DK1854789T3 - Quinazolinderivat med tyrosin-kinase inhibitorisk aktivitet - Google Patents
Quinazolinderivat med tyrosin-kinase inhibitorisk aktivitetInfo
- Publication number
- DK1854789T3 DK1854789T3 DK06714265.3T DK06714265T DK1854789T3 DK 1854789 T3 DK1854789 T3 DK 1854789T3 DK 06714265 T DK06714265 T DK 06714265T DK 1854789 T3 DK1854789 T3 DK 1854789T3
- Authority
- DK
- Denmark
- Prior art keywords
- inhibitoric
- tyrosin
- kinase
- activity
- quinazoline derivatives
- Prior art date
Links
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical class N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005047383 | 2005-02-23 | ||
| JP2005156828 | 2005-05-30 | ||
| PCT/JP2006/303125 WO2006090717A1 (ja) | 2005-02-23 | 2006-02-22 | チロシンキナーゼ阻害作用を有するキナゾリン誘導体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1854789T3 true DK1854789T3 (da) | 2013-10-21 |
Family
ID=36927355
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK06714265.3T DK1854789T3 (da) | 2005-02-23 | 2006-02-22 | Quinazolinderivat med tyrosin-kinase inhibitorisk aktivitet |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US8202879B2 (da) |
| EP (1) | EP1854789B1 (da) |
| JP (1) | JP4137174B2 (da) |
| KR (1) | KR100910333B1 (da) |
| CN (1) | CN101163684B (da) |
| AU (1) | AU2006216266C1 (da) |
| BR (1) | BRPI0606905B1 (da) |
| CA (1) | CA2599328C (da) |
| DK (1) | DK1854789T3 (da) |
| ES (1) | ES2431843T3 (da) |
| NO (1) | NO343403B1 (da) |
| PL (1) | PL1854789T3 (da) |
| PT (1) | PT1854789E (da) |
| RU (1) | RU2414457C2 (da) |
| TW (1) | TWI372147B (da) |
| WO (1) | WO2006090717A1 (da) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100910333B1 (ko) * | 2005-02-23 | 2009-07-31 | 시오노기세이야쿠가부시키가이샤 | 타이로신 키나아제 억제 활성을 갖는 퀴나졸린 유도체 |
| CN101003514A (zh) * | 2006-01-20 | 2007-07-25 | 上海艾力斯医药科技有限公司 | 喹唑啉衍生物、其制备方法及用途 |
| US7547781B2 (en) * | 2006-09-11 | 2009-06-16 | Curis, Inc. | Quinazoline based EGFR inhibitors containing a zinc binding moiety |
| CN101535279B (zh) | 2006-09-11 | 2015-05-20 | 柯瑞斯公司 | 含锌结合基的喹唑啉基egfr抑制剂 |
| ES2646630T3 (es) | 2008-11-07 | 2017-12-14 | Massachusetts Institute Of Technology | Lipidoides aminoalcohólicos y usos de los mismos |
| TWI466872B (zh) * | 2008-12-25 | 2015-01-01 | Shionogi & Co | 喹唑啉衍生物之製造方法 |
| US9238716B2 (en) | 2011-03-28 | 2016-01-19 | Massachusetts Institute Of Technology | Conjugated lipomers and uses thereof |
| KR102451116B1 (ko) * | 2011-10-27 | 2022-10-06 | 메사추세츠 인스티튜트 오브 테크놀로지 | 약물 캡슐화 마이크로스피어를 형성할 수 있는, ｎ-말단 상에 관능화된 아미노산 유도체 |
| CN103288756B (zh) * | 2012-02-29 | 2016-04-20 | 江苏先声药物研究有限公司 | 一种喹唑啉中间体的甲醇溶剂合物及其制备方法 |
| JP6464139B2 (ja) | 2013-03-14 | 2019-02-06 | コンバージーン・リミテッド・ライアビリティ・カンパニーＣｏｎｖｅｒｇｅｎｅ Ｌｌｃ | ブロモドメイン含有タンパク質の阻害のための方法および組成物 |
