NO20071685L - Tricykliske adamantylamidderivater som 11-beta hydroksysteroid-dehydrogenaseinhibitorer - Google Patents

Tricykliske adamantylamidderivater som 11-beta hydroksysteroid-dehydrogenaseinhibitorer

Info

Publication number
NO20071685L
NO20071685L NO20071685A NO20071685A NO20071685L NO 20071685 L NO20071685 L NO 20071685L NO 20071685 A NO20071685 A NO 20071685A NO 20071685 A NO20071685 A NO 20071685A NO 20071685 L NO20071685 L NO 20071685L
Authority
NO
Norway
Prior art keywords
tricyclic
hydroxysteroid dehydrogenase
dehydrogenase inhibitors
beta hydroxysteroid
adamantylamide
Prior art date
Application number
NO20071685A
Other languages
English (en)
Inventor
Louis Jozef Elisabeth Va Veken
Joannes Theodorus Mari Linders
Gustaaf Henri Maria Willemsens
Libuse Jaroskova
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2005/054198 external-priority patent/WO2006024628A1/en
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO20071685L publication Critical patent/NO20071685L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
    • C07D209/64—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles with an oxygen atom in position 1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Forbindelser med formel (I) og (I '^) er nyttige som 1 IBETA-HSDl-inhibitorer for behandling av obesitet.
NO20071685A 2004-08-30 2007-03-30 Tricykliske adamantylamidderivater som 11-beta hydroksysteroid-dehydrogenaseinhibitorer NO20071685L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04104147 2004-08-30
US60784004P 2004-09-08 2004-09-08
PCT/EP2005/054198 WO2006024628A1 (en) 2004-08-30 2005-08-26 Tricyclic lactam derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors

Publications (1)

Publication Number Publication Date
NO20071685L true NO20071685L (no) 2007-03-30

Family

ID=35432565

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20071685A NO20071685L (no) 2004-08-30 2007-03-30 Tricykliske adamantylamidderivater som 11-beta hydroksysteroid-dehydrogenaseinhibitorer

Country Status (3)

Country Link
US (3) US9150512B2 (no)
DE (1) DE602005017159D1 (no)
NO (1) NO20071685L (no)

