DK1753720T3 - Fremgangsmåde til fremstilling af perindopril og salte deraf - Google Patents

Fremgangsmåde til fremstilling af perindopril og salte deraf

Info

Publication number
DK1753720T3
DK1753720T3 DK05748048.5T DK05748048T DK1753720T3 DK 1753720 T3 DK1753720 T3 DK 1753720T3 DK 05748048 T DK05748048 T DK 05748048T DK 1753720 T3 DK1753720 T3 DK 1753720T3
Authority
DK
Denmark
Prior art keywords
perindopril
salts
preparation
Prior art date
Application number
DK05748048.5T
Other languages
English (en)
Inventor
Marjo Merslavic
Janja Smid
Zdenka Tomsic
Original Assignee
Servier S A Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34969318&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1753720(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Servier S A Lab filed Critical Servier S A Lab
Application granted granted Critical
Publication of DK1753720T3 publication Critical patent/DK1753720T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK05748048.5T 2004-05-14 2005-05-10 Fremgangsmåde til fremstilling af perindopril og salte deraf DK1753720T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SI200400143A SI21800A (sl) 2004-05-14 2004-05-14 Nov postopek sinteze perindoprila
SI200400235A SI21852A (sl) 2004-05-14 2004-08-05 Nov postopek sinteze perindoprila
PCT/EP2005/005048 WO2005113500A1 (en) 2004-05-14 2005-05-10 Process for the preparation of perindopril and salts thereof

Publications (1)

Publication Number Publication Date
DK1753720T3 true DK1753720T3 (da) 2014-06-30

Family

ID=34969318

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05748048.5T DK1753720T3 (da) 2004-05-14 2005-05-10 Fremgangsmåde til fremstilling af perindopril og salte deraf

Country Status (17)

Country Link
US (1) US7674814B2 (da)
EP (1) EP1753720B1 (da)
JP (1) JP5032983B2 (da)
AU (1) AU2005245087B2 (da)
CA (1) CA2566754C (da)
CY (1) CY1115222T1 (da)
DK (1) DK1753720T3 (da)
EA (1) EA011322B1 (da)
ES (1) ES2466248T3 (da)
HR (1) HRP20140487T1 (da)
NO (1) NO337892B1 (da)
PL (1) PL1753720T3 (da)
PT (1) PT1753720E (da)
SI (3) SI21800A (da)
UA (1) UA83139C2 (da)
WO (1) WO2005113500A1 (da)
ZA (1) ZA200609915B (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4948392B2 (ja) * 2004-03-29 2012-06-06 レ ラボラトア セルビエ 固形薬学的組成物を調製するためのプロセス
US7291745B2 (en) 2005-03-21 2007-11-06 Glenmark Pharmaceuticals Limited Process for the preparation of perindopril
JP2006290825A (ja) * 2005-04-13 2006-10-26 Shiono Chemical Co Ltd アルファ型ペリンドプリルエルブミンの製造法
SI22543A (sl) 2007-06-27 2008-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nove soli perindoprila
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
PH12018502155B1 (en) 2016-04-20 2024-03-27 Servier Lab Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid

Family Cites Families (41)

