NO20071253L - Fremgangsmate for syntese av C-2, C-3 substituerte N-alkylerte indoler anvendbare som CPLA2-inhibitorer. - Google Patents

Fremgangsmate for syntese av C-2, C-3 substituerte N-alkylerte indoler anvendbare som CPLA2-inhibitorer.

Info

Publication number
NO20071253L
NO20071253L NO20071253A NO20071253A NO20071253L NO 20071253 L NO20071253 L NO 20071253L NO 20071253 A NO20071253 A NO 20071253A NO 20071253 A NO20071253 A NO 20071253A NO 20071253 L NO20071253 L NO 20071253L
Authority
NO
Norway
Prior art keywords
synthesis
substituted
cpla2 inhibitors
indoles useful
compound
Prior art date
Application number
NO20071253A
Other languages
English (en)
Inventor
Panolil Raveendranath
Ronald Stanley Michalak
Mahmut Levent
Frederick J Vyverberg
Ara R Boyajian
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of NO20071253L publication Critical patent/NO20071253L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/14—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/38—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Foreliggende oppfinnelse tilveiebringer metode for fremstilling av en forbindelse med formelen 1: som omfatter trinnene med omsetning av forbindelser med formel 2 og 3: for å fremstille en forbindelse med formelen 4: hvor R1, R2, R3, R4 og R5 er definert som beskrevet her. Forbindelsen med formel 4 blir deretter omdannet til forbindelsen med formel 1. Oppfinnelsen omfatter videre forbindelser med formel 3 og 4 og metoder for fremstilling av forbindelser med formel 3 og 4.
NO20071253A 2004-08-19 2007-03-07 Fremgangsmate for syntese av C-2, C-3 substituerte N-alkylerte indoler anvendbare som CPLA2-inhibitorer. NO20071253L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60312404P 2004-08-19 2004-08-19
PCT/US2005/029338 WO2006023611A1 (en) 2004-08-19 2005-08-18 Process for the synthesis c-2, c-3 substituted n-alkylated indoles useful as cpla2 inhibitors

Publications (1)

Publication Number Publication Date
NO20071253L true NO20071253L (no) 2007-05-15

Family

ID=35219553

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20071253A NO20071253L (no) 2004-08-19 2007-03-07 Fremgangsmate for syntese av C-2, C-3 substituerte N-alkylerte indoler anvendbare som CPLA2-inhibitorer.

Country Status (24)

Country Link
US (3) US7582772B2 (no)
EP (1) EP1778629B1 (no)
JP (1) JP2008510707A (no)
KR (1) KR20070043036A (no)
CN (2) CN101830837A (no)
AR (1) AR053410A1 (no)
AT (1) ATE517084T1 (no)
AU (1) AU2005277392A1 (no)
BR (1) BRPI0514431A (no)
CA (1) CA2576008A1 (no)
CR (1) CR8936A (no)
EC (1) ECSP077244A (no)
GT (1) GT200500224A (no)
HN (1) HN2005000474A (no)
IL (1) IL181364A0 (no)
MX (1) MX2007002042A (no)
NO (1) NO20071253L (no)
PE (1) PE20060628A1 (no)
RU (1) RU2401829C2 (no)
SG (1) SG155214A1 (no)
SV (1) SV2006002200A (no)
TW (1) TW200609214A (no)
UA (1) UA85428C2 (no)
WO (1) WO2006023611A1 (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7605156B2 (en) 2001-12-03 2009-10-20 Wyeth Methods for the use of inhibitors of cytosolic phospholipase A2
US7713964B2 (en) * 2001-12-03 2010-05-11 Wyeth Llc Methods for treating asthmatic conditions
US7342119B2 (en) * 2003-09-30 2008-03-11 Wyeth Holdings Corporation Process for the synthesis of a CPLA2 inhibitor
HN2004000536A (es) 2003-12-16 2009-02-18 Wyeth Corp Un procediemiento de sintesis para la alquilacion reductiva de la posicon c-3 de indoles
TW200718687A (en) * 2005-05-27 2007-05-16 Wyeth Corp Inhibitors of cytosolic phospholipase A2
WO2008055148A2 (en) * 2006-10-31 2008-05-08 Wyeth Semi-solid formulations of phospholipase enzyme inhibitors
CL2007003143A1 (es) * 2006-10-31 2008-01-25 Wyeth Corp Composicion farmaceutica que comprende un compuesto derivado de indol y un sistema portador que comprende 10-50% de un primer solubilizante, 5-50% de un segundo solubilizante, 10-30% de un primer diluyente y 1-15% de un segundo diluyente; proceso de prepracion; y forma de dosificacion.

