NO20063456L - Azadecalin glukokortikoid reseptor modulatorer - Google Patents

Azadecalin glukokortikoid reseptor modulatorer

Info

Publication number
NO20063456L
NO20063456L NO20063456A NO20063456A NO20063456L NO 20063456 L NO20063456 L NO 20063456L NO 20063456 A NO20063456 A NO 20063456A NO 20063456 A NO20063456 A NO 20063456A NO 20063456 L NO20063456 L NO 20063456L
Authority
NO
Norway
Prior art keywords
receptor modulators
glucocorticoid receptor
azadecaline
compounds
methods
Prior art date
Application number
NO20063456A
Other languages
English (en)
Norwegian (no)
Inventor
Robin Douglas Clark
Paul Blaney
Nicholas C Ray
Christopher Hurley
Karen Williams
Hazel Hunt
David Clark
Original Assignee
Corcept Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corcept Therapeutics Inc filed Critical Corcept Therapeutics Inc
Publication of NO20063456L publication Critical patent/NO20063456L/no

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    • C07D217/02Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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    • C07D217/02Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
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    • C07D217/02Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
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    • C07D217/08Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with a hetero atom directly attached to the ring nitrogen atom
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    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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  • Animal Behavior & Ethology (AREA)
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  • Biomedical Technology (AREA)
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  • Diabetes (AREA)
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  • Pain & Pain Management (AREA)
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NO20063456A 2004-01-09 2006-07-26 Azadecalin glukokortikoid reseptor modulatorer NO20063456L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53546004P 2004-01-09 2004-01-09
PCT/US2005/000607 WO2005070893A2 (fr) 2004-01-09 2005-01-10 Composes d'azadecaline utilises en tant que modulateurs du recepteur glucocorticoide

Publications (1)

Publication Number Publication Date
NO20063456L true NO20063456L (no) 2006-09-26

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Application Number Title Priority Date Filing Date
NO20063456A NO20063456L (no) 2004-01-09 2006-07-26 Azadecalin glukokortikoid reseptor modulatorer

Country Status (18)

Country Link
US (2) US7678813B2 (fr)
EP (1) EP1761497B1 (fr)
JP (1) JP4851345B2 (fr)
KR (1) KR101135885B1 (fr)
CN (1) CN101119970A (fr)
AT (1) ATE407122T1 (fr)
AU (1) AU2005206497B2 (fr)
CA (1) CA2552419C (fr)
CY (1) CY1110491T1 (fr)
DE (1) DE602005009530D1 (fr)
DK (1) DK1761497T3 (fr)
ES (1) ES2313296T3 (fr)
IL (1) IL176706A (fr)
NO (1) NO20063456L (fr)
NZ (1) NZ548374A (fr)
PT (1) PT1761497E (fr)
WO (1) WO2005070893A2 (fr)
ZA (1) ZA200605634B (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE447572T1 (de) * 2005-01-26 2009-11-15 Hoffmann La Roche Phenylmethanonderivate und ihre verwendung als glycin-transporter-1-hemmer
TW200820977A (en) 2006-08-08 2008-05-16 Organon Nv Use of glucocorticoid receptor antagonists for treatment of infectious conditions
DE602008002644D1 (de) * 2007-06-25 2010-11-04 Terumo Corp Medizinische Vorrichtung
EP2532350A1 (fr) * 2007-10-17 2012-12-12 Laboratoire HRA Pharma Combinaisons pharmacéutiques avec un antagoniste du recepteur de glucocorticoide et un inhibiteur de la synthese du cortisol de traiter le syndrome de cushing
AU2009267016B2 (en) * 2008-07-01 2014-07-03 Corcept Therapeutics, Inc. Use of mifepristone for the treatment of Amyotrophic Lateral Sclerosis
KR20130106378A (ko) 2010-08-27 2013-09-27 코어셉트 쎄라퓨틱스, 잉크. 피리딜-아민 융합된 아자데칼린 조절제
US8829024B2 (en) 2011-01-07 2014-09-09 Corcept Therapeutics, Inc. Combination steroid and glucocorticoid receptor antagonist therapy
DK2685827T3 (en) * 2011-03-18 2016-05-17 Corcept Therapeutics Inc PYRIMIDIN -cyclohexyl- glucocorticoid receptor MODULATORS
US12226412B2 (en) 2012-05-25 2025-02-18 Corcept Therapeutics, Inc. Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
US8859774B2 (en) 2012-05-25 2014-10-14 Corcept Therapeutics, Inc. Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
FI3848027T3 (fi) 2013-11-25 2023-05-04 Corcept Therapeutics Inc Oktahydrofuusioituja atsadekaliiniglukokortikoidireseptorin modulaattoreita
ES2865334T3 (es) 2015-08-13 2021-10-15 Corcept Therapeutics Inc Método de diagnóstico diferencial de síndrome de Cushing dependiente de ACTH
CA3011728A1 (fr) 2016-01-19 2017-07-27 Corcept Therapeutics, Inc. Diagnostic differentiel du syndrome de cushing ectopique
IL297201A (en) 2016-03-01 2022-12-01 Corcept Therapeutics Inc Use of glucocorticoid receptor modulators to increase the activity of checkpoint inhibitors
CA3055076C (fr) 2017-03-31 2022-02-22 Corcept Therapeutics, Inc. Modulateurs du recepteur de glucocorticoides destines au traitement du cancer du col de l'uterus
US11234971B2 (en) 2018-12-19 2022-02-01 Corcept Therapeutics Incorporated Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent
WO2020132046A1 (fr) 2018-12-19 2020-06-25 Corcept Therapeutics Incorporated Méthodes de traitement du cancer comprenant l'administration d'un modulateur du récepteur des glucocorticoïdes et d'un agent chimiothérapeutique anticancéreux
FI3897589T3 (fi) 2018-12-19 2026-01-13 Corcept Therapeutics Inc Farmaseuttisia formulaatioita, jotka sisältävät relakorilanttia, heteroaryyliketonifusoitua atsekaliiniyhdistettä
JP7789561B2 (ja) 2019-02-22 2025-12-22 コーセプト セラピューティクス, インコーポレイテッド レラコリラント、ヘテロアリール-ケトン縮合アザデカリングルココルチコイド受容体調節物質の治療用途
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KR20240125035A (ko) 2021-12-21 2024-08-19 코어셉트 쎄라퓨틱스 인코포레이티드 이환 인다졸 글루코코르티코이드 수용체 길항제
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WO2024092195A1 (fr) 2022-10-28 2024-05-02 Corcept Therapeutics Incorporated Traitements de la sclérose latérale amyotrophique à l'aide de dazucorilant

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS322220B1 (fr) * 1954-11-30 1957-04-11
JP3160941B2 (ja) * 1991-06-17 2001-04-25 東レ株式会社 カルバゾール誘導体および免疫抑制剤
FR2697252B1 (fr) 1992-10-28 1994-12-09 Fournier Ind & Sante Dérivés de 1,2,3,5,6,7,8,8a-octahydro-5,5,8a-triméthyl-(8abeta)-6-isoquinolineamine, leur procédé de préparation et leur utilisation en thérapeutique.
TW200503994A (en) 2003-01-24 2005-02-01 Novartis Ag Organic compounds

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EP1761497B1 (fr) 2008-09-03
CN101119970A (zh) 2008-02-06
NZ548374A (en) 2010-05-28
DE602005009530D1 (de) 2008-10-16
WO2005070893A2 (fr) 2005-08-04
JP4851345B2 (ja) 2012-01-11
JP2007517894A (ja) 2007-07-05
US8324203B2 (en) 2012-12-04
KR20070009561A (ko) 2007-01-18
CY1110491T1 (el) 2015-04-29
US20100120759A1 (en) 2010-05-13
IL176706A (en) 2012-06-28
US7678813B2 (en) 2010-03-16
KR101135885B1 (ko) 2012-04-16
PT1761497E (pt) 2008-09-25
ATE407122T1 (de) 2008-09-15
IL176706A0 (en) 2006-10-31
CA2552419A1 (fr) 2005-08-04
ZA200605634B (en) 2007-12-27
HK1097409A1 (en) 2007-06-22
CA2552419C (fr) 2013-04-23
AU2005206497B2 (en) 2011-02-10
WO2005070893A3 (fr) 2007-01-18
EP1761497A2 (fr) 2007-03-14

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