NO20065695L - Fremgangsmate for fremstilling av perindopril og salter derav - Google Patents

Fremgangsmate for fremstilling av perindopril og salter derav

Info

Publication number
NO20065695L
NO20065695L NO20065695A NO20065695A NO20065695L NO 20065695 L NO20065695 L NO 20065695L NO 20065695 A NO20065695 A NO 20065695A NO 20065695 A NO20065695 A NO 20065695A NO 20065695 L NO20065695 L NO 20065695L
Authority
NO
Norway
Prior art keywords
preparation
salts
perindopril
oxopropyl
octahydro
Prior art date
Application number
NO20065695A
Other languages
English (en)
Other versions
NO337892B1 (no
Inventor
Marjo Merslavic
Janja Smid
Zdenka Tomisc
Original Assignee
Krka Tovarna Zdravil Dd Novo M
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34969318&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20065695(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Krka Tovarna Zdravil Dd Novo M filed Critical Krka Tovarna Zdravil Dd Novo M
Publication of NO20065695L publication Critical patent/NO20065695L/no
Publication of NO337892B1 publication Critical patent/NO337892B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Det er beskrevet en fremgangsmåte for fremstilling av ACE inhibitoren 2S,3aS,7aS)-l-((2S)-2-((( 1S)-1 - (etoksykarbonyl)butyl)amino)-l -oksopropyl)oktahydro-l H-indol-2-syre og av farmasøytisk akseptable salter derav så vel som mellomprodukter som er nyttige i nevnte fremgangsmåte.
NO20065695A 2004-05-14 2006-12-11 Fremgangsmåte for fremstilling av perindopril og salter derav NO337892B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SI200400143A SI21800A (sl) 2004-05-14 2004-05-14 Nov postopek sinteze perindoprila
SI200400235A SI21852A (sl) 2004-05-14 2004-08-05 Nov postopek sinteze perindoprila
PCT/EP2005/005048 WO2005113500A1 (en) 2004-05-14 2005-05-10 Process for the preparation of perindopril and salts thereof

Publications (2)

Publication Number Publication Date
NO20065695L true NO20065695L (no) 2006-12-11
NO337892B1 NO337892B1 (no) 2016-07-04

Family

ID=34969318

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20065695A NO337892B1 (no) 2004-05-14 2006-12-11 Fremgangsmåte for fremstilling av perindopril og salter derav

Country Status (17)

Country Link
US (1) US7674814B2 (no)
EP (1) EP1753720B1 (no)
JP (1) JP5032983B2 (no)
AU (1) AU2005245087B2 (no)
CA (1) CA2566754C (no)
CY (1) CY1115222T1 (no)
DK (1) DK1753720T3 (no)
EA (1) EA011322B1 (no)
ES (1) ES2466248T3 (no)
HR (1) HRP20140487T1 (no)
NO (1) NO337892B1 (no)
PL (1) PL1753720T3 (no)
PT (1) PT1753720E (no)
SI (3) SI21800A (no)
UA (1) UA83139C2 (no)
WO (1) WO2005113500A1 (no)
ZA (1) ZA200609915B (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1729739T (pt) * 2004-03-29 2016-12-01 Servier Lab Processo para a preparação de uma composição farmacêutica sólida
US7291745B2 (en) 2005-03-21 2007-11-06 Glenmark Pharmaceuticals Limited Process for the preparation of perindopril
JP2006290825A (ja) * 2005-04-13 2006-10-26 Shiono Chemical Co Ltd アルファ型ペリンドプリルエルブミンの製造法
SI22543A (sl) 2007-06-27 2008-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nove soli perindoprila
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
PH12018502155B1 (en) 2016-04-20 2024-03-27 Servier Lab Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid

Family Cites Families (41)

* Cited by examiner, † Cited by third party
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US4508729A (en) 1979-12-07 1985-04-02 Adir Substituted iminodiacids, their preparation and pharmaceutical compositions containing them
FR2503155A2 (fr) 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
IE52663B1 (en) 1980-04-02 1988-01-20 Warner Lambert Co Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids
US4350704A (en) 1980-10-06 1982-09-21 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
US4425355A (en) 1981-02-17 1984-01-10 Warner-Lambert Company Substituted acyl derivatives of chair form of octahydro-1H-indole-2-carboxylic acids
US4743450A (en) 1987-02-24 1988-05-10 Warner-Lambert Company Stabilized compositions
FR2620700B1 (fr) 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et leurs esters. application a la synthese de carboxyalkyl dipeptides
FR2620703B1 (fr) 1987-09-17 1991-10-04 Adir Procede de synthese industrielle de l'acide perhydroindole carboxylique - 2(2s, 3as, 7as). application a la synthese de carboxyalkyl dipeptides
FR2620699B1 (fr) 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et de leurs esters. application a la synthese de carboxyalkyl dipeptides
FR2620709B1 (fr) 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
US5258525A (en) 1991-03-27 1993-11-02 Mcneilab, Inc. Processes for preparing [2S-(2α,3aβ,7aβ)]octahydro-1H-indole-2-carboxylic acid and esters
SI9111842A (sl) 1991-11-25 1998-04-30 Krka Stabilna formulacija soli enalaprila, postopek za njeno pripravo in njena uporaba
SI9600169A (en) 1996-05-22 1997-12-31 Krka Tovarna Zdravil Process for preparation of compounds with ace inhibitory effect
FR2771010B1 (fr) 1997-11-19 2003-08-15 Adir Utilisation d'une combinaison d'un inhibiteur de l'enzyme de conversion de l'angiotensine et d'un diuretique pour le traitement des desordres microcirculatoires
FR2807037B1 (fr) 2000-03-31 2002-05-10 Adir NOUVEAU PROCEDE DE SYNTHESE DES ESTERS DE LA N-[(s)-1- CARBOXYBUTYL]-(S)-ALANINE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL
FR2807431B1 (fr) 2000-04-06 2002-07-19 Adir Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
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FR2811318B1 (fr) 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline gamma du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811320B1 (fr) 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline alpha du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
DE10131217A1 (de) 2001-06-28 2003-01-09 Solvay Pharm Gmbh 3-Phenyl-3,7-diazabicyclo 3,3,1 nonan-Verbindungen sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE60222160T2 (de) 2001-10-12 2008-06-12 Elan Pharma International Ltd., Athlone Zusammensetzungen mit einer kombination aus eigenschaften sofortiger freisetzung und kontrollierter freisetzung
EA007981B1 (ru) 2002-01-15 2007-02-27 Актавис Груп Хф. Фармацевтический состав, содержащий хинаприл или фармацевтически приемлемую его соль
ATE365714T1 (de) 2002-01-30 2007-07-15 Servier Lab Verfahren zur herstellung von hochreinem perindopril und zwischenverbindungen nützlich in der synthese
AU2003217916A1 (en) 2002-03-08 2003-09-22 Teva Pharmeceuticals Usa, Inc. Stable formulations of angiotensin converting enzyme (ace) inhibitors
FR2838648B1 (fr) 2002-04-18 2004-05-21 Servier Lab Nouveau sel de perindopril et les compositions pharmaceutiques qui le contiennent
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EP1603558B1 (en) * 2003-02-28 2008-05-21 Les Laboratoires Servier S.A. Process for preparation of perindopril and salts thereof
ATE307801T1 (de) 2003-02-28 2005-11-15 Servier Lab Verfahren zur synthese des (2s,3as,7as)- perhydroindol-2-carbonsäures und seiner estern, verwendung in der synthese von perindopril
EP1323729B1 (fr) 2003-03-12 2004-11-03 Les Laboratoires Servier Nouveau procédé de synthèse de l'acide (2S, 3aS, 7aS)-perhydroindole-2-carboxylique et de ses esters, et application à la synthèse du perindopril
SI1367061T1 (sl) * 2003-06-30 2006-04-30 Servier Lab Nov postopek za sintezo perindoprila in njegovih farmacevtsko sprejemljivih soli
US6869963B2 (en) 2003-07-11 2005-03-22 Sandoz Ag Stable pharmaceutical compositions containing an ACE inhibitor
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SI1367063T1 (sl) * 2003-07-31 2006-10-31 Servier Lab Nov postopek sinteze perindoprila in njegovih farmacevtsko sprejemljivih soli
ES2271497T3 (es) * 2003-07-31 2007-04-16 Les Laboratoires Servier Nuevo procedimiento de sintesis de perindopril y de sus sales farmaceuticamente aceptables.
DE60329648D1 (de) 2003-09-01 2009-11-26 Servier Lab Neues Verfahren zur Herstellung von Estern des N-((S)-1-Carboxybutyl)-(S)-alanins und seine Verwendung in der Synthese von Perindopril
EP1400531B1 (fr) 2003-09-30 2006-01-04 Les Laboratoires Servier Procédé de synthèse de la N-[(S)-1-carbéthoxybutyl]-(S)-alanine et application à la synthèse du perindopril
DK1403278T3 (da) 2003-09-30 2005-10-03 Servier Lab Syntesefremgangsmåde for N-[(S)-1-ethoxycarbonylbutyl]-(S)-alanin og anvendelse heraf ved syntesen af perindopril
GB2394660A (en) 2003-12-17 2004-05-05 Niche Generics Ltd Stabilisation of pharmaceutical compositions comprising ACE inhibitor by absence of acidic excipients having large specific surface area, eg silicon dioxide
PT1729739T (pt) 2004-03-29 2016-12-01 Servier Lab Processo para a preparação de uma composição farmacêutica sólida

Also Published As

Publication number Publication date
SI21800A (sl) 2005-12-31
NO337892B1 (no) 2016-07-04
US20080051584A1 (en) 2008-02-28
AU2005245087B2 (en) 2010-12-16
ZA200609915B (en) 2008-05-28
EA200602117A1 (ru) 2007-04-27
JP2007537189A (ja) 2007-12-20
SI21852A (sl) 2006-02-28
US7674814B2 (en) 2010-03-09
DK1753720T3 (da) 2014-06-30
JP5032983B2 (ja) 2012-09-26
EP1753720A1 (en) 2007-02-21
AU2005245087A1 (en) 2005-12-01
HRP20140487T1 (hr) 2014-07-04
SI1753720T1 (sl) 2014-08-29
PT1753720E (pt) 2014-08-04
EP1753720B1 (en) 2014-05-07
UA83139C2 (uk) 2008-06-10
WO2005113500A1 (en) 2005-12-01
EA011322B1 (ru) 2009-02-27
CY1115222T1 (el) 2017-01-04
CA2566754C (en) 2012-09-18
PL1753720T3 (pl) 2014-09-30
ES2466248T3 (es) 2014-06-09
CA2566754A1 (en) 2005-12-01

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