NO20065957L - Metastinderivater og anvendelse derav - Google Patents

Metastinderivater og anvendelse derav

Info

Publication number
NO20065957L
NO20065957L NO20065957A NO20065957A NO20065957L NO 20065957 L NO20065957 L NO 20065957L NO 20065957 A NO20065957 A NO 20065957A NO 20065957 A NO20065957 A NO 20065957A NO 20065957 L NO20065957 L NO 20065957L
Authority
NO
Norway
Prior art keywords
metastine
derivatives
secretion
cancer
activity
Prior art date
Application number
NO20065957A
Other languages
English (en)
Norwegian (no)
Inventor
Chieko Kitada
Taiji Asami
Naoki Nishizawa
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34971534&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20065957(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of NO20065957L publication Critical patent/NO20065957L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity
    • C07K14/4703Inhibitors; Suppressors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06Antiabortive agents; Labour repressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30Oestrogens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10Antioedematous agents; Diuretics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Neurosurgery (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
NO20065957A 2004-06-25 2006-12-21 Metastinderivater og anvendelse derav NO20065957L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2004187671 2004-06-25
JP2004363311 2004-12-15
PCT/JP2005/012021 WO2006001499A2 (fr) 2004-06-25 2005-06-23 Derives de metastine et leur utilisation

Publications (1)

Publication Number Publication Date
NO20065957L true NO20065957L (no) 2007-01-25

Family

ID=34971534

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20065957A NO20065957L (no) 2004-06-25 2006-12-21 Metastinderivater og anvendelse derav

Country Status (20)

