NO20073797L - Humane monoklonale antistoffer mot prostata spesifikt membran antigen (PSMA) - Google Patents
Humane monoklonale antistoffer mot prostata spesifikt membran antigen (PSMA)Info
- Publication number
- NO20073797L NO20073797L NO20073797A NO20073797A NO20073797L NO 20073797 L NO20073797 L NO 20073797L NO 20073797 A NO20073797 A NO 20073797A NO 20073797 A NO20073797 A NO 20073797A NO 20073797 L NO20073797 L NO 20073797L
- Authority
- NO
- Norway
- Prior art keywords
- monoclonal antibodies
- psma
- human monoclonal
- antibodies
- antibodies against
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
SAMMENDRAG Foreliggende oppfinnelse tilveiebringer isolerte monoklonale antistoffer, spesielt humane monoklonale antistoffer, som spesifikt binder til PSMA med høy affinitet. Nukleinsyremolekyler som koder for antistoffene ifølge oppfinnelsen, ekspresjonsvektorer, vertsceller og fremgangsmåter for å uttrykke antistoffene ifølge oppfinnelsen tilveiebringes også. Immunokonjugater, bispesifikke molekyler og farmasøytiske blandinger omfattende antistoffene ifølge oppfinnelsen er også gitt. Oppfinnelsen tilveiebringer også fremgangsmåter for behandling av kreft.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65412505P | 2005-02-18 | 2005-02-18 | |
| US72049905P | 2005-09-26 | 2005-09-26 | |
| US74841705P | 2005-12-08 | 2005-12-08 | |
| PCT/US2006/005852 WO2006089230A2 (en) | 2005-02-18 | 2006-02-17 | Human monoclonal antibodies to prostate specific membrane antigen (psma) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20073797L true NO20073797L (no) | 2007-09-12 |
Family
ID=36658707
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20073797A NO20073797L (no) | 2005-02-18 | 2007-07-20 | Humane monoklonale antistoffer mot prostata spesifikt membran antigen (PSMA) |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20090297438A1 (no) |
| EP (1) | EP1851250B1 (no) |
| JP (1) | JP2008529556A (no) |
| KR (1) | KR20070115967A (no) |
| CN (1) | CN101124249B (no) |
| AU (1) | AU2006214031A1 (no) |
| BR (1) | BRPI0607757A2 (no) |
| CA (1) | CA2598522A1 (no) |
| CY (1) | CY1113089T1 (no) |
| DK (1) | DK1851250T3 (no) |
| ES (1) | ES2386366T3 (no) |
| HR (1) | HRP20120709T1 (no) |
| IL (1) | IL184733A (no) |
| MX (1) | MX2007009878A (no) |
| NO (1) | NO20073797L (no) |
| NZ (1) | NZ556661A (no) |
| PL (1) | PL1851250T3 (no) |
| PT (1) | PT1851250E (no) |
| WO (1) | WO2006089230A2 (no) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003034903A2 (en) | 2001-10-23 | 2003-05-01 | Psma Development Company, L.L.C. | Psma antibodies and protein multimers |
| US20050215472A1 (en) | 2001-10-23 | 2005-09-29 | Psma Development Company, Llc | PSMA formulations and uses thereof |
| EP1726650A1 (en) * | 2005-05-27 | 2006-11-29 | Universitätsklinikum Freiburg | Monoclonal antibodies and single chain antibody fragments against cell-surface prostate specific membrane antigen |
| DE102008010363A1 (de) * | 2008-02-18 | 2009-08-20 | Lang, Florian, Prof. Dr.med. | Sgk1 als therapeutisches und diagnostisches Target für karzinomatöse Erkrankungen |
| WO2009127046A1 (en) * | 2008-04-14 | 2009-10-22 | Proscan Rx Pharma Inc. | Prostate specific membrane antigen antibodies and antigen binding fragments |
