1994-12-30 1998-11-10 Alko Group Ltd. Methods of modifying carbohydrate moieties
JPH08336387A (ja) 1995-06-12 1996-12-24 Green Cross Corp:The ピキア属酵母由来の糖鎖伸長タンパク及びそのｄｎａ
DE60032370T2 (de) * 1999-08-19 2007-10-11 Kirin Beer K.K. Hefevarianten und verfahren zur herstellung von glykoprotein enthaltenden zuckerketten vom säugetiertyp
US7598055B2 (en) * 2000-06-28 2009-10-06 Glycofi, Inc. N-acetylglucosaminyltransferase III expression in lower eukaryotes
ES2252261T3 (es) 2000-06-28 2006-05-16 Glycofi, Inc. Metodos para producir glicoproteinas modificadas.
US7449308B2 (en) 2000-06-28 2008-11-11 Glycofi, Inc. Combinatorial DNA library for producing modified N-glycans in lower eukaryotes
EP1294910B1 (de) * 2000-06-30 2008-11-19 VIB vzw Modifikation der proteinglycosylierung in pichia pastoris
ES2411007T3 (es) * 2001-10-10 2013-07-04 Novo Nordisk A/S Remodelación y glicoconjugación de péptidos
CA2471551C (en) 2001-12-27 2014-09-30 Glycofi, Inc. Methods to engineer mammalian-type carbohydrate structures
US7972809B2 (en) * 2002-04-26 2011-07-05 National Institute Of Advanced Industrial Science & Technology Methylotrophic yeast producing mammalian type sugar chain
IL165717A0 (en) * 2002-06-26 2006-01-15 Flanders Interuniversity Inst A strain of methylotrophic yeast for producing proteins
AU2005233387B2 (en) 2004-04-15 2011-05-26 Glycofi, Inc. Production of galactosylated glycoproteins in lower eukaryotes

Also Published As

Publication number Publication date
EP1706480A1 (de) 2006-10-04
IL175567A0 (en) 2006-09-05
US20090263863A1 (en) 2009-10-22
JP2007511223A (ja) 2007-05-10
CA2545693C (en) 2013-07-30
WO2005049807A1 (en) 2005-06-02
IL175567A (en) 2014-01-30
EP1706480A4 (de) 2007-06-13
CA2545693A1 (en) 2005-06-02
US20050106664A1 (en) 2005-05-19
AU2004291886A1 (en) 2005-06-02
JP4794455B2 (ja) 2011-10-19
AU2004291886B2 (en) 2009-04-30
US7507573B2 (en) 2009-03-24
CN1894398A (zh) 2007-01-10
US8058053B2 (en) 2011-11-15

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