Country Link
US (2) US7625869B2 (fr)
EP (2) EP2113513B1 (fr)
JP (3) JP4346650B2 (fr)
CN (2) CN101845091A (fr)
AR (1) AR049938A1 (fr)
AU (1) AU2005257484A1 (fr)
BR (1) BRPI0512397A (fr)
CA (1) CA2571420A1 (fr)
CL (1) CL2008003730A1 (fr)
CR (1) CR8828A (fr)
IL (1) IL179640A0 (fr)
MA (1) MA28903B1 (fr)
MX (1) MXPA06014206A (fr)
NO (1) NO20065957L (fr)
NZ (1) NZ552029A (fr)
PE (2) PE20060371A1 (fr)
RU (1) RU2006145886A (fr)
SG (1) SG153865A1 (fr)
TW (1) TW200607816A (fr)
WO (1) WO2006001499A2 (fr)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003080149A2 (fr) 2002-03-20 2003-10-02 Mannkind Corporation Appareil d'inhalation
CN1761680A (zh) 2002-12-26 2006-04-19 武田药品工业株式会社 肿瘤迁移抑制素衍生物及其用途
CA2518541C (fr) 2003-03-12 2013-05-21 Takeda Pharmaceutical Company Limited Agents ameliorant la fonction gonadique
WO2005113147A2 (fr) 2004-04-08 2005-12-01 Biomatrica, Inc. Integration du stockage et de la gestion d'echantillons pour les sciences de la vie
CA2571420A1 (fr) 2004-06-25 2006-01-05 Takeda Pharmaceutical Company Limited Derives de metastine et leur utilisation
PL1786784T3 (pl) 2004-08-20 2011-04-29 Mannkind Corp Kataliza syntezy diketopiperazyn
KR101644250B1 (ko) 2004-08-23 2016-07-29 맨카인드 코포레이션 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염
CN104324362B (zh) 2005-09-14 2018-04-24 曼金德公司 以提高活性试剂对结晶微粒表面的亲和力为基础的药物配制方法
US20090093615A1 (en) * 2005-12-22 2009-04-09 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
AR058584A1 (es) 2005-12-22 2008-02-13 Takeda Pharmaceutical Derivados de metastina y uso de los mismos
US8404643B2 (en) * 2005-12-22 2013-03-26 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
IN2015DN00888A (fr) 2006-02-22 2015-07-10 Mannkind Corp
WO2007125619A1 (fr) * 2006-04-26 2007-11-08 Kyoto University Nouveau compose ayant une activite agoniste de gpr54
ITMI20061607A1 (it) 2006-08-09 2008-02-10 Maria Vincenza Carriero Peptidi con attivita farmacologica
JO3048B1 (ar) * 2006-10-25 2016-09-05 Takeda Pharmaceuticals Co مشتقات متاستين واستخدامها
ZA200902452B (en) * 2006-10-25 2010-07-28 Takeda Pharmaceutical Metastin derivatives and use thereof
EP2277900A4 (fr) 2008-04-24 2011-08-03 Takeda Pharmaceutical Dérivé de métastine et son utilisation
EP2275433B1 (fr) * 2008-04-30 2017-06-07 Kyoto University Dérivé de metastine et son utilisation
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
ES2929343T3 (es) 2008-06-13 2022-11-28 Mannkind Corp Inhalador de polvo seco accionado por aspiración para la administración de fármacos
KR101628410B1 (ko) 2008-06-20 2016-06-08 맨카인드 코포레이션 흡입 활동에 관한 실시간 프로파일링을 위한 대화형 장치 및 방법
LT2314609T (lt) * 2008-07-30 2017-04-10 Takeda Pharmaceutical Company Limited Metastino darinys ir jo panaudojimas
JP2012513982A (ja) 2008-12-29 2012-06-21 武田薬品工業株式会社 癌の予防・治療剤
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
WO2010137022A1 (fr) 2009-05-27 2010-12-02 Yeda Research And Development Co. Ltd Agonistes ou antagonistes de gpr54 utiles dans le traitement de maladies impliquant des anomalies du comportement
CN102665690A (zh) 2009-12-22 2012-09-12 武田药品工业株式会社 缓释制剂
IL223742A (en) 2010-06-21 2016-06-30 Mannkind Corp A dry powder inhaler and preparation for it
WO2012018639A2 (fr) 2010-07-26 2012-02-09 Biomatrica, Inc. Compositions de stabilisation d'adn, d'arn, de protéines salivaires et d'autres échantillons biologiques lors du transport et du stockage à températures ambiantes
EP2598660B1 (fr) 2010-07-26 2017-03-15 Biomatrica, INC. Compositions de stabilisation d'adn, d'arn, de protéines dans le sang et d'autres échantillons biologiques lors du transport et du stockage à températures ambiantes
AU2012236150B2 (en) 2011-04-01 2016-03-31 Mannkind Corporation Blister package for pharmaceutical cartridges
WO2012174472A1 (fr) 2011-06-17 2012-12-20 Mannkind Corporation Microparticules de dicétopipérazine de capacité élevée
EP2755690B1 (fr) 2011-08-04 2020-04-01 Merck Sharp & Dohme B.V. Conjugués du kisspeptide avec un pentasaccharide
BR112014009686A2 (pt) 2011-10-24 2018-08-07 Mannkind Corp composição analgésica inalável, pó seco e método para tratar dor
CN104350064A (zh) 2012-03-14 2015-02-11 耶达研究及发展有限公司 修饰的吻素肽和其用途
CN104619369B (zh) 2012-07-12 2018-01-30 曼金德公司 干粉药物输送系统和方法
US9725703B2 (en) 2012-12-20 2017-08-08 Biomatrica, Inc. Formulations and methods for stabilizing PCR reagents
WO2014119753A1 (fr) * 2013-01-31 2014-08-07 学校法人 東京薬科大学 Peptide inhibiteur de la myostatine
MX375448B (es) 2013-07-18 2025-03-06 Mannkind Corp Composiciones farmacéuticas en polvo seco estables al calor y métodos.
US10220069B2 (en) * 2014-01-22 2019-03-05 The Johns Hopkins University Compositions and methods for treating diabetes
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
ES2786373T3 (es) 2014-06-10 2020-10-09 Biomatrica Inc Estabilización de trombocitos a temperaturas ambiente
KR20250047404A (ko) 2015-12-08 2025-04-03 바이오매트리카 인코포레이티드 적혈구 침강 속도의 감소
TWI778979B (zh) 2016-09-30 2022-10-01 瑞士商麥歐文科學有限公司 治療女性不孕症之方法
CN109206481B (zh) 2017-07-05 2023-08-18 尚华医药科技(江西)有限公司 一种肽类化合物、其应用及含其的组合物
CN108752233B (zh) * 2018-07-18 2020-10-16 河北师范大学 小分子凝胶因子、凝胶材料及制备方法和应用
US20230159450A1 (en) * 2020-05-08 2023-05-25 The Feinstein Institutes For Medical Research Dimers for use in synthesis of peptidomimetics
WO2025217074A1 (fr) 2024-04-08 2025-10-16 Radionetics Oncology, Inc. Agents thérapeutiques ciblant le récepteur de la kisspeptine (kiss1r) et leurs utilisations

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1524747A (en) * 1976-05-11 1978-09-13 Ici Ltd Polypeptide
FR2488253A1 (fr) * 1980-08-08 1982-02-12 Roques Bernard Nouveaux peptides et leur application en therapeutique
IL74827A (en) * 1984-05-21 1989-06-30 Salk Inst For Biological Studi Peptides active as gnrh antagonists and pharmaceutical compositions containing them
MX9100717A (es) * 1990-08-24 1992-04-01 Syntex Inc Antagonistas de la bradiquinina
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
CN1200114A (zh) 1995-10-19 1998-11-25 武田药品工业株式会社 作为gnrh拮抗剂的喹啉衍生物
JPH09169735A (ja) 1995-10-19 1997-06-30 Takeda Chem Ind Ltd キノリン誘導体、その製造法および用途
JP2000510453A (ja) 1996-04-19 2000-08-15 ノボ ノルディスク アクティーゼルスカブ 成長ホルモン遊離特性を有する化合物
WO1998039448A2 (fr) 1997-03-07 1998-09-11 Human Genome Sciences, Inc. 186 nouvelles proteines secretees
JP4486187B2 (ja) 1998-10-27 2010-06-23 武田薬品工業株式会社 新規g蛋白質共役型レセプター蛋白質、そのdnaおよびそのリガンド
US6528054B1 (en) 1998-12-28 2003-03-04 Corixa Corporation Compositions and methods for the therapy and diagnosis of breast cancer
PL353057A1 (en) 1999-06-28 2003-10-06 Basf Aktiengesellschaft Method for preventing tumoral growth
US6638906B1 (en) 1999-12-13 2003-10-28 Nobex Corporation Amphiphilic polymers and polypeptide conjugates comprising same
JP2001231581A (ja) * 1999-12-17 2001-08-28 Takeda Chem Ind Ltd KiSS−1ペプチドの製造法
CN1411509A (zh) * 1999-12-17 2003-04-16 武田药品工业株式会社 Kiss-1肽的制造方法
JP2004526401A (ja) 2000-03-29 2004-09-02 コリクサ コーポレイション 肺癌の治療および診断のための組成物および方法
AU2001244609A1 (en) 2000-03-30 2001-10-15 Takeda Chemical Industries Ltd. Novel protein, dna thereof and process for producing the same
US7834141B1 (en) 2000-03-31 2010-11-16 Theresa Siler-Khodr Non-mammalian GnRH analogs and uses thereof in tumor cell growth regulation and cancer therapy
RU2311920C2 (ru) 2000-09-20 2007-12-10 Корикса Корпорейшн Композиции и способы для лечения и диагностики рака легких
JP2003026601A (ja) 2000-11-29 2003-01-29 Takeda Chem Ind Ltd 医薬組成物およびその製造法
JP2002320496A (ja) 2001-02-26 2002-11-05 Takeda Chem Ind Ltd 新規マウス型KiSS−1レセプタータンパク質およびそのDNA
WO2002085399A1 (fr) 2001-04-20 2002-10-31 Takeda Chemical Industries, Ltd. Preparations contenant un peptide
KR100599419B1 (ko) * 2001-05-17 2006-07-10 가부시키가이샤 시마즈세이사쿠쇼 펩티드의 제조법
US7112662B2 (en) * 2001-09-19 2006-09-26 Takeda Pharmaceutical Company Limited Anti-metasin antibodies and their methods of use
WO2003060125A1 (fr) 2002-01-11 2003-07-24 Takeda Chemical Industries, Ltd. Procede de production du peptide kiss-1
JP2003300906A (ja) 2002-04-12 2003-10-21 Daiichi Fine Chemical Co Ltd がん転移抑制因子の安定化
JPWO2004035089A1 (ja) * 2002-10-09 2006-02-09 協和醗酵工業株式会社 ホルモン依存性癌の治療剤
DE60327344D1 (de) 2002-10-25 2009-06-04 Takeda Pharmaceutical Gpr54 'knock-out' säugetiere und screening-verfahren, die sie verwenden
CN1761680A (zh) * 2002-12-26 2006-04-19 武田药品工业株式会社 肿瘤迁移抑制素衍生物及其用途
JP4804714B2 (ja) 2002-12-26 2011-11-02 武田薬品工業株式会社 メタスチン誘導体およびその用途