| EP2326350B1 (en) | 2008-09-08 | 2013-09-04 | Psma Development Company, L.L.C. | Compounds for killing psma-expressing, taxane-resistant cancer cells |
| PL2352763T5 (pl) | 2008-10-01 | 2023-01-30 | Amgen Research (Munich) Gmbh | Bispecyficzne przeciwciała jednołańcuchowe o specyficzności wobec antygenów docelowych o dużej masie cząsteczkowej |
| JP6126782B2 (ja) | 2008-10-01 | 2017-05-10 | アムゲン リサーチ (ミュンヘン) ゲーエムベーハー | 異種間特異的psma×cd3二重特異性単鎖抗体 |
| CN101891818B (zh) * | 2009-01-16 | 2012-07-25 | 中国人民解放军第四军医大学 | 抗人前列腺特异性膜抗原胞外区单链抗体及其应用 |
| US8629247B2 (en) * | 2009-04-14 | 2014-01-14 | Proscan Rx Pharma Inc. | Antibodies against prostate specific membrane antigen |
| AU2010249719A1 (en) | 2009-05-19 | 2012-05-31 | Aic Blab Company | Composite current collector and methods therefor |
| US8394922B2 (en) | 2009-08-03 | 2013-03-12 | Medarex, Inc. | Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof |
| TWI629357B (zh) * | 2009-10-02 | 2018-07-11 | 安進研究(慕尼黑)有限責任公司 | 跨物種特異性的PSMAxCD3雙特異性單鏈抗體 |
| TWI653333B (zh) | 2010-04-01 | 2019-03-11 | 安進研究(慕尼黑)有限責任公司 | 跨物種專一性之PSMAxCD3雙專一性單鏈抗體 |
| US8956859B1 (en) | 2010-08-13 | 2015-02-17 | Aviex Technologies Llc | Compositions and methods for determining successful immunization by one or more vaccines |
| UA118950C2 (uk) | 2011-04-22 | 2019-04-10 | Аптево Рісьорч Енд Девелопмент Ллс | Поліпептид, який зв'язує специфічний мембранний антиген простати та комплекс т-клітинного рецептора |
| US8852599B2 (en) | 2011-05-26 | 2014-10-07 | Bristol-Myers Squibb Company | Immunoconjugates, compositions for making them, and methods of making and use |
| CA2887047A1 (en) * | 2012-10-05 | 2014-04-10 | Cornell University | Androgen suppression, prostate-specific membrane antigen and the concept of conditionally enhanced vulnerability |
| RS56169B1 (sr) | 2013-02-14 | 2017-11-30 | Bristol Myers Squibb Co | Jedinjenja tubulisina, metode pripreme i primena |
| KR20160068738A (ko) | 2013-08-14 | 2016-06-15 | 윌리엄 마쉬 라이스 유니버시티 | 운시알라마이신의 유도체, 합성 방법 및 항종양 제제로서 이들의 용도 |
| US10077287B2 (en) | 2014-11-10 | 2018-09-18 | Bristol-Myers Squibb Company | Tubulysin analogs and methods of making and use |
| JP6668345B2 (ja) | 2014-11-21 | 2020-03-18 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 修飾された重鎖定常領域を含む抗体 |
| JP6676058B2 (ja) | 2015-01-14 | 2020-04-08 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | ヘテロアリーレン架橋したベンゾジアゼピン二量体、そのコンジュゲート、ならびに製造および使用方法 |
| CA2979219A1 (en) * | 2015-03-10 | 2016-09-15 | Sorrento Therapeutics, Inc. | Antibody therapeutics that bind psma |
| JOP20160154B1 (ar) * | 2015-07-31 | 2021-08-17 | Regeneron Pharma | أجسام ضادة مضاد لل psma، وجزيئات رابطة لمستضد ثنائي النوعية الذي يربط psma و cd3، واستخداماتها |
| EP3352760B1 (en) | 2015-09-21 | 2026-03-11 | Aptevo Research and Development LLC | Cd3 binding polypeptides |
| AU2016377371A1 (en) | 2015-12-21 | 2018-08-09 | Bristol-Myers Squibb Company | Variant antibodies for site-specific conjugation |
| WO2017122019A1 (en) | 2016-01-12 | 2017-07-20 | Crescendo Biologics Limited | Immunoconjugates that bind prostate specific membrane antigen (psma) |
| CN105504061A (zh) * | 2016-02-03 | 2016-04-20 | 南昌大学 | 针对前列腺特异性膜抗原的纳米抗体 |
| CN105542008A (zh) * | 2016-02-03 | 2016-05-04 | 南昌大学 | 能特异结合前列腺特异性膜抗原的单域重链抗体 |
| CN105524171A (zh) * | 2016-02-03 | 2016-04-27 | 中国人民解放军第三军医大学第三附属医院 | 一种针对前列腺特异性膜抗原的纳米抗体 |
