NO20063326L - Kombinasjon av (a) N-{5-[4-(4-metyl-piperazinometyl)-benzoylamid]-2-metylfenyl}-4-(3-pyridyl)-2-pyrimidinamin og (b) minst en hypusineringsinhibitor og anvendelse derav - Google Patents

Kombinasjon av (a) N-{5-[4-(4-metyl-piperazinometyl)-benzoylamid]-2-metylfenyl}-4-(3-pyridyl)-2-pyrimidinamin og (b) minst en hypusineringsinhibitor og anvendelse derav

Info

Publication number: NO20063326L
Authority: NO; Norway
Prior art keywords: combination; pyrimidinamine; methylphenyl; pyridyl; inhibitor
Prior art date: 2003-12-19

Application number

NO20063326A

Other languages

English (en)

Norwegian (no)

Inventor

Tim H Bruemmendorf

Stefan Balabanov

Ulrike Hartmann

Winfried Kammer

Alfred Nordheim

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-12-19

Filing date

2006-07-18

Publication date

2006-09-19

2006-07-18 Application filed by Novartis Ag filed Critical Novartis Ag

2006-09-19 Publication of NO20063326L publication Critical patent/NO20063326L/no

Links

239000003112 inhibitor Substances 0.000 title abstract 3
-1 4-methyl-piperazinomethyl Chemical group 0.000 title abstract 2
201000010099 disease Diseases 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
208000032839 leukemia Diseases 0.000 abstract 2
230000002062 proliferating effect Effects 0.000 abstract 2
239000005517 L01XE01 - Imatinib Substances 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
239000003937 drug carrier Substances 0.000 abstract 1
KTUFNOKKBVMGRW-UHFFFAOYSA-N imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 abstract 1
229960002411 imatinib Drugs 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Dermatology (AREA)
Oncology (AREA)
Hematology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)

NO20063326A 2003-12-19 2006-07-18 Kombinasjon av (a) N-{5-[4-(4-metyl-piperazinometyl)-benzoylamid]-2-metylfenyl}-4-(3-pyridyl)-2-pyrimidinamin og (b) minst en hypusineringsinhibitor og anvendelse derav NO20063326L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US53156303P	2003-12-19	2003-12-19
PCT/EP2004/014439 WO2005058320A1 (en)	2003-12-19	2004-12-17	COMBINATION OF (a) N-{5-[4-(4-METHYL-PIPERAZINO-METHYL)-BENZOYLAMIDO]-2METHYLPHENYL}-4-(3-PYRIDYL)-2-PYRIMIDINE-AMINE AND (b) AT LEAST ONE HYPUSINATION INHIBITOR AND THE USE THEREOF

Publications (1)

Publication Number	Publication Date
NO20063326L true NO20063326L (no)	2006-09-19

Family

ID=34700180

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20063326A NO20063326L (no)	2003-12-19	2006-07-18	Kombinasjon av (a) N-{5-[4-(4-metyl-piperazinometyl)-benzoylamid]-2-metylfenyl}-4-(3-pyridyl)-2-pyrimidinamin og (b) minst en hypusineringsinhibitor og anvendelse derav

Country Status (17)