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2510945A (en) 1945-04-24 1950-06-13 Us Agriculture Nu-cyclohexyl nicotinamide
US2524643A (en) 1947-12-04 1950-10-03 Maltbie Lab Inc 3-phenyl-2-piperidones
US3201466A (en) 1963-03-08 1965-08-17 Gulf Oil Corp Substituted cyclopropanecarboxanilide herbicides
FR1399615A (fr) 1963-03-08 1965-05-21 Chemical Investors Sa Nouveaux composés chimiques et composition herbicide contenant ceux-ci
US3526656A (en) 1967-05-25 1970-09-01 Parke Davis & Co (1-arylcyclobutyl)carbonyl carbamic acid derivatives
US3622567A (en) 1968-05-13 1971-11-23 Little Inc A Norcamphane derivatives
NL6917600A (no) 1968-11-29 1970-06-02
US3919313A (en) 1973-07-23 1975-11-11 Schering Corp Novel 1-N-({60 -aminoacetyl) aminoadamantanes
HU177576B (en) 1975-06-02 1981-11-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing 2-amino-cyclohexane carboxylic acid,its amides and similar compounds
EP0117462A3 (en) 1983-02-28 1986-08-20 American Cyanamid Company N-(2-4-(1h-imidazol-1-yl)alkyl)arylamides
CH655103A5 (de) 1983-03-11 1986-03-27 Sandoz Ag Azolderivate, verfahren zu ihrer herstellung und ihre verwendung.
JPH0386853A (ja) 1989-05-23 1991-04-11 Sankyo Co Ltd 置換フェノール誘導体およびその用途
CA2017287A1 (en) 1989-05-23 1990-11-23 Shunji Naruto Substituted phenol derivatives and their use
FR2653123B1 (fr) 1989-10-17 1992-01-17 Roussel Uclaf Nouveaux derives de la pyridone, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
CA2053340C (en) 1990-10-18 2002-04-02 Timothy P. Burkholder Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
DE4035961A1 (de) 1990-11-02 1992-05-07 Thomae Gmbh Dr K Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
GB9312893D0 (en) 1993-06-22 1993-08-04 Boots Co Plc Therapeutic agents
FR2714291B1 (fr) 1993-12-24 1996-03-01 Roussel Uclaf Application des dérivés de la pyridone à titre de médicaments anesthésiques.
JPH10504545A (ja) 1994-07-29 1998-05-06 藤沢薬品工業株式会社 ベンゾジアゼピン誘導体
US5776959A (en) 1995-06-05 1998-07-07 Washington University Anticonvulsant and anxiolytic lactam and thiolactam derivatives
US6211199B1 (en) 1995-11-17 2001-04-03 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
WO1997019074A1 (en) 1995-11-17 1997-05-29 Hoechst Marion Roussel, Inc. Substituted 4-(1h-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
PL327146A1 (en) 1995-12-14 1998-11-23 Merck & Co Inc Antagonists of the gonadotrophin liberating hormone
US6194406B1 (en) 1995-12-20 2001-02-27 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
WO1997022604A1 (en) 1995-12-20 1997-06-26 Hoechst Marion Roussel, Inc. Novel substituted 4-(1h-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
US6423704B2 (en) 1995-12-20 2002-07-23 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
AU4172197A (en) 1996-09-10 1998-04-02 Pharmacia & Upjohn Company 8-hydroxy-7-substituted quinolines as anti-viral agents
AU771358B2 (en) 1997-11-21 2004-03-18 Astrazeneca Ab Metabotropic glutamate receptor antagonists for treating central nervous system diseases
CO5180581A1 (es) 1999-09-30 2002-07-30 Pfizer Prod Inc Compuestos para el tratamiento de la isquemia ciones farmaceuticas que los contienen para el tratamiento de la isquemia
US6867299B2 (en) 2000-02-24 2005-03-15 Hoffmann-La Roche Inc. Oxamide IMPDH inhibitors
CA2402384A1 (en) 2000-03-16 2001-09-20 Inflazyme Pharmaceuticals Ltd. Benzylated pde4 inhibitors
SE0001899D0 (sv) 2000-05-22 2000-05-22 Pharmacia & Upjohn Ab New compounds
AU2001296961A1 (en) 2000-09-29 2002-04-08 Bayer Pharmaceuticals Corporation 17-beta-hydroxysteroid dehydrogenase-ii inhibitors
WO2003065983A2 (en) 2002-02-01 2003-08-14 Merck & Co., Inc. 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia
AR040241A1 (es) 2002-06-10 2005-03-23 Merck & Co Inc Inhibidores de la 11-beta-hidroxiesteroide deshidrogrenasa 1 para el tratamiento de la diabetes obesidad y dislipidemia
WO2004056744A1 (en) 2002-12-23 2004-07-08 Janssen Pharmaceutica N.V. Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors
TW200503994A (en) 2003-01-24 2005-02-01 Novartis Ag Organic compounds
WO2004075847A2 (en) 2003-02-21 2004-09-10 Message Pharmaceuticals, Inc. METHODS AND COMPOUNDS FOR THE TREATMENT OF Aß­ ASSOCIATED DISEASES, DISORDERS, AND CONDITIONS
WO2004089416A2 (en) 2003-04-11 2004-10-21 Novo Nordisk A/S Combination of an 11beta-hydroxysteroid dehydrogenase type 1 inhibitor and an antihypertensive agent
WO2004089415A2 (en) 2003-04-11 2004-10-21 Novo Nordisk A/S COMBINATIONS OF AN 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITOR AND A GLUCOCORTICOID RECEPTOR AGONIST
DE602004027171D1 (de) 2003-04-11 2010-06-24 High Point Pharmaceuticals Llc Verbindungen mit Aktivität an der 11Beta-Hydroxasteroiddehydrogenase
US20050245534A1 (en) 2004-04-29 2005-11-03 Link James T Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme
CA2565630C (en) 2004-05-07 2013-05-28 Janssen Pharmaceutica N.V. Pyrrolidin-2-one and piperidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
EP1747198B1 (en) 2004-05-07 2008-06-04 Janssen Pharmaceutica N.V. Adamantyl pyrrolidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
MY141198A (en) 2004-08-30 2010-03-31 Janssen Pharmaceutica Nv Tricyclic adamantylamide derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
CN101300005B (zh) 2004-08-30 2013-05-01 詹森药业有限公司 作为11-β羟类固醇脱氢酶抑制剂的N-2金刚烷基-2-苯氧基-乙酰胺衍生物