| KR102466763B1 (ko) * | 2016-04-13 | 2022-11-11 | 오리맵스 리미티드 | 항- psma 항체 및 이의 용도 |
| GB201607968D0 (en) | 2016-05-06 | 2016-06-22 | Crescendo Biolog Ltd | Chimeric antigen receptor |
| KR20190005924A (ko) | 2016-05-10 | 2019-01-16 | 브리스톨-마이어스 스큅 컴퍼니 | 향상된 안정성을 갖는 튜부리신 유사체의 항체-약물 접합체 |
| GB201614162D0 (en) | 2016-08-18 | 2016-10-05 | Polytherics Ltd | Antibodies, uses thereof and conjugates thereof |
| CN109641911B (zh) | 2016-08-19 | 2023-02-21 | 百时美施贵宝公司 | seco-环丙吡咯并吲哚化合物和其抗体-药物缀合物以及制备和使用方法 |
| US10398783B2 (en) | 2016-10-20 | 2019-09-03 | Bristol-Myers Squibb Company | Antiproliferative compounds and conjugates made therefrom |
| JP7183163B2 (ja) | 2017-01-06 | 2022-12-05 | クレシェンド・バイオロジックス・リミテッド | プログラム細胞死(pd-1)に対するシングルドメイン抗体 |
| BR112019024556A2 (pt) | 2017-05-24 | 2020-06-23 | Novartis Ag | Proteínas enxertadas com citocina de anticorpo e métodos para uso no tratamento de câncer |
| IL270596B2 (en) | 2017-05-25 | 2026-01-01 | Bristol Myers Squibb Co | Antibodies containing heavy constant regions are adapted for use in cancer therapy |
| GB201711068D0 (en) | 2017-07-10 | 2017-08-23 | Crescendo Biologics Ltd | Therapeutic molecules binding PSMA |
| US10508115B2 (en) | 2017-08-16 | 2019-12-17 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having heteroatom-linked aromatic moieties, conjugates thereof, and methods and uses therefor |
| US10494370B2 (en) | 2017-08-16 | 2019-12-03 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a pyridine or pyrazine moiety, conjugates thereof, and methods and uses therefor |
| US10472361B2 (en) | 2017-08-16 | 2019-11-12 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a benzotriazole moiety, conjugates thereof, and methods and uses therefor |
| US10457681B2 (en) | 2017-08-16 | 2019-10-29 | Bristol_Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor |
| US10487084B2 (en) | 2017-08-16 | 2019-11-26 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a heterobiaryl moiety, conjugates thereof, and methods and uses therefor |
| WO2019092452A1 (en) | 2017-11-13 | 2019-05-16 | Crescendo Biologics Limited | Molecules that bind to cd137 and psma |
| GB201802573D0 (en) | 2018-02-16 | 2018-04-04 | Crescendo Biologics Ltd | Therapeutic molecules that bind to LAG3 |
| MX2020009272A (es) | 2018-03-06 | 2021-01-08 | Univ Pennsylvania | Receptores de antígeno quimérico del antígeno de membrana específico de próstata y métodos de uso de los mismos. |
| WO2019209811A1 (en) | 2018-04-24 | 2019-10-31 | Bristol-Myers Squibb Company | Macrocyclic toll-like receptor 7 (tlr7) agonists |
| CN112188902A (zh) | 2018-05-29 | 2021-01-05 | 百时美施贵宝公司 | 用于前药和缀合物的经修饰的自消灭部分以及使用和制造方法 |
| WO2019246514A1 (en) * | 2018-06-21 | 2019-12-26 | Regeneron Pharmaceuticals, Inc. | Bispecific anti-psma x anti-cd28 antibodies and uses thereof |
| US11554120B2 (en) | 2018-08-03 | 2023-01-17 | Bristol-Myers Squibb Company | 1H-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (TLR7) agonists and methods and uses therefor |
| EP3887397A1 (en) | 2018-11-28 | 2021-10-06 | Bristol-Myers Squibb Company | Antibodies comprising modified heavy constant regions |
| ES2943474T3 (es) | 2018-11-30 | 2023-06-13 | Bristol Myers Squibb Co | Anticuerpo que comprende una extensión carboxiterminal de una cadena ligera que contiene glutamina, conjugados del mismo, y métodos y usos |