Country	Link
US (1)	US20080139480A1 (pt)
EP (1)	EP1696917A1 (pt)
JP (1)	JP2007514699A (pt)
KR (1)	KR20060125810A (pt)
CN (1)	CN1889952A (pt)
AU (2)	AU2004298761A1 (pt)
BR (1)	BRPI0417759A (pt)
CA (1)	CA2547196A1 (pt)
EC (1)	ECSP066656A (pt)
IL (1)	IL176070A0 (pt)
MA (1)	MA28240A1 (pt)
MX (1)	MXPA06006925A (pt)
NO (1)	NO20063326L (pt)
RU (1)	RU2006125741A (pt)
TN (1)	TNSN06182A1 (pt)
WO (1)	WO2005058320A1 (pt)
ZA (1)	ZA200603904B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL2197440T3 (pl)	2007-08-31	2013-05-31	Janssen Pharmaceutica Nv	Kombinacje imazalilu i hydroksypirydonów
WO2009036753A2 (de) *	2007-09-20	2009-03-26	Schebo Biotech Ag	Neue pharmazeutika, verfahren zu ihrer herstellung und ihre verwendung in der medizinischen therapie
US8575187B2 (en)	2008-02-06	2013-11-05	Janssen Pharmaceutica, Nv	Combinations of anilinopyrimidines and pyrion compounds
CA2711762C (en)	2008-02-06	2016-11-01	Jan Pieter Hendrik Bosselaers	Combinations of phenylpyrroles and pyrion compounds
WO2010048712A1 (en) *	2008-10-31	2010-05-06	University Health Network	Ciclopirox and cytarabine for the treatment of leukemic disorders
AU2011261501B2 (en) *	2010-06-01	2016-01-21	Biotheryx, Inc.	Methods of treating hematologic malignancies using 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone
WO2011153197A1 (en) *	2010-06-01	2011-12-08	Biotheryx, Inc.	Hydroxypyridone derivatives, pharmaceutical compositions thereof, and their therapeutic use for treating proliferative diseases
AU2011263720B2 (en)	2010-06-10	2013-11-07	Janssen Pharmaceutica Nv	Combinations of pyrimethanil and monoterpenes
WO2012001028A1 (en)	2010-07-01	2012-01-05	Janssen Pharmaceutica Nv	Antimicrobial combinations of pyrion compounds with polyethyleneimines
CN103191110A (zh) *	2013-03-28	2013-07-10	中国科学院昆明植物研究所	环吡酮及环吡酮胺在制备防治黑色素瘤的药物中的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0227593A1 (en) *	1985-11-25	1987-07-01	The Hospital For Sick Children	Use of chelating agents
GB8528983D0 (en) *	1985-11-25	1986-01-02	Ciba Geigy Ag	Use of chelating agents
MY129541A (en) *	1996-06-25	2007-04-30	Novartis Ag	Substituded 3,5-diphenyl-1,2,4-triazoles and their use as pharmaceutical metal chelators
DK1379257T3 (da) *	2001-03-23	2009-12-14	Enzon Inc	Anticancer-profarmakon anvendende substituerede aromatiske syrer
AU2003251875A1 (en) *	2002-07-15	2004-02-02	Combinatorx, Incorporated	Combination therapy for the treatment of neoplasms

2004
- 2004-12-17 CN CNA2004800362740A patent/CN1889952A/zh active Pending
- 2004-12-17 KR KR1020067012061A patent/KR20060125810A/ko not_active Withdrawn
- 2004-12-17 WO PCT/EP2004/014439 patent/WO2005058320A1/en not_active Ceased
- 2004-12-17 AU AU2004298761A patent/AU2004298761A1/en not_active Abandoned
- 2004-12-17 US US10/583,107 patent/US20080139480A1/en not_active Abandoned
- 2004-12-17 RU RU2006125741/14A patent/RU2006125741A/ru not_active Application Discontinuation
- 2004-12-17 BR BRPI0417759-2A patent/BRPI0417759A/pt not_active IP Right Cessation
- 2004-12-17 CA CA002547196A patent/CA2547196A1/en not_active Abandoned
- 2004-12-17 JP JP2006544368A patent/JP2007514699A/ja active Pending
- 2004-12-17 EP EP04804040A patent/EP1696917A1/en not_active Withdrawn
- 2004-12-17 MX MXPA06006925A patent/MXPA06006925A/es not_active Application Discontinuation
2006
- 2006-05-16 ZA ZA200603904A patent/ZA200603904B/en unknown
- 2006-05-31 IL IL176070A patent/IL176070A0/en unknown
- 2006-06-15 TN TNP2006000182A patent/TNSN06182A1/en unknown
- 2006-06-19 EC EC2006006656A patent/ECSP066656A/es unknown
- 2006-06-26 MA MA29141A patent/MA28240A1/fr unknown
- 2006-07-18 NO NO20063326A patent/NO20063326L/no not_active Application Discontinuation
2009
- 2009-04-28 AU AU2009201694A patent/AU2009201694A1/en not_active Abandoned

Also Published As

Publication number	Publication date
AU2004298761A1 (en)	2005-06-30
JP2007514699A (ja)	2007-06-07
AU2009201694A1 (en)	2009-05-28
TNSN06182A1 (en)	2007-11-15
CA2547196A1 (en)	2005-06-30
US20080139480A1 (en)	2008-06-12
KR20060125810A (ko)	2006-12-06
MXPA06006925A (es)	2006-08-23
CN1889952A (zh)	2007-01-03
RU2006125741A (ru)	2008-01-27
ZA200603904B (en)	2007-09-26
WO2005058320A1 (en)	2005-06-30
IL176070A0 (en)	2006-10-05
MA28240A1 (fr)	2006-10-02
BRPI0417759A (pt)	2007-04-10
ECSP066656A (es)	2006-10-25
EP1696917A1 (en)	2006-09-06

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Legal Events

Date	Code	Title	Description
2010-07-19	FC2A	Withdrawal, rejection or dismissal of laid open patent application