NO20074311L - Kinazolinderivat med tyrosinkinase-inhiberendeaktivitet - Google Patents

Kinazolinderivat med tyrosinkinase-inhiberendeaktivitet

Info

Publication number
NO20074311L
NO20074311L NO20074311A NO20074311A NO20074311L NO 20074311 L NO20074311 L NO 20074311L NO 20074311 A NO20074311 A NO 20074311A NO 20074311 A NO20074311 A NO 20074311A NO 20074311 L NO20074311 L NO 20074311L
Authority
NO
Norway
Prior art keywords
substituted
alkyl group
hydrogen atom
tyrosine kinase
inhibitory activity
Prior art date
Application number
NO20074311A
Other languages
English (en)
Other versions
NO343403B1 (no
Inventor
Masaharu Kume
Kenji Matsuo
Naoki Omori
Masami Takayama
Aiko Omori
Takeshi Endo
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of NO20074311L publication Critical patent/NO20074311L/no
Publication of NO343403B1 publication Critical patent/NO343403B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

En forbindelse representert ved den generelle formel (I) eller et farmasøytisk aksepterbart salt derav eller et solvat av forbindelsen eller saltet: (I) hvor Rx representerer en gruppe representert ved formel (II): hvor representerer et hydrogenatom, en alkylgmppe som kan være substituert eller lignende,. Z representerer -O-, -N(R)- eller lignende, Rrepresenterer et hydrogenatom, en alkylgruppe eller lignende, Rrepresenterer et hydrogenatom, en alkylgruppe som kan være substituert eller lignende, R representerer et hydrogenatom, en alkylgruppe som kan være substituert eller lignende, Rrepresenterer en alkylgruppe som kan være substituert eller lignende, Wrepresenterer en ikke-aromatisk nitrogenert heterocyklisk gruppe som kan være substituert, og Rrepresenterer et hydrogenatom, en alkylgruppe som kan være substituert eller lignende; Rog Rrepresenterer uavhengig et hydrogenatom, en alkylgruppe som kan være substituert eller lignende; X representerer -O-, -S-, -N(R)- eller lignende; R representerer et hydrogenatom, en alkylgruppe eller lignende; og A representerer en fenylgruppe som kan være substituert eller lignende. Forbindelsen kan inhibere både EGF reseptor-tyrosinkinase og HER2 tyrosinkinase.
NO20074311A 2005-02-23 2007-08-23 Kinazolinderivat med tyrosinkinase-inhiberende aktivitet og farmasøytisk sammensetning NO343403B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2005047383 2005-02-23
JP2005156828 2005-05-30
PCT/JP2006/303125 WO2006090717A1 (ja) 2005-02-23 2006-02-22 チロシンキナーゼ阻害作用を有するキナゾリン誘導体

Publications (2)

Publication Number Publication Date
NO20074311L true NO20074311L (no) 2007-11-23
NO343403B1 NO343403B1 (no) 2019-02-25

Family

ID=36927355

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20074311A NO343403B1 (no) 2005-02-23 2007-08-23 Kinazolinderivat med tyrosinkinase-inhiberende aktivitet og farmasøytisk sammensetning

Country Status (16)

Country Link
US (2) US8202879B2 (no)
EP (1) EP1854789B1 (no)
JP (1) JP4137174B2 (no)
KR (1) KR100910333B1 (no)
CN (1) CN101163684B (no)
AU (1) AU2006216266C1 (no)
BR (1) BRPI0606905B1 (no)
CA (1) CA2599328C (no)
DK (1) DK1854789T3 (no)
ES (1) ES2431843T3 (no)
NO (1) NO343403B1 (no)
PL (1) PL1854789T3 (no)
PT (1) PT1854789E (no)
RU (1) RU2414457C2 (no)
TW (1) TWI372147B (no)
WO (1) WO2006090717A1 (no)

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KR100910333B1 (ko) * 2005-02-23 2009-07-31 시오노기세이야쿠가부시키가이샤 타이로신 키나아제 억제 활성을 갖는 퀴나졸린 유도체
CN101003514A (zh) * 2006-01-20 2007-07-25 上海艾力斯医药科技有限公司 喹唑啉衍生物、其制备方法及用途
US7547781B2 (en) * 2006-09-11 2009-06-16 Curis, Inc. Quinazoline based EGFR inhibitors containing a zinc binding moiety
CN101535279B (zh) 2006-09-11 2015-05-20 柯瑞斯公司 含锌结合基的喹唑啉基egfr抑制剂
ES2646630T3 (es) 2008-11-07 2017-12-14 Massachusetts Institute Of Technology Lipidoides aminoalcohólicos y usos de los mismos
TWI466872B (zh) * 2008-12-25 2015-01-01 Shionogi & Co 喹唑啉衍生物之製造方法
US9238716B2 (en) 2011-03-28 2016-01-19 Massachusetts Institute Of Technology Conjugated lipomers and uses thereof
KR102451116B1 (ko) * 2011-10-27 2022-10-06 메사추세츠 인스티튜트 오브 테크놀로지 약물 캡슐화 마이크로스피어를 형성할 수 있는, ｎ-말단 상에 관능화된 아미노산 유도체
CN103288756B (zh) * 2012-02-29 2016-04-20 江苏先声药物研究有限公司 一种喹唑啉中间体的甲醇溶剂合物及其制备方法
JP6464139B2 (ja) 2013-03-14 2019-02-06 コンバージーン・リミテッド・ライアビリティ・カンパニーＣｏｎｖｅｒｇｅｎｅ Ｌｌｃ ブロモドメイン含有タンパク質の阻害のための方法および組成物
EP3150573A4 (en) * 2014-05-29 2018-02-21 Shionogi & Co., Ltd. Method for producing alkynyl ketone derivative
PL3330267T3 (pl) * 2015-07-29 2022-04-04 Shionogi&Co., Ltd. Sól pochodnej chinazoliny lub jej kryształ oraz sposób wytwarzania soli pochodnej chinazoliny lub jej kryształu
KR20180086187A (ko) 2015-10-05 2018-07-30 더 트러스티이스 오브 콜롬비아 유니버시티 인 더 시티 오브 뉴욕 자가포식 유동의 활성체 및 포스포리파제 d 및 타우를 포함하는 단백질 응집물의 클리어런스 및 단백질질환의 치료
CA3006300C (en) 2015-11-25 2024-02-27 Convergene Llc Bicyclic bet bromodomain inhibitors and uses thereof
US20180030403A1 (en) 2016-07-28 2018-02-01 Bobban Subhadra Devices, systems and methods for the production of humanized gut commensal microbiota
JP7191446B2 (ja) * 2017-01-30 2022-12-19 塩野義製薬株式会社 キナゾリン誘導体を含有する固形製剤
EP4424379A3 (en) 2019-04-24 2024-10-30 Convergene Llc Small molecule bromodomain inhibitors and uses thereof

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US5409930A (en) 1991-05-10 1995-04-25 Rhone-Poulenc Rorer Pharmaceuticals Inc. Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
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Also Published As

Publication number Publication date
AU2006216266B2 (en) 2010-02-18
JPWO2006090717A1 (ja) 2008-07-24
RU2414457C2 (ru) 2011-03-20
DK1854789T3 (da) 2013-10-21
NO343403B1 (no) 2019-02-25
TWI372147B (en) 2012-09-11
EP1854789A4 (en) 2009-06-17
KR100910333B1 (ko) 2009-07-31
TW200640880A (en) 2006-12-01
EP1854789A1 (en) 2007-11-14
RU2007135023A (ru) 2009-03-27
BRPI0606905A2 (pt) 2009-07-28
US8202879B2 (en) 2012-06-19
CN101163684B (zh) 2012-08-29
AU2006216266C1 (en) 2010-08-26
EP1854789B1 (en) 2013-10-09
BRPI0606905B1 (pt) 2021-06-01
JP4137174B2 (ja) 2008-08-20
PT1854789E (pt) 2013-10-23
US20120123114A1 (en) 2012-05-17
US8349857B2 (en) 2013-01-08
PL1854789T3 (pl) 2014-03-31
AU2006216266A8 (en) 2009-04-02
CN101163684A (zh) 2008-04-16
AU2006216266A1 (en) 2006-08-31
CA2599328C (en) 2012-04-17
US20090143414A1 (en) 2009-06-04
KR20070098941A (ko) 2007-10-05
WO2006090717A1 (ja) 2006-08-31
ES2431843T3 (es) 2013-11-28
AU2006216266A2 (en) 2006-08-31
CA2599328A1 (en) 2006-08-31

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