Also Published As

Publication number Publication date
US20160002229A1 (en) 2016-01-07
US9422284B2 (en) 2016-08-23
US9630921B2 (en) 2017-04-25
US9150512B2 (en) 2015-10-06
DE602005017159D1 (de) 2009-11-26
US20140179732A1 (en) 2014-06-26
US20160318865A1 (en) 2016-11-03

Similar Documents

Publication Publication Date Title
WO2009016462A3 (en) Substituted bicyclolactam compounds
NO20074959L (no) Substituerte pyridinderivater
NO20075809L (no) DNA-PK inhibitorer
NO20084912L (no) Bisykliske derivater som CETP-inhibitorer
NO20061157L (no) 4-pyramidonderivater og deres anvendelse som peptidylpeptidmeinbibitorer
NO20070933L (no) Indazoler anvendbare i behandling av kardiovaskulaere sykdommer
NO20074666L (no) Imidazo(1,2-A)pyridinforbindelser som VEGF-R2-inhibitorer
NO20075082L (no) Pyridin-3-karboksamidderivater som CB1-inversagonister
AP2006003633A0 (en) Benzenesulfonylamino-pyridin-2-yl derivatives and related compounds as inhibitors of 11-BETA-hydroxysteroid dehydrogenase type 1 (11-BETA-HSD-1) for the treatment of diabetes and obesity
NO20062561L (no) Kinoliner nyttige for behandling av kardiovaskulaere sykdommer
NO20080675L (no) P38-Map kinaseinhibitorer og metoder for deres anvendelse
EA200501348A1 (ru) Замещенные арильные и гетероарильные производные, используемые в качестве модуляторов метаболизма глюкозы и для профилактики и лечения связанных с ним расстройств
NO20073849L (no) Indolderivater for behandling av virale infeksjoner
NO20082594L (no) Pyrimidinylbenzotiofenforbindelser
NO20092412L (no) Hydantoinderivater anvendes som MMP-inhibitorer
NO20044995L (no) Heterosykliske forbindelser
NO20083480L (no) Piperidinoylpyrrolidiner som melanokortin type 4 reseptor agonister
ATE449099T1 (de) Derivate des 2-trifluormethyl-6-aminopurins als phosphodiesterase 4 inhibitoren
NO20082496L (no) Pyrazinderivater
NO20082096L (no) Azaindol-2-karboksamidderivativer
NO20065320L (no) Imidazolderivater anvendt som tafiainhibitorer
NO20082214L (no) 1,1-Diokso-tiomorfolinyl-indolyl-metanonderivater for anvendelse som H3-modulatorer
NO20071805L (no) Alkylidentetrahydronaftalenderivater, fremgangsmate for deres fremstilling og deres anvendelse som betennelseshemmere.
NO20070550L (no) Fremgangsmate for fremstilling av pyrrolotriazinforbindelser
ATE419242T1 (de) Pyrrolidinylharnstoffderivate als angiogeneseinhibitoren

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application