US6800611B2 (en) * 2003-01-06 2004-10-05 Takeda Chemical Industries, Ltd. Metastin derivatives and their use
KR100595364B1 (ko) 2003-02-20 2006-07-03 재단법인 목암생명공학연구소 Lk8 단백질을 유효성분으로 포함하는 항암제
CA2518541C (fr) 2003-03-12 2013-05-21 Takeda Pharmaceutical Company Limited Agents ameliorant la fonction gonadique
EP1464652A1 (fr) 2003-04-02 2004-10-06 Institut National De La Sante Et De La Recherche Medicale (Inserm) Agoniste et antagoniste du récepteur GPR54 utiles pour le traitement des maladies associées à la gonadotrophine
US20050002935A1 (en) 2003-04-17 2005-01-06 Vincent Ling Use of B7-H3 as an immunoregulatory agent
EP1618384A2 (fr) 2003-04-28 2006-01-25 Wyeth Procedes et compositions permettant de moduler le recepteur 54 couple a une proteine g
WO2004101747A2 (fr) 2003-05-07 2004-11-25 The General Hospital Corporation Identification et utilisation de gpr54 et de ses ligands pour les troubles de la reproduction et la contraception
EP1633702B1 (fr) 2003-05-30 2008-07-02 Prozymex A/S Inhibiteurs de protease
EP1688498B1 (fr) 2003-11-03 2011-03-09 Beijing Sunbio Biotech Co., Ltd. Proteine de recombinaison anticancereuse, ses genes codant et ses utilisations
RU2333221C2 (ru) 2003-11-03 2008-09-10 Бейцзин Санбио Байотек Ко., Лтд. Рекомбинантный белок, обладающий противораковым действием, кодирующий его ген и его применение
WO2005095973A2 (fr) 2004-03-25 2005-10-13 Bayer Healthcare Ag Methodes diagnostiques et therapeutiques pour des maladies associees au recepteur 54 couple a la proteine g (gpr54)
JP2007533748A (ja) 2004-04-23 2007-11-22 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ 不妊症の処置のためのgpcr54リガンドの使用
CA2571420A1 (fr) 2004-06-25 2006-01-05 Takeda Pharmaceutical Company Limited Derives de metastine et leur utilisation
WO2007084211A2 (fr) 2005-11-11 2007-07-26 The General Hospital Corporation Utilisation de ligands du gpr54 pour le traitement de troubles de la reproduction, de troubles proliferatifs et pour la contraception
US8404643B2 (en) * 2005-12-22 2013-03-26 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
AR058584A1 (es) * 2005-12-22 2008-02-13 Takeda Pharmaceutical Derivados de metastina y uso de los mismos
US20090099334A1 (en) * 2005-12-22 2009-04-16 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
US20090093615A1 (en) * 2005-12-22 2009-04-09 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
MX2008012055A (es) 2006-03-20 2008-10-02 Merck & Co Inc Agonistas del receptor de neuromedina u y usos de los mismos.
US20100215637A1 (en) * 2006-03-28 2010-08-26 Biopharmica Ltd Agent for the Treatment of Hormone-Dependent Disorders and Uses Thereof
JO3048B1 (ar) 2006-10-25 2016-09-05 Takeda Pharmaceuticals Co مشتقات متاستين واستخدامها
CA2701612A1 (fr) * 2007-10-05 2009-04-09 Takeda Pharmaceutical Company Limited Derive de neuromedine u
EP2277900A4 (fr) 2008-04-24 2011-08-03 Takeda Pharmaceutical Dérivé de métastine et son utilisation
EP2340047A1 (fr) 2008-09-19 2011-07-06 Nektar Therapeutics Conjugués de polymère de peptides kiss1

