NO20072004L - Substituerte kromanderivater, medikamenter og anvendelse i terapi - Google Patents

Substituerte kromanderivater, medikamenter og anvendelse i terapi

Info

Publication number
NO20072004L
NO20072004L NO20072004A NO20072004A NO20072004L NO 20072004 L NO20072004 L NO 20072004L NO 20072004 A NO20072004 A NO 20072004A NO 20072004 A NO20072004 A NO 20072004A NO 20072004 L NO20072004 L NO 20072004L
Authority
NO
Norway
Prior art keywords
drugs
therapy
chroman derivatives
substituted chroman
substituted
Prior art date
Application number
NO20072004A
Other languages
English (en)
Inventor
Andrew Heaton
Alan James Husband
Original Assignee
Novogen Res Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/AU2004/001619 external-priority patent/WO2005049008A1/en
Priority claimed from AU2005201855A external-priority patent/AU2005201855B2/en
Application filed by Novogen Res Pty Ltd filed Critical Novogen Res Pty Ltd
Publication of NO20072004L publication Critical patent/NO20072004L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/34—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only
    • C07D311/38—2,3-Dihydro derivatives, e.g. isoflavanones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Nye substituerte kromanderivater og intermediatforbindelser, preparater inneholdende disse, fremgangsmåte for deres fremstilling samt deres anvendelse som terapeutiske midler, særlig som anti-cancer- og kjemoterapeutisk selektive midler.
NO20072004A 2004-09-21 2007-04-19 Substituerte kromanderivater, medikamenter og anvendelse i terapi NO20072004L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US61130004P 2004-09-21 2004-09-21
PCT/AU2004/001619 WO2005049008A1 (en) 2003-11-19 2004-11-19 Combinational radiotherapy and chemotherapy compositions and methods
AU2005201855A AU2005201855B2 (en) 2004-09-21 2005-05-03 Chroman derived compounds and formulations thereof for use in therapy
PCT/AU2005/001435 WO2006032085A1 (en) 2004-09-21 2005-09-21 Substituted chroman derivatives, medicaments and use in therapy

Publications (1)

Publication Number Publication Date
NO20072004L true NO20072004L (no) 2007-05-30

Family

ID=36089770

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20072004A NO20072004L (no) 2004-09-21 2007-04-19 Substituerte kromanderivater, medikamenter og anvendelse i terapi

Country Status (11)

Country Link
US (6) US7601855B2 (no)
EP (2) EP2407462B1 (no)
CN (1) CN101056868B (no)
AT (1) ATE532777T1 (no)
AU (1) AU2005287865B2 (no)
CA (1) CA2581316C (no)
IL (1) IL182034A (no)
MX (1) MX2007003216A (no)
NO (1) NO20072004L (no)
NZ (1) NZ553834A (no)
WO (1) WO2006032085A1 (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2581316C (en) * 2004-09-21 2013-09-10 Novogen Research Pty Ltd Substituted chroman derivatives, medicaments and use in therapy
US8080675B2 (en) 2004-09-21 2011-12-20 Marshall Edwards, Inc. Chroman derivatives, medicaments and use in therapy
NZ561574A (en) * 2005-03-24 2010-03-26 Novogen Res Pty Ltd Anti-inflammatory modalities for use against pain, oedema, and erythema (benzotetrahydropyrans, benzopyran derivatives, isoflavonoid derivatives)
WO2008113100A1 (en) * 2007-03-16 2008-09-25 Novogen Research Pty Ltd Method for inducing autophagy
WO2010022467A1 (en) * 2008-08-29 2010-03-04 Novogen Research Pty Ltd Immunomodulating activities
EP2635273B1 (en) 2010-11-01 2020-01-08 MEI Pharma, Inc. Isoflavonoid compositions and methods for the treatment of cancer
US20120251630A1 (en) * 2011-03-29 2012-10-04 Marshall Edwards, Inc. Remission therapy of cancer with isoflavonoids
US8911935B2 (en) 2011-10-17 2014-12-16 New York University Mitochondria and human immunodefiency virus type 1
KR101459195B1 (ko) 2012-12-28 2014-11-07 경기대학교 산학협력단 항암 활성을 갖는 4-니트로알킬크로만 유도체, 이의 제조방법 및 이를 포함하는 약학 조성물
MX368063B (es) 2014-02-07 2019-09-18 Novogen ltd Compuestos de benzopirano funcionalizados y uso de los mismos.
CN116139125A (zh) 2015-02-02 2023-05-23 梅制药公司 联合治疗
CA3058503A1 (en) 2016-04-06 2017-10-12 Noxopharm Limited Isoflavonoid composition with improved pharmacokinetics
CA3058492A1 (en) * 2016-04-06 2017-10-12 Noxopharm Limited Radiotherapy improvements
EP4125870A1 (en) 2020-03-30 2023-02-08 Noxopharm Limited Methods for the treatment of inflammation associated with infection
WO2023090829A1 (ko) * 2021-11-17 2023-05-25 엘젠테라퓨틱스 주식회사 Mll1-wdr5 상호작용을 조절하는 저분자 화합물 및 이의 용도
WO2024232597A1 (ko) * 2023-05-10 2024-11-14 엘젠테라퓨틱스 주식회사 Wdr5를 분해하는 4-크로만온 화합물 및 이의 용도
CN118005595B (zh) * 2023-05-24 2024-10-29 内蒙古大学 具有烯丙醇结构色满衍生物的合成及抗肿瘤活性