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02115157A (ja) * 1988-10-24 1990-04-27 Hokko Chem Ind Co Ltd スルホニルグリシン誘導体および除草剤
UA81596C2 (en) * 1999-12-09 2008-01-25 Авентис Кропсаенс Гмбх Nitro-sulfobenzamides
US6984735B2 (en) * 2001-12-03 2006-01-10 Wyeth Process for making an aldehyde
US7605156B2 (en) 2001-12-03 2009-10-20 Wyeth Methods for the use of inhibitors of cytosolic phospholipase A2
US7713964B2 (en) * 2001-12-03 2010-05-11 Wyeth Llc Methods for treating asthmatic conditions
US6797708B2 (en) * 2001-12-03 2004-09-28 Wyeth Inhibitors of cytosolic phospholipase A2
US7101875B2 (en) * 2001-12-03 2006-09-05 Wyeth Methods for treating arthritic disorders
HUP0402577A3 (en) * 2001-12-03 2011-05-30 Wyeth Corp Indole derivatives as inhibitors of cytosolic phospholipase a2, process for producing them and pharmaceutical compositions containing them
US6635771B2 (en) * 2001-12-03 2003-10-21 Wyeth N-benzhydryl indole compounds
TW200510305A (en) * 2003-07-25 2005-03-16 Wyeth Corp Process for the preparation of CPLA2 inhibitors
WO2005012235A1 (en) 2003-07-29 2005-02-10 Ciba Specialty Chemicals Holding Inc. 3-aryl-2-cyano-3-hydroxy-acrylic acid derivatives
US7582771B2 (en) * 2003-09-03 2009-09-01 Wyeth Process for the synthesis of cPLA2 inhibitors
US7342119B2 (en) * 2003-09-30 2008-03-11 Wyeth Holdings Corporation Process for the synthesis of a CPLA2 inhibitor
HN2004000536A (es) * 2003-12-16 2009-02-18 Wyeth Corp Un procediemiento de sintesis para la alquilacion reductiva de la posicon c-3 de indoles

Also Published As

Publication number Publication date
CN101006048B (zh) 2011-07-06
ECSP077244A (es) 2007-03-29
KR20070043036A (ko) 2007-04-24
JP2008510707A (ja) 2008-04-10
HN2005000474A (es) 2009-04-07
AR053410A1 (es) 2007-05-09
US20060041005A1 (en) 2006-02-23
TW200609214A (en) 2006-03-16
AU2005277392A1 (en) 2006-03-02
CN101006048A (zh) 2007-07-25
US8034960B2 (en) 2011-10-11
GT200500224A (es) 2006-03-21
EP1778629B1 (en) 2011-07-20
RU2401829C2 (ru) 2010-10-20
US7582772B2 (en) 2009-09-01
SG155214A1 (en) 2009-09-30
US20090306428A1 (en) 2009-12-10
ATE517084T1 (de) 2011-08-15
US7842837B2 (en) 2010-11-30
EP1778629A1 (en) 2007-05-02
PE20060628A1 (es) 2006-08-14
US20110054189A1 (en) 2011-03-03
UA85428C2 (ru) 2009-01-26
CN101830837A (zh) 2010-09-15
SV2006002200A (es) 2006-05-09
BRPI0514431A (pt) 2008-06-10
CR8936A (es) 2007-04-26
RU2007105231A (ru) 2008-09-27
IL181364A0 (en) 2007-07-04
CA2576008A1 (en) 2006-03-02
MX2007002042A (es) 2007-03-29
WO2006023611A1 (en) 2006-03-02

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