Also Published As

Publication number Publication date
EP2113513A3 (fr) 2010-11-03
PE20091567A1 (es) 2009-11-03
IL179640A0 (en) 2007-05-15
EP2113513A2 (fr) 2009-11-04
SG153865A1 (en) 2009-07-29
JP4346650B2 (ja) 2009-10-21
WO2006001499A2 (fr) 2006-01-05
AR049938A1 (es) 2006-09-13
JP2008506632A (ja) 2008-03-06
US8778871B2 (en) 2014-07-15
BRPI0512397A (pt) 2008-03-04
WO2006001499A3 (fr) 2006-03-02
CA2571420A1 (fr) 2006-01-05
MXPA06014206A (es) 2007-02-14
CN101863971A (zh) 2010-10-20
RU2006145886A (ru) 2008-06-27
EP2113513B1 (fr) 2016-05-18
CN101845091A (zh) 2010-09-29
MA28903B1 (fr) 2007-10-01
US7625869B2 (en) 2009-12-01
EP1758932A2 (fr) 2007-03-07
US20080312155A1 (en) 2008-12-18
JP4654284B2 (ja) 2011-03-16
JP2009227687A (ja) 2009-10-08
CR8828A (es) 2007-07-19
TW200607816A (en) 2006-03-01
AU2005257484A1 (en) 2006-01-05
JP2009024028A (ja) 2009-02-05
PE20060371A1 (es) 2006-06-15
NZ552029A (en) 2009-01-31
US20090298765A1 (en) 2009-12-03
CL2008003730A1 (es) 2009-05-04

Similar Documents

Publication Publication Date Title
NO20065957L (no) Metastinderivater og anvendelse derav
DK3911648T3 (da) 6'-[[(1s,3s)-3-[[5-(difluormethoxy)-2-pyrimidinyl]amino]cyclopentyl]amino][1(2h),3'-bipyridin]-2-on som pcsk9-hæmmer og fremgangsmåder til anvendelse deraf
DK1799235T3 (da) Sammensætninger af fosterhudcelleprotein til behandling af hudtilstande, -lidelser eller -sygdomme og fremgangsmåder til fremstilling og anvendelse deraf
EA200870446A1 (ru) Пиридон сульфонамиды и пиридон сульфамиды в качестве ингибиторов мек
DK1751302T3 (da) Analytsensorer og fremgangsmåder til fremstilling og anvendelse heraf
EA200801291A1 (ru) Карбониламинопирролопиразолы в качестве эффективных ингибиторов киназ
DK2089369T3 (da) 2,4-pyrimidindiaminderivater som hæmmere af JAK-kinaser til behandling af autoimmune sygdomme
NO20082595L (no) Metastinderivater og deres anvendelse derav
WO2009143024A3 (fr) Composés et procédés de modulation des kinases, et indications associées
TN2009000128A1 (en) Dihydropyridine derivatives useful as protein kinase inhibitors
NO20070983L (no) Stabil injiserbar blanding av alfa-tokoferylsuksinat, analoger og salter derav
MXPA06011327A (es) Azaindoles utiles como inhibidores de jak y otras proteinas cinasas.
NO20076413L (no) Multisykliske forbindelser og fremgangsmater for deres anvendelse
NO20064976L (no) Azanidoler som er nyttige som inhibitorer av rock og andre proteinkinaser
EA200802213A1 (ru) Способы лечения заболеваний крови
EP1584923A3 (fr) Stabilisation de biomolecules dans des échantillons
NO20062876L (no) Sammensetninger til kombinert radio- og kjemoterapi, og fremgangsmater
MY175797A (en) Agonists of src homology-2 containing protein tyrosine phosphatase-1 and treatment methods using the same
MY144970A (en) Heterocyclic compounds
NO20081713L (no) Pyrimidinderivater og deres anvendelse som KCNQ-kaliumkanalapnere
NO20070640L (no) Forbedrede aprotininvananter
MX2008001538A (es) Aril piridinas y metodos para su uso.
EA200800357A1 (ru) Новые фармацевтические соединения
UA87494C2 (en) Azaindoles useful as inhibitors of jak and other protein kinases
EA200700648A1 (ru) 4-((феноксиалкил)тио)феноксиуксусные кислоты и аналоги

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application