TR200401488T4 - CNS bozukluklarının tedavisinde faydalı indol türevleri - Google Patents

CNS bozukluklarının tedavisinde faydalı indol türevleri

Info

Publication number
TR200401488T4
TR200401488T4 TR2004/01488T TR200401488T TR200401488T4 TR 200401488 T4 TR200401488 T4 TR 200401488T4 TR 2004/01488 T TR2004/01488 T TR 2004/01488T TR 200401488 T TR200401488 T TR 200401488T TR 200401488 T4 TR200401488 T4 TR 200401488T4
Authority
TR
Turkey
Prior art keywords
alkyl
heteroaryl
aryl
indole derivatives
treatment
Prior art date
Application number
TR2004/01488T
Other languages
English (en)
Inventor
Felding Jakop
Bang-Andersen Benny
Paul Smith Garrick
Andersen Kim
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of TR200401488T4 publication Critical patent/TR200401488T4/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Mevcut bulus formül I' in FORMÜL (I) R1' in hidrojen veya istege bagli olarak ikame edilen C1-6-alkil, C2-6-alkenil, C2-6-alkinil, C3-8-sikloalkil veya C3-8sikloalkil-C1-6-alkil oldugu, veya R1' in istege bagli olarak ikame edilen aril, aril-C1-6-alkil, heteroaril, heteroaril-C1-6-alkil oldugu, veya R1' in R' ve R''' in hidrojen ve istege bagli olarak ikame edilen C1-6-alkil, aril, aril-C1-6-alkil, heteroaril ve heteroaril-C1-6-alkil arasindan bagimsiz olarak seçildigi -NR'R'' oldugu, veya R1' in O veya S arasindan seçilen bir, iki veya üç hetero atom ve R9' un hidrojen veya istege bagli olarak ikame edilen C1-6alkil oldugu N-R9 grubunu içeren doymus veya kismi olarak doymus 5-ila 6-üyeli bir halka oldugu; R2' nin C1-6-alkil oldugu W, n, X, R3-R8' in tanimda açiklandigi gibi oldugu; ikame edilmis indol türevleriyle ilgilidir. Bulusun bilesikleri güçlü dopamin D4 ligandlaridir.
TR2004/01488T 2000-07-21 2001-07-17 CNS bozukluklarının tedavisinde faydalı indol türevleri TR200401488T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200001123 2000-07-21

Publications (1)

Publication Number Publication Date
TR200401488T4 true TR200401488T4 (tr) 2004-08-23

Family

ID=8159625

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2004/01488T TR200401488T4 (tr) 2000-07-21 2001-07-17 CNS bozukluklarının tedavisinde faydalı indol türevleri

Country Status (28)