Family Cites Families (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3340276A (en) * 1964-04-01 1967-09-05 Ciba Geigy Corp 3, 4-diphenyl-chromans
DE1518002C3 (de) * 1965-01-02 1975-01-23 Merck Patent Gmbh, 6100 Darmstadt Isoflavane und Isoflavene und Verfahren zu Ihrer Herstellung sowie diese enthaltende Arzneimittel
DE1543749A1 (de) * 1966-02-16 1969-12-11 Merck Ag E Verfahren zur Herstellung von 3,4-cis-4-Aryl-isoflavanen
GB1433013A (no) 1973-06-08 1976-04-22
US4218489A (en) * 1977-06-08 1980-08-19 Z-L Limited Partnership Antioxidants, antioxidant compositions and methods of preparing and using same
US4157984A (en) * 1977-06-08 1979-06-12 Z-L Limited Antioxidants, antioxidant compositions and methods of preparing and using same
US4264509A (en) 1977-06-08 1981-04-28 Z-L Limited Partnership Isoflavones and related compounds, methods of preparing and using and antioxidant compositions containing same
US4232122A (en) * 1979-01-17 1980-11-04 Z-L Limited Partnership Antioxidants, antioxidant compositions and methods of preparing and using same
US4234577A (en) * 1979-03-19 1980-11-18 Z-L Limited Partnership Ergostadientriols, compositions containing same, and methods of preparing and using same
US4368264A (en) * 1979-03-19 1983-01-11 Z-L Limited Partnership Fermentation methods of preparing ergostadientriols
US4366082A (en) * 1979-04-11 1982-12-28 Z-L Limited Partnership Isoflavones and related compounds, methods of preparing and using and antioxidant compositions containing same
US4390559A (en) * 1979-04-11 1983-06-28 Z-L Limited Partnership Isoflavones and related compounds, methods of preparing and using and antioxidant compositions containing same
US4366248A (en) * 1979-04-11 1982-12-28 Z-L Limited Partnership Fermentation method of preparing antioxidants
US4447622A (en) * 1981-09-22 1984-05-08 Council Of Scientific And Industrial Research Rafi Marg Preparation of l- and d-isomers of dl-3,4-trans-2,2-disubstituted-3,4-diarylchromans and derivatives thereof
US4644012A (en) 1983-12-21 1987-02-17 Takeda Chemical Industries, Ltd. Treatment for osteoporosis
GB8626344D0 (en) 1986-11-04 1986-12-03 Zyma Sa Bicyclic compounds
US5059609A (en) * 1987-10-19 1991-10-22 Pfizer Inc. Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases
MX13485A (es) 1987-10-19 1993-05-01 Pfizer Procedimiento para obtener tetralinas, cromados y compuestos relacionados, sustituidos
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
EP0470310B1 (en) 1990-08-09 1995-11-29 Council of Scientific and Industrial Research Novel benzopyrans and process for their production
PL308473A1 (en) 1992-10-21 1995-08-07 Pfizer Enabntiomeric cis-3-(4,6-dihydoxychroman-3-yl methyl)bezoic acids
US5280040A (en) * 1993-03-11 1994-01-18 Zymogenetics, Inc. Methods for reducing bone loss using centchroman derivatives
US5451603A (en) 1993-03-11 1995-09-19 Zymogenetics, Inc. 3,4-diarylchromans for treatment of dermatitis
US5389646A (en) * 1993-12-30 1995-02-14 Zymogenetics, Inc. Methods for treatment and prevention of bone loss using 2,3-benzopyrans
US5792776A (en) 1994-06-27 1998-08-11 Cytomed, Inc., Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
HUP9702244A3 (en) 1995-01-13 1999-12-28 Novo Nordisk As Use of 3,4-diphenyl chromans for manufacture of a pharmaceutical composition for treatment or prophylaxis of gynaecological disorders
AU702407B2 (en) 1995-01-13 1999-02-18 Novo Nordisk A/S Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for the treatment of prophylaxis of idiopathic or physiologic gynaecomastia
EP0804189A1 (en) 1995-01-13 1997-11-05 Novo Nordisk A/S Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for the treatment or prophylaxis of hyperlipoproteinaemia, hypertriglyceridaemia, hyperlipidaemia or hypercholesterolaemia or arteriosclerosis or for anticoagulative treatment
CA2208856A1 (en) * 1995-01-20 1996-07-25 Novo Nordisk A/S Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for the treatment or prophylaxis of cerebral degenerative disorders
CZ211897A3 (en) 1995-01-20 1997-12-17 Novo Nordisk As Use of 3,4-diphenylchromans for preparing pharmaceutical preparations used for dilation of vessels
TW448046B (en) 1995-01-20 2001-08-01 Novo Nordisk As Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for the treatment or prophylaxis of obesity
US5849461A (en) * 1995-08-01 1998-12-15 Shin-Etsu Chemical Co., Ltd. Chemically amplified positive resist composition
US5726202A (en) 1996-01-11 1998-03-10 Novo Nordisk A/S Benign prostatic hypertrophy
US5747059A (en) 1996-01-11 1998-05-05 Novo Nordisk A/S Atrophy of skin/mucous membrane
WO1997025035A1 (en) 1996-01-11 1997-07-17 Novo Nordisk A/S Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for the treatment or prophylaxis of menopausal symptoms
US5883118A (en) 1996-01-11 1999-03-16 Nova Nordisk A/S Prostatic carcinoma
US5756539A (en) * 1996-07-11 1998-05-26 Novo Nordis A/S 3, 4-diphenyl chromans for inhibiting one or more psychiatric disorders
AU3433997A (en) 1996-07-12 1998-02-09 Novo Nordisk A/S Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for lowering intraocular pressure
EP0954307A1 (en) 1996-07-12 1999-11-10 Novo Nordisk A/S Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for inhibiting one or more symptoms of premenstrual syndrome
US5780502A (en) * 1996-07-12 1998-07-14 Novo Nordisk A/S Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for inhibiting one or more symptoms of premenstrual syndrome
AUPO203996A0 (en) * 1996-08-30 1996-09-26 Novogen Research Pty Ltd Therapeutic uses
GB9621757D0 (en) 1996-10-18 1996-12-11 Ciba Geigy Ag Phenyl-substituted bicyclic heterocyclyl derivatives and their use
JP2001502711A (ja) 1996-10-28 2001-02-27 ノボ ノルディスク アクティーゼルスカブ エストロゲン関連疾患又は症候群の予防又は治療において有用な新規のシス―３、４―クロマン誘導体
US5919817A (en) * 1996-10-28 1999-07-06 Novo Nordisk A/S Cis-3, 4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
JP2001502704A (ja) 1996-10-28 2001-02-27 ノボ ノルディスク アクティーゼルスカブ エストロゲン関連疾患又は症候群の予防又は処置において有用な新規ｃｉｓ―３，４―クロマン誘導体の新規の（―）―鏡像異性体
US5958967A (en) * 1996-10-28 1999-09-28 Novo Nordisk A/S Cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
CA2270057A1 (en) 1996-10-28 1998-05-07 Novo Nordisk A/S Novel cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
DK0937060T3 (da) 1996-10-28 2003-04-07 Novo Nordisk As Nye cis-3,4-chroman-derivater, der er nyttige i forebyggelsen eller behandlingen af østrogen-relaterede sygdomme eller syndromer
ZA979644B (en) 1996-10-28 1998-04-28 Novo Nordisk As Heterocyclic compounds, compositions and uses.
US5985306A (en) * 1996-10-28 1999-11-16 Novo Nordisk A/S (+)-enantiomers of cis-3,4-chroman derivatives useful in prevention or treatment of estrogen diseases or syndromes
US5994390A (en) * 1996-10-28 1999-11-30 Novo Nordisk Trans-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
US6316494B1 (en) * 1996-10-28 2001-11-13 Novo Nordisk A/S cis3, 4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
US6043269A (en) * 1996-10-28 2000-03-28 Novo Nordisk A/S cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
ZA979642B (en) * 1996-10-28 1998-04-28 Novo Nordisk As Heterocyclic compounds, compositions and uses.
WO1998018770A1 (en) 1996-10-28 1998-05-07 Novo Nordisk A/S A process for the preparation of (-)-3,4-trans-diarylchromans
WO1998018778A1 (en) 1996-10-28 1998-05-07 Novo Nordisk A/S Novel cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
AU744403B2 (en) 1996-10-28 2002-02-21 Novo Nordisk A/S Novel trans-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
US6153768A (en) * 1996-12-13 2000-11-28 C & C Research Laboratories Benzopyran derivatives
AU5550398A (en) 1997-01-29 1998-08-25 Novo Nordisk A/S Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical compositionfor inhibiting senescence-associated motor impairment
AU5550298A (en) 1997-01-29 1998-08-25 Novo Nordisk A/S Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical compositionfor increasing libido in post-menopausal women
AU5550498A (en) 1997-01-29 1998-08-18 Novo Nordisk A/S Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical compositionfor inhibiting one or more psychiatric disorders
AU3456499A (en) 1998-03-30 1999-10-18 University Of Mississippi, The Isoflavones for treating giardiasis and malaria
JP2002512807A (ja) 1998-04-28 2002-05-08 ノボ ノルディスク アクティーゼルスカブ （−）−３．４−トランス−ジアリールクロマンを得るための酵素的分割
FR2778404B1 (fr) 1998-05-06 2000-06-30 Hoechst Marion Roussel Inc Derives du dihydro ou tetrahydronaphtalene, et les compositions pharmaceutiques les renfermant
US6465445B1 (en) 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
KR20000001793A (ko) * 1998-06-13 2000-01-15 이경하 신규한 벤조피란 또는 티오벤조피란 유도체
AUPP868599A0 (en) 1999-02-15 1999-03-11 Novogen Research Pty Ltd Production of isoflavone derivatives
AUPQ008299A0 (en) * 1999-04-30 1999-05-27 G.J. Consultants Pty Ltd Isoflavone metabolites
AUPQ266199A0 (en) 1999-09-06 1999-09-30 Novogen Research Pty Ltd Compositions and therapeutic methods involving isoflavones and analogues thereof
AU7896100A (en) 1999-10-14 2001-04-23 Endorecherche Inc. Selective estrogen receptor modulators in the treatment or reduction of the riskof acquiring hypertension, cardiovascular diseases, and insulin resistance
EP1241165A4 (en) * 1999-12-13 2003-03-19 Chugai Pharmaceutical Co Ltd OPTICALLY ACTIVE CHROMAN AND THIOCHROME DERIVATIVES
BR0108107A (pt) 2000-01-28 2003-03-11 Endorech Inc Moduladores seletivos dos receptores de estrogênio em combinação com estrogênios; kits e composições farmacêuticas para praticar tal combinação; bem como a administração da referida combinação
FI20001593A7 (fi) 2000-07-03 2002-01-04 Orion Yhtymo Oyj Comt-entsyymiõ inhiboivaa aktiivisuutta omaavia kumariinijohdannaisia
PT1355906E (pt) * 2001-01-24 2005-05-31 Chiesi Farma Spa Derivados de 2h-1-benzopirano processos para a sua preparacao e as suas composicoes farmaceuticas
PL374215A1 (en) 2001-08-11 2005-10-03 Bristol-Myers Squibb Pharma Company Selective estrogen receptor modulators
AUPR846401A0 (en) 2001-10-25 2001-11-15 Novogen Research Pty Ltd 6-Hydroxy isoflavones, derivatives and medicaments involving same
JP2005524630A (ja) * 2002-01-14 2005-08-18 ノルディック・ビオサイエンス・エー／エス エストロゲン受容体を介する軟骨破壊の抑制
WO2003086386A1 (en) 2002-04-09 2003-10-23 Novogen Research Pty Ltd Therapeutic methods and compositions involving isoflav-3-ene and isoflavan structures
AU2002951833A0 (en) 2002-10-02 2002-10-24 Novogen Research Pty Ltd Compositions and therapeutic methods invloving platinum complexes
CA2542351A1 (en) * 2003-11-19 2005-06-02 Novogen Research Pty Ltd. Combinational radiotherapy and chemotherapy compositions and methods
EP2436680B1 (en) 2004-09-21 2016-05-18 Marshall Edwards, Inc. Chroman derivatives, medicaments and use in therapy
CA2581316C (en) 2004-09-21 2013-09-10 Novogen Research Pty Ltd Substituted chroman derivatives, medicaments and use in therapy
US8080675B2 (en) 2004-09-21 2011-12-20 Marshall Edwards, Inc. Chroman derivatives, medicaments and use in therapy
JP4976649B2 (ja) 2004-09-21 2012-07-18 マーシャル エドワーズ，インク． 化合物
WO2008113100A1 (en) 2007-03-16 2008-09-25 Novogen Research Pty Ltd Method for inducing autophagy
WO2010022467A1 (en) 2008-08-29 2010-03-04 Novogen Research Pty Ltd Immunomodulating activities
EP2635273B1 (en) * 2010-11-01 2020-01-08 MEI Pharma, Inc. Isoflavonoid compositions and methods for the treatment of cancer
US20120251630A1 (en) 2011-03-29 2012-10-04 Marshall Edwards, Inc. Remission therapy of cancer with isoflavonoids

Also Published As

Publication number Publication date
US7601855B2 (en) 2009-10-13
EP2407462B1 (en) 2014-07-30
CN101056868A (zh) 2007-10-17
IL182034A (en) 2012-10-31
EP1794141B1 (en) 2011-11-09
ATE532777T1 (de) 2011-11-15
US9138478B2 (en) 2015-09-22
AU2005287865B2 (en) 2012-02-16
US9381186B2 (en) 2016-07-05
EP1794141A1 (en) 2007-06-13
MX2007003216A (es) 2008-03-10
US20120114766A1 (en) 2012-05-10
US20160287555A1 (en) 2016-10-06
EP1794141A4 (en) 2009-05-27
IL182034A0 (en) 2007-07-24
US8084628B2 (en) 2011-12-27
US20150352074A1 (en) 2015-12-10
CA2581316C (en) 2013-09-10
EP2407462A1 (en) 2012-01-18
US8697891B2 (en) 2014-04-15
CA2581316A1 (en) 2006-03-30
CN101056868B (zh) 2012-05-02
NZ553834A (en) 2010-03-26
US20060074127A1 (en) 2006-04-06
US20140170243A1 (en) 2014-06-19
WO2006032085A1 (en) 2006-03-30
AU2005287865A1 (en) 2006-03-30
US20090317490A1 (en) 2009-12-24

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