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US4508729A (en) * 1979-12-07 1985-04-02 Adir Substituted iminodiacids, their preparation and pharmaceutical compositions containing them
FR2503155A2 (fr) 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
US4350704A (en) * 1980-10-06 1982-09-21 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
IE52663B1 (en) 1980-04-02 1988-01-20 Warner Lambert Co Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids
US4425355A (en) * 1981-02-17 1984-01-10 Warner-Lambert Company Substituted acyl derivatives of chair form of octahydro-1H-indole-2-carboxylic acids
US4743450A (en) 1987-02-24 1988-05-10 Warner-Lambert Company Stabilized compositions
FR2620699B1 (fr) 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et de leurs esters. application a la synthese de carboxyalkyl dipeptides
FR2620703B1 (fr) * 1987-09-17 1991-10-04 Adir Procede de synthese industrielle de l'acide perhydroindole carboxylique - 2(2s, 3as, 7as). application a la synthese de carboxyalkyl dipeptides
FR2620700B1 (fr) 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et leurs esters. application a la synthese de carboxyalkyl dipeptides
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
US5258525A (en) * 1991-03-27 1993-11-02 Mcneilab, Inc. Processes for preparing [2S-(2α,3aβ,7aβ)]octahydro-1H-indole-2-carboxylic acid and esters
YU48602B (sh) * 1991-11-25 1998-12-23 Krka Tovarna Zdravil P.O. Postupak za dobijanje stabilne formulacije soli enalaprila
SI9600169A (en) 1996-05-22 1997-12-31 Krka Tovarna Zdravil Process for preparation of compounds with ace inhibitory effect
FR2771010B1 (fr) * 1997-11-19 2003-08-15 Adir Utilisation d'une combinaison d'un inhibiteur de l'enzyme de conversion de l'angiotensine et d'un diuretique pour le traitement des desordres microcirculatoires
FR2807037B1 (fr) 2000-03-31 2002-05-10 Adir NOUVEAU PROCEDE DE SYNTHESE DES ESTERS DE LA N-[(s)-1- CARBOXYBUTYL]-(S)-ALANINE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL
FR2807431B1 (fr) * 2000-04-06 2002-07-19 Adir Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
FR2807430B1 (fr) 2000-04-11 2002-05-17 Adir Nouveau procede de synthese des esters de la n-[(s)-1- carboxybutyl]-(s)-alanine et application a la synthese du perindopril
FR2811319B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline beta du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811320B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline alpha du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811318B1 (fr) 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline gamma du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
DE10131217A1 (de) * 2001-06-28 2003-01-09 Solvay Pharm Gmbh 3-Phenyl-3,7-diazabicyclo 3,3,1 nonan-Verbindungen sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
JP2005508939A (ja) * 2001-10-12 2005-04-07 エラン ファーマ インターナショナル，リミティド 即時放出および徐放特性を組み合わせて有する組成物
US20050118259A1 (en) 2002-01-15 2005-06-02 Renir Eyjolfsson Formulations of quinapril and related ace nhibitors
DK1333026T3 (da) 2002-01-30 2007-10-22 Servier Lab Fremgangsmåde til fremstilling af perindopril med höj renhed og nyttige mellemforbindelser til syntesen
WO2003075842A2 (en) 2002-03-08 2003-09-18 Teva Pharmeceuticals Usa, Inc. Stable formulations of angiotensin converting enzyme (ace) inhibitors
FR2838648B1 (fr) 2002-04-18 2004-05-21 Servier Lab Nouveau sel de perindopril et les compositions pharmaceutiques qui le contiennent
EP1511467A1 (en) * 2002-06-10 2005-03-09 Elan Pharma International Limited Nanoparticulate polycosanol formulations and novel polycosanol combinations
AU2003303583A1 (en) * 2002-12-23 2004-07-29 Power Measurement Ltd. Power monitoring integrated circuit with communication interface
PT1603558E (pt) * 2003-02-28 2008-08-19 Servier S A Lab Processo para a preparação de perindopril e dos seus sais
DK1338591T3 (da) * 2003-02-28 2006-01-23 Servier Lab Fremgangsmåde til syntese af (2S,3aS,7aS)-perhydroindol-2-carboxylsyre og estere heraf samt anvendelse heraf ved syntese af perindopril
ES2231760T3 (es) 2003-03-12 2005-05-16 Les Laboratoires Servier Nuevo procedimiento de sintesis del acido(2s, 3as,7as)perhidroindol-2-carboxilico y de sus esteres, y su aplicacion a la sintesis de perindopril.
ATE315043T1 (de) * 2003-06-30 2006-02-15 Servier Lab Verfahren für die synthese von perindopril und seiner pharmazeutischen annehmbaren salzen
US6869963B2 (en) * 2003-07-11 2005-03-22 Sandoz Ag Stable pharmaceutical compositions containing an ACE inhibitor
GB2404336A (en) 2003-07-30 2005-02-02 Cipla Ltd Stabilisation of therapeutic agents using a carbonate salt of an amino acid, preferably in the presence of a saccharide, & pharmaceutical compositions thereof
ATE338058T1 (de) * 2003-07-31 2006-09-15 Servier Lab Verfahren für die synthese von perindopril und seiner pharmazeutischen annehmbaren salzen
ES2271498T3 (es) * 2003-07-31 2007-04-16 Les Laboratoires Servier Nuevo procedimiento de sintesis de perindopril y de sus sales farmaceuticamente aceptables.
DE60329648D1 (de) 2003-09-01 2009-11-26 Servier Lab Neues Verfahren zur Herstellung von Estern des N-((S)-1-Carboxybutyl)-(S)-alanins und seine Verwendung in der Synthese von Perindopril
SI1403278T1 (en) 2003-09-30 2005-10-31 Les Laboratoires Servier Process for the synthesis of N-((S)-1-(ethoxycarbonyl)butyl)-(S)-alanine and use in the synthese of perindopril
ATE315046T1 (de) 2003-09-30 2006-02-15 Servier Lab Verfahren zur herstellung von n-((s)-1- (etoxycarbonyl)butyl)-(s)-alanin und verwendung in der synthese von perindopril
GB2394660A (en) 2003-12-17 2004-05-05 Niche Generics Ltd Stabilisation of pharmaceutical compositions comprising ACE inhibitor by absence of acidic excipients having large specific surface area, eg silicon dioxide
JP4948392B2 (ja) * 2004-03-29 2012-06-06 レ ラボラトア セルビエ 固形薬学的組成物を調製するためのプロセス

Also Published As

Publication number Publication date
PT1753720E (pt) 2014-08-04
NO20065695L (no) 2006-12-11
US20080051584A1 (en) 2008-02-28
ZA200609915B (en) 2008-05-28
CY1115222T1 (el) 2017-01-04
UA83139C2 (uk) 2008-06-10
WO2005113500A1 (en) 2005-12-01
AU2005245087B2 (en) 2010-12-16
US7674814B2 (en) 2010-03-09
SI21800A (sl) 2005-12-31
NO337892B1 (no) 2016-07-04
EA011322B1 (ru) 2009-02-27
JP2007537189A (ja) 2007-12-20
CA2566754C (en) 2012-09-18
CA2566754A1 (en) 2005-12-01
JP5032983B2 (ja) 2012-09-26
SI21852A (sl) 2006-02-28
SI1753720T1 (sl) 2014-08-29
EP1753720B1 (en) 2014-05-07
EA200602117A1 (ru) 2007-04-27
PL1753720T3 (pl) 2014-09-30
HRP20140487T1 (hr) 2014-07-04
EP1753720A1 (en) 2007-02-21
ES2466248T3 (es) 2014-06-09
AU2005245087A1 (en) 2005-12-01

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