Country Link
US (1) US6743809B2 (tr)
EP (1) EP1305307B1 (tr)
JP (1) JP2004504396A (tr)
KR (1) KR100851793B1 (tr)
CN (1) CN1264838C (tr)
AR (1) AR029858A1 (tr)
AT (1) ATE266024T1 (tr)
AU (2) AU8173801A (tr)
BG (1) BG107528A (tr)
BR (1) BR0112998A (tr)
CA (1) CA2416212C (tr)
CZ (1) CZ301114B6 (tr)
DE (1) DE60103162T2 (tr)
EA (1) EA004749B1 (tr)
ES (1) ES2219554T3 (tr)
HR (1) HRP20030015A2 (tr)
HU (1) HUP0302820A3 (tr)
IL (2) IL153605A0 (tr)
IS (1) IS2172B (tr)
MX (1) MXPA02012927A (tr)
NO (1) NO323799B1 (tr)
NZ (1) NZ523436A (tr)
PT (1) PT1305307E (tr)
SK (1) SK286701B6 (tr)
TR (1) TR200401488T4 (tr)
UA (1) UA73995C2 (tr)
WO (1) WO2002008223A1 (tr)
ZA (1) ZA200300287B (tr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA06004626A (es) 2003-11-17 2006-06-27 Boehringer Ingelheim Int Indoles sustituidos con piperidina o sus heteroderivados y su uso como moduladores del receptor de quemocina (ccr3).
TWI391387B (zh) * 2004-05-12 2013-04-01 Eisai R&D Man Co Ltd 具有哌啶環之吲哚衍生物
WO2006117314A2 (en) 2005-04-30 2006-11-09 Boehringer Ingelheim International Gmbh Novel piperidin- substituted indoles and their use as ccr-3 modulators
ATE537166T1 (de) 2006-10-27 2011-12-15 Boehringer Ingelheim Int Piperidylpropanthiole als ccr3-modulatoren
CN101486654B (zh) * 2009-03-04 2012-10-10 西安近代化学研究所 2-甲基-3-硝基苯乙酸合成方法
CN110041318B (zh) * 2018-01-17 2022-07-29 中国科学院上海药物研究所 一类多巴胺d5受体激动剂及其制备和应用
CN110498789B (zh) * 2018-05-17 2022-04-05 上海医药工业研究院 芳烷哌啶类衍生物及其在多靶点抗抑郁症中的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2322470A1 (de) * 1973-05-04 1974-11-21 Boehringer Sohn Ingelheim Neue indolyl-piperidino-(bzw. 1,2,5,6tetrahydro-pyridyl-)butyrophenone und verfahren zu ihrer herstellung
AT332401B (de) * 1973-11-26 1976-09-27 Roussel Uclaf Verfahren zur herstellung von neuen (4'-(3''-indolyl)-piperidino)-alkylarylketonderivaten
GB8719167D0 (en) 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
PH24976A (en) * 1987-08-13 1990-12-26 Glaxo Group Ltd Indole derivatives
AU675964B2 (en) * 1992-08-05 1997-02-27 John Wyeth & Brother Limited Amide derivatives
KR960701865A (ko) * 1993-04-22 1996-03-28 데이비드 존. 우드 편두통에 사용하는 5-HT1 유사 효능제인 인돌 유도체(Indole Derivatives as 5-HT, -Like Agonists for Use in Migraine)
ES2063700B1 (es) * 1993-04-28 1995-07-16 Vita Invest Sa Agente activo sobre el sistema nervioso central, proceso para su preparacion y composiciones farmaceuticas que lo contengan.
US5576321A (en) * 1995-01-17 1996-11-19 Eli Lilly And Company Compounds having effects on serotonin-related systems
GB9718712D0 (en) * 1997-09-03 1997-11-12 Merck Sharp & Dohme Theraputic Agents

Also Published As

Publication number Publication date
IL153605A (en) 2008-07-08
UA73995C2 (en) 2005-10-17
SK286701B6 (sk) 2009-03-05
CA2416212C (en) 2007-10-30
IS2172B (is) 2006-11-15
CA2416212A1 (en) 2002-01-31
IS6663A (is) 2002-12-23
BR0112998A (pt) 2003-06-24
NO20030127D0 (no) 2003-01-10
US20030166664A1 (en) 2003-09-04
HUP0302820A2 (hu) 2003-12-29
ES2219554T3 (es) 2004-12-01
US6743809B2 (en) 2004-06-01
NO323799B1 (no) 2007-07-09
KR20030017643A (ko) 2003-03-03
EP1305307A1 (en) 2003-05-02
HUP0302820A3 (en) 2006-04-28
PT1305307E (pt) 2004-09-30
CZ301114B6 (cs) 2009-11-11
EA004749B1 (ru) 2004-08-26
AU2001281738B2 (en) 2006-12-21
HK1059782A1 (en) 2004-07-16
IL153605A0 (en) 2003-07-06
HRP20030015A2 (en) 2005-02-28
CN1264838C (zh) 2006-07-19
BG107528A (bg) 2003-10-31
CZ2003196A3 (cs) 2003-05-14
EP1305307B1 (en) 2004-05-06
WO2002008223A1 (en) 2002-01-31
CN1451002A (zh) 2003-10-22
DE60103162T2 (de) 2005-05-04
NZ523436A (en) 2004-07-30
KR100851793B1 (ko) 2008-08-13
AU8173801A (en) 2002-02-05
AR029858A1 (es) 2003-07-16
MXPA02012927A (es) 2003-05-15
PL359157A1 (en) 2004-08-23
JP2004504396A (ja) 2004-02-12
NO20030127L (no) 2003-01-10
SK2032003A3 (en) 2003-06-03
ZA200300287B (en) 2004-03-02
ATE266024T1 (de) 2004-05-15
EA200300179A1 (ru) 2003-06-26
DE60103162D1 (de) 2004-06-09

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