| EP3150573A4 (en) * | 2014-05-29 | 2018-02-21 | Shionogi & Co., Ltd. | Method for producing alkynyl ketone derivative |
| PL3330267T3 (pl) * | 2015-07-29 | 2022-04-04 | Shionogi&Co., Ltd. | Sól pochodnej chinazoliny lub jej kryształ oraz sposób wytwarzania soli pochodnej chinazoliny lub jej kryształu |
| KR20180086187A (ko) | 2015-10-05 | 2018-07-30 | 더 트러스티이스 오브 콜롬비아 유니버시티 인 더 시티 오브 뉴욕 | 자가포식 유동의 활성체 및 포스포리파제 d 및 타우를 포함하는 단백질 응집물의 클리어런스 및 단백질질환의 치료 |
| CA3006300C (en) | 2015-11-25 | 2024-02-27 | Convergene Llc | Bicyclic bet bromodomain inhibitors and uses thereof |
| US20180030403A1 (en) | 2016-07-28 | 2018-02-01 | Bobban Subhadra | Devices, systems and methods for the production of humanized gut commensal microbiota |
| JP7191446B2 (ja) * | 2017-01-30 | 2022-12-19 | 塩野義製薬株式会社 | キナゾリン誘導体を含有する固形製剤 |
| EP4424379A3 (en) | 2019-04-24 | 2024-10-30 | Convergene Llc | Small molecule bromodomain inhibitors and uses thereof |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5409930A (en) | 1991-05-10 | 1995-04-25 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
| NZ243082A (en) | 1991-06-28 | 1995-02-24 | Ici Plc | 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof |
| AU661533B2 (en) | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
| GB9323290D0 (en) | 1992-12-10 | 1994-01-05 | Zeneca Ltd | Quinazoline derivatives |
| MX9707453A (es) * | 1995-03-30 | 1997-12-31 | Pfizer | Derivados de quinazolina. |
| GB9624482D0 (en) * | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| GB9603095D0 (en) | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
| ID19609A (id) | 1996-07-13 | 1998-07-23 | Glaxo Group Ltd | Senyawa-senyawa heterosiklik |
| KR20020032608A (ko) | 1999-09-21 | 2002-05-03 | 다비드 에 질레스 | 퀴나졸린 화합물 및 이를 함유하는 제약 조성물 |
| RU2276151C2 (ru) * | 2000-06-06 | 2006-05-10 | Астразенека Аб | Хиназолиновые производные для лечения опухолей |
| EP1369418B1 (en) | 2001-02-21 | 2010-07-28 | Mitsubishi Tanabe Pharma Corporation | Quinazoline derivatives |
| EP1578722A4 (en) | 2001-10-12 | 2006-09-06 | Irm Llc | KINASEINHIBITOR SCAFFOLD AND METHOD FOR THE PRODUCTION THEREOF |
| CA2497971A1 (en) * | 2002-09-18 | 2004-04-01 | Pfizer Products Inc. | Triazole derivatives as transforming growth factor (tgf) inhibitors |
| WO2004069145A2 (en) | 2003-02-07 | 2004-08-19 | Dr. Reddy's Laboratories Ltd. | Anticancer compounds, process for their preparation and pharmaceutical compositions containing them |
| PA8603801A1 (es) | 2003-05-27 | 2004-12-16 | Janssen Pharmaceutica Nv | Derivados de la quinazolina |
| JP2007537717A (ja) | 2004-01-07 | 2007-12-27 | ブリストル−マイヤーズ スクイブ カンパニー | 上皮増殖因子受容体モデュレーターに対する感受性を決定するためのバイオマーカーおよび方法 |
| US8017321B2 (en) | 2004-01-23 | 2011-09-13 | The Regents Of The University Of Colorado, A Body Corporate | Gefitinib sensitivity-related gene expression and products and methods related thereto |
| KR100910333B1 (ko) * | 2005-02-23 | 2009-07-31 | 시오노기세이야쿠가부시키가이샤 | 타이로신 키나아제 억제 활성을 갖는 퀴나졸린 유도체 |
-
2006
- 2006-02-22 KR KR1020077019256A patent/KR100910333B1/ko not_active Expired - Lifetime
- 2006-02-22 BR BRPI0606905-3A patent/BRPI0606905B1/pt active IP Right Grant
- 2006-02-22 EP EP06714265.3A patent/EP1854789B1/en not_active Expired - Lifetime
- 2006-02-22 JP JP2007504734A patent/JP4137174B2/ja not_active Expired - Lifetime
- 2006-02-22 AU AU2006216266A patent/AU2006216266C1/en not_active Expired
- 2006-02-22 WO PCT/JP2006/303125 patent/WO2006090717A1/ja not_active Ceased
- 2006-02-22 DK DK06714265.3T patent/DK1854789T3/da active
- 2006-02-22 ES ES06714265T patent/ES2431843T3/es not_active Expired - Lifetime
- 2006-02-22 US US11/884,819 patent/US8202879B2/en active Active
- 2006-02-22 RU RU2007135023/04A patent/RU2414457C2/ru active
- 2006-02-22 PT PT67142653T patent/PT1854789E/pt unknown
- 2006-02-22 PL PL06714265T patent/PL1854789T3/pl unknown
- 2006-02-22 CN CN2006800136753A patent/CN101163684B/zh not_active Expired - Lifetime
- 2006-02-22 CA CA2599328A patent/CA2599328C/en not_active Expired - Lifetime
- 2006-02-23 TW TW095106013A patent/TWI372147B/zh active
-
2007
- 2007-08-23 NO NO20074311A patent/NO343403B1/no unknown
-
2012
- 2012-01-26 US US13/359,326 patent/US8349857B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU2006216266B2 (en) | 2010-02-18 |
| JPWO2006090717A1 (ja) | 2008-07-24 |
| RU2414457C2 (ru) | 2011-03-20 |
| NO20074311L (no) | 2007-11-23 |
| NO343403B1 (no) | 2019-02-25 |
| TWI372147B (en) | 2012-09-11 |
| EP1854789A4 (en) | 2009-06-17 |
| KR100910333B1 (ko) | 2009-07-31 |
| TW200640880A (en) | 2006-12-01 |
| EP1854789A1 (en) | 2007-11-14 |
| RU2007135023A (ru) | 2009-03-27 |
| BRPI0606905A2 (pt) | 2009-07-28 |
| US8202879B2 (en) | 2012-06-19 |
| CN101163684B (zh) | 2012-08-29 |
| AU2006216266C1 (en) | 2010-08-26 |
| EP1854789B1 (en) | 2013-10-09 |
| BRPI0606905B1 (pt) | 2021-06-01 |
| JP4137174B2 (ja) | 2008-08-20 |
| PT1854789E (pt) | 2013-10-23 |
| US20120123114A1 (en) | 2012-05-17 |
| US8349857B2 (en) | 2013-01-08 |
| PL1854789T3 (pl) | 2014-03-31 |
| AU2006216266A8 (en) | 2009-04-02 |
| CN101163684A (zh) | 2008-04-16 |
| AU2006216266A1 (en) | 2006-08-31 |
| CA2599328C (en) | 2012-04-17 |
| US20090143414A1 (en) | 2009-06-04 |
| KR20070098941A (ko) | 2007-10-05 |
| WO2006090717A1 (ja) | 2006-08-31 |
| ES2431843T3 (es) | 2013-11-28 |
| AU2006216266A2 (en) | 2006-08-31 |
| CA2599328A1 (en) | 2006-08-31 |
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