| KR20210102334A (ko) | 2018-12-12 | 2021-08-19 | 브리스톨-마이어스 스큅 컴퍼니 | 트랜스글루타미나제 접합을 위해 변형된 항체, 그의 접합체, 및 방법 및 용도 |
| CN110407939B (zh) * | 2019-03-12 | 2023-09-29 | 广东医科大学附属第二医院 | 一种人源化抗psma单链抗体及其应用 |
| WO2021050656A1 (en) * | 2019-09-11 | 2021-03-18 | The Trustees Of The Univeristy Of Pennsylvania | Compositions and methods comprising prostate stem cell antigen (psca) chimeric antigen receptors (cars) |
| WO2021055306A1 (en) | 2019-09-16 | 2021-03-25 | Bristol-Myers Squibb Company | Dual capture method for analysis of antibody-drug conjugates |
| CN113024670A (zh) * | 2019-12-25 | 2021-06-25 | 百奥泰生物制药股份有限公司 | Ctla-4抗体及其制备方法 |
| CN116323667A (zh) | 2020-07-08 | 2023-06-23 | 拉法医疗股份有限公司 | 结合PSMA和γ-δT细胞受体的抗体 |
| WO2023088966A1 (en) | 2021-11-19 | 2023-05-25 | Adc Therapeutics Sa | Anti-psma conjugates |
| KR20250158048A (ko) | 2023-03-03 | 2025-11-05 | 아스널 바이오사이언시스, 인크. | Psma 및 ca9을 표적으로 하는 시스템 |
| CN116462762B (zh) * | 2023-06-14 | 2023-08-25 | 天健生物制药(天津)有限公司 | 一种抗前列腺特异性抗原单克隆抗体及其应用 |
| CN118027203A (zh) * | 2023-12-11 | 2024-05-14 | 合肥天港免疫药物有限公司 | Psma抗体及其应用 |
| WO2025149029A1 (zh) * | 2024-01-12 | 2025-07-17 | 信达生物制药(苏州)有限公司 | 抗cd28抗体及其用途 |
| WO2025188694A1 (en) | 2024-03-05 | 2025-09-12 | Bristol-Myers Squibb Company | Tricyclic tlr7 agonists and uses thereof |
| WO2025188693A1 (en) | 2024-03-05 | 2025-09-12 | Bristol-Myers Squibb Company | Bicyclic tlr7 agonists and uses thereof |
| CN120446482B (zh) * | 2025-07-10 | 2025-09-19 | 杭州华得森生物技术有限公司 | 微流控芯片psma前列腺癌循环肿瘤细胞免疫富集检测试剂盒及制备方法 |
Family Cites Families (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4391904A (en) * | 1979-12-26 | 1983-07-05 | Syva Company | Test strip kits in immunoassays and compositions therein |
| US4671958A (en) * | 1982-03-09 | 1987-06-09 | Cytogen Corporation | Antibody conjugates for the delivery of compounds to target sites |
| US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4912227A (en) * | 1984-02-21 | 1990-03-27 | The Upjohn Company | 1,2,8,8A-tetrahydrocyclopropa(c)pyrrolo(3,2-e)-indol-4-(5H)-ones and related compounds |
| US5225539A (en) * | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| WO1987006265A1 (fr) * | 1986-04-17 | 1987-10-22 | Kyowa Hakko Kogyo Co., Ltd. | Nouveaux composes dc-88a et dc-89a1, et procede pour leur preparation |
| US5332837A (en) * | 1986-12-19 | 1994-07-26 | The Upjohn Company | CC-1065 analogs |
| US5773435A (en) * | 1987-08-04 | 1998-06-30 | Bristol-Myers Squibb Company | Prodrugs for β-lactamase and uses thereof |
| US5036003A (en) * | 1987-08-21 | 1991-07-30 | Monsanto Company | Antibodies to VPF |
| US4952394A (en) * | 1987-11-23 | 1990-08-28 | Bristol-Myers Company | Drug-monoclonal antibody conjugates |
| US4994578A (en) * | 1987-11-27 | 1991-02-19 | Meiji Seika Kaisha, Ltd. | Certain anti-tumor duocarmycin antibiotics from streptomyces |
| JP2642165B2 (ja) * | 1988-07-22 | 1997-08-20 | 協和醗酵工業株式会社 | 新規dc−89化合物およびその製造法 |
| US5084468A (en) * | 1988-08-11 | 1992-01-28 | Kyowa Hakko Kogyo Co., Ltd. | Dc-88a derivatives |
| US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5176996A (en) * | 1988-12-20 | 1993-01-05 | Baylor College Of Medicine | Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| JP2598116B2 (ja) * | 1988-12-28 | 1997-04-09 | 協和醗酵工業株式会社 | 新規物質dc113 |
| US5187186A (en) * | 1989-07-03 | 1993-02-16 | Kyowa Hakko Kogyo Co., Ltd. | Pyrroloindole derivatives |
| US5495009A (en) * | 1989-10-24 | 1996-02-27 | Gilead Sciences, Inc. | Oligonucleotide analogs containing thioformacetal linkages |
| US5334528A (en) * | 1989-10-30 | 1994-08-02 | The Regents Of The University Of California | Monoclonal antibodies to cyclodiene insecticides and method for detecting the same |
| US6075181A (en) * | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| AU648313B2 (en) * | 1990-04-25 | 1994-04-21 | Pharmacia & Upjohn Company | Novel CC-1065 analogs |
| US5427908A (en) * | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| US5137877B1 (en) * | 1990-05-14 | 1996-01-30 | Bristol Myers Squibb Co | Bifunctional linking compounds conjugates and methods for their production |
| US6172197B1 (en) * | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
| DE69121334T2 (de) * | 1990-07-26 | 1997-03-20 | Kyowa Hakko Kogyo Kk | DC-89-Derivate als Antitumor-Wirkstoffe |
| US5770429A (en) * | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5877397A (en) * | 1990-08-29 | 1999-03-02 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5625126A (en) * | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5545806A (en) * | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5633425A (en) * | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5874299A (en) * | 1990-08-29 | 1999-02-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| ES2341666T3 (es) * | 1991-12-02 | 2010-06-24 | Medimmune Limited | Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos. |
| US5622929A (en) * | 1992-01-23 | 1997-04-22 | Bristol-Myers Squibb Company | Thioether conjugates |
| US5227471A (en) * | 1992-01-30 | 1993-07-13 | Eastern Virginia Medical School Of The Medical College Of Hampton Roads | Monoclonal antibody PD41 that binds to a prostate mucin antigen that is expressed in human prostatic carcinoma |
| EP1306095A3 (en) * | 1992-03-05 | 2003-06-25 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
| US5965132A (en) * | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
| JP3514490B2 (ja) * | 1992-08-21 | 2004-03-31 | 杏林製薬株式会社 | トリフルオロメチルピロロインドールカルボン酸エステル誘導体及びその製造方法 |
| US5288514A (en) * | 1992-09-14 | 1994-02-22 | The Regents Of The University Of California | Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support |
| US5324483B1 (en) * | 1992-10-08 | 1996-09-24 | Warner Lambert Co | Apparatus for multiple simultaneous synthesis |
| US5489525A (en) * | 1992-10-08 | 1996-02-06 | The United States Of America As Represented By The Department Of Health And Human Services | Monoclonal antibodies to prostate cells |
| ES2276390T3 (es) * | 1992-11-05 | 2007-06-16 | Sloan-Kettering Institute For Cancer Research | Antigeno de membrana especifico de la prostata. |
| US6214345B1 (en) * | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
| US5786377A (en) * | 1993-11-19 | 1998-07-28 | Universidad De Santiago De Compostela | Pyrrolo 3,2-E!indol derivatives, process for the preparation thereof and applications |
| CA2165819C (en) * | 1994-04-22 | 2005-12-27 | Nobuyoshi Amishiro | Dc-89 derivatives |
| US5773001A (en) * | 1994-06-03 | 1998-06-30 | American Cyanamid Company | Conjugates of methyltrithio antitumor agents and intermediates for their synthesis |
| JP4157600B2 (ja) * | 1994-08-19 | 2008-10-01 | ラ レフィオン バロンネ | 化合物、製剤用組成物及びこれらを含む診断装置とこれらの利用 |
| CN1051552C (zh) * | 1994-11-29 | 2000-04-19 | 杏林制药株式会社 | 丙烯酰胺衍生物及其制造方法 |
| US5643786A (en) * | 1995-01-27 | 1997-07-01 | The United States Of America As Represented By The Department Of Health And Human Services | Method for isolating dendritic cells |
| US5773292A (en) * | 1995-06-05 | 1998-06-30 | Cornell University | Antibodies binding portions, and probes recognizing an antigen of prostate epithelial cells but not antigens circulating in the blood |
| US5714586A (en) * | 1995-06-07 | 1998-02-03 | American Cyanamid Company | Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates |
| US5712374A (en) * | 1995-06-07 | 1998-01-27 | American Cyanamid Company | Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates |
| US6548530B1 (en) * | 1995-10-03 | 2003-04-15 | The Scripps Research Institute | CBI analogs of CC-1065 and the duocarmycins |
| ATE272058T1 (de) * | 1995-10-17 | 2004-08-15 | Combichem Inc | Matrize für die synthese kombinatorischer bibliotheken in lösung |
| ATE234635T1 (de) * | 1995-12-22 | 2003-04-15 | Bristol Myers Squibb Co | Verzweigte hydrazongruppen enthaltende kuppler |
| US6107090A (en) * | 1996-05-06 | 2000-08-22 | Cornell Research Foundation, Inc. | Treatment and diagnosis of prostate cancer with antibodies to extracellur PSMA domains |
| WO1997045411A1 (en) * | 1996-05-31 | 1997-12-04 | The Scripps Research Institute | Analogs of cc-1065 and the duocarmycins |
| JPH1087666A (ja) * | 1996-09-18 | 1998-04-07 | Kyorin Pharmaceut Co Ltd | デュオカルマイシンsa及びその誘導体の製造中間体と製造方法 |
| US6759509B1 (en) * | 1996-11-05 | 2004-07-06 | Bristol-Myers Squibb Company | Branched peptide linkers |
| US6194152B1 (en) * | 1997-08-20 | 2001-02-27 | Dendreon Corporation | Prostate tumor polynucleotide compositions and methods of detection thereof |
| AU756721B2 (en) * | 1997-10-14 | 2003-01-23 | Scripps Research Institute, The | iso-CBI and iso-CI analogs of CC-1065 and the duocarmycins |
| NZ504884A (en) * | 1997-12-08 | 2002-10-25 | Scripps Research Inst | Synthesis of the dihydroindole C-ring of CC-1065/duocarmycin analogs and certain intermediates |
| JP3045706B1 (ja) * | 1998-09-14 | 2000-05-29 | 科学技術振興事業団 | Dnaの特定塩基配列をアルキル化する化合物及びその合成法 |
| CA2380783C (en) * | 1999-07-29 | 2009-01-27 | Yashwant Deo | Human monoclonal antibodies to prostate specific membrane antigen |
| CN1427839A (zh) * | 2000-03-16 | 2003-07-02 | 根索福特股份有限公司 | 含有核酸结合部分的带电荷化合物及其用途 |
| JP2004510702A (ja) * | 2000-06-14 | 2004-04-08 | メダレックス,インコーポレイティド | イソロイシンを有するプロドラッグ化合物 |
| US7214663B2 (en) * | 2000-06-14 | 2007-05-08 | Medarex, Inc. | Tripeptide prodrug compounds |
| EP1243276A1 (en) * | 2001-03-23 | 2002-09-25 | Franciscus Marinus Hendrikus De Groot | Elongated and multiple spacers containing activatible prodrugs |
| US6884869B2 (en) * | 2001-04-30 | 2005-04-26 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
| US20030083263A1 (en) * | 2001-04-30 | 2003-05-01 | Svetlana Doronina | Pentapeptide compounds and uses related thereto |
| US6762179B2 (en) * | 2001-05-31 | 2004-07-13 | Vertex Pharmaceuticals Incorporated | Thiazole compounds useful as inhibitors of protein kinase |
| US7129261B2 (en) * | 2001-05-31 | 2006-10-31 | Medarex, Inc. | Cytotoxic agents |
| DE60239679D1 (de) * | 2001-06-11 | 2011-05-19 | Medarex Inc | Methode für die ausarbeitung von cd10-aktivierten prodrug-verbindungen |
| CA2459308A1 (en) * | 2001-09-07 | 2003-03-20 | Dale L. Boger | Cbi analogues of cc-1065 and the duocarmycins |
| US7091186B2 (en) * | 2001-09-24 | 2006-08-15 | Seattle Genetics, Inc. | p-Amidobenzylethers in drug delivery agents |
| WO2003034903A2 (en) * | 2001-10-23 | 2003-05-01 | Psma Development Company, L.L.C. | Psma antibodies and protein multimers |
| BR0307216A (pt) * | 2002-01-28 | 2005-12-20 | Medarex Inc | Anticorpos monoclonais humanos para antìgeno de membrana especìfica de próstata (psma) |
| US6534660B1 (en) * | 2002-04-05 | 2003-03-18 | Immunogen, Inc. | CC-1065 analog synthesis |
| US20040132140A1 (en) * | 2002-04-09 | 2004-07-08 | Kyowa Hakko Kogyo Co., Ltd. | Production process for antibody composition |
| EA200401325A1 (ru) * | 2002-04-09 | 2005-04-28 | Киова Хакко Когио Ко., Лтд. | Клетки с модифицированным геномом |
| US20040032828A1 (en) * | 2002-08-16 | 2004-02-19 | Cellglide Technologies Corp. | Service management in cellular networks |
| WO2004101767A2 (en) * | 2003-05-13 | 2004-11-25 | The Scripps Research Institute | Cbi analogues of the duocarmycins and cc-1065 |
| KR100552478B1 (ko) * | 2003-11-20 | 2006-02-15 | 삼성전자주식회사 | 파워 인렛 소켓 |
| JP4806680B2 (ja) * | 2004-05-19 | 2011-11-02 | メダレックス インコーポレイテッド | 自己犠牲リンカー及び薬剤複合体 |
| RU2402548C2 (ru) * | 2004-05-19 | 2010-10-27 | Медарекс, Инк. | Химические линкеры и их конъюгаты |
| BRPI0607796A2 (pt) * | 2005-02-18 | 2009-06-13 | Medarex Inc | composto ou um sal farmaceuticamente aceitável do mesmo, processo para preparação e uso do mesmo, e, composição farmacêutica |
-
2006
- 2006-02-17 NZ NZ556661A patent/NZ556661A/en not_active IP Right Cessation
- 2006-02-17 DK DK06735489.4T patent/DK1851250T3/da active
- 2006-02-17 MX MX2007009878A patent/MX2007009878A/es not_active Application Discontinuation
- 2006-02-17 KR KR1020077021333A patent/KR20070115967A/ko not_active Withdrawn
- 2006-02-17 PT PT06735489T patent/PT1851250E/pt unknown
- 2006-02-17 HR HRP20120709TT patent/HRP20120709T1/hr unknown
- 2006-02-17 WO PCT/US2006/005852 patent/WO2006089230A2/en not_active Ceased
- 2006-02-17 CN CN2006800053479A patent/CN101124249B/zh not_active Expired - Fee Related
- 2006-02-17 US US11/918,153 patent/US20090297438A1/en not_active Abandoned
- 2006-02-17 EP EP06735489A patent/EP1851250B1/en not_active Expired - Lifetime
- 2006-02-17 CA CA002598522A patent/CA2598522A1/en not_active Abandoned
- 2006-02-17 PL PL06735489T patent/PL1851250T3/pl unknown
- 2006-02-17 JP JP2007556368A patent/JP2008529556A/ja active Pending
- 2006-02-17 ES ES06735489T patent/ES2386366T3/es not_active Expired - Lifetime
- 2006-02-17 AU AU2006214031A patent/AU2006214031A1/en not_active Abandoned
- 2006-02-17 BR BRPI0607757-9A patent/BRPI0607757A2/pt not_active Application Discontinuation
-
2007
- 2007-07-19 IL IL184733A patent/IL184733A/en not_active IP Right Cessation
- 2007-07-20 NO NO20073797A patent/NO20073797L/no not_active Application Discontinuation
-
2012
- 2012-09-04 CY CY20121100788T patent/CY1113089T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20120709T1 (hr) | 2012-10-31 |
| DK1851250T3 (da) | 2012-07-09 |
| CY1113089T1 (el) | 2016-04-13 |
| PT1851250E (pt) | 2012-08-27 |
| KR20070115967A (ko) | 2007-12-06 |
| JP2008529556A (ja) | 2008-08-07 |
| PL1851250T3 (pl) | 2012-10-31 |
| CN101124249A (zh) | 2008-02-13 |
| IL184733A (en) | 2015-07-30 |
| IL184733A0 (en) | 2007-12-03 |
| EP1851250A2 (en) | 2007-11-07 |
| ES2386366T3 (es) | 2012-08-17 |
| BRPI0607757A2 (pt) | 2009-10-06 |
| WO2006089230A2 (en) | 2006-08-24 |
| MX2007009878A (es) | 2007-10-03 |
| US20090297438A1 (en) | 2009-12-03 |
| WO2006089230A3 (en) | 2006-11-16 |
| CN101124249B (zh) | 2011-06-29 |
| EP1851250B1 (en) | 2012-06-06 |
| AU2006214031A1 (en) | 2006-08-24 |
| CA2598522A1 (en) | 2006-08-24 |
| NZ556661A (en) | 2010-10-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20073797L (no) | Humane monoklonale antistoffer mot prostata spesifikt membran antigen (PSMA) | |
| NO20083053L (no) | Humane monoklonale antistoffer mot O8E | |
| NO20081987L (no) | Humane, monoklonale antistoffer mot CD70 | |
| NO20092285L (no) | Humane, monoklonale antistoffer til BTLA og fremgangsmater for anvendelse | |
| NO20082559L (no) | Humane monoklonale antistoffer mot protein tyrosin kinase 7 (PTK7) og fremgangsmater for anvendelse av anti-PTK7 antistoffer | |
| NO20083062L (no) | Humane monoklonale antistoffer mot fukosyl-GM1 og fremgangsmater for anvendelse av anti-fukosyl-GM1 | |
| CY1118949T1 (el) | Ανθρωπινα αντισωματα που προσδενουν cxcr4 και χρησεις αυτων | |
| NO20080362L (no) | CD19-antistoffer og deres anvendelser | |
| EA201000238A1 (ru) | Антигенсвязывающие белки для il-18 рецептора и их применение | |
| EA201101516A1 (ru) | Антитела, специфические для кадгерина-17 | |
| WO2005058815A3 (en) | Ip-10 antibodies and their uses | |
| MY150246A (en) | Alpha 5 - beta 1 antibodies and their uses | |
| MX2010005830A (es) | Conjugado de anticuerpo monoclonal anti-b7h4 - farmaco y metodos de uso del mismo. | |
| NO20064866L (no) | IRTA-5 antistoffer og deres anvendelse | |
| MX2009006277A (es) | Anticuerpos humanos que se enlazan a cd70 y usos de los mismos. | |
| SG163554A1 (en) | Human monoclonal antibodies to programmed death ligand 1 (pd-l1) | |
| WO2006002438A3 (en) | Human monoclonal antibodies to fc gamma receptor i (cd64) | |
| EA201101242A1 (ru) | Полностью человеческие антитела, специфические для cadm1 | |
| NZ761636A (en) | Antigen binding proteins binding to 5t4 and 4-1bb and related compositions and methods | |
| MX2010001237A (es) | Nuevos anticuerpos. | |
| DE602005027399D1 (de) | Für humane matriptase spezifische bindungsproteine | |
| WO2008109533A3 (en) | Human antibodies that bind multiple irta family proteins, and uses thereof | |
| GEAP202416592A (en) | Anti-cd38 binding molecules and uses thereof | |
| WO2006116192A3 (en) | Irta-1 antibodies and their uses | |
| CY1113958T1 (el) | Ανθρωπινα μονοκλωνικα αντισωματα σε φουκοζυλ-gμ1 και μεθοδοι για τη χρηση αντι-φουκοζυλ-gμ1 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CHAD | Change of the owner's name or address (par. 44 patent law, par. patentforskriften) |
Owner name: MEDAREX LLC, US |
|
| CHAD | Change of the owner's name or address (par. 44 patent law, par. patentforskriften) |
Owner name: E.R. SQUIBB & SONS, US |
|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |