NO20064329L - Derivater av heteroaryl-alkylkarbamater, fremgangsmate for fremstilling derav og anvendelse derav som FAAH enzyminhibitorer - Google Patents

Derivater av heteroaryl-alkylkarbamater, fremgangsmate for fremstilling derav og anvendelse derav som FAAH enzyminhibitorer

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Publication number
NO20064329L
NO20064329L NO20064329A NO20064329A NO20064329L NO 20064329 L NO20064329 L NO 20064329L NO 20064329 A NO20064329 A NO 20064329A NO 20064329 A NO20064329 A NO 20064329A NO 20064329 L NO20064329 L NO 20064329L
Authority
NO
Norway
Prior art keywords
group
optionally substituted
heteroaryl
alkylcarbamates
derivatives
Prior art date
Application number
NO20064329A
Other languages
English (en)
Norwegian (no)
Inventor
Regine Bartsch-Li
Christian Hoornaert
Ahmed Abouabdellah
Antoine Ravet
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of NO20064329L publication Critical patent/NO20064329L/no

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NO20064329A 2004-02-26 2006-09-25 Derivater av heteroaryl-alkylkarbamater, fremgangsmate for fremstilling derav og anvendelse derav som FAAH enzyminhibitorer NO20064329L (no)

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FR0401949A FR2866886B1 (fr) 2004-02-26 2004-02-26 Derives d'aryl-et d'heteroaryl-akylcarbamates, leur preparation et leur application en therapeutique
PCT/FR2005/000451 WO2005090292A1 (fr) 2004-02-26 2005-02-25 Derives d’heteroaryl-alkylcarbamates, leur preparation et leur application comme inhibiteurs de l’enzyme faah

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Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2866885B1 (fr) * 2004-02-26 2007-08-31 Sanofi Synthelabo Derives de piperidinylalkylcarbamates, leur prepation et leur application en therapeutique
FR2866884B1 (fr) * 2004-02-26 2007-08-31 Sanofi Synthelabo Derives d'aryl-et d'heteroaryl-piperidinecarboxylates, leur preparation et leur application en therapeutique
WO2008136382A1 (ja) 2007-04-26 2008-11-13 Takeda Pharmaceutical Company Limited 二環性化合物およびその医薬用途
WO2009070497A1 (en) * 2007-11-28 2009-06-04 Smithkline Beecham Corporation SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE
KR101799429B1 (ko) * 2010-05-03 2017-11-21 에스케이바이오팜 주식회사 신경 세포 사멸 또는 신경 퇴화를 억제하기 위한 약학적 조성물

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2866734A (en) * 1956-12-05 1958-12-30 Us Vitamin Corp 3-pyridylethyl 2, 4-oxazolidinediones and process
US3054794A (en) * 1958-01-17 1962-09-18 Us Vitamin Pharm Corp Process for preparing 3-(aminoalkyl)-oxazolidine-2, 4-diones
US3742022A (en) * 1967-05-08 1973-06-26 A Verbiscar Carbamate esters of physiologically active ph enenthylamines
US3876661A (en) * 1971-03-02 1975-04-08 Anthony J Verbiscar Carbamate esters of serotonin and analogs
DE19647382A1 (de) * 1996-11-15 1998-05-20 Hoechst Ag Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten
AU740588B2 (en) * 1997-11-24 2001-11-08 Scripps Research Institute, The Inhibitors of gap junction communication
US6509366B2 (en) * 2000-01-18 2003-01-21 Neurogen Corporation Substituted imidazoles as selective modulators of Bradykinin B2 receptors
MXPA03009850A (es) * 2001-04-27 2004-02-12 Bristol Myers Squibb Co Inhibidores de bisarilimidazolil de hidrolasa de amida del acido graso.
CA2483228C (en) * 2002-04-27 2011-07-05 Merck Patent Gesellschaft Mit Beschraenkter Haftung Carboxamides
FR2843964B1 (fr) * 2002-08-29 2004-10-01 Sanofi Synthelabo Derives de dioxane-2-alkylcarbamates, leur preparation et leur application en therapeutique
EP1558591B1 (de) * 2002-10-07 2014-05-07 The Regents of The University of California Modulation von angstzuständen durch blockade der anandamidhydrolyse
AU2003275493A1 (en) * 2002-10-08 2004-05-04 The Scripps Research Institute Inhibitors of fatty acid amide hydrolase
US7309701B2 (en) * 2002-11-19 2007-12-18 Sanofi-Aventis Deutschland Gmbh Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them
FR2850377B1 (fr) * 2003-01-23 2009-02-20 Sanofi Synthelabo Derives d'arylalkylcarbamates, leur preparation et leur application en therapeutique
FR2854633B1 (fr) * 2003-05-07 2005-06-24 Sanofi Synthelabo Derives de piperidinyl-et piperazinyl-alkylcarbamates, leur preparation et leur application en therapeutique
UA82695C2 (uk) * 2003-06-06 2008-05-12 Нисан Кемикал Индастриз, Лтд. Гетероароматичні сполуки як активатори рецептора тромбопоетину
JP2007527397A (ja) * 2003-07-01 2007-09-27 マイクロバイア インコーポレイテッド Ｃｏｘ−２及びｆａａｈ阻害剤
US7598412B2 (en) * 2003-10-08 2009-10-06 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
FR2866885B1 (fr) * 2004-02-26 2007-08-31 Sanofi Synthelabo Derives de piperidinylalkylcarbamates, leur prepation et leur application en therapeutique
EP1574511A1 (de) * 2004-03-03 2005-09-14 Bayer CropScience S.A. 2-Pyridinylethylcarboxamid-Derivate und ihre Verwendung als Fungizide
WO2007017728A2 (en) * 2005-08-05 2007-02-15 Orchid Research Laboratories Limited Novel heterocyclic compounds
RU2008115499A (ru) * 2005-09-22 2009-10-27 Санофи-Авентис (Fr) Новые производные аминокиламидов в качестве антагонистов лигандов рецепторов ccr3
FR2894578B1 (fr) * 2005-12-12 2008-02-01 Sanofi Aventis Sa Derives heterocycliques, leur preparation et leur application en therapeutique.
CA2640090A1 (en) * 2006-01-25 2007-08-02 Synta Pharmaceuticals Corp. Substituted aromatic compounds for inflammation and immune-related uses
JO2754B1 (en) * 2006-12-21 2014-03-15 استرازينكا ايه بي Amylendazoleil derivatives for the treatment of glucocorticoid-mediated disorders
US9549982B2 (en) * 2009-11-23 2017-01-24 Foundational Biosystems, Llc Ultra low dose nutraceutical compositions for enhancing sleep quality and treating sleep disorders

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TW200533637A (en) 2005-10-16
NZ550008A (en) 2010-06-25
AR047973A1 (es) 2006-03-15
ZA200606724B (en) 2007-12-27
IL177329A (en) 2012-01-31
RU2364586C2 (ru) 2009-08-20
CA2554609A1 (fr) 2005-09-29
CY1109716T1 (el) 2014-08-13
EP1720829A1 (de) 2006-11-15
FR2866886A1 (fr) 2005-09-02
SI1720829T1 (sl) 2010-02-26
JP2007524705A (ja) 2007-08-30
EP2251324A1 (de) 2010-11-17
HRP20100017T1 (hr) 2010-02-28
US20100069405A1 (en) 2010-03-18
AU2005223423A1 (en) 2005-09-29
DK1720829T3 (da) 2010-03-01
CN1926097A (zh) 2007-03-07
EP1720829B1 (de) 2009-10-14
IL177329A0 (en) 2006-12-10
RS51246B (sr) 2010-12-31
BRPI0508193A (pt) 2007-08-14
US20110237595A1 (en) 2011-09-29
US20070021426A1 (en) 2007-01-25
AU2005223423B2 (en) 2011-04-14
FR2866886B1 (fr) 2007-08-31
CN1926097B (zh) 2011-06-08
RU2006134026A (ru) 2008-04-10
DE602005017122D1 (de) 2009-11-26
US7645757B2 (en) 2010-01-12
PL1720829T3 (pl) 2010-03-31
JP4824668B2 (ja) 2011-11-30
KR20070011297A (ko) 2007-01-24
ES2334449T3 (es) 2010-03-10
MA28367A1 (fr) 2006-12-01
ATE445592T1 (de) 2009-10-15
HK1101759A1 (en) 2007-10-26
PT1720829E (pt) 2010-01-13
WO2005090292A1 (fr) 